메뉴 건너뛰기




Volumn 8, Issue 4, 2009, Pages 397-409

The multiple faces of quercetin in neuroprotection

Author keywords

BBB; In vitro studies; In vivo studies; Neurodegeneration; Quercetin; Quercetin aglycone; Quercetin glycosides; Quercetin metabolites; Quercetin safety; Quercetin toxicity

Indexed keywords

2' GLUTATHIONYLQUERCETIN; 3 HYDROXYMETHYLQUERCETIN; 4' O METHYLQUERCETIN; AGLYCONE; DRUG METABOLITE; GLUCURONIC ACID; ISORHAMNETIN; LIPOSOME; QUERCETIN; QUERCETIN 3 GLUCURONIDE; QUERCETIN 3 METHYL ETHER; QUERCETIN 3 SULFATE; QUERCETIN 7 GLUCURONIDE; UNCLASSIFIED DRUG;

EID: 67650529189     PISSN: 14740338     EISSN: None     Source Type: Journal    
DOI: 10.1517/14740330903026944     Document Type: Review
Times cited : (138)

References (111)
  • 1
    • 34249882770 scopus 로고    scopus 로고
    • Effects of dietary flavonoids on apoptotic pathways related to cancer chemoprevention
    • DOI 10.1016/j.jnutbio.2006.11.004, PII S0955286306002646
    • Ramos S. Effects of dietary flavonoids on apoptotic pathways related to cancer chemoprevention. J Nutr Biochem 2007;18:427-442 (Pubitemid 46874924)
    • (2007) Journal of Nutritional Biochemistry , vol.18 , Issue.7 , pp. 427-442
    • Ramos, S.1
  • 2
    • 43049176634 scopus 로고    scopus 로고
    • Health effects of quercetin: From antioxidant to nutraceutical
    • Boots AW, Haenen GR, Bast A. Health effects of quercetin: from antioxidant to nutraceutical. Eur J Pharmacol 2008;585:325-337
    • (2008) Eur J Pharmacol , vol.585 , pp. 325-337
    • Boots, A.W.1    Haenen, G.R.2    Bast, A.3
  • 3
    • 55149104161 scopus 로고    scopus 로고
    • Quercetin: Potentials in the prevention and therapy of disease
    • Bischoff SC. Quercetin: potentials in the prevention and therapy of disease. Curr Opin Clin Nutr Metab Care 2008;11:733-740
    • (2008) Curr Opin Clin Nutr Metab Care , vol.11 , pp. 733-740
    • Bischoff, S.C.1
  • 5
    • 70450223158 scopus 로고    scopus 로고
    • The neuroprotective potential of flavonoids: A multiplicity of effects
    • Vauzour D, Vafeiadou K, Rodriguez-Mateos A, et al. The neuroprotective potential of flavonoids: a multiplicity of effects. Genes Nutr 2008;3:115-126
    • (2008) Genes Nutr , vol.3 , pp. 115-126
    • Vauzour, D.1    Vafeiadou, K.2    Rodriguez-Mateos, A.3
  • 6
    • 0028793218 scopus 로고
    • Absorption of dietary quercetin glycosides and quercetin in healthy ileostomy volunteers
    • Hollman PC, de Vries JH, van Leeuwen SD, et al. Absorption of dietary quercetin glycosides and quercetin in healthy ileostomy volunteers. Am J Clin Nutr 1995;62:1276-1282
    • (1995) Am J Clin Nutr , vol.62 , pp. 1276-1282
    • Hollman, P.C.1    De Vries, J.H.2    Van Leeuwen, S.D.3
  • 7
    • 4043089112 scopus 로고    scopus 로고
    • Pharmacokinetics and metabolism of dietary flavonoids in humans
    • DOI 10.1080/10715760410001727858
    • Manach C, Donovan JL. Pharmacokinetics and metabolism of dietary flavonoids in humans. Free Radic Res 2004;38:771-785 (Pubitemid 39077365)
    • (2004) Free Radical Research , vol.38 , Issue.8 , pp. 771-785
    • Manach, C.1    Donovan, J.L.2
  • 8
    • 17744396286 scopus 로고    scopus 로고
    • Pharmacokinetics and bioavailability of quercetin glycosides in humans
    • In human plasma, only quercetin glucuronides, but not quercetin aglycone, was detected
    • Graefe EU, Wittig J, Mueller S, et al. Pharmacokinetics and bioavailability of quercetin glycosides in humans. J Clin Pharmacol 2001;41:492-9 • In human plasma, only quercetin glucuronides, but not quercetin aglycone, was detected.
