KLF family members regulate intrinsic axon regeneration ability

Science

Volumn 326, Issue 5950, 2009, Pages 298-301

  Moore, Darde L ^a,b   Blackmore, Murray G ^c   Hu, Ying ^a   Kaestner, Klaus H ^d   Bixby, John L ^b,c   Lemmon, Vance P ^b,c   Goldberg, Jeffrey L ^a,b  

^a UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF MIAMI   (United States)

^d UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

KRUPPEL LIKE FACTOR 4;

CYTOLOGY; DEVELOPMENTAL BIOLOGY; GENE EXPRESSION; GENETIC ANALYSIS; GROWTH RATE; NERVOUS SYSTEM;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; DOWN REGULATION; GENE EXPRESSION REGULATION; GENE FUNCTION; MOUSE; NERVE FIBER GROWTH; NERVE FIBER REGENERATION; NONHUMAN; OPTIC NERVE INJURY; PERINATAL PERIOD; PRIORITY JOURNAL; RAT; RETINA GANGLION CELL; TRANSCRIPTION REGULATION; UPREGULATION;

ANIMALS; AXONS; CELL COUNT; CELL SURVIVAL; CELLS, CULTURED; DOWN-REGULATION; GENE KNOCKOUT TECHNIQUES; GROWTH CONES; HIPPOCAMPUS; KRUPPEL-LIKE TRANSCRIPTION FACTORS; MICE; NERVE CRUSH; NERVE REGENERATION; NEURITES; NEURONS; OPTIC NERVE INJURIES; RATS; RETINAL GANGLION CELLS; TRANSCRIPTION, GENETIC; TRANSFECTION; UP-REGULATION;

EID: 70349884323     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1175737     Document Type: Article

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41. This work was funded by a National Eye Institute (NEI) R03 grant (EY016790, J.L.G.) and subsequently by a National Institute of Neurological Disorders and Stroke (NINDS) R01 grant (NS061348, J.LG.) and critical funding from The Glaucoma Foundation and the Seigal Foundation (J.L.G.), the C. H. Neilsen Foundation (V.P.L. and J.L.G.), the Ralph Wilson Medical Research Foundation and the W.G. Ross Foundation (V.P.L), The Buoniconti Fund to Cure Paralysis (V.P.L. and J.L.B.), an NEI P30 grant (EY014801), and an unrestricted grant from Research to Prevent Blindness to the University of Miami. D.L.M. is a Lois Pope LIFE Fellow, with support from NINDS training grants T32 NS07492 and T32 NS007459. We are indebted for generous gifts of FLAG-tagged KLF4 (C. Liu, University of Texas), mCherry (R. Tsien, University of California, San Diego), and KLF2 constructs (J. Lingrel, University of Cincinnati). We are grateful to W. Feuer (University of Miami) for statistical contributions and to R. Corredor (University of Miami) for optimizing RGC electroporation. We thank the following lab members and collaborators for their meaningful contributions: Ne. Patel, Ni. Patel, J. Gallardo, N. Sharifai, E. Walford, M. Velarde, A. Sloan, M. Benny, A. Oliva, Y. Shi, E. Hernandez, G. Lambert, and G. Gaidosh. The authors declare they have no conflicts of interest.