Calcium-dependent and calcium-independent activation of the endothelial NO synthase

Journal of Vascular Research

Volumn 34, Issue 3, 1997, Pages 165-174

  Fleming, Ingrid ^a   Bauersachs, Johann ^a   Busse, Rudi ^a  

^a UNIVERSITY HOSPITAL FRANKFURT   (Germany)

Author keywords

Endothelial cells; Nitric oxide; Phospholipase C; Protein tyrosine phosphatase; Shear stress; Tyrosine kinase

Indexed keywords

CALCIUM ION; CALMODULIN; CALMODULIN INHIBITOR; CATION CHANNEL; ERBSTATIN; GENISTEIN; INOSITOL 1,4,5 TRISPHOSPHATE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; PHOSPHOLIPASE C; PROTEIN TYROSINE KINASE INHIBITOR; PROTEIN TYROSINE PHOSPHATASE; STAUROSPORINE;

ANIMAL TISSUE; CALCIUM CELL LEVEL; CONFERENCE PAPER; FEMALE; HUMAN; HUMAN TISSUE; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RABBIT; SHEAR STRESS; SIGNAL TRANSDUCTION; UMBILICAL VEIN; VASCULAR ENDOTHELIUM;

EID: 0030990083     PISSN: 10181172     EISSN: 14230135     Source Type: Journal    
DOI: 10.1159/000159220     Document Type: Article

References (57)

