Synergistic neuroprotection by epicatechin and quercetin: Activation of convergent mitochondrial signaling pathways

Neuroscience

Volumn 308, Issue , 2015, Pages 75-94

  Nichols, M ^a   Zhang, J ^a   Polster, B M ^b   Elustondo, P A ^a   Thirumaran, A ^a   Pavlov, E V ^c   Robertson, G S ^a,d  

^a DALHOUSIE UNIVERSITY   (Canada)

^b UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^c NEW YORK UNIVERSITY   (United States)

^d QUEEN ELIZABETH II HEALTH SCIENCES CENTRE   (Canada)

Author keywords

CAMP response element binding protein; Flavonoid; Mitochondria; Neuroprotection; Nitric oxide synthase; Protein kinase B

Indexed keywords

CALCIUM ION; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; EPICATECHIN; EPICATECHIN PLUS QUERCETIN; NITRIC OXIDE SYNTHASE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; PROTEIN BCL 2; PROTEIN KINASE B; QUERCETIN; UNCLASSIFIED DRUG; CALCIUM; CATECHIN; GLUCOSE; NEUROPROTECTIVE AGENT;

ADULT; ANIMAL CELL; ANIMAL CELL CULTURE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOGENESIS; BRAIN CELL; BRAIN MITOCHONDRION; CALCIUM CELL LEVEL; CELL FUNCTION; CELL SURVIVAL; CELLULAR PARAMETERS; CONTROLLED STUDY; CYTOSOL; DRUG POTENTIATION; EMBRYO; ENZYME ACTIVATION; ENZYME INHIBITION; FEMALE; GENE EXPRESSION; GENE TARGETING; HYPOXIC ISCHEMIC ENCEPHALOPATHY; MALE; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRIAL RESPIRATION; MOUSE; NERVE CELL; NERVE CELL NECROSIS; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; TREATMENT DURATION; ANIMAL; BRAIN CORTEX; BRAIN ISCHEMIA; CELL CULTURE; CELL DEATH; CELL HYPOXIA; DEFICIENCY; DRUG EFFECTS; METABOLISM; MITOCHONDRION; OXYGEN CONSUMPTION; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY;

ANIMALS; BRAIN ISCHEMIA; CALCIUM; CATECHIN; CELL DEATH; CELL HYPOXIA; CELL SURVIVAL; CELLS, CULTURED; CEREBRAL CORTEX; DRUG SYNERGISM; GLUCOSE; MALE; MEMBRANE POTENTIAL, MITOCHONDRIAL; MICE; MITOCHONDRIA; NEURONS; NEUROPROTECTIVE AGENTS; OXYGEN CONSUMPTION; QUERCETIN;

EID: 84942279063     PISSN: 03064522     EISSN: 18737544     Source Type: Journal    
DOI: 10.1016/j.neuroscience.2015.09.012     Document Type: Article

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