Binding of the adenomatous polyposis coli protein to microtubules increases microtubule stability and is regulated by GSK3β phosphorylation

Current Biology

Volumn 11, Issue 1, 2001, Pages 44-49

  Zumbrunn, Jürg ^a   Kinoshita, Kazuhisa ^b   Hyman, Anthony A ^b   Näthke, Inke S ^a  

^a UNIVERSITY OF DUNDEE   (United Kingdom)

^b EUROPEAN MOLECULAR BIOLOGY LABORATORY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 0035176077     PISSN: 09609822     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-9822(01)00002-1     Document Type: Article

References (19)

1. Adenomatous Polyposis Coli (APC) protein moves along microtubules and concentrates at their growing ends in epithelial cells
2. The adenomatous polyposis coli tumor suppressor protein localizes to plasma membrane sites involved in active cell migration
3. Mutations in the APC gene and their implications for protein structure and function
4. The adenomatous polyposis coli (APC) tumor suppressor
5. The APC gene product associates with microtubules in vivo and promotes their assembly in vitro
6. Wild-type but not mutant APC associates with the microtubule cytoskeleton
7. A domain within the tumor suppressor protein APC shows very similar biochemical properties as the microtubule-associated protein tau
8. Mechanism of the single-headed processivity: Diffusional anchoring between the K-loop of kinesin and the C terminus of tubulin
9. Functional interaction of an axin homolog, conductin, with beta-catenin, APC, and GSK3beta
10. Biochemical interactions in the wnt pathway
11. Downregulation of β-catenin by human axin and its association with the APC tumor suppressor, β-catenin and GSK3β
12. GSK-3beta-dependent phosphorylation of adenomatous polyposis coli gene product can be modulated by beta-catenin and protein phosphatase 2A, complexed with Axin
13. Regulation and function of the interaction between the APC tumour suppressor protein and EB1
14. The dynamic behavior of the APC-binding protein EB1 on the distal ends of microtubules
15. Binding of GSK3beta to the APC-beta-catenin complex and regulation of complex assembly
16. Preparations of modified tubulins
17. Distinct roles of PP1 and PP2A-like phosphatases in control of microtubule dynamics during mitosis
18. Dynamics of cadherin/catenin complex formation: Novel protein interactions and pathways of complex assembly