ROCK inhibition and CNTF interact on intrinsic signalling pathways and differentially regulate survival and regeneration in retinal ganglion cells

Brain

Volumn 131, Issue 1, 2008, Pages 250-263

  Lingor, Paul ^a,b   Tönges, Lars ^a   Pieper, Nicole ^a   Bermel, Christina ^a   Barski, Elisabeth ^a,b   Planchamp, Veronique ^a,c   Bähr, Mathias ^a,b  

^a UNIVERSITY OF GÖTTINGEN   (Germany)

^b Deutsche Forschungsgemeinschaft   (Germany)

^c European Research Training Network (RTN) 'Nervous System Repair'

Author keywords

Axotomy; CNTF; Regeneration; Retinal ganglion cells; Rho kinase

Indexed keywords

4 (1 AMINOETHYL) N (4 PYRIDYL)CYCLOHEXANECARBOXAMIDE; CILIARY NEUROTROPHIC FACTOR; MITOGEN ACTIVATED PROTEIN KINASE; NEUROTROPHIC FACTOR; PROTEIN KINASE B; RHO KINASE; STAT3 PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL REGENERATION; CELL SURVIVAL; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; FEMALE; NERVE FIBER GROWTH; NERVE FIBER TRANSECTION; NONHUMAN; OPTIC NERVE INJURY; PRIORITY JOURNAL; PROTEIN INTERACTION; PROTEIN PHOSPHORYLATION; RAT; RETINA GANGLION CELL;

AMIDES; ANIMALS; CELL SIZE; CELL SURVIVAL; CELLS, CULTURED; CILIARY NEUROTROPHIC FACTOR; DRUG SYNERGISM; ENZYME INHIBITORS; FEMALE; HUMANS; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; NERVE CRUSH; NERVE REGENERATION; NEURITES; OPTIC NERVE; PROTO-ONCOGENE PROTEINS C-AKT; PYRIDINES; RATS; RATS, WISTAR; RETINA; RETINAL GANGLION CELLS; RHO-ASSOCIATED KINASES; SIGNAL TRANSDUCTION; STAT3 TRANSCRIPTION FACTOR; UP-REGULATION;

EID: 37549015155     PISSN: 00068950     EISSN: 14602156     Source Type: Journal    
DOI: 10.1093/brain/awm284     Document Type: Article

References (42)

