Injured adult retinal axons with Pten and Socs3 co-deletion reform active synapses with suprachiasmatic neurons

Neurobiology of Disease

Volumn 73, Issue , 2015, Pages 366-376

  Li, Songshan ^a   He, Qinghai ^a   Wang, Hao ^b   Tang, Xuming ^a   Ho, Kam Wing ^b   Gao, Xin ^a   Zhang, Qian ^a   Shen, Yang ^a   Cheung, Annie ^a   Wong, Francis ^a   Wong, Yung Hou ^a   Ip, Nancy Y ^a   Jiang, Liwen ^b   Yung, Wing Ho ^b   Liu, Kai ^a  

^a HONG KONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Hong Kong)

^b and Hong Kong Branch of CAS Center for Excellence in Animal Evolution and Genetics   (Hong Kong)

Author keywords

Axon regeneration and rewiring; Intrinsic mechanisms; Pre chiasm lesion; Retinal ganglion cells; Suprachiasmatic nucleus

Indexed keywords

PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN C FOS; SUPPRESSOR OF CYTOKINE SIGNALING 3; PTEN PROTEIN, MOUSE; SOCS3 PROTEIN, MOUSE; SUPPRESSOR OF CYTOKINE SIGNALING;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL MATURATION; CONTROLLED STUDY; EVOKED RESPONSE; GENE DELETION; IMMUNOFLUORESCENCE; INNERVATION; MOUSE; NERVE CELL DIFFERENTIATION; NERVE CELL NETWORK; NERVE CELL STIMULATION; NERVE CRUSH; NERVE FIBER REGENERATION; NONHUMAN; OPTIC CHIASM; OPTIC NERVE INJURY; PHOTOSTIMULATION; PTEN GENE; QUANTITATIVE ANALYSIS; RETINA GANGLION CELL; SOCS3 GENE; SUPRACHIASMATIC NUCLEUS; TRANSMISSION ELECTRON MICROSCOPY; ANIMAL; AXON; C57BL MOUSE; GENETICS; HYPOTHALAMUS; NERVE REGENERATION; OPTIC NERVE; PATHOLOGY; PHYSIOLOGY; SYNAPSE; TRANSGENIC MOUSE;

ANIMALS; AXONS; HYPOTHALAMUS; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; NERVE REGENERATION; OPTIC NERVE; PTEN PHOSPHOHYDROLASE; RETINAL GANGLION CELLS; SUPPRESSOR OF CYTOKINE SIGNALING PROTEINS; SUPRACHIASMATIC NUCLEUS; SYNAPSES;

EID: 84909960038     PISSN: 09699961     EISSN: 1095953X     Source Type: Journal    
DOI: 10.1016/j.nbd.2014.09.019     Document Type: Article

References (38)