    • (2001) J Clin Pharmacol , vol.41 , pp. 492-499
    • Graefe, E.U.1    Wittig, J.2    Mueller, S.3
  • 12
    • 0026737244 scopus 로고
    • Glucuronidation of drugs. a re-evaluation of the pharmacological significance of the conjugates and modulating factors
    • Kroemer HK, Klotz U. Glucuronidation of drugs. A re-evaluation of the pharmacological significance of the conjugates and modulating factors. Clin Pharmacokinet 1992;23:292-310
    • (1992) Clin Pharmacokinet , vol.23 , pp. 292-310
    • Kroemer, H.K.1    Klotz, U.2
  • 13
    • 44049084958 scopus 로고    scopus 로고
    • Macrophage as a target of quercetin glucuronides in human atherosclerotic arteries: Implication in the anti-atherosclerotic mechanism of dietary flavonoids
    • Kawai Y, Nishikawa T, Shiba Y, et al. Macrophage as a target of quercetin glucuronides in human atherosclerotic arteries: implication in the anti-atherosclerotic mechanism of dietary flavonoids. J Biol Chem 2008;283:9424-9434
    • (2008) J Biol Chem , vol.283 , pp. 9424-9434
    • Kawai, Y.1    Nishikawa, T.2    Shiba, Y.3
  • 14
    • 0029057329 scopus 로고
    • Quercetin metabolites in plasma of rats fed diets containing rutin or quercetin
    • Manach C, Morand C, Texier O, et al. Quercetin metabolites in plasma of rats fed diets containing rutin or quercetin. J Nutr 1995;125:1911-1922
    • (1995) J Nutr , vol.125 , pp. 1911-1922
    • Manach, C.1    Morand, C.2    Texier, O.3
  • 15
    • 51049095905 scopus 로고    scopus 로고
    • Daily quercetin supplementation dose-dependently increases plasma quercetin concentrations in healthy humans
    • Egert S, Wolffram S, Bosy-Westphal A, et al. Daily quercetin supplementation dose-dependently increases plasma quercetin concentrations in healthy humans. J Nutr 2008;138:1615-1621
    • (2008) J Nutr , vol.138 , pp. 1615-1621
    • Egert, S.1    Wolffram, S.2    Bosy-Westphal, A.3
  • 16
    • 0346748147 scopus 로고    scopus 로고
    • Cell culture protection and in vivo neuroprotective capacity of flavonoids
    • In rats, after single intraperitoneal injection of free quercetin (30 mg/kg), no quercetin was detected in the brain tissue during the period 30 min - 4 h. Quercetin-lecithin preparation augmented the access of quercetin into the brain
    • Dajas F, Rivera F, Blasina F, et al. Cell culture protection and in vivo neuroprotective capacity of flavonoids. Neurotox Res 2003;5:425-32 • In rats, after single intraperitoneal injection of free quercetin (30 mg/kg), no quercetin was detected in the brain tissue during the period 30 min - 4 h. Quercetin-lecithin preparation augmented the access of quercetin into the brain.
    • (2003) Neurotox Res , vol.5 , pp. 425-432
    • Dajas, F.1    Rivera, F.2    Blasina, F.3
  • 18
    • 49449084484 scopus 로고    scopus 로고
    • Tissue distribution of quercetin in pigs after long-term dietary supplementation
    • Bieger J, Cermak R, Blank R, et al. Tissue distribution of quercetin in pigs after long-term dietary supplementation. J Nutr 2008;138:1417-1420
    • (2008) J Nutr , vol.138 , pp. 1417-1420
    • Bieger, J.1    Cermak, R.2    Blank, R.3
  • 19
    • 0037627453 scopus 로고    scopus 로고
    • Disposition of the flavonoid quercetin in rats after single intravenous and oral doses
    • DOI 10.1081/DDC-120018375
    • Khaled KA, El-Sayed YM, Al-Hadiya BM. Disposition of the flavonoid quercetin in rats after single intravenous and oral doses. Drug Dev Ind Pharm 2003;29:397-403 (Pubitemid 36528607)
    • (2003) Drug Development and Industrial Pharmacy , vol.29 , Issue.4 , pp. 397-403
    • Khaled, K.A.1    El-Sayed, Y.M.2    Al-Hadiya, B.M.3
  • 22
    • 10644277049 scopus 로고    scopus 로고
    • Protective effects of quercetin and vitamin C against oxidative stress-induced neurodegeneration
    • Heo HJ, Lee CY. Protective effects of quercetin and vitamin C against oxidative stress-induced neurodegeneration. J Agric Food Chem 2004;52:7514-7517
    • (2004) J Agric Food Chem , vol.52 , pp. 7514-7517
    • Heo, H.J.1    Lee, C.Y.2
  • 23
    • 0037422406 scopus 로고    scopus 로고
    • Protective effects of flavonoids on the cytotoxicity of linoleic acid hydroperoxide toward rat pheochromocytoma PC12 cells
    • DOI 10.1016/S0009-2797(02)00248-X, PII S000927970200248X
    • Sasaki N, Toda T, Kaneko T, et al. Protective effects of flavonoids on the cytotoxicity of linoleic acid hydroperoxide toward rat pheochromocytoma PC12 cells. Chem Biol Interact 2003;145:101-116 (Pubitemid 36246614)
    • (2003) Chemico-Biological Interactions , vol.145 , Issue.1 , pp. 101-116
    • Sasaki, N.1    Toda, T.2    Kaneko, T.3    Baba, N.4    Matsuo, M.5
  • 24
    • 56949098646 scopus 로고    scopus 로고
    • Oxidative DNA damage protection and repair by polyphenolic compounds in PC12 cells
    • Silva JP, Gomes AC, Coutinho OP. Oxidative DNA damage protection and repair by polyphenolic compounds in PC12 cells. Eur J Pharmacol 2008;601:50-60
    • (2008) Eur J Pharmacol , vol.601 , pp. 50-60
    • Silva, J.P.1    Gomes, A.C.2    Coutinho, O.P.3
  • 25
    • 0242467845 scopus 로고    scopus 로고
