Gene-silencing screen for mammalian axon regeneration identifies Inpp5f (Sac2) as an endogenous suppressor of repair after spinal cord injury

Journal of Neuroscience

Volumn 35, Issue 29, 2015, Pages 10429-10439

  Zou, Yixiao ^a   Stagi, Massimiliano ^a   Wang, Xingxing ^a   Yigitkanli, Kazim ^a   Siegel, Chad S ^a   Nakatsu, Fubito ^a   Cafferty, William B J ^a   Strittmatter, Stephen M ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Axon regeneration; Inositol phosphate; Sac2; siRNA; Spinal cord injury

Indexed keywords

MESSENGER RNA; PHOSPHATIDYLINOSITOL 3, 4, 5 TRISPHOSPHATE 3 PHOSPHATASE; RAPAMYCIN; SHORT HAIRPIN RNA; SYNAPTOJANIN; UNCLASSIFIED DRUG; INOSITOL-POLYPHOSPHATE 5-PHOSPHATASE; PHOSPHATASE;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DNA EXTRACTION; EMBRYO; EXPERIMENTAL BEHAVIORAL TEST; FEMALE; GENE SILENCING; HIGH THROUGHPUT SEQUENCING; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MALE; MOUSE; NERVE FIBER REGENERATION; NONHUMAN; PRIORITY JOURNAL; PYRAMIDAL TRACT; RNA INTERFERENCE; SEROTONINERGIC NERVE CELL; SPINAL CORD INJURY; ANIMAL; C57BL MOUSE; CONVALESCENCE; DEFICIENCY; DISEASE MODEL; GENETICS; KNOCKOUT MOUSE; METABOLISM; NERVE FIBER; NERVE REGENERATION; PATHOLOGY; PHYSIOLOGY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ANIMALS; AXONS; DISEASE MODELS, ANIMAL; GENE KNOCKDOWN TECHNIQUES; IMMUNOHISTOCHEMISTRY; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; NERVE REGENERATION; PHOSPHORIC MONOESTER HYDROLASES; RECOVERY OF FUNCTION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SPINAL CORD INJURIES;

EID: 84937683329     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.1718-15.2015     Document Type: Article

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