1. Aguayo A.J., et al. Influences of the glial environment on the elongation of axons after injury: transplantation studies in adult rodents. J. Exp. Biol. 1981, 95:231-240.
2. Alto L.T., et al. Chemotropic guidance facilitates axonal regeneration and synapse formation after spinal cord injury. Nat. Neurosci. 2009, 12:1106-1113.
3. Beazley L.D., et al. Training on a visual task improves the outcome of optic nerve regeneration. J. Neurotrauma 2003, 20:1263-1270.
4. Berson D.M., et al. Phototransduction by retinal ganglion cells that set the circadian clock. Science 2002, 295:1070-1073.
5. Bradke F., et al. Assembly of a new growth cone after axotomy: the precursor to axon regeneration. Nat. Rev. Neurosci. 2012, 13:183-193.
6. Carter D.A., et al. Regenerated retinal ganglion cell axons can form well-differentiated synapses in the superior colliculus of adult hamsters. J. Neurosci. 1989, 9:4042-4050.
7. Dani A., et al. Superresolution imaging of chemical synapses in the brain. Neuron 2010, 68:843-856.
8. de Lima S., et al. Full-length axon regeneration in the adult mouse optic nerve and partial recovery of simple visual behaviors. Proc. Natl. Acad. Sci. U. S. A. 2012, 109:9149-9154.
9. Dickendesher T.L., et al. NgR1 and NgR3 are receptors for chondroitin sulfate proteoglycans. Nat. Neurosci. 2013, 15:703-712.
10. Feng D., et al. Stepping into the third dimension. J. Neurosci. 2007, 27:12757-12760.
11. Filbin M.T. Recapitulate development to promote axonal regeneration: good or bad approach?. Philos. Trans. R. Soc. Lond. B Biol. Sci. 2006, 361:1565-1574.
12. Fujiyama F., et al. Changes of immunocytochemical localization of vesicular glutamate transporters in the rat visual system after the retinofugal denervation. J. Comp. Neurol. 2003, 465:234-249.
13. Giger R.J., et al. Guidance molecules in axon regeneration. Cold Spring Harb. Perspect. Biol. 2010, 2:a001867.
14. Harel N.Y., Strittmatter S.M. Can regenerating axons recapitulate developmental guidance during recovery from spinal cord injury?. Nat. Rev. Neurosci. 2006, 7:603-616.
15. Hattar S., et al. Melanopsin-containing retinal ganglion cells: architecture, projections, and intrinsic photosensitivity. Science 2002, 295:1065-1070.
16. Hooks B.M., Chen C. Distinct roles for spontaneous and visual activity in remodeling of the retinogeniculate synapse. Neuron 2006, 52:281-291.
17. Jiao J., et al. Bcl-2 enhances Ca(2+) signaling to support the intrinsic regenerative capacity of CNS axons. EMBO J. 2005, 24:1068-1078.
18. Keirstead S.A., et al. Electrophysiologic responses in hamster superior colliculus evoked by regenerating retinal axons. Science 1989, 246:255-257.
19. Kornhauser J.M., et al. Photic and circadian regulation of c-fos gene expression in the hamster suprachiasmatic nucleus. Neuron 1990, 5:127-134.
20. Leon S., et al. Lens injury stimulates axon regeneration in the mature rat optic nerve. J. Neurosci. 2000, 20:4615-4626.
21. Liu K., et al. PTEN deletion enhances the regenerative ability of adult corticospinal neurons. Nat. Neurosci. 2010, 13:1075-1081.
22. Liu K., et al. Neuronal intrinsic mechanisms of axon regeneration. Annu. Rev. Neurosci. 2011, 34:131-152.
23. Luo X., et al. Three-dimensional evaluation of retinal ganglion cell axon regeneration and pathfinding in whole mouse tissue after injury. Exp. Neurol. 2013, 247:653-662.
24. Mohawk J.A., et al. Central and peripheral circadian clocks in mammals. Annu. Rev. Neurosci. 2012, 35:445-462.
25. Moldavan M.G., Allen C.N. Retinohypothalamic tract synapses in the rat suprachiasmatic nucleus demonstrate short-term synaptic plasticity. J. Neurophysiol. 2010, 103:2390-2399.
26. Moore D.L., et al. KLF family members regulate intrinsic axon regeneration ability. Science 2009, 326:298-301.
27. Park K.K., et al. Promoting axon regeneration in the adult CNS by modulation of the PTEN/mTOR pathway. Science 2008, 322:963-966.
28. Petros T.J., et al. Retinal axon growth at the optic chiasm: to cross or not to cross. Annu. Rev. Neurosci. 2008, 31:295-315.
29. Pickard G.E., et al. Intravitreal injection of the attenuated pseudorabies virus PRV Bartha results in infection of the hamster suprachiasmatic nucleus only by retrograde transsynaptic transport via autonomic circuits. J. Neurosci. 2002, 22:2701-2710.
30. Schmidt J.T. Formation of retinotopic connections: selective stabilization by an activity-dependent mechanism. Cell. Mol. Neurobiol. 1985, 5:65-84.
31. Schmidt T.M., et al. Intrinsically photosensitive retinal ganglion cells: many subtypes, diverse functions. Trends Neurosci. 2011, 34:572-580.
32. Schwab M.E., Bartholdi D. Degeneration and regeneration of axons in the lesioned spinal cord. Physiol. Rev. 1996, 76:319-370.
33. Smith P.D., et al. SOCS3 deletion promotes optic nerve regeneration in vivo. Neuron 2009, 64:617-623.
34. Sun F., et al. Sustained axon regeneration induced by co-deletion of PTEN and SOCS3. Nature 2011, 480:372-375.
35. Tse Y.C., et al. Identification of multivesicular bodies as prevacuolar compartments in Nicotiana tabacum BY-2 cells. Plant Cell 2004, 16:672-693.
36. Winzeler A.M., et al. The lipid sulfatide is a novel myelin-associated inhibitor of CNS axon outgrowth. J. Neurosci. 2011, 31:6481-6492.
37. Zeng B.Y., et al. Regenerative and other responses to injury in the retinal stump of the optic nerve in adult albino rats: transection of the intracranial optic nerve. J. Anat. 1995, 186(Pt 3):495-508.
38. Zheng B., et al. Genetic mouse models for studying inhibitors of spinal axon regeneration. Trends Neurosci. 2006, 29:640-646.