    • Elevation of oxidative free radicals in Alzheimer's disease models can be attenuated by Ginkgo biloba extract EGb 761
    • Smith JV, Luo Y. Elevation of oxidative free radicals in Alzheimer's disease models can be attenuated by Ginkgo biloba extract EGb 761. J Alzheimers Dis 2003;5:287-300 (Pubitemid 37411776)
    • (2003) Journal of Alzheimer's Disease , vol.5 , Issue.4 , pp. 287-300
    • Vining Smith, J.1    Luo, Y.2
  • 26
    • 27744563958 scopus 로고    scopus 로고
    • Effects of naturally occurring compounds on fibril formation and oxidative stress of beta-amyloid
    • Kim H, Park BS, Lee KG, et al. Effects of naturally occurring compounds on fibril formation and oxidative stress of beta-amyloid. J Agric Food Chem 2005;53:8537-8541
    • (2005) J Agric Food Chem , vol.53 , pp. 8537-8541
    • Kim, H.1    Park, B.S.2    Lee, K.G.3
  • 28
    • 38349125358 scopus 로고    scopus 로고
    • Quercetin 3-glucoside protects neuroblastoma (SH-SY5Y) cells in vitro against oxidative damage by inducing sterol regulatory element-binding protein-2-mediated cholesterol biosynthesis
    • Soundararajan R, Wishart AD, Rupasinghe HP, et al. Quercetin 3-glucoside protects neuroblastoma (SH-SY5Y) cells in vitro against oxidative damage by inducing sterol regulatory element-binding protein-2-mediated cholesterol biosynthesis. J Biol Chem 2008;283:2231-2245
    • (2008) J Biol Chem , vol.283 , pp. 2231-2245
    • Soundararajan, R.1    Wishart, A.D.2    Rupasinghe, H.P.3
  • 30
    • 0037352890 scopus 로고    scopus 로고
    • The immunophilin-ligands FK506 and V-10,367 mediate neuroprotection by the heat shock response
    • DOI 10.1038/sj.bjp.0705132
    • Klettner A, Herdegen T. The immunophilin-ligands FK506 and V-10,367 mediate neuroprotection by the heat shock response. Br J Pharmacol 2003;138:1004-1012 (Pubitemid 36390658)
    • (2003) British Journal of Pharmacology , vol.138 , Issue.5 , pp. 1004-1012
    • Klettner, A.1    Herdegen, T.2
  • 32
    • 47849085831 scopus 로고    scopus 로고
    • Time-dependent protective and harmful effects of quercetin on 6-OHDA-induced toxicity in neuronal SH-SY5Y cells
    • DOI 10.1016/j.tox.2008.04.001, PII S0300483X08001662
    • Ossola B, Kääriäinen TM, Raasmaja A, Männistö PT. Time-dependent protective and harmful effects of quercetin on 6-OHDA-induced toxicity in neuronal SH-SY5Y cells. Toxicology 2008;250:1-8 • Quercetin protective concentrations become toxic after prolonged exposures (> 24 h). Moreover, the toxic effects of quercetin occurred at a concentration only twofold higher than the one that produced the greatest protection. (Pubitemid 352040761)
    • (2008) Toxicology , vol.250 , Issue.1 , pp. 1-8
    • Ossola, B.1    Kaariainen, T.M.2    Raasmaja, A.3    Mannisto, P.T.4
  • 33
    • 33749239851 scopus 로고    scopus 로고
    • Effect of a conjugated quercetin metabolite, quercetin 3-glucuronide, on lipid hydroperoxide-dependent formation of reactive oxygen species in differentiated PC-12 cells
    • DOI 10.1080/10715760600794287, PII T43JR880P1157173, Polyphenols and Health
    • Shirai M, Kawai Y, Yamanishi R, et al. Effect of a conjugated quercetin metabolite, quercetin 3-glucuronide, on lipid hydroperoxide-dependent formation of reactive oxygen species in differentiated PC-12 cells. Free Radic Res 2006;40:1047-1053 (Pubitemid 44480545)
    • (2006) Free Radical Research , vol.40 , Issue.10 , pp. 1047-1053
    • Shirai, M.1    Kawai, Y.2    Yamanishi, R.3    Kinoshita, T.4    Chuman, H.5    Terao, J.6
  • 34
    • 61949439773 scopus 로고    scopus 로고
    • Different sensitivity of neurons and neuroblastoma cells to quercetin treatment
    • Jakubowicz-Gil J, Rzeski W, Zdzisinska B, et al. Different sensitivity of neurons and neuroblastoma cells to quercetin treatment. Acta Neurobiol Exp (Wars) 2008;68:463-476
    • (2008) Acta Neurobiol Exp (Wars) , vol.68 , pp. 463-476
    • Jakubowicz-Gil, J.1    Rzeski, W.2    Zdzisinska, B.3
  • 35
    • 0041816456 scopus 로고    scopus 로고
    • Modulation of pro-survival Akt/protein kinase B and ERK1/2 signaling cascades by quercetin and its in vivo metabolites underlie their action on neuronal viability
    • DOI 10.1074/jbc.M305063200
    • Spencer JP, Rice-Evans C, Williams RJ. Modulation of pro-survival Akt/protein kinase B and ERK1/2 signaling cascades by quercetin and its in vivo metabolites underlie their action on neuronal viability. J Biol Chem 2003;278:34783-34793 (Pubitemid 37102237)
    • (2003) Journal of Biological Chemistry , vol.278 , Issue.37 , pp. 34783-34793
    • Spencer, J.P.E.1    Rice-Evans, C.2    Williams, R.J.3
  • 37
    • 52049092512 scopus 로고    scopus 로고
    • Glial metabolism of quercetin reduces its neurotoxic potential
    • Vafeiadou K, Vauzour D, Rodriguez-Mateos A, et al. Glial metabolism of quercetin reduces its neurotoxic potential. Arch Biochem Biophys 2008;478:195-200
    • (2008) Arch Biochem Biophys , vol.478 , pp. 195-200
    • Vafeiadou, K.1    Vauzour, D.2    Rodriguez-Mateos, A.3
  • 38
    • 48049106637 scopus 로고    scopus 로고
    • Peroxynitrite induced formation of the neurotoxins 5-S-cysteinyl-dopamine and DHBT-1: Implications for Parkinson's disease and protection by polyphenols