1. Busse R, Mülsch A: Calcium-dependent nitric oxide synthesis in endothelial cytosol is mediated by calmodulin, FEBS Lett 1990:265: 133-136.
2. Exton JH: Phosphatidylcholine breakdown and signal transduction, Biochim Biophvs Acta 1994:1212:26-42.
3. Newby AC, Henderson AH: Stimulus-secretion coupling in vascular endothelial cells, Annu Rev Physiol 1990;52:661-674.
4. Singer AH, Peach MJ: Calicum-and endothe-lial-mediated vascular smooth muscle relaxation in rabbit aorta, Hypertension 1982:4:1119-1125.
5. Lückhofl A, Pohl U, Miilsch A, Busse R: Differential role of extra-and intracellular calcium in the release of EDRF and prostacyclin from cultured endothelial cells, Br J Pharmacol 1988:95:189-196.
6. Adams DJ, Barakeh J, Laskey R, van Bremen C: Ion channels and regulation of intracellular calcium in vascular endothelial cells, FASEB J 1989:3:2389-2400.
7. Freay A, Johns A, Adams DJ, Ryan US, van Breemen C: Bradykinin and inositol 1,4.5-tris-phosphate-stimulated calcium release from intracellular stores in cultured bovine endothelial cells, Pflügers Arch 1989:414:377-384.
8. Pirotton S, Raspe F., Demolle D, Emeux C, Boeynacms JM: Involvement of inositol 1.4.5-trisphosphate and calcium in the action of adenosine nucleotides on aortic endothelial cells, J Biol Chem 1987:262:17461-17466.
9. Fleming I, Flecker M, Busse R: Intracellular alkalinization induced by bradykinin sustains activation of the constitutive nitric oxide synthase in endothelial cells, Circ Res 1994:74: 1220-1226.
10. Ruchan MJ, Frangos JA: Role of calcium and calmodulin in flow-induced nitric oxide production in endothelial cells. Am J Physiol 1994; 266:C628-C636.
11. Ayajiki K, Icindcrmann M, Hecker M, Fleming I, Busse R: Intracellular pH and tyrosine phosphorylation but not calcium determine shear stress-induced nitric oxide production in native endothelial cells, Circ Res 1996:78:750-758.
12. 2+. Am J Physiol 1995;269:C863-C869.
13. Busse R, Lamontagne D: Endothelium-derived bradvkinin is responsible for the increase in calcium produced by angiotensin-converting enzyme inhibitors in human endothelial cells, Naunyn Schmicdebcrgs Arch Pharmacol 1991: 344:126-129.
14. Fleming I, Fisslthalcr B, Busse R: Calcium signaling in endothelial cells involves activation of tyrosine kinases and leads to activation of MAP kinase, Circ Res 1995:76:522-529.
15. −response to hypoxia, Pflügers Arch 1983:397: 78-80.
16. 2+ influx and the formation of endothelium-derived relaxing factor mediated by a G protein? Eur J Pharmacol 1992:225:43-49.
17. Liao JK, Homey CJ: The G proteins of the Go, and the Go, family couple the bradvkinin receptor to the release of endothelium-derived relaxing factor, J Clin Invest 1993:92:2168-2172.
18. Derian CK, Maskowitz MA: Polyphosphoinositide hydrolysis in endothelial cells and carotid artery segments (Bradykinin-2 receptor stimulation is calcium-independent), J Biol Chem 1986:261:3831-3837.
19. Lambert TL, Kent RS, Whorton AR: Bradykinin stimulation of inositol polyphosphate production in porcine aortic endothelial cells, J Biol Chem 1986;261:15288-15293.
20. Qa subunit gene family activate phospholipase Cß isozymes, J Biol Chem 1992,267:16044-16047.
21. Nishibe S, Wahl MI, Hernández-Sotomayor SMT, Tonks NK, Rhee SG, Carpenter G: Increase of the catalytic activity of phospholipase C-y I by tyrosine phosphorylation, Science 1990:250:1253-1256.
22. Rhee SG, Choi KD: Regulation of inositol phospholipid-specific phospholipase C isozymes, J Biol Chem 1992:267:12393-12396.
23. Fleming I, Fisslthalcr B, Busse R: Interdependence of calcium signaling and protein tyrosine phosphorylation in human endothelial cells, J Biol Chem 1996:271:11009-11015.
24. Paxton WG, Marrero MB, Klein JD, Delafon-tainc P, Berk BC, Bernstein KE: The angiotensin II AT receptor is tyrosine and serine phos-phorylaled and can serve as a substrate for the SRC family of tyrosine kinases, Biochem Bio-phys Res Commun 1994,200:260-267.
25. Marrero MB, Paxton WG, Dutf JL, Berk BC, Bernstein KE: Angiotensin II stimulates tyrosine phosphorylation of phospholipase C-y I in vascular smooth muscle cells, J Biol Chem 1994;269:10935-10939.
26. Putney JW: Capacitativc calcium-entry revisited, Cell Calcium 1990:11:611-624.
27. Dolor RJ, Hurowitz LM, Mirza Z, Strauss HC, Whorton AR: Regulation of extracellular calcium entry in endothelial cells: Role of intracellular calcium pool. Am J Physiol 1992:262: C171-C181.
