The pro-survival pathways of mTOR and protein kinase B target glycogen synthase kinase-3β and nuclear factor-κB to foster endogenous microglial cell protection

International Journal of Molecular Medicine

Volumn 19, Issue 2, 2007, Pages 263-272

  Chong, Zhao Zhong ^a   Li, Faqi ^a   Maiese, Kenneth ^a  

^a WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Akt1; Apoptosis; Gene silencing; GSK 3 ; Inflammation; Macrophage; Microglia; NF B; Oxidative stress; Oxygen glucose deprivation; Phosphatidylserine; Protein kinase B; siRNA

Indexed keywords

DNA FRAGMENT; GLUCOSE; GLYCOGEN SYNTHASE KINASE 3; GLYCOGEN SYNTHASE KINASE 3 BETA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MAMMALIAN TARGET OF RAPAMYCIN; OXYGEN; PHOSPHATIDYLSERINE; PROTEIN KINASE; PROTEIN KINASE B; PROTEIN KINASE INHIBITOR; PROTEIN SUBUNIT; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

ANIMAL; ARTICLE; CELL CULTURE; CELL MEMBRANE; CELL PROTECTION; CELL SURVIVAL; CHEMISTRY; CYTOLOGY; CYTOSOL; DRUG ANTAGONISM; DRUG EFFECT; ENZYME ACTIVATION; GENETICS; GLIA; METABOLISM; PROTEIN TRANSPORT; RAT; SIGNAL TRANSDUCTION;

ANIMALS; CELL MEMBRANE; CELL SURVIVAL; CELLS, CULTURED; CYTOPROTECTION; CYTOSOL; DNA FRAGMENTATION; ENZYME ACTIVATION; GLUCOSE; GLYCOGEN SYNTHASE KINASE 3; NEUROGLIA; NF-KAPPA B; OXYGEN; PHOSPHATIDYLSERINES; PROTEIN KINASE INHIBITORS; PROTEIN KINASES; PROTEIN SUBUNITS; PROTEIN TRANSPORT; PROTO-ONCOGENE PROTEINS C-AKT; RATS; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION;

EID: 33847797307     PISSN: 11073756     EISSN: 1791244X     Source Type: Journal    
DOI: 10.3892/ijmm.19.2.263     Document Type: Article

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