    • Vauzour D, Ravaioli G, Vafeiadou K, et al. Peroxynitrite induced formation of the neurotoxins 5-S-cysteinyl-dopamine and DHBT-1: implications for Parkinson's disease and protection by polyphenols. Arch Biochem Biophys 2008;476:145-151
    • (2008) Arch Biochem Biophys , vol.476 , pp. 145-151
    • Vauzour, D.1    Ravaioli, G.2    Vafeiadou, K.3
  • 39
    • 61349146539 scopus 로고    scopus 로고
    • Curcumin, quercetin and tBHQ modulate glutathione levels in astrocytes and neurons: Importance of the glutamate cysteine ligase modifier subunit
    • Lavoie S, Chen Y, Dalton TP, et al. Curcumin, quercetin and tBHQ modulate glutathione levels in astrocytes and neurons: importance of the glutamate cysteine ligase modifier subunit. J Neurochem 2009;108:1410-1422
    • (2009) J Neurochem , vol.108 , pp. 1410-1422
    • Lavoie, S.1    Chen, Y.2    Dalton, T.P.3
  • 40
    • 27644544444 scopus 로고    scopus 로고
    • In vitro cytotoxicity assays: Comparison of LDH, neutral red, MTT and protein assay in hepatoma cell lines following exposure to cadmium chloride
    • Fotakis G, Timbrell JA. In vitro cytotoxicity assays: comparison of LDH, neutral red, MTT and protein assay in hepatoma cell lines following exposure to cadmium chloride. Toxicol Lett 2006;160:171-177
    • (2006) Toxicol Lett , vol.160 , pp. 171-177
    • Fotakis, G.1    Timbrell, J.A.2
  • 41
    • 12244283706 scopus 로고    scopus 로고
    • Neuroprotective effects of antioxidative flavonoids, quercetin, (+)-dihydroquercetin and quercetin 3-methyl ether, isolated from Opuntia ficus-indica var. saboten
    • DOI 10.1016/S0006-8993(02)04150-1
    • Dok-Go H, Lee KH, Kim HJ, et al. Neuroprotective effects of antioxidative flavonoids, quercetin, (+)-dihydroquercetin and quercetin 3-methyl ether, isolated from Opuntia ficus-indica var. saboten. Brain Res 2003;965:130-136 (Pubitemid 36183694)
    • (2003) Brain Research , vol.965 , Issue.1-2 , pp. 130-136
    • Dok-Go, H.1    Lee, K.H.2    Kim, H.J.3    Lee, E.H.4    Lee, J.5    Song, Y.S.6    Lee, Y.-H.7    Jin, C.8    Lee, Y.S.9    Cho, J.10
  • 42
    • 61749103704 scopus 로고    scopus 로고
    • Protective effect of quercetin in primary neurons against Abeta(1-42): Relevance to Alzheimer's disease
    • Ansari MA, Abdul HM, Joshi G, et al. Protective effect of quercetin in primary neurons against Abeta(1-42): relevance to Alzheimer's disease. J Nutr Biochem 2008;20:269-275
    • (2008) J Nutr Biochem , vol.20 , pp. 269-275
    • Ansari, M.A.1    Abdul, H.M.2    Joshi, G.3
  • 43
    • 13844271390 scopus 로고    scopus 로고
    • Dietary polyphenols protect dopamine neurons from oxidative insults and apoptosis: Investigations in primary rat mesencephalic cultures
    • DOI 10.1016/j.bcp.2004.09.018
    • Mercer LD, Kelly BL, Horne MK, Beart PM. Dietary polyphenols protect dopamine neurons from oxidative insults and apoptosis: investigations in primary rat mesencephalic cultures. Biochem Pharmacol 2005;69:339-345 (Pubitemid 41556580)
    • (2005) Biochemical Pharmacology , vol.69 , Issue.2 , pp. 339-345
    • Mercer, L.D.1    Kelly, B.L.2    Horne, M.K.3    Beart, P.M.4
  • 44
    • 33845942205 scopus 로고    scopus 로고
    • Resveratrol protects dopaminergic neurons in midbrain slice culture from multiple insults
    • DOI 10.1016/j.bcp.2006.11.003, PII S0006295206007362
    • Okawara M, Katsuki H, Kurimoto E, et al. Resveratrol protects dopaminergic neurons in midbrain slice culture from multiple insults. Biochem Pharmacol 2007;73:550-560 (Pubitemid 46038859)
    • (2007) Biochemical Pharmacology , vol.73 , Issue.4 , pp. 550-560
    • Okawara, M.1    Katsuki, H.2    Kurimoto, E.3    Shibata, H.4    Kume, T.5    Akaike, A.6
  • 45
    • 33749989574 scopus 로고    scopus 로고
    • A proposed dual role of neuromelanin in the pathogenesis of Parkinson's disease
    • PII 0000611420061010200003
    • Zecca L, Zucca FA, Albertini A, et al. A proposed dual role of neuromelanin in the pathogenesis of Parkinson's disease. Neurology 2006;67:S8-11 (Pubitemid 44568828)
    • (2006) Neurology , vol.67 , Issue.7 SUPPL. 2
    • Zecca, L.1    Zucca, F.A.2    Albertini, A.3    Rizzio, E.4    Fariello, R.G.5
  • 46
    • 84880185810 scopus 로고    scopus 로고
    • Inflammation, anti-inflammatory agents and Alzheimer disease: The last 12 years
    • McGeer PL, Rogers J, McGeer EG. Inflammation, anti-inflammatory agents and Alzheimer disease: the last 12 years. J Alzheimers Dis 2006;9:271-276 (Pubitemid 44253320)
    • (2006) Journal of Alzheimer's Disease , vol.9 , Issue.SUPPL. 3 , pp. 271-276
    • McGeer, P.L.1    Rogers, J.2    McGeer, E.G.3
  • 48
    • 26444594915 scopus 로고    scopus 로고
    • Inhibition of iNOS gene expression by quercetin is mediated by the inhibition of IkappaB kinase, nuclear factor-kappa B and STAT1, and depends on heme oxygenase-1 induction in mouse BV-2 microglia
    • DOI 10.1016/j.ejphar.2005.08.005, PII S0014299905007880
