메뉴 건너뛰기




Volumn 63, Issue 2, 2015, Pages 95-105

mTOR pathway - novel modulator of astrocyte activity

Author keywords

Astrocytes; Central nervous system; mTOR; Rapamycin

Indexed keywords

MAMMALIA;

EID: 84937061525     PISSN: 00155497     EISSN: 17349168     Source Type: Journal    
DOI: 10.3409/fb63_2.95     Document Type: Review
Times cited : (14)

References (137)
  • 1
    • 29244463365 scopus 로고    scopus 로고
    • Astrocyteendothelial interactions at the blood-brain barrier
    • ABBOTT N.J, RONNBACK L., HANSSON E. 2006. Astrocyteendothelial interactions at the blood-brain barrier. Nat. Rev. Neurosci. 7: 41-53.
    • (2006) Nat. Rev. Neurosci. , vol.7 , pp. 41-53
    • Abbott, N.J.1    Ronnback, L.2    Hansson, E.3
  • 4
    • 0041343303 scopus 로고    scopus 로고
    • Upregulation of phosphorylated/activated p70 S6 kinase and its relationship to neurofibrillary pathology in Alzheimer's disease
    • AN W.L., COWBURN R.F., LI L., BRAAK H., ALAFUZOFF I., IQBAL K., IQBAL G., WIINBLAND B., PEI J.J. 2003. Upregulation of phosphorylated/activated p70 S6 kinase and its relationship to neurofibrillary pathology in Alzheimer's disease. Am. J. Pathol. 163: 591-607.
    • (2003) Am. J. Pathol. , vol.163 , pp. 591-607
    • An, W.L.1    Cowburn, R.F.2    Li, L.3    Braak, H.4    Alafuzoff, I.5    Iqbal, K.6    Iqbal, G.7    Wiinbland, B.8    Pei, J.J.9
  • 9
    • 2342471420 scopus 로고    scopus 로고
    • The bloodbrain barrier: an overview: structure, regulation, and clinical implications
    • BALLABH P., BRAUN A., NEDERGAARD M. 2004. The bloodbrain barrier: an overview: structure, regulation, and clinical implications. Neurobiol. Dis. 16: 1-13.
    • (2004) Neurobiol. Dis. , vol.16 , pp. 1-13
    • Ballabh, P.1    Braun, A.2    Nedergaard, M.3
  • 10
    • 55049084760 scopus 로고    scopus 로고
    • The mystery and magic of glia: a perspective on their roles in health and disease
    • BARRES B.A. 2008. The mystery and magic of glia: a perspective on their roles in health and disease. Neuron 60: 430-440.
    • (2008) Neuron , vol.60 , pp. 430-440
    • Barres, B.A.1
  • 11
  • 14
    • 34547761212 scopus 로고    scopus 로고
    • Astrocyte glycogen and brain energy metabolism
    • BROWN A.M., RANSOM B.R. 2007. Astrocyte glycogen and brain energy metabolism. Glia 55: 1263-1271.
    • (2007) Glia , vol.55 , pp. 1263-1271
    • Brown, A.M.1    Ransom, B.R.2
  • 15
    • 40949116686 scopus 로고    scopus 로고
    • The TORrid affairs of viruses: effects of mammalian DNA viruses on the PI3K-AKT-mTOR signaling pathway
    • BUCHKOVICH N.J., YU Y., ZAMPIERI C.A., ALWINE J.C. 2008. The TORrid affairs of viruses: effects of mammalian DNA viruses on the PI3K-AKT-mTOR signaling pathway. Nat. Rev. Microbiol. 6: 266-275.
    • (2008) Nat. Rev. Microbiol. , vol.6 , pp. 266-275
    • Buchkovich, N.J.1    Yu, Y.2    Zampieri, C.A.3    Alwine, J.C.4
  • 16
    • 67649382228 scopus 로고    scopus 로고
    • Inhibition of the mammalian target of rapamycin signaling pathway suppresses dentate granule cell axon sprouting in a rodent model of temporal lobe epilepsy
    • BUCKMASTER P.S., INGRAM E.A., WEN X. 2009. Inhibition of the mammalian target of rapamycin signaling pathway suppresses dentate granule cell axon sprouting in a rodent model of temporal lobe epilepsy. J. Neurosci. 29: 8259-8269.
    • (2009) J. Neurosci. , vol.29 , pp. 8259-8269
    • Buckmaster, P.S.1    Ingram, E.A.2    Wen, X.3
  • 17
    • 0036139877 scopus 로고    scopus 로고
    • Protoplasmic astrocytes in CA1 atratum radiatum occupy separate anatomical domains
    • BUSHONG E.A., MARTONE M.A., JONES Y.Z., ELLISMAN M.H. 2002.Protoplasmic astrocytes in CA1 atratum radiatum occupy separate anatomical domains. J. Neurosci. 22: 183-192.
    • (2002) J. Neurosci. , vol.22 , pp. 183-192
    • Bushong, E.A.1    Martone, M.A.2    Jones, Y.Z.3    Ellisman, M.H.4
  • 18
    • 33644899143 scopus 로고    scopus 로고
    • Microarray-based method for monitoring yeast overexpression strains reveals small-molecule targets in TOR pathway
    • BUTCHER R.A., BHULLAR B.S., PERLSTEIN E.O., MARSISSCHKY G., LABAER J., SCHREIBER S.L. 2006. Microarray-based method for monitoring yeast overexpression strains reveals small-molecule targets in TOR pathway. Nat. Chem. Biol. 2: 103-109.
    • (2006) Nat. Chem. Biol. , vol.2 , pp. 103-109
    • Butcher, R.A.1    Bhullar, B.S.2    Perlstein, E.O.3    Marsisschky, G.4    Labaer, J.5    Schreiber, S.L.6
  • 19
    • 25444457577 scopus 로고    scopus 로고
    • hVps34 is a nutrient-regulated lipid kinase required for activation of p70 S6 kinase
    • BYFIELD M.P., MURRAY J.T., BACKER J.M. 2005. hVps34 is a nutrient-regulated lipid kinase required for activation of p70 S6 kinase. J. Biol. Chem. 280: 33076-33082.
    • (2005) J. Biol. Chem. , vol.280 , pp. 33076-33082
    • Byfield, M.P.1    Murray, J.T.2    Backer, J.M.3
  • 20
    • 0344630216 scopus 로고    scopus 로고
    • Timerestricted role for dendritic activation of the mTOR-p70S6K pathway in the induction of late-phase long-term potentiation in the CA1
    • CAMMALLERI M., LUTJENS R., BERTON F., KING A.R., SIMP-SON C., FRANCESCONI W., SANNA P.P. 2003. Timerestricted role for dendritic activation of the mTOR-p70S6K pathway in the induction of late-phase long-term potentiation in the CA1. Proc. Natl. Acad. Sci. USA. 100: 14368-14373.
