Expressing constitutively active rheb in adult neurons after a complete spinal cord injury enhances axonal regeneration beyond a chondroitinase-treated glial scar

Journal of Neuroscience

Volumn 35, Issue 31, 2015, Pages 11068-11080

  Wu, Di ^a   Klaw, Michelle C ^a   Connors, Theresa ^a   Kholodilov, Nikolai ^b   Burke, Robert E ^b   Tom, Veronica J ^a  

^a DREXEL UNIVERSITY COLLEGE OF MEDICINE   (United States)

^b Department of Medicine   (United States)

Author keywords

Axon regeneration; Chondroitinase; Glial scar; Rheb; Spinal cord injury; Transplantation

Indexed keywords

CHONDROITIN ABC LYASE; CYCLOSPORIN A; FLUOROGOLD; GREEN FLUORESCENT PROTEIN; MAMMALIAN TARGET OF RAPAMYCIN; NEUROMODULIN; PARVOVIRUS VECTOR; RHEB PROTEIN; S6 KINASE; SYNAPTOPHYSIN; VESICULAR GLUTAMATE TRANSPORTER 2; MONOMERIC GUANINE NUCLEOTIDE BINDING PROTEIN; NEUROPEPTIDE; RHEB PROTEIN, RAT;

ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONFOCAL MICROSCOPY; CONTROLLED STUDY; DOWN REGULATION; FEMALE; GENETIC TRANSFECTION; HISTOLOGY; IMMUNOHISTOCHEMISTRY; INJECTION; LAMINECTOMY; MYELINATION; NERVE FIBER GROWTH; NERVE FIBER REGENERATION; NERVE GRAFT; NERVE POTENTIAL; NERVE SPROUTING; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT; SCAR; SPINAL CORD INJURY; SYNAPSE; ANIMAL; CICATRIX; DISEASE MODEL; DRUG EFFECTS; GENETICS; GLIA; NERVE CELL; NERVE FIBER; NERVE REGENERATION; PHYSIOLOGY; SPINAL CORD INJURIES; TREATMENT OUTCOME; WISTAR RAT;

ANIMALS; AXONS; CHONDROITIN ABC LYASE; CICATRIX; DISEASE MODELS, ANIMAL; FEMALE; MONOMERIC GTP-BINDING PROTEINS; NERVE REGENERATION; NEUROGLIA; NEURONS; NEUROPEPTIDES; RATS; RATS, WISTAR; SPINAL CORD INJURIES; TREATMENT OUTCOME;

EID: 84938767959     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.0719-15.2015     Document Type: Article

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