    • Chen JC, Ho FM, Pei-Dawn LEE, et al. Inhibition of iNOS gene expression by quercetin is mediated by the inhibition of IkappaB kinase, nuclear factor-kappa B and STAT1, and depends on heme oxygenase-1 induction in mouse BV-2 microglia. Eur J Pharmacol 2005;521:9-20 (Pubitemid 41427784)
    • (2005) European Journal of Pharmacology , vol.521 , Issue.1-3 , pp. 9-20
    • Chen, J.-C.1    Ho, F.-M.2    Chao, P.-D.L.3    Chen, C.-P.4    Jeng, K.-C.G.5    Hsu, H.-B.6    Lee, S.-T.7    Wen, T.W.8    Lin, W.-W.9
  • 50
    • 38849203188 scopus 로고    scopus 로고
    • Resveratrol and quercetin, two natural polyphenols, reduce apoptotic neuronal cell death induced by neuroinflammation
    • DOI 10.1002/jnr.21503
    • Bureau G, Longpre F, Martinoli MG. Resveratrol and quercetin, two natural polyphenols, reduce apoptotic neuronal cell death induced by neuroinflammation. J Neurosci Res 2008;86:403-410 • Quercetin aglycone, at concentration as low as 0.1 μM, decreased the toxicity of LPS-activated microglia towards PC12 neurons. (Pubitemid 351196745)
    • (2008) Journal of Neuroscience Research , vol.86 , Issue.2 , pp. 403-410
    • Bureau, G.1    Longpre, F.2    Martinoli, M.-G.3
  • 51
    • 34548536510 scopus 로고    scopus 로고
    • Influence of Hypericum perforatum extract and its single compounds on amyloid-beta mediated toxicity in microglial cells
    • DOI 10.1016/j.lfs.2007.07.020, PII S0024320507005279
    • Kraus B, Wolff H, Heilmann J, Elstner EF. Influence of Hypericum perforatum extract and its single compounds on amyloid-beta mediated toxicity in microglial cells. Life Sci 2007;81:884-894 (Pubitemid 47381364)
    • (2007) Life Sciences , vol.81 , Issue.11 , pp. 884-894
    • Kraus, B.1    Wolff, H.2    Heilmann, J.3    Elstner, E.F.4
  • 52
    • 0031897688 scopus 로고    scopus 로고
    • Neuronal death: Is there a role for astrocytes?
    • Tacconi MT. Neuronal death: is there a role for astrocytes? Neurochem Res 1998;23:759-765
    • (1998) Neurochem Res , vol.23 , pp. 759-765
    • Tacconi, M.T.1
  • 53
    • 29744458225 scopus 로고    scopus 로고
    • Quercetin protects C6 glial cells from oxidative stress induced by tertiary-butylhydroperoxide
    • DOI 10.1080/10715760500335447, PII T257243717406
    • Gitika B, Sai Ram M, Sharma SK, et al. Quercetin protects C6 glial cells from oxidative stress induced by tertiary-butylhydroperoxide. Free Radic Res 2006;40:95-102 (Pubitemid 43023790)
    • (2006) Free Radical Research , vol.40 , Issue.1 , pp. 95-102
    • Gitika, B.1    Sairam, M.2    Sharma, S.K.3    Ilavazhagan, G.4    Banerjee, P.K.5
  • 54
    • 33646578517 scopus 로고    scopus 로고
    • Quercetin inhibition of ROS-dependent and -independent apoptosis in rat glioma C6 cells
    • DOI 10.1016/j.tox.2006.03.007, PII S0300483X06001594
    • Chen TJ, Jeng JY, Lin CW, et al. Quercetin inhibition of ROS-dependent and-independent apoptosis in rat glioma C6 cells. Toxicology 2006;223:113-126 (Pubitemid 43728620)
    • (2006) Toxicology , vol.223 , Issue.1-2 , pp. 113-126
    • Chen, T.-J.1    Jeng, J.-Y.2    Lin, C.-W.3    Wu, C.-Y.4    Chen, Y.-C.5
  • 55
    • 34248146559 scopus 로고    scopus 로고
    • Modulation of interleukin-1beta mediated inflammatory response in human astrocytes by flavonoids: Implications in neuroprotection
    • DOI 10.1016/j.brainresbull.2007.01.016, PII S0361923007000664
    • Sharma V, Mishra M, Ghosh S, et al. Modulation of interleukin-1beta mediated inflammatory response in human astrocytes by flavonoids: implications in neuroprotection. Brain Res Bull 2007;73:55-63 (Pubitemid 46710246)
    • (2007) Brain Research Bulletin , vol.73 , Issue.1-3 , pp. 55-63
    • Sharma, V.1    Mishra, M.2    Ghosh, S.3    Tewari, R.4    Basu, A.5    Seth, P.6    Sen, E.7
  • 56
    • 1042287039 scopus 로고    scopus 로고
    • Dietary compounds prevent oxidative damage and nitric oxide production by cells involved in demyelinating disease
    • DOI 10.1016/j.bcp.2003.10.018
    • van Meeteren ME, Hendriks JJ, Dijkstra CD, van Tol EA. Dietary compounds prevent oxidative damage and nitric oxide production by cells involved in demyelinating disease. Biochem Pharmacol 2004;67:967-975 (Pubitemid 38201642)
    • (2004) Biochemical Pharmacology , vol.67 , Issue.5 , pp. 967-975
    • Van Meeteren, M.E.1    Hendriks, J.J.A.2    Dijkstra, C.D.3    Van Tol, E.A.F.4
  • 57
    • 42149109611 scopus 로고    scopus 로고
    • Influence of the metabolic profile on the in vivo antioxidant activity of quercetin under a low dosage oral regimen in rats
    • Santos MR, Rodriguez-Gomez MJ, Justino GC, et al. Influence of the metabolic profile on the in vivo antioxidant activity of quercetin under a low dosage oral regimen in rats. Br J Pharmacol 2008;153:1750-1761
    • (2008) Br J Pharmacol , vol.153 , pp. 1750-1761
    • Santos, M.R.1    Rodriguez-Gomez, M.J.2    Justino, G.C.3
  • 58
    • 0038291933 scopus 로고    scopus 로고
    • Intracellular metabolism and bioactivity of quercetin and its in vivo metabolites
    • DOI 10.1042/BJ20021972
    • Spencer JP, Kuhnle GG, Williams RJ, Rice-Evans C. Intracellular metabolism and bioactivity of quercetin and its in vivo metabolites. Biochem J 2003;372:173-181 (Pubitemid 36609619)
    • (2003) Biochemical Journal , vol.372 , Issue.1 , pp. 173-181