    • (2003) Proc. Natl. Acad. Sci. USA. , vol.100 , pp. 14368-14373
    • Cammalleri, M.1    Lutjens, R.2    Berton, F.3    King, A.R.4    Simpson, C.5    Francesconi, W.6    Sanna, P.P.7
  • 21
    • 77954145923 scopus 로고    scopus 로고
    • Ammonia and proinflammatory cytokines modify expression of genes coding for astrocytic proteins implicated in brain edema in acute liver failure
    • CHASTRE A., JIANG W., DESJARDINS P., BUTTERWORTH R.F. 2010. Ammonia and proinflammatory cytokines modify expression of genes coding for astrocytic proteins implicated in brain edema in acute liver failure. Metab. Brain Dis. 25: 17-21.
    • (2010) Metab. Brain Dis. , vol.25 , pp. 17-21
    • Chastre, A.1    Jiang, W.2    Desjardins, P.3    Butterworth, R.F.4
  • 22
    • 84863278527 scopus 로고    scopus 로고
    • Rapamycin prevents the mutant huntingtin suppressed GLT-1 expression in cultured astrocytes
    • CHEN L., WU J., WANG L., WANG J., QIN Z., DIFIGLIA M., LIN F. 2012. Rapamycin prevents the mutant huntingtin suppressed GLT-1 expression in cultured astrocytes. Acta Pharmacol. Sin. 33: 385-392.
    • (2012) Acta Pharmacol. Sin. , vol.33 , pp. 385-392
    • Chen, L.1    Wu, J.2    Wang, L.3    Wang, J.4    Qin, Z.5    Difiglia, M.6    Lin, F.7
  • 23
    • 21844468767 scopus 로고    scopus 로고
    • Phosphorylation of mammalian target of rapamycin (mTOR) at Ser-2448 is mediated by p70S6 kinase
    • CHING G.G., ABRAHAM R.T. 2005. Phosphorylation of mammalian target of rapamycin (mTOR) at Ser-2448 is mediated by p70S6 kinase. J. Biol. Chem. 280: 25485-25490.
    • (2005) J. Biol. Chem. , vol.280 , pp. 25485-25490
    • Ching, G.G.1    Abraham, R.T.2
  • 24
    • 72849127046 scopus 로고    scopus 로고
    • A novel mTOR activating protein protects dopamine neurons against oxidative stress by repressing autophagy related cell death
    • CHOI K.C., KIM S.H., HA J.Y., KIM S.T., SON J.H. 2010. A novel mTOR activating protein protects dopamine neurons against oxidative stress by repressing autophagy related cell death. J. Neurochem. 112: 366-376.
    • (2010) J. Neurochem. , vol.112 , pp. 366-376
    • Choi, K.C.1    Kim, S.H.2    Ha, J.Y.3    Kim, S.T.4    Son, J.H.5
  • 25
    • 79951529849 scopus 로고    scopus 로고
    • Mammalian target of rapamycin: hitting the bull's-eye forneurologicaldisorders
    • CHONG Z.Z, SHANG Y.C., ZHANG L., WANG S., MAIESE K. 2010. Mammalian target of rapamycin: hitting the bull's-eye forneurologicaldisorders. Oxid. Med. CellLongev. 3:374-391.
    • (2010) Oxid. Med. CellLongev. , vol.3 , pp. 374-391
    • Chong, Z.Z.1    Shang, Y.C.2    Zhang, L.3    Wang, S.4    Maiese, K.5
  • 26
    • 84867897183 scopus 로고    scopus 로고
    • Shedding new light on neurodegenerative diseases through the mammalian target of rapamycin
    • CHONG Z.Z, SHANG Y.C., WANG S., MAIESE K. 2012. Shedding new light on neurodegenerative diseases through the mammalian target of rapamycin. Prog. Neurobiol. 99: 128-148.
    • (2012) Prog. Neurobiol. , vol.99 , pp. 128-148
    • Chong, Z.Z.1    Shang, Y.C.2    Wang, S.3    Maiese, K.4
  • 27
    • 84879051700 scopus 로고    scopus 로고
    • Huntington's disease: the past, present, and future search for disease modifiers
    • CLABOUGH E.B. 2013. Huntington's disease: the past, present, and future search for disease modifiers. Yale J. Biol. Med. 86: 217-233.
    • (2013) Yale J. Biol. Med. , vol.86 , pp. 217-233
    • Clabough, E.B.1
  • 30
    • 38348998584 scopus 로고    scopus 로고
    • Amyotrophic lateral sclerosis: from current developments in the laboratory to clinical implications
    • COZZOLINO M., FERRI A., CARRÌ M.T. 2008. Amyotrophic lateral sclerosis: from current developments in the laboratory to clinical implications. Antioxid. Redox Signal. 10: 405-444.
    • (2008) Antioxid. Redox Signal. , vol.10 , pp. 405-444
    • Cozzolino, M.1    Ferri, A.2    Carrì, M.T.3
  • 31
  • 32
    • 33644513730 scopus 로고    scopus 로고
    • Beyond PTEN mutations: the PI3K pathway as an integrator of multiple inputs during tumorigenesis
    • CULLY M., YOU H., LEVINE A.J., MAK T.W. 2006. Beyond PTEN mutations: the PI3K pathway as an integrator of multiple inputs during tumorigenesis. Nat. Rev. Cancer 6: 184-192.
    • (2006) Nat. Rev. Cancer , vol.6 , pp. 184-192
    • Cully, M.1    You, H.2    Levine, A.J.3    Mak, T.W.4
  • 33
    • 4544355954 scopus 로고    scopus 로고
    • Tuberous sclerosis complex: frombasic scienceto clinical phenotypes
    • MacKeithPress, London
    • CURATOLO P. 2003. Tuberous sclerosis complex: frombasic scienceto clinical phenotypes. MacKeithPress, London. Pp. 328.
    • (2003) , pp. 328
    • Curatolo, P.1
  • 35
    • 84874849789 scopus 로고    scopus 로고
    • mTOR inhibitors in tuberous sclerosis complex
    • CURATOLO P., MOAVERO R. 2012. mTOR inhibitors in tuberous sclerosis complex. Curr. Neuropharmacol. 10: 404-415.
    • (2012) Curr. Neuropharmacol. , vol.10 , pp. 404-415
    • Curatolo, P.1    Moavero, R.2
  • 36
    • 83455164990 scopus 로고    scopus 로고
    • Everolimus: in patients with subependymal giant cell astrocytoma associated with tuberous sclerosis complex
    • CURRAN M.P. 2012. Everolimus: in patients with subependymal giant cell astrocytoma associated with tuberous sclerosis complex. Pediatr. Drugs 14: 51-60.
    • (2012) Pediatr. Drugs , vol.14 , pp. 51-60
    • Curran, M.P.1
  • 37
    • 69549139978 scopus 로고    scopus 로고
    • Involvement of mTOR kinase in cytokine-dependent microglial activation and cell proliferation
    • DELLO RUSSO C., LISI L., TRINGALI G., NAVARRA P. 2009. Involvement of mTOR kinase in cytokine-dependent microglial activation and cell proliferation. Biochem. Pharmacol. 78: 1242-1251.