1. Avwenagha O, Campbell G, Bird MM. The outgrowth response of the axons of developing and regenerating rat retinal ganglion cells in vitro to neurotrophin treatment. J Neurocytol 2003; 32: 1055-75.
2. Bahr M. Live or let die - retinal ganglion cell death and survival during development and in the lesioned adult CNS. Trends Neurosci 2000; 23: 483-90.
3. Barres BA, Silverstein BE, Corey DP, Chun LL. Immunological, morphological, and electrophysiological variation among retinal ganglion cells purified by panning. Neuron 1988; 1: 791-803.
4. Benson MD, Romero MI, Lush ME, Lu QR, Henkemeyer M, Parada LF. Ephrin-B3 is a myelin-based inhibitor of neurite outgrowth. Proc Natl Acad Sci USA 2005; 102: 10694-9.
5. Berkelaar M, Clarke DB, Wang YC, Bray GM, Aguayo AJ. Axotomy results in delayed death and apoptosis of retinal ganglion cells in adult rats. J Neurosci 1994; 14: 4368-74.
6. Bertrand J, Winton MJ, Rodriguez-Hernandez N, Campenot RB, McKerracher L. Application of Rho antagonist to neuronal cell bodies promotes neurite growth in compartmented cultures and regeneration of retinal ganglion cell axons in the optic nerve of adult rats. J Neurosci 2005; 25: 1113-21.
7. Broude E, McAtee M, Kelley MS, Bregman BS. c-Jun expression in adult rat dorsal root ganglion neurons: differential response after central or peripheral axotomy. Exp Neurol 1997; 148: 367-77.
8. Chierzi S, Ratto GM, Verma P, Fawcett JW. The ability of axons to regenerate their growth cones depends on axonal type and age, and is regulated by calcium, cAMP and ERK. Eur J Neurosci 2005; 21: 2051-62.
9. Choi BH, Hur EM, Lee JH, Jun DJ, Kim KT. Protein kinase Cdelta-mediated proteasomal degradation of MAP kinase phosphatase-1 contributes to glutamate-induced neuronal cell death. J Cell Sci 2006; 119: 1329-40.
10. Cui Q, Harvey AR. CNTF promotes the regrowth of retinal ganglion cell axons into murine peripheral nerve grafts. Neuroreport 2000; 11: 3999-4002.
11. Cui Q, Yip HK, Zhao RC, So KF, Harvey AR. Intraocular elevation of cyclic AMP potentiates ciliary neurotrophic factor-induced regeneration of adult rat retinal ganglion cell axons. Mol Cell Neurosci 2003; 22: 49-61.
12. Debidda M, Wang L, Zang H, Poli V, Zheng Y. A role of STAT3 in Rho GTPase-regulated cell migration and proliferation. J Biol Chem 2005; 280: 17275-85.
13. Dubreuil CI, Winton MJ, McKerracher L. Rho activation patterns after spinal cord injury and the role of activated Rho in apoptosis in the central nervous system. J Cell Biol 2003; 162: 233-43.
14. Fawcett JW. Overcoming inhibition in the damaged spinal cord. J Neurotrauma 2006; 23: 371-83.
15. Fischer D, Petkova V, Thanos S, Benowitz LI. Switching mature retinal ganglion cells to a robust growth state in vivo: gene expression and synergy with RhoA inactivation. J Neurosci 2004; 24: 8726-40.
16. Fu X, Gong MC, Jia T, Somlyo AV, Somlyo AP. The effects of the Rho-kinase inhibitor Y-27632 on arachidonic acid-, GTPgammaS-, and phorbol ester-induced Ca2+-sensitization of smooth muscle. FEBS Lett 1998; 440: 183-7.
17. Goldshmit Y, Galea MP, Wise G, Bartlett PF, Turnley AM. Axonal regeneration and lack of astrocytic gliosis in EphA4-deficient mice. J Neurosci 2004; 24: 10064-73.
18. Gupta R, Rummler LS, Palispis W, Truong L, Chao T, Rowshan K, et al. Local down-regulation of myelin-associated glycoprotein permits axonal sprouting with chronic nerve compression injury. Exp Neurol 2006; 200: 418-29.
19. Hull M, Bahr M. Regulation of immediate-early gene expression in rat retinal ganglion cells after axotomy and during regeneration through a peripheral nerve graft. J Neurobiol 1994; 25: 92-105.
20. Ip NY, McClain J, Barrezueta NX, Aldrich TH, Pan L, Li Y, et al. The alpha component of the CNTF receptor is required for signaling and defines potential CNTF targets in the adult and during development. Neuron 1993; 10: 89-102.
21. Ji JZ, Elyaman W, Yip HK, Lee VW, Yick LW, Hugon J, et al. CNTF promotes survival of retinal ganglion cells after induction of ocular hypertension in rats: the possible involvement of STAT3 pathway. Eur J Neurosci 2004; 19: 265-72.
22. Kretz A, Happold CJ, Marticke JK, Isenmann S. Erythropoietin promotes regeneration of adult CNS neurons via Jak2/Stat3 and PI3K/AKT pathway activation. Mol Cell Neurosci 2005; 29: 569-79.
23. Krishnamoorthy RR, Agarwal P, Prasanna G, Vopat K, Lambert W, Sheedlo HJ, et al. Characterization of a transformed rat retinal ganglion cell line. Brain Res Mol Brain Res 2001; 86: 1-12.
24. Lai A, Frishman WH. Rho-kinase inhibition in the therapy of cardiovascular disease. Cardiol Rev 2005; 13: 285-92.
25. Lingor P, Koeberle P, Kugler S, Bahr M. Down-regulation of apoptosis mediators by RNAi inhibits axotomy-induced retinal ganglion cell death in vivo. Brain 2005; 128: 550-8.
26. Lingor P, Teusch N, Schwarz K, Mueller R, Mack H, Bähr M, et al. Inhibition of Rho kinase (ROCK) increases neurite outgrowth on CSPG in vitro and axonal regeneration in the adult optic nerve in vivo. J Neurochem 2007; 103: 181-9.
27. Maier K, Rau CR, Storch MK, Sattler MB, Demmer I, Weissert R, et al. Ciliary neurotrophic factor protects retinal ganglion cells from secondary cell death during acute autoimmune optic neuritis in rats. Brain Pathol 2004; 14: 378-87.
28. Mey J, Thanos S. Intravitreal injections of neurotrophic factors support the survival of axotomized retinal ganglion cells in adult rats in vivo. Brain Res 1993; 602: 304-17.
29. Meyer-Franke A, Kaplan MR, Pfrieger FW, Barres BA. Characterization of the signaling interactions that promote the survival and growth of developing retinal ganglion cells in culture. Neuron 1995; 15: 805-19.
30. Pasterkamp RJ, Giger RJ, Verhaagen J. Regulation of semaphorin III/collapsin-1 gene expression during peripheral nerve regeneration. Exp Neurol 1998; 153: 313-27.
31. Peterson WM, Wang Q, Tzekova R, Wiegand SJ. Ciliary neurotrophic factor and stress stimuli activate the Jak-STAT pathway in retinal neurons and glia. J Neurosci 2000; 20: 4081-90.
32. Pot C, Simonen M, Weinmann O, Schnell L, Christ F, Stoeckle S, et al. Nogo-A expressed in Schwann cells impairs axonal regeneration after peripheral nerve injury. J Cell Biol 2002; 159: 29-35.
33. Ridley AJ. Rho GTPases and actin dynamics in membrane protrusions and vesicle trafficking. Trends Cell Biol 2006; 16: 522-9.
34. Rios-Munoz W, Soto I, Duprey-Diaz MV, Blagburn J, Blanco RE. Fibroblast growth factor 2 applied to the optic nerve after axotomy increases Bcl-2 and decreases Bax in ganglion cells by activating the extracellular signal-regulated kinase signaling pathway. J Neurochem 2005; 93: 1422-33.
35. Schaden H, Stuermer CA, Bahr M. GAP-43 immunoreactivity and axon regeneration in retinal ganglion cells of the rat. J Neurobiol 1994; 25: 1570-8.
36. Schreyer DJ, Skene JH. Injury-associated induction of GAP-43 expression displays axon branch specificity in rat dorsal root ganglion neurons. J Neurobiol 1993; 24: 959-70.
37. Seigel GM, Notter MF. Lectin-induced differentiation of transformed neuroretinal cells in vitro. Exp Cell Res 1992; 199: 240-7.
38. Shirao S, Kashiwagi S, Sato M, Miwa S, Nakao F, Kurokawa T, et al. Sphingosylphosphorylcholine is a novel messenger for Rho-kinase-mediated Ca2+ sensitization in the bovine cerebral artery: unimportant role for protein kinase C. Circ Res 2002; 91: 112-9.
39. Tanabe K, Tachibana T, Yamashita T, Che YH, Yoneda Y, Ochi T, et al. The small GTP-binding protein TC10 promotes nerve elongation in neuronal cells, and its expression is induced during nerve regeneration in rats. J Neurosci 2000; 20: 4138-44.
40. Thanos S, Naskar R, Heiduschka P. Regenerating ganglion cell axons in the adult rat establish retinofugal topography and restore visual function. Exp Brain Res 1997; 114: 483-91.
41. Verma P, Chierzi S, Codd AM, Campbell DS, Meyer RL, Holt CE, et al. Axonal protein synthesis and degradation are necessary for efficient growth cone regeneration. J Neurosci 2005; 25: 331-42.
42. Wettschureck N, Offermanns S. Rho/Rho-kinase mediated signaling in physiology and pathophysiology. J Mol Med 2002; 80: 629-38.