28. Vostal JG, Shafer B: Thapsigargin-induced calcium influx in the absence of detectable tyrosine phosphorylation in human platelets, J Biol Chem 1996:271:19524-19529.
29. Bird GSJ, Putney JW': Inhibition of thapsigar-gin-induccd calcium entry by microinjected guanine nucleotide analogues, J Biol Chem 1993;268:21486-21488.
30. Fasolato C, Hoth M, Penner R: A G TP-dependent step in the activation mechanism of capacitai ive calcium influx, J Biol Chem 1993:268: 20737-20740.
31. 2+ inflow in hepatocytes, FEBS Lett 1994:346:235-240.
32. Hajnóczky G, Lin C, Thomas AP: Luminal communication between intracellular calcium stores modulated by GTP and the cytoskeleton, J Biol Chem 1994:269:10280-10287.
33. 2+ influx. Nature 1993:364:809-814.
34. 2+, J Biol Chem 1995:270:29-32.
35. 2+ and K* current by means of a phosphatase and a diffusible messenger. Nature 1993:364:814-818.
36. Bird GSJ, Bian X, Putney JW Jr.: Calcium entry signal? Nature 1995:373:481-482.
37. 2+ store depletion in human platelets is more susceptible to cytochrome P-450 inhibitors than receptor-mediated calcium entry, Cell Calcium 1992:13:553-564.
38. 2’ influx. Biochem J 1991;274:193-197.
39. 2+-dcpcndent K+ channels by cytochrome P-450 inhibitors, J Biol Chem 1992:267:11789-11793.
40. 2+ entry in human and bovine endothelial cells. J Physiol (Lond) 1995:482:259-274.
41. Fleming I, Bara A, Busse R: Calcium signalling and autacoid production in endothelial cells are modulated by changes in tyrosine kinase and phosphatase activity. J Vase Res 1996:33: 225-234.
42. Nakaikc R, Shomokawa H, Owada MK, Toku-naga O, Yasutake H, Kishimoto T, Imada C, Shiraishi T, Engashira K, Takeshita A: Vanadate eauses synthesis of endothelium-derived NO via a pertussis toxin-sensitive G protein in pigs. Am J Physiol 1996;271:H296-H302.
43. Caselli A, Camici G, Manao G, Moneti G, Pazzagl L, Cappugi G, Ramponi G: Nitric oxide causes inactivation of the low molecular weight phosphotvrosine protein phosphatase, J Biol Chem 1994;269:24878-24882.
44. Pcranovich TMS, Da Silva AM, Fries DM, Stem A, Monteiro HP: Nitric oxide stimulates tyrosine phosphorylation in murine fibroblasts in the absence and presence of epidermal growth factor. Biochem J 1995:305:613-619.
45. Griffith TM, Edwards DH: Myogenic autoreg-ulat on of flow may be inversely related to endothelium-derived relaxing factor activity. Am J Physiol 1990;258:H1171-H1180.
46. Pohl U, Herían K, Huang A, Bassenge E: EDRF-mediatcd shear-induced dilation opposes myogenic vasoconstriction in small rabbit arteries. Am J Physiol 1991:261:H2016-H2023.
47. Busse R, Mülsch A, Fleming I, Hecker M: Mechanisms of nitric oxide release from the vascular endothelium, Circulation 1993:87: V18-V25.
48. Sigurdson WJ, Sachs F, Diamond SL: Mechanical perturbation of cultured human endothelial cells causes rapid increases of intracellular calcium. Am J Physiol 1993;264:H1745-H1752.
49. Demer LL, Wortham CM, Dirksen ER, Sanderson MJ: Mechanical stimulation induced intracellular calcium signalling in bovine aortic endothelial cells. Am J Physiol 1993;264: H2094-H2102.
50. 2+ transients in endothelial cells from human umbilical vein. Proc Natl Acad Sci USA 1994;91:2940-2944.
51. Schwarz G, Callewacrt G, Droogmans G, Nilius B: Shear-stress-induced calcium transients in endothelial cells from human umbilical cord veins. J Physiol (Lond) 1992:458:527-538.
52. 2+ signaling of vascular endothelial cells: Effects of shear stress and ATP. Am J Physiol 1991:260:H1698-H1707.
53. Shcn J, Luscinskas FW, Connolly A, Dewey CF Jr., Gimbrone MA Jr.: Fluid shear stress modulates cytosolic free calcium in vascular endothelial’cells. Am J Physiol 1992;262:C384-C390.
54. Schwarz G, Droogmans G, Nilius B: Shear stress induced membrane currents and calcium transients in human vascular endothelial cells, Pflügers Arch 1992;421:394-396.
55. Davis PD, Hill CH, Keech E, Lawton G, Nixon JS, Sedgwick AD, Wadsworth J, Wcstmacott D, Wilkinson SE: Potent selective inhibitors of protein kinase C, FEBS Lett 1989:259:61-63.
56. Fleming I, Bauersachs J, Fisslthalcr B, Busse R: Calcium-independent activation of the endothelial NO synthase via shear stress and tyrosine phosphatase inhibition (abstract), FASEB J 1996; 10:A3031.
57. Fleming I, Fisslthalcr B, Bauersachs T, Scholz D, Busse R: Redistribution of the endothelial nitric oxide synthase to the cytoskeleton by tyrosine phosphatase inhibitors and shear stress is associated with its calcium-independent activation, submitted.