    • (2009) Biochem. Pharmacol. , vol.78 , pp. 1242-1251
    • Dello Russo, C.1    Lisi, L.2    Tringali, G.3    Navarra, P.4
  • 38
    • 84872609730 scopus 로고    scopus 로고
    • mTOR kinase, a key player in the regulation of glial functions: relevance for the therapy of multiple sclerosis
    • DELLO RUSSO C., LISI L., FEINSTEIN D. L., NAVARRA P. 2013. mTOR kinase, a key player in the regulation of glial functions: relevance for the therapy of multiple sclerosis. Glia 61: 301-311.
    • (2013) Glia , vol.61 , pp. 301-311
    • Dello Russo, C.1    Lisi, L.2    Feinstein, D.L.3    Navarra, P.4
  • 39
    • 34247473080 scopus 로고    scopus 로고
    • Non-cell autonomous effect of glia on motor neurons in an embryonic stem cell-based ALS model
    • DIGIORGIO F.P., CARRASCO M.A., SIAO M.C., MANIATIS T., EGGAN K. 2007. Non-cell autonomous effect of glia on motor neurons in an embryonic stem cell-based ALS model. Nat. Neurosci. 10: 608-614.
    • (2007) Nat. Neurosci. , vol.10 , pp. 608-614
    • Digiorgio, F.P.1    Carrasco, M.A.2    Siao, M.C.3    Maniatis, T.4    Eggan, K.5
  • 40
    • 0035153212 scopus 로고    scopus 로고
    • Immune function of astrocytes
    • DONG Y., BENVENISTE E.N. 2001. Immune function of astrocytes. Glia. 36: 180-190.
    • (2001) Glia. , vol.36 , pp. 180-190
    • Dong, Y.1    Benveniste, E.N.2
  • 41
    • 0037245494 scopus 로고    scopus 로고
    • Virological and immunological aspects of seizure disorders
    • EEG-OLOFSSON O. 2003. Virological and immunological aspects of seizure disorders. Brain Dev. 25: 9-13.
    • (2003) Brain Dev. , vol.25 , pp. 9-13
    • Eeg-Olofsson, O.1
  • 42
    • 0034305621 scopus 로고    scopus 로고
    • Glial ?brillary acidic protein: GFAP-thirty-one years (1969-2000)
    • ENG L.F., GHIRNIKAR R.S., LEE Y.L. 2000. Glial ?brillary acidic protein: GFAP-thirty-one years (1969-2000). Neurochem. Res. 25: 1439-1451.
    • (2000) Neurochem. Res. , vol.25 , pp. 1439-1451
    • Eng, L.F.1    Ghirnikar, R.S.2    Lee, Y.L.3
  • 43
    • 84862835713 scopus 로고    scopus 로고
    • Corticostriatal dysfunction and glutamate transporter 1 (GLT1) in Huntington's disease: interactions between neurons and astrocytes
    • ESTRADA-SÁNCHEZ A.M., REBEC G.V. 2012. Corticostriatal dysfunction and glutamate transporter 1 (GLT1) in Huntington's disease: interactions between neurons and astrocytes. Basal Ganglia 2: 57-66.
    • (2012) Basal Ganglia , vol.2 , pp. 57-66
    • Estrada-Sánchez, A.M.1    Rebec, G.V.2
  • 45
    • 84555187723 scopus 로고    scopus 로고
    • Inhibition of PI3K-Akt-mTOR signaling in glioblastoma by mTORC1/2 inhibitors
    • FAN Q.W., WEISS W.A. 2012. Inhibition of PI3K-Akt-mTOR signaling in glioblastoma by mTORC1/2 inhibitors. Methods Mol. Biol. 821: 349-359.
    • (2012) Methods Mol. Biol. , vol.821 , pp. 349-359
    • Fan, Q.W.1    Weiss, W.A.2
  • 47
    • 0028144361 scopus 로고
    • Nitric oxide synthase expression in glial cells: suppression by tyrosine kinase inhibitors
    • FEINSTEIN D.L., GALEA E., CERMAK J., CHUGH P., LYAND-VERT L., REIS D.J. 1994. Nitric oxide synthase expression in glial cells: suppression by tyrosine kinase inhibitors. J. Neurochem. 62: 811-814.
    • (1994) J. Neurochem. , vol.62 , pp. 811-814
    • Feinstein, D.L.1    Galea, E.2    Cermak, J.3    Chugh, P.4    Lyand-Vert, L.5    Reis, D.J.6
  • 48
    • 2342545519 scopus 로고    scopus 로고
    • Target of rapamycin (TOR): an integrator of nutrient and growth factor signals and coordinator of cell growth and cell cycle progression
    • FINGAR D.C., BLENIS J. 2004. Target of rapamycin (TOR): an integrator of nutrient and growth factor signals and coordinator of cell growth and cell cycle progression. Oncogene 23: 3151-3171.
    • (2004) Oncogene , vol.23 , pp. 3151-3171
    • Fingar, D.C.1    Blenis, J.2
  • 50
    • 1442274664 scopus 로고    scopus 로고
    • Minireview:Role of glia in neuroendocrine function
    • GARCIA-SEGURA L.M., MCCARTHY M. 2004. Minireview:Role of glia in neuroendocrine function. Endocrinology 145: 1082-1086.
    • (2004) Endocrinology , vol.145 , pp. 1082-1086
    • Garcia-Segura, L.M.1    Mccarthy, M.2
  • 51
    • 39749165710 scopus 로고    scopus 로고
    • Viruses and the immune system: their roles in seizure cascade development
    • GETTS D.R., BALCAR V.J., MATSUMOTO I., MULLER M., KING N.J.C. 2008. Viruses and the immune system: their roles in seizure cascade development. J. Neurochem. 104: 1167-1176.
    • (2008) J. Neurochem. , vol.104 , pp. 1167-1176
    • Getts, D.R.1    Balcar, V.J.2    Matsumoto, I.3    Muller, M.4    King, N.J.C.5
  • 52
    • 0032520009 scopus 로고    scopus 로고
    • 4E-BP1, a repressor of mRNA translation, is phosphorylated and inactivated by the Akt(PKB) signaling pathway
    • GINGRAS A.C., SCOTT G., KENNEDY S.G., O'LEARY M.A., SONENBERG N., HAY N. 1998. 4E-BP1, a repressor of mRNA translation, is phosphorylated and inactivated by the Akt(PKB) signaling pathway. Genes Dev. 12: 502-513.
    • (1998) Genes Dev. , vol.12 , pp. 502-513
    • Gingras, A.C.1    Scott, G.2    Kennedy, S.G.3    O'leary, M.A.4    Sonenberg, N.5    Hay, N.6
  • 53
    • 16244391770 scopus 로고    scopus 로고
    • Activation of Akt/PKB, increased phosphorylation of Akt substrates and loss and altered distribution of Akt and PTEN are features of Alzheimer's disease pathology
    • GRIFFIN R.J., MOLONEY A., KELLIHER M., JOHNSTON J.A., RAVID R., DOCKERY P., O'CONNOR R., O'NEILL C. 2005. Activation of Akt/PKB, increased phosphorylation of Akt substrates and loss and altered distribution of Akt and PTEN are features of Alzheimer's disease pathology. J. Neurochem. 93: 105-117.
    • (2005) J. Neurochem. , vol.93 , pp. 105-117
    • Griffin, R.J.1    Moloney, A.2    Kelliher, M.3    Johnston, J.A.4    Ravid, R.5    Dockery, P.6    O'connor, R.7    O'neill, C.8
  • 54
    • 20944431926 scopus 로고    scopus 로고
    • Pathological cell-cell interactions elicited by a neuropathogenic form of mutant Huntingtin contribute to cortical pathogenesis in HD mice
    • GU X., LI C., WEI W., LO V., GONG S., LI S., IWASATO T., ITOHARA S., LI X.J., MODY I., HEINTZ N., YANG X.W. 2005. Pathological cell-cell interactions elicited by a neuropathogenic form of mutant Huntingtin contribute to cortical pathogenesis in HD mice. Neuron 46: 433-444.
    • (2005) Neuron , vol.46 , pp. 433-444
    • Gu, X.1    Li, C.2    Wei, W.3    Lo, V.4    Gong, S.5    Li, S.6    Iwasato, T.7    Itohara, S.8    Li, X.J.9    Mody, I.10    Heintz, N.11    Yang, X.W.12
  • 55
    • 34249864115 scopus 로고    scopus 로고
    • Pathological cell-cell interactions are necessary for striatal pathogenesis in a conditional mouse model of Huntington's disease
    • GU X., ANDRE V., CEPEDA C., LI S., LI X.J., LEVINE M., YANG X. W. 2007. Pathological cell-cell interactions are necessary for striatal pathogenesis in a conditional mouse model of Huntington's disease. Mol. Neurodegener. 2: 1-11.
    • (2007) Mol. Neurodegener. , vol.2 , pp. 1-11
    • Gu, X.1    Andre, V.2    Cepeda, C.3    Li, S.4    Li, X.J.5    Levine, M.6    Yang, X.W.7
  • 57
    • 33846621575 scopus 로고    scopus 로고
    • The tripartite synapse: roles for gliotransmission in health and disease
    • HALASSA M.M., FELLIN T., HAYDON P.G. 2007. The tripartite synapse: roles for gliotransmission in health and disease. Trends Mol. Med. 13: 54-63.
    • (2007) Trends Mol. Med. , vol.13 , pp. 54-63
    • Halassa, M.M.1    Fellin, T.2    Haydon, P.G.3
  • 58
    • 79960419102 scopus 로고    scopus 로고
    • Burden of disease and unmet needs in tuberous sclerosis complex with neurological manifestations: systematic review
    • HALLETT L., FOSTER T., LIU Z., BLIEDEN M., VALENTIM J. 2011. Burden of disease and unmet needs in tuberous sclerosis complex with neurological manifestations: systematic review. Curr. Med. Res. Opin. 27: 1571-1583.
    • (2011) Curr. Med. Res. Opin. , vol.27 , pp. 1571-1583
    • Hallett, L.1    Foster, T.2    Liu, Z.3    Blieden, M.4    Valentim, J.5
  • 59
    • 4043171462 scopus 로고    scopus 로고
    • Upstream and downstream of mTOR
    • HAY N., SONENBERG N. 2004. Upstream and downstream of mTOR. Genes Dev. 18: 1926-1945.
    • (2004) Genes Dev. , vol.18 , pp. 1926-1945
    • Hay, N.1    Sonenberg, N.2
  • 60
    • 0025776523 scopus 로고
    • Targets for cell cycle arrest by the immunosuppressant rapamycin in yeast
    • HEITMAN J., MOVVA N. R., HALL M. N. 1991. Targets for cell cycle arrest by the immunosuppressant rapamycin in yeast. Science 253: 905-909.
    • (1991) Science , vol.253 , pp. 905-909
    • Heitman, J.1    Movva, N.R.2    Hall, M.N.3
  • 61
    • 34247164656 scopus 로고    scopus 로고
    • Tuberous sclerosis complex and epilepsy: recent developments and future challenges
    • HOLMES G.L., STAFSTROM C.E. 2007. Tuberous sclerosis complex and epilepsy: recent developments and future challenges. Epilepsia 48: 617-630.
    • (2007) Epilepsia , vol.48 , pp. 617-630
    • Holmes, G.L.1    Stafstrom, C.E.2
  • 62
    • 3242724040 scopus 로고    scopus 로고
    • Activation of the phosphoinositide 3-kinase-Akt-mammalian target of rapamycin signaling pathway is required for metabotropic glutamate receptordependent long-termdepression
    • HOU L., KLANN E. 2004. Activation of the phosphoinositide 3-kinase-Akt-mammalian target of rapamycin signaling pathway is required for metabotropic glutamate receptordependent long-termdepression. J. Neurosci. 24: 6352-6361.
    • (2004) J. Neurosci. , vol.24 , pp. 6352-6361
    • Hou, L.1    Klann, E.2
  • 64
    • 0030984042 scopus 로고    scopus 로고
    • Neuronal expression and intracellular localization of presenilins in normal and Alzheimer disease brains
    • HUYNH D.P., VINTERS H.V., HO D.H., HO V.V., PULST S.M. 1997. Neuronal expression and intracellular localization of presenilins in normal and Alzheimer disease brains. J. Neuropathol. Exp. Neurol. 56: 1009-1017.
    • (1997) J. Neuropathol. Exp. Neurol. , vol.56 , pp. 1009-1017
    • Huynh, D.P.1    Vinters, H.V.2    Ho, D.H.3    Ho, V.V.4    Pulst, S.M.5
  • 65
    • 51949090816 scopus 로고    scopus 로고
    • Phosphorylation of 4E-BP byLRRK2affects the maintenance of dopaminergic neurons in Drosophila
    • IMAI Y., GEHRKE S., WANG H-Q., TAKAHASHI R., HASE-GAWA K., OOTA E., LU B. 2008. Phosphorylation of 4E-BP byLRRK2affects the maintenance of dopaminergic neurons in Drosophila. EMBO J. 27: 2432-2443.
    • (2008) EMBO J. , vol.27 , pp. 2432-2443
    • Imai, Y.1    Gehrke, S.2    Wang, H.-Q.3    Takahashi, R.4    Hase-Gawa, K.5    Oota, E.6    Lu, B.7
  • 69
    • 5344244073 scopus 로고    scopus 로고
    • Translational regulatory mechanisms in persistent forms of synaptic plasticity
    • KELLEHER R.J. 3RD., GOVINDARAJAN A., TONEGAWA S. 2004. Translational regulatory mechanisms in persistent forms of synaptic plasticity. Neuron 44: 59-73.
    • (2004) Neuron , vol.44 , pp. 59-73
    • Kelleher, R.J.1    Govindarajan, A.2    Tonegawa, S.3
  • 71
    • 84864065714 scopus 로고    scopus 로고
    • Sodium dynamics: another key to astroglial excitability?
    • KIRISCHUK S., PARPURA V., VERKHRATSKY A. 2012. Sodium dynamics: another key to astroglial excitability? Trends Neurosci. 35: 497-506.
    • (2012) Trends Neurosci. , vol.35 , pp. 497-506
    • Kirischuk, S.1    Parpura, V.2    Verkhratsky, A.3
  • 72
    • 4644359359 scopus 로고    scopus 로고
    • Regulation of the expression of inducible nitric oxide synthase
    • KLEINERT H., PAUTZ A., LINKER K., SCHWARZ P.M. 2004. Regulation of the expression of inducible nitric oxide synthase. Eur. J. Pharmacol. 500: 255-266.
    • (2004) Eur. J. Pharmacol. , vol.500 , pp. 255-266
    • Kleinert, H.1    Pautz, A.2    Linker, K.3    Schwarz, P.M.4
  • 73
    • 53549125236 scopus 로고    scopus 로고
    • Regression of subependymal giant cell astrocytoma with rapamycin in tuberous sclerosis complex
    • KOENIG M.K., BUTLER I.J., NORTHRUP H. 2008. Regression of subependymal giant cell astrocytoma with rapamycin in tuberous sclerosis complex. J. Child. Neurol. 23: 1238-1239.
    • (2008) J. Child. Neurol. , vol.23 , pp. 1238-1239
    • Koenig, M.K.1    Butler, I.J.2    Northrup, H.3
  • 75
    • 61349096009 scopus 로고    scopus 로고
    • Synchronous hyperactivity and intercellular calcium waves in astrocytes in Alzheimer mice
    • KUCHIBHOTLA K.V., LATTARULO C.R., HYMAN B.T., BACSKAI B.J. 2009. Synchronous hyperactivity and intercellular calcium waves in astrocytes in Alzheimer mice. Science 323: 1211-1215.
    • (2009) Science , vol.323 , pp. 1211-1215
    • Kuchibhotla, K.V.1    Lattarulo, C.R.2    Hyman, B.T.3    Bacskai, B.J.4
  • 76
    • 84864359502 scopus 로고    scopus 로고
    • Astrocytic cytoskeletal atrophy in the medial prefrontal cortex of a triple transgenic mouse model of Alzheimer's disease
    • KULIJEWICZ-NAWROT M., VERKHRATSKY A., CHVATAL A., SYKOVA E., RODRIGUEZ J.J. 2012. Astrocytic cytoskeletal atrophy in the medial prefrontal cortex of a triple transgenic mouse model of Alzheimer's disease. J. Anat. 221: 252-262.
    • (2012) J. Anat. , vol.221 , pp. 252-262
    • Kulijewicz-Nawrot, M.1    Verkhratsky, A.2    Chvatal, A.3    Sykova, E.4    Rodriguez, J.J.5
  • 77
    • 78650777704 scopus 로고    scopus 로고
    • The mTOR kinase inhibitor rapamycin decreases iNOS mRNAstability in astrocytes
    • LISI L., NAVARRA P., FEINSTEIN D.L., DELLO RUSSO C. 2011. The mTOR kinase inhibitor rapamycin decreases iNOS mRNAstability in astrocytes. J. Neuroinflammation 8: 1-11.
    • (2011) J. Neuroinflammation , vol.8 , pp. 1-11
    • Lisi, L.1    Navarra, P.2    Feinstein, D.L.3    Dello Russo, C.4
  • 78
    • 68349100270 scopus 로고    scopus 로고
    • Rapamycin suppresses seizures and neuronal hypertrophy in a mouse model of cortical dysplasia
    • LJUNGBERG M.C., SUNNEN C.N., LUGO J.N., ANDERSON A.E., D'ARCANGELO G. 2009. Rapamycin suppresses seizures and neuronal hypertrophy in a mouse model of cortical dysplasia. Dis. Model Mech. 2: 389-398.
    • (2009) Dis. Model Mech. , vol.2 , pp. 389-398
    • Ljungberg, M.C.1    Sunnen, C.N.2    Lugo, J.N.3    Anderson, A.E.4    D'arcangelo, G.5
  • 79
    • 35549006420 scopus 로고    scopus 로고
    • Glial cells as intrinsic components of non-cell-autonomous neurodegenerative disease
    • LOBSIGER C.S., CLEVELAND D.W. 2007. Glial cells as intrinsic components of non-cell-autonomous neurodegenerative disease. Nat. Neurosci. 10: 1355-1360.
    • (2007) Nat. Neurosci. , vol.10 , pp. 1355-1360
    • Lobsiger, C.S.1    Cleveland, D.W.2
  • 80
    • 84871721552 scopus 로고    scopus 로고
    • mTOR: on target for novel therapeutic strategies in the nervous system
    • MAIESE K., CHONG Z.Z, SHANG Y. Ch., WANG Sh. 2013. mTOR: on target for novel therapeutic strategies in the nervous system. Trends Mol. Med. 19: 51-60.
    • (2013) Trends Mol. Med. , vol.19 , pp. 51-60
    • Maiese, K.1    Chong, Z.Z.2    Shang, Y.C.3    Wang, S.4
  • 81
    • 33749166640 scopus 로고    scopus 로고
    • RTP801 is elevated in Parkinson brain substantia nigral neurons and mediates death in cellular models of Parkinson's disease by a mechanism involving mammalian target of rapamycin inactivation
    • MALAGELADA C., RYU E.J., BISWAS S.C., JACKSON-LEWIS V., GREENE L.A. 2006. RTP801 is elevated in Parkinson brain substantia nigral neurons and mediates death in cellular models of Parkinson's disease by a mechanism involving mammalian target of rapamycin inactivation. J. Neurosci. 26: 9996-10005.
    • (2006) J. Neurosci. , vol.26 , pp. 9996-10005
    • Malagelada, C.1    Ryu, E.J.2    Biswas, S.C.3    Jackson-Lewis, V.4    Greene, L.A.5
  • 82
    • 34250788809 scopus 로고    scopus 로고
    • AKT/PKB signaling:navigating downstream
    • MANNING B.D., CANTLEY L.C. 2007. AKT/PKB signaling:navigating downstream. Cell 129: 1261-1274.
    • (2007) Cell , vol.129 , pp. 1261-1274
    • Manning, B.D.1    Cantley, L.C.2
  • 83
    • 13544263608 scopus 로고    scopus 로고
    • Increased expression of the astrocytic glutamate transporter GLT-1 in the prefrontal cortex of schizophrenics
    • MATUTE C., MELONE M., VALLEJO-ILLARRAMENDI A., CONTI F. 2005. Increased expression of the astrocytic glutamate transporter GLT-1 in the prefrontal cortex of schizophrenics. Glia 49: 451-455.
    • (2005) Glia , vol.49 , pp. 451-455
    • Matute, C.1    Melone, M.2    Vallejo-Illarramendi, A.3    Conti, F.4
  • 84
    • 15044350668 scopus 로고    scopus 로고
    • The expanding TOR signaling network
    • MARTIN D.E., HALL M.N. 2005. The expanding TOR signaling network. Curr. Opin. Cell Biol. 17: 158-166.
    • (2005) Curr. Opin. Cell Biol. , vol.17 , pp. 158-166
    • Martin, D.E.1    Hall, M.N.2
  • 85
    • 47349104402 scopus 로고    scopus 로고
    • Glial reactions in Parkinson's disease
    • MCGEER P.L, MCGEER E.G. 2008. Glial reactions in Parkinson's disease. Mov. Disord. 23: 474-483.
    • (2008) Mov. Disord. , vol.23 , pp. 474-483
    • Mcgeer, P.L.1    Mcgeer, E.G.2
  • 86
    • 34250626014 scopus 로고    scopus 로고
    • A mouse model of tuberous sclerosis: neuronal loss of Tsc1 causes dysplastic and ectopic neurons, reduced myelination, seizure activity, and limited survival
    • MEIKLE L., TALOS D.M., ONDA H., POLLIZZI K., ROTEN-BERG A., SAHIN M., JENSEN F.E., KWIATKOWSKI D.J. 2007. A mouse model of tuberous sclerosis: neuronal loss of Tsc1 causes dysplastic and ectopic neurons, reduced myelination, seizure activity, and limited survival. J. Neurosci. 27: 5546-5558.
    • (2007) J. Neurosci. , vol.27 , pp. 5546-5558
    • Meikle, L.1    Talos, D.M.2    Onda, H.3    Pollizzi, K.4    Roten-Berg, A.5    Sahin, M.6    Jensen, F.E.7    Kwiatkowski, D.J.8
  • 87
    • 57449104707 scopus 로고    scopus 로고
    • Glial cells as players in parkinsonism: the 'good', the 'bad' and the 'mysterious' glia
    • MENA M.A., GARCIA DE YEBENES J. 2008. Glial cells as players in parkinsonism: the 'good', the 'bad' and the 'mysterious' glia. Neuroscientist 14: 544-560.
    • (2008) Neuroscientist , vol.14 , pp. 544-560
    • Mena, M.A.1    Garcia De Yebenes, J.2
  • 88
    • 50249146917 scopus 로고    scopus 로고
    • Viral encephalitis and epilepsy
    • MISRA U.K., TAN C.T., KALITA J. 2008. Viral encephalitis and epilepsy. Epilepsia 49: 13-18.
    • (2008) Epilepsia , vol.49 , pp. 13-18
    • Misra, U.K.1    Tan, C.T.2    Kalita, J.3
  • 91
    • 2542481651 scopus 로고    scopus 로고
    • Contribution of glial cells to the development of amyloid plaques in Alzheimer's disease
    • NAGELE R.G., WEGIEL J., VENKATARAMAN V., IMAKI H., WANG K.C. 2004. Contribution of glial cells to the development of amyloid plaques in Alzheimer's disease. Neurobiol. Aging 25: 663-674.
    • (2004) Neurobiol. Aging , vol.25 , pp. 663-674
    • Nagele, R.G.1    Wegiel, J.2    Venkataraman, V.3    Imaki, H.4    Wang, K.C.5
  • 93
    • 0018776955 scopus 로고
    • Distribution of glutamine synthetase in the rat central nervous system
    • NORENBERG M.D. 1979. Distribution of glutamine synthetase in the rat central nervous system. J. Histochem. Cytochem. 27: 756-762.
    • (1979) J. Histochem. Cytochem. , vol.27 , pp. 756-762
    • Norenberg, M.D.1
  • 94
    • 0141533205 scopus 로고    scopus 로고
    • New roles for astrocytes: redefining the functional architecture of the brain
    • NEDERGAARD M., RANSOM B., GOLDMAN S.A. 2003. New roles for astrocytes: redefining the functional architecture of the brain. Trends Neurosci. 26: 523-530.
    • (2003) Trends Neurosci. , vol.26 , pp. 523-530
    • Nedergaard, M.1    Ransom, B.2    Goldman, S.A.3
  • 95
    • 0032537401 scopus 로고    scopus 로고
    • Prevalence of tuberous sclerosis estimated by capture-recapture analysis
    • O'CALLAGHAN F.J., SHIELL A.W., OSBORNE J.P., MARTYN C.N. 1998. Prevalence of tuberous sclerosis estimated by capture-recapture analysis. Lancet 351: 1490.
    • (1998) Lancet , vol.351 , pp. 1490
    • O'callaghan, F.J.1    Shiell, A.W.2    Osborne, J.P.3    Martyn, C.N.4
  • 96
    • 77952573750 scopus 로고    scopus 로고
    • Concomitant astroglial atrophy and astrogliosis in a triple transgenic animal model of Alzheimer's disease
    • OLABARRIA M., NORISTANI H.N., VERKHRATSKY A., RODRIGUEZ J.J. 2010. Concomitant astroglial atrophy and astrogliosis in a triple transgenic animal model of Alzheimer's disease. Glia 58: 831-838.
    • (2010) Glia , vol.58 , pp. 831-838
    • Olabarria, M.1    Noristani, H.N.2    Verkhratsky, A.3    Rodriguez, J.J.4
  • 97
    • 79960887452 scopus 로고    scopus 로고
    • Age-dependent decrease in glutamine synthetase expression in the hippocampal astroglia of the triple transgenic Alzheimer's disease mouse model: mechanism for deficient glutamatergic transmission? Mol
    • OLABARRIA M., NORISTANI H.N., VERKHRATSKY A., RODRIGUEZ J.J. 2011. Age-dependent decrease in glutamine synthetase expression in the hippocampal astroglia of the triple transgenic Alzheimer's disease mouse model: mechanism for deficient glutamatergic transmission? Mol. Neurodegener. 6: 55.
    • (2011) Neurodegener. , vol.6 , pp. 55
    • Olabarria, M.1    Noristani, H.N.2    Verkhratsky, A.3    Rodriguez, J.J.4
  • 98
    • 25444528296 scopus 로고    scopus 로고
    • Adenovirus overrides cellular checkpoints for protein translation
    • O'SHEA C.C., CHOI S., MCCORMICK F., STOKOE D. 2005. Adenovirus overrides cellular checkpoints for protein translation. Cell Cycle 4: 883-888.
    • (2005) Cell Cycle , vol.4 , pp. 883-888
    • O'shea, C.C.1    Choi, S.2    Mccormick, F.3    Stokoe, D.4
  • 102
    • 68049143450 scopus 로고    scopus 로고
    • Tripartite synapses:astrocytes process and control synaptic information
    • PEREA G., NAVARRETE M., ARAQUE A. 2009. Tripartite synapses:astrocytes process and control synaptic information. Trends Neurosci. 32: 421-431.
    • (2009) Trends Neurosci. , vol.32 , pp. 421-431
    • Perea, G.1    Navarrete, M.2    Araque, A.3
  • 105
    • 84871313202 scopus 로고    scopus 로고
    • Regulated in development and DNA damage responses-1 (REDD1) protein contributes to insulin signaling pathway in adipocytes
    • REGAZZETTI C., DUMAS K., MARCHAND-BRUSTEY L., PERALDI P., OISTANTI J.F., GIORGETTI-PERALDI S. 2012. Regulated in development and DNA damage responses-1 (REDD1) protein contributes to insulin signaling pathway in adipocytes. PLOS ONE. 7: e52154. DOI: 10.1371/journal. pone.0052154.
    • (2012) PLOS ONE. , vol.7 , pp. e52154
    • Regazzetti, C.1    Dumas, K.2    Marchand-Brustey, L.3    Peraldi, P.4    Oistanti, J.F.5    Giorgetti-Peraldi, S.6
  • 106
    • 78751677843 scopus 로고    scopus 로고
    • The stem cell potential of glia: lessons from reactive gliosis
    • ROBEL S., BERNINGER B., GOTZ M. 2011. The stem cell potential of glia: lessons from reactive gliosis. Nat. Rev. Neurosci. 12: 88-104.
    • (2011) Nat. Rev. Neurosci. , vol.12 , pp. 88-104
    • Robel, S.1    Berninger, B.2    Gotz, M.3
  • 107
    • 80053563760 scopus 로고    scopus 로고
    • Induction of autophagy with catalytic mTOR inhibitors reduces huntingtin aggregates in a neuronal cell model
    • ROSCIC A., BALDO B., CROCHEMORE C., MARCELLIN D., PAGANETTI P. 2011. Induction of autophagy with catalytic mTOR inhibitors reduces huntingtin aggregates in a neuronal cell model. J. Neurochem. 119: 398-407.
    • (2011) J. Neurochem. , vol.119 , pp. 398-407
    • Roscic, A.1    Baldo, B.2    Crochemore, C.3    Marcellin, D.4    Paganetti, P.5
  • 109
    • 70349425672 scopus 로고    scopus 로고
    • Astrocytic dysfunction: Insights on the role in neurodegeneration
    • ROSSI D., VOLTERRA A. 2009. Astrocytic dysfunction: Insights on the role in neurodegeneration. Brain Res. Bull. 80: 224-232.
    • (2009) Brain Res. Bull. , vol.80 , pp. 224-232
    • Rossi, D.1    Volterra, A.2
  • 111
  • 112
    • 3342895823 scopus 로고    scopus 로고
    • Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptorindependent pathway that regulates the cytoskeleton
    • SARBASSOV D.D., ALI S.M., KIM D.H., GUERTIN D.A., LATEK R.R., ERDJUMENT-BROMAGE H., TEMPST P., SABATINI D.M. 2004. Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptorindependent pathway that regulates the cytoskeleton. Curr. Biol. 14: 1296-1302.
    • (2004) Curr. Biol. , vol.14 , pp. 1296-1302
    • Sarbassov, D.D.1    Ali, S.M.2    Kim, D.H.3    Guertin, D.A.4    Latek, R.R.5    Erdjument-Bromage, H.6    Tempst, P.7    Sabatini, D.M.8
  • 113
    • 48549083976 scopus 로고    scopus 로고
    • Two forms of astrocyte calcium excitability have distinct effects on NMDA receptor-mediated slow inward currents in pyramidal neurons
    • SHIGETOMI E., BOWSER D.N., SOFRONIEW M.V., KHAKH B.S. 2008. Two forms of astrocyte calcium excitability have distinct effects on NMDA receptor-mediated slow inward currents in pyramidal neurons. J. Neurosci. 28: 6659-6663.
    • (2008) J. Neurosci. , vol.28 , pp. 6659-6663
    • Shigetomi, E.1    Bowser, D.N.2    Sofroniew, M.V.3    Khakh, B.S.4
  • 114
    • 0028464350 scopus 로고
    • Roles for protein kinases in the induction of nitric oxide synthase in astrocytes
    • SIMMONS M.L., MURPHY S. 1994. Roles for protein kinases in the induction of nitric oxide synthase in astrocytes. Glia 11: 227-334.
    • (1994) Glia , vol.11 , pp. 227-334
    • Simmons, M.L.1    Murphy, S.2
  • 116
    • 67650289960 scopus 로고    scopus 로고
    • BDNF activates mTOR to regulateGluR1 expression required formemory formation
    • SLIPCZUK L., BEKINSCHTEIN P., KATCHE C., CAMMAROTA M., IZQUIERDO I., MEDINA J.H. 2009. BDNF activates mTOR to regulateGluR1 expression required formemory formation. PLoS One. 4: e6007. DOI: 10.1371/journal.pone.0006007.
    • (2009) PLoS One. , vol.4 , pp. e6007
    • Slipczuk, L.1    Bekinschtein, P.2    Katche, C.3    Cammarota, M.4    Izquierdo, I.5    Medina, J.H.6
  • 117
    • 25144440471 scopus 로고    scopus 로고
    • Reactive astrocytes in neural repair and protection
    • SOFRONIEW M.V. 2005. Reactive astrocytes in neural repair and protection. Neuroscientist 11: 400-407.
    • (2005) Neuroscientist , vol.11 , pp. 400-407
    • Sofroniew, M.V.1
  • 118
    • 70449678738 scopus 로고    scopus 로고
    • Molecular dissection of reactive astrogliosis and glial scar formation
    • SOFRONIEW M.V. 2009. Molecular dissection of reactive astrogliosis and glial scar formation. Trends Neurosci. 32: 638-647.
    • (2009) Trends Neurosci. , vol.32 , pp. 638-647
    • Sofroniew, M.V.1
  • 120
    • 70350550208 scopus 로고    scopus 로고
    • Beclin 1 gene transfer activates autophagy and ameliorates the neurodegenerative pathology in alphasynuclein models of Parkinson's and Lewy body diseases
    • SPENCER B., POTKAR R., TREJO M., ROCKENSTEIN E., PATRICK C., GINDI R., ADAME A., WYSS-CORAY T., MASLIAH E. 2009. Beclin 1 gene transfer activates autophagy and ameliorates the neurodegenerative pathology in alphasynuclein models of Parkinson's and Lewy body diseases. J. Neurosci. 29: 13578-13588.
    • (2009) J. Neurosci. , vol.29 , pp. 13578-13588
    • Spencer, B.1    Potkar, R.2    Trejo, M.3    Rockenstein, E.4    Patrick, C.5    Gindi, R.6    Adame, A.7    Wyss-Coray, T.8    Masliah, E.9
  • 121
    • 77956305343 scopus 로고    scopus 로고
    • Inhibition of mTOR by rapamycin abolishes cognitive deficits and reduces amyloid-beta levels in a mouse model of Alzheimer's disease
    • SPILMAN P., PODLUTSKAYA N., HART M.J., DEBNATH J., GOROSTIZA O., BREDESEN D., RICHARDSON A., STRONG R., GALVAN V. 2010. Inhibition of mTOR by rapamycin abolishes cognitive deficits and reduces amyloid-beta levels in a mouse model of Alzheimer's disease. PLoS One 5:e9979. DOI: 10.1371/journal.pone.0009979.
    • (2010) PLoS One , vol.5 , pp. e9979
    • Spilman, P.1    Podlutskaya, N.2    Hart, M.J.3    Debnath, J.4    Gorostiza, O.5    Bredesen, D.6    Richardson, A.7    Strong, R.8    Galvan, V.9
  • 122
    • 70349446525 scopus 로고    scopus 로고
    • Astrocytes in amyotrophic lateral sclerosis: direct effects on motor neuron survival
    • STAATS K.A., VAN DEN BOSCH L. 2009. Astrocytes in amyotrophic lateral sclerosis: direct effects on motor neuron survival. J. Biol. Phys. 35: 337-346.
    • (2009) J. Biol. Phys. , vol.35 , pp. 337-346
    • Staats, K.A.1    Van Den Bosch, L.2
  • 124
    • 0037039358 scopus 로고    scopus 로고
    • A rapamycin-sensitive signaling pathway contributes to long-term synaptic plasticity in the hippocampus
    • TANG S.J., REIS G., KANG H., GINGRAS A.C., SONENBERG N., SCHUMAN E.M. 2002. A rapamycin-sensitive signaling pathway contributes to long-term synaptic plasticity in the hippocampus. Proc. Natl. Acad. Sci. USA 99: 467-472.
    • (2002) Proc. Natl. Acad. Sci. USA , vol.99 , pp. 467-472
    • Tang, S.J.1    Reis, G.2    Kang, H.3    Gingras, A.C.4    Sonenberg, N.5    Schuman, E.M.6
  • 125
    • 0033774694 scopus 로고    scopus 로고
    • Amyloid beta-protein (Abeta)-containing astrocytes are located preferentially near N-terminal-truncated Abeta deposits in the human entorhinal cortex
    • THAL D.R., SCHULTZ C., DEHGHANI F., YAMAGUCHI H., BRAAK H., BRAAK E. 2000. Amyloid beta-protein (Abeta)-containing astrocytes are located preferentially near N-terminal-truncated Abeta deposits in the human entorhinal cortex. Acta Neuropathol. 100: 608-617.
    • (2000) Acta Neuropathol. , vol.100 , pp. 608-617
    • Thal, D.R.1    Schultz, C.2    Dehghani, F.3    Yamaguchi, H.4    Braak, H.5    Braak, E.6
  • 126
    • 33644873636 scopus 로고    scopus 로고
    • Enhanced episodic-like memory and kindling epilepsy in a rat model of tuberous sclerosis
    • WALTEREIT R., WELZL H., DICHGANS J., LIPP H.P., SCHMIDT W.J., WELLER M. 2006. Enhanced episodic-like memory and kindling epilepsy in a rat model of tuberous sclerosis. J. Neurochem. 96: 407-413.
    • (2006) J. Neurochem. , vol.96 , pp. 407-413
    • Waltereit, R.1    Welzl, H.2    Dichgans, J.3    Lipp, H.P.4    Schmidt, W.J.5    Weller, M.6
  • 127
    • 78650550891 scopus 로고    scopus 로고
    • Astrocyte loss of mutant SOD1 delays ALS disease onset and progression in G85R transgenic mice
    • WANG L., GUTMANN D.H., ROOS R.P. 2011. Astrocyte loss of mutant SOD1 delays ALS disease onset and progression in G85R transgenic mice. Hum. Mol. Genet. 20: 286-293.
    • (2011) Hum. Mol. Genet. , vol.20 , pp. 286-293
    • Wang, L.1    Gutmann, D.H.2    Roos, R.P.3
  • 128
    • 80755190061 scopus 로고    scopus 로고
    • Proline-rich Akt substrate of 40kDa (PRAS40): a novel downstream target of PI3k/Akt signaling pathway
    • WANG H., ZHANG Q., WEN Q., ZHENG Y., LAZAROVICI P., JIANG H., LIN J., ZHENG W. 2012. Proline-rich Akt substrate of 40kDa (PRAS40): a novel downstream target of PI3k/Akt signaling pathway. Cell Signal. 24: 17-24.
    • (2012) Cell Signal. , vol.24 , pp. 17-24
    • Wang, H.1    Zhang, Q.2    Wen, Q.3    Zheng, Y.4    Lazarovici, P.5    Jiang, H.6    Lin, J.7    Zheng, W.8
  • 129
    • 0032487575 scopus 로고    scopus 로고
    • Prominent expression of presenilin-1 in senile plaques and reactive astrocytes in Alzheimer's disease brain
    • WEGGEN S., DIEHLMANN A., BUSLEI R., BEYREUTHER K., BAYER T.A. 1998. Prominent expression of presenilin-1 in senile plaques and reactive astrocytes in Alzheimer's disease brain. Neuroreport 9: 3279-3283.
    • (1998) Neuroreport , vol.9 , pp. 3279-3283
    • Weggen, S.1    Diehlmann, A.2    Buslei, R.3    Beyreuther, K.4    Bayer, T.A.5
  • 131
    • 32044465506 scopus 로고    scopus 로고
    • TOR signaling in growth and metabolism
    • WULLSCHLEGER S., LOEWITH R., HALL M.N. 2006. TOR signaling in growth and metabolism. Cell 124: 471-484.
    • (2006) Cell , vol.124 , pp. 471-484
    • Wullschleger, S.1    Loewith, R.2    Hall, M.N.3
  • 134
    • 27844611259 scopus 로고    scopus 로고
    • Induction and maintenance of late-phase long-term potentiation in isolated dendrites of rat hippocampal CA1 pyramidal neurones
    • VICKERS C.A., DICKSON K.S., WYLLIE D.J. 2005. Induction and maintenance of late-phase long-term potentiation in isolated dendrites of rat hippocampal CA1 pyramidal neurones. J. Physiol. 568: 803-813.
    • (2005) J. Physiol. , vol.568 , pp. 803-813
    • Vickers, C.A.1    Dickson, K.S.2    Wyllie, D.J.3
  • 136
    • 84856990170 scopus 로고    scopus 로고
    • Early astrocytic atrophy in the entorhinal cortex of a triple transgenic animal model of Alzheimer's disease
    • YEH C.Y., VADHWANA B., VERKHRATSKY A., RODRIGUEZ J.J. 2012. Early astrocytic atrophy in the entorhinal cortex of a triple transgenic animal model of Alzheimer's disease. ASN Neuro 3: 271-279.
    • (2012) ASN Neuro , vol.3 , pp. 271-279
    • Yeh, C.Y.1    Vadhwana, B.2    Verkhratsky, A.3    Rodriguez, J.J.4
  • 137
    • 42949140259 scopus 로고    scopus 로고
    • Rapamycin prevents epilepsy in a mouse model of tuberous sclerosis complex
    • ZENG L.H., XU L., GUTMANN D.H., WONG M. 2008. Rapamycin prevents epilepsy in a mouse model of tuberous sclerosis complex. Ann. Neurol. 63: 444-445.
    • (2008) Ann. Neurol. , vol.63 , pp. 444-445
    • Zeng, L.H.1    Xu, L.2    Gutmann, D.H.3    Wong, M.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.