    • Spencer, J.P.E.1    Kuhnle, G.G.C.2    Williams, R.J.3    Rice-Evans, C.4
  • 59
    • 57649232223 scopus 로고    scopus 로고
    • Quercetin inhibits vascular superoxide production induced by endothelin-1: Role of NADPH oxidase, uncoupled eNOS and PKC
    • Romero M, Jimenez R, Sanchez M, et al. Quercetin inhibits vascular superoxide production induced by endothelin-1: role of NADPH oxidase, uncoupled eNOS and PKC. Atherosclerosis 2009;202:58-67
    • (2009) Atherosclerosis , vol.202 , pp. 58-67
    • Romero, M.1    Jimenez, R.2    Sanchez, M.3
  • 61
    • 51449084637 scopus 로고    scopus 로고
    • Flavonoids as substrates and inhibitors of myeloperoxidase: Molecular actions of aglycone and metabolites
    • Shiba Y, Kinoshita T, Chuman H, et al. Flavonoids as substrates and inhibitors of myeloperoxidase: molecular actions of aglycone and metabolites. Chem Res Toxicol 2008;21:1600-1609
    • (2008) Chem Res Toxicol , vol.21 , pp. 1600-1609
    • Shiba, Y.1    Kinoshita, T.2    Chuman, H.3
  • 62
    • 4444237686 scopus 로고    scopus 로고
    • Role of oxidative stress in neurodegeneration: Recent developments in assay methods for oxidative stress and nutraceutical antioxidants
    • DOI 10.1016/j.pnpbp.2004.05.023, PII S0278584604000806
    • Cui K, Luo X, Xu K, Ven Murthy MR. Role of oxidative stress in neurodegeneration: recent developments in assay methods for oxidative stress and nutraceutical antioxidants. Prog Neuropsychopharmacol Biol Psychiatry 2004;28:771-799 (Pubitemid 39195270)
    • (2004) Progress in Neuro-Psychopharmacology and Biological Psychiatry , vol.28 , Issue.5 , pp. 771-799
    • Cui, K.1    Luo, X.2    Xu, K.3    Ven Murthy, M.R.4
  • 63
    • 34247623639 scopus 로고    scopus 로고
    • Oxidative stress, mitochondrial DNA mutation, and apoptosis in aging
    • Lee HC, Wei YH. Oxidative stress, mitochondrial DNA mutation, and apoptosis in aging. Exp Biol Med (Maywood) 2007;232:592-606 (Pubitemid 46683384)
    • (2007) Experimental Biology and Medicine , vol.232 , Issue.5 , pp. 592-606
    • Lee, H.-C.1    Wei, Y.-H.2
  • 64
    • 33847774008 scopus 로고    scopus 로고
    • Improved quantitative structure-activity relationship models to predict antioxidant activity of flavonoids in chemical, enzymatic, and cellular systems
    • DOI 10.1016/j.bmc.2006.11.037, PII S0968089606009795
    • Khlebnikov AI, Schepetkin IA, Domina NG, et al. Improved quantitative structure-activity relationship models to predict antioxidant activity of flavonoids in chemical, enzymatic, and cellular systems. Bioorg Med Chem 2007;15:1749-1770 (Pubitemid 46394047)
    • (2007) Bioorganic and Medicinal Chemistry , vol.15 , Issue.4 , pp. 1749-1770
    • Khlebnikov, A.I.1    Schepetkin, I.A.2    Domina, N.G.3    Kirpotina, L.N.4    Quinn, M.T.5
  • 65
    • 33748750998 scopus 로고    scopus 로고
    • Dual effects of antioxidants in neurodegeneration: Direct neuroprotection against oxidative stress and indirect protection via suppression of glia-mediated inflammation
    • DOI 10.2174/138161206778343109
    • Wang JY, Wen LL, Huang YN, et al. Dual effects of antioxidants in neurodegeneration: direct neuroprotection against oxidative stress and indirect protection via suppression of glia-mediated inflammation. Curr Pharm Des 2006;12:3521-3533 (Pubitemid 44400489)
    • (2006) Current Pharmaceutical Design , vol.12 , Issue.27 , pp. 3521-3533
    • Wang, J.-Y.1    Wen, L.-L.2    Huang, Y.-N.3    Chen, Y.-T.4    Ku, M.-C.5
  • 66
    • 34548620779 scopus 로고    scopus 로고
    • Mechanism of 6-hydroxydopamine neurotoxicity: The role of NADPH oxidase and microglial activation in 6-hydroxydopamine-induced degeneration of dopaminergic neurons
    • DOI 10.1111/j.1471-4159.2007.04699.x
    • Rodriguez-Pallares J, Parga JA, Munoz A, et al. Mechanism of 6-hydroxydopamine neurotoxicity: the role of NADPH oxidase and microglial activation in 6-hydroxydopamine-induced degeneration of dopaminergic neurons. J Neurochem 2007;103:145-156 (Pubitemid 47404195)
    • (2007) Journal of Neurochemistry , vol.103 , Issue.1 , pp. 145-156
    • Rodriguez-Pallares, J.1    Parga, J.A.2    Munoz, A.3    Rey, P.4    Guerra, M.J.5    Labandeira-Garcia, J.L.6
  • 67
    • 17444422528 scopus 로고    scopus 로고
    • Histological, behavioural and neurochemical evaluation of medial forebrain bundle and striatal 6-OHDA lesions as rat models of Parkinson's disease
    • DOI 10.1016/j.jneumeth.2004.10.004
    • Yuan H, Sarre S, Ebinger G, Michotte Y. Histological, behavioural and neurochemical evaluation of medial forebrain bundle and striatal 6-OHDA lesions as rat models of Parkinson's disease. J Neurosci Methods 2005;144:35-45 (Pubitemid 40546300)
    • (2005) Journal of Neuroscience Methods , vol.144 , Issue.1 , pp. 35-45
    • Yuan, H.1    Sarre, S.2    Ebinger, G.3    Michotte, Y.4
  • 68
    • 25444508963 scopus 로고    scopus 로고
    • Neuroprotective properties of the natural phenolic antioxidants curcumin and naringenin but not quercetin and fisetin in a 6-OHDA model of Parkinson's disease
    • DOI 10.1080/10715760500233113
    • Zbarsky V, Datla KP, Parkar S, et al. Neuroprotective properties of the natural phenolic antioxidants curcumin and naringenin but not quercetin and fisetin in a 6-OHDA model of Parkinson's disease. Free Radic Res 2005;39:1119-1125 (Pubitemid 41358566)
    • (2005) Free Radical Research , vol.39 , Issue.10 , pp. 1119-1125
    • Zbarsky, V.1    Datla, K.P.2    Parkar, S.3    Rai, D.K.4    Aruoma, O.I.5    Dexter, D.T.6
  • 69
    • 40949085989 scopus 로고    scopus 로고
    • Lack of robust protective effect of quercetin in two types of 6-hydroxydopamine-induced parkinsonian models in rats and dopaminergic cell cultures
    • Kääriäinen TM, Piltonen M, Ossola B, et al. Lack of robust protective effect of quercetin in two types of 6-hydroxydopamine-induced parkinsonian models in rats and dopaminergic cell cultures. Brain Res 2008;1203:149-159
    • (2008) Brain Res , vol.1203 , pp. 149-159
    • Kääriäinen, T.M.1    Piltonen, M.2    Ossola, B.3
  • 74
    • 0033973418 scopus 로고    scopus 로고
    • Tissue tears in the white matter after lateral fluid percussion brain injury in the rat: Relevance to human brain injury
    • Graham DI, Raghupathi R, Saatman KE, et al. Tissue tears in the white matter after lateral fluid percussion brain injury in the rat: relevance to human brain injury. Acta Neuropathol 2000;99:117-124 (Pubitemid 30093417)
    • (2000) Acta Neuropathologica , vol.99 , Issue.2 , pp. 117-124
    • Graham, D.I.1    Raghupathi, R.2    Saatman, K.E.3    Meaney, D.4    McIntosh, T.K.5
  • 75
    • 0036644958 scopus 로고    scopus 로고
    • Extracellular proteolysis in brain injury and inflammation: Role for plasminogen activators and matrix metalloproteinases
    • DOI 10.1002/jnr.10270
    • Lo EH, Wang X, Cuzner ML. Extracellular proteolysis in brain injury and inflammation: role for plasminogen activators and matrix metalloproteinases. J Neurosci Res 2002;69:1-9 (Pubitemid 34734159)
    • (2002) Journal of Neuroscience Research , vol.69 , Issue.1 , pp. 1-9
    • Lo, E.H.1    Wang, X.2    Louise Cuzner, M.3
  • 76
    • 33746533375 scopus 로고    scopus 로고
    • Protective effect of quercetin, a natural flavonoid against neuronal damage after transient global cerebral ischemia
    • DOI 10.1016/j.neulet.2006.06.010, PII S0304394006005660
    • Cho JY, Kim IS, Jang YH, et al. Protective effect of quercetin, a natural flavonoid against neuronal damage after transient global cerebral ischemia. Neurosci Lett 2006;404:330-335 (Pubitemid 44131626)
    • (2006) Neuroscience Letters , vol.404 , Issue.3 , pp. 330-335
    • Cho, J.-Y.1    Kim, I.-S.2    Jang, Y.-H.3    Kim, A.-R.4    Lee, S.-R.5
  • 79
    • 1642305688 scopus 로고    scopus 로고
    • Neurogenic inflammation is associated with development of edema and functional deficits following traumatic brain injury in rats
    • DOI 10.1016/j.npep.2003.12.003
    • Nimmo AJ, Cernak I, Heath DL, et al. Neurogenic inflammation is associated with development of edema and functional deficits following traumatic brain injury in rats. Neuropeptides 2004;38:40-47 (Pubitemid 38372964)
    • (2004) Neuropeptides , vol.38 , Issue.1 , pp. 40-47
    • Nimmo, A.J.1    Cernak, I.2    Heath, D.L.3    Hu, X.4    Bennett, C.J.5    Vink, R.6
  • 80
    • 22944483792 scopus 로고    scopus 로고
    • The blood-brain barrier/neurovascular unit in health and disease
    • DOI 10.1124/pr.57.2.4
    • Hawkins BT, Davis TP. The blood-brain barrier/neurovascular unit in health and disease. Pharmacol Rev 2005;57:173-185 (Pubitemid 41043883)
    • (2005) Pharmacological Reviews , vol.57 , Issue.2 , pp. 173-185
    • Hawkins, B.T.1    Davis, T.P.2
  • 81
    • 48849095338 scopus 로고    scopus 로고
    • Regulation of cerebral vasculature in normal and ischemic brain
    • Kulik T, Kusano Y, Aronhime S, et al. Regulation of cerebral vasculature in normal and ischemic brain. Neuropharmacology 2008;55:281-288
    • (2008) Neuropharmacology , vol.55 , pp. 281-288
    • Kulik, T.1    Kusano, Y.2    Aronhime, S.3
  • 82
    • 0036262303 scopus 로고    scopus 로고
    • Antioxidant therapy in acute central nervous system injury: Current state
    • DOI 10.1124/pr.54.2.271
    • Gilgun-Sherki Y, Rosenbaum Z, Melamed E, Offen D. Antioxidant therapy in acute central nervous system injury: current state. Pharmacol Rev 2002;54:271-284 (Pubitemid 34575717)
    • (2002) Pharmacological Reviews , vol.54 , Issue.2 , pp. 271-284
    • Gilgun-Sherki, Y.1    Rosenbaum, Z.2    Melamed, E.3    Offen, D.4
  • 83
    • 42149124306 scopus 로고    scopus 로고
    • Food for thought: The role of dietary flavonoids in enhancing human memory, learning and neuro-cognitive performance
    • DOI 10.1017/S0029665108007088, PII S0029665108007088
    • Spencer JP. Food for thought: the role of dietary flavonoids in enhancing human memory, learning and neuro-cognitive performance. Proc Nutr Soc 2008;67:238-252 (Pubitemid 351543406)
    • (2008) Proceedings of the Nutrition Society , vol.67 , Issue.2 , pp. 238-252
    • Spencer, J.P.E.1
  • 85
    • 54449090666 scopus 로고    scopus 로고
    • Quercetin-mediated longevity in Caenorhabditis elegans: Is DAF-16 involved?
    • Saul N, Pietsch K, Menzel R, Steinberg CE. Quercetin-mediated longevity in Caenorhabditis elegans: is DAF-16 involved? Mech Ageing Dev 2008;129:611-613
    • (2008) Mech Ageing Dev , vol.129 , pp. 611-613
    • Saul, N.1    Pietsch, K.2    Menzel, R.3    Steinberg, C.E.4
  • 86
    • 34047152197 scopus 로고    scopus 로고
    • Investigations of protective effects of the flavonoids quercetin and rutin on stress resistance in the model organism Caenorhabditis elegans
    • DOI 10.1016/j.tox.2007.02.006, PII S0300483X0700100X
    • Kampkötter A, Nkwonkam CG, Zurawski RF, et al. Investigations of protective effects of the flavonoids quercetin and rutin on stress resistance in the model organism Caenorhabditis elegans. Toxicology 2007;234:113-123 (Pubitemid 46517831)
    • (2007) Toxicology , vol.234 , Issue.1-2 , pp. 113-123
    • Kampkotter, A.1    Nkwonkam, C.G.2    Zurawski, R.F.3    Timpel, C.4    Chovolou, Y.5    Watjen, W.6    Kahl, R.7
  • 87
    • 11444259804 scopus 로고    scopus 로고
    • Behavioural study of the D-galactose induced aging model in C57BL/6J mice
    • DOI 10.1016/j.bbr.2004.07.003, PII S016643280400261X
    • Wei H, Li L, Song Q, et al. Behavioural study of the D-galactose induced aging model in C57BL/6J mice. Behav Brain Res 2005;157:245-251 (Pubitemid 40082567)
    • (2005) Behavioural Brain Research , vol.157 , Issue.2 , pp. 245-251
    • Wei, H.1    Li, L.2    Song, Q.3    Ai, H.4    Chu, J.5    Li, W.6
  • 88
    • 33745377482 scopus 로고    scopus 로고
    • Quercetin reverses d-galactose induced neurotoxicity in mouse brain
    • DOI 10.1016/j.bbr.2006.03.043, PII S0166432806001975
    • Lu J, Zheng YL, Luo L, et al. Quercetin reverses D-galactose induced neurotoxicity in mouse brain. Behav Brain Res 2006;171:251-260 (Pubitemid 43946498)
    • (2006) Behavioural Brain Research , vol.171 , Issue.2 , pp. 251-260
    • Lu, J.1    Zheng, Y.-L.2    Luo, L.3    Wu, D.-M.4    Sun, D.-X.5    Feng, Y.-J.6
  • 89
    • 0037006018 scopus 로고    scopus 로고
    • Involvement of microtubule integrity in memory impairment caused by colchicine
    • DOI 10.1016/S0091-3057(01)00634-7, PII S0091305701006347
    • Nakayama T, Sawada T. Involvement of microtubule integrity in memory impairment caused by colchicine. Pharmacol Biochem Behav 2002;71:119-138 (Pubitemid 34102471)
    • (2002) Pharmacology Biochemistry and Behavior , vol.71 , Issue.1-2 , pp. 119-138
    • Nakayama, T.1    Sawada, T.2
  • 90
    • 57549084304 scopus 로고    scopus 로고
    • Protective effect of quercetin against ICV colchicine-induced cognitive dysfunctions and oxidative damage in rats
    • Kumar A, Sehgal N, Kumar P, et al. Protective effect of quercetin against ICV colchicine-induced cognitive dysfunctions and oxidative damage in rats. Phytother Res 2008;22:1563-1569
    • (2008) Phytother Res , vol.22 , pp. 1563-1569
    • Kumar, A.1    Sehgal, N.2    Kumar, P.3
  • 91
    • 52449115580 scopus 로고    scopus 로고
    • The lipopolysaccharide Parkinson's disease animal model: Mechanistic studies and drug discovery
    • Dutta G, Zhang P, Liu B. The lipopolysaccharide Parkinson's disease animal model: mechanistic studies and drug discovery. Fundam Clin Pharmacol 2008;22:453-464
    • (2008) Fundam Clin Pharmacol , vol.22 , pp. 453-464
    • Dutta, G.1    Zhang, P.2    Liu, B.3
  • 92
    • 0032509740 scopus 로고    scopus 로고
    • Chronic neuroinflammation in rats reproduces components of the neurobiology of Alzheimer's disease
    • DOI 10.1016/S0006-8993(97)01215-8, PII S0006899397012158
    • Hauss-Wegrzyniak B, Dobrzanