Mammalian target of Rapamycin’s distinct roles and effectiveness in promoting compensatory axonal sprouting in the injured CNS

Journal of Neuroscience

Volumn 34, Issue 46, 2014, Pages 15347-15355

  Lee, Do Hun ^a   Luo, Xueting ^a   Yungher, Benjamin J ^a   Bray, Eric ^a   Lee, Jae K ^a   Park, Kevin K ^a  

^a UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

Author keywords

Axon growth; Axon regeneration; Axon sprouting; MTOR; PTEN; Pyramidotomy

Indexed keywords

CHONDROITIN ABC LYASE; MAMMALIAN TARGET OF RAPAMYCIN; PHOSPHATIDYLINOSITOL 3, 4, 5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEOCHONDROITIN SULFATE; RAPAMYCIN; UNCLASSIFIED DRUG; MTOR PROTEIN, MOUSE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PTEN PROTEIN, MOUSE; TARGET OF RAPAMYCIN KINASE;

ADENO ASSOCIATED VIRUS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN INJURY; CELL COUNTING; CONTROLLED STUDY; CRANIOTOMY; ENZYME INHIBITION; FEMALE; IMMUNOHISTOCHEMISTRY; MOUSE; NERVE CELL PLASTICITY; NERVE FIBER REGENERATION; NERVE SPROUTING; NONHUMAN; PERINATAL PERIOD; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PYRAMIDAL TRACT; PYRAMIDOTOMY; SURGICAL TECHNIQUE; YOUNG ADULT; AGING; ANIMAL; ANTAGONISTS AND INHIBITORS; DRUG EFFECTS; GENETICS; KNOCKOUT MOUSE; MALE; NERVE FIBER; NERVE REGENERATION; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; TRANSGENIC MOUSE;

AGING; ANIMALS; AXONS; BRAIN INJURIES; CHONDROITIN ABC LYASE; CHONDROITIN SULFATE PROTEOGLYCANS; FEMALE; MALE; MICE; MICE, KNOCKOUT; MICE, TRANSGENIC; NERVE REGENERATION; PTEN PHOSPHOHYDROLASE; PYRAMIDAL TRACTS; SIROLIMUS; TOR SERINE-THREONINE KINASES;

EID: 84909951876     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.1935-14.2014     Document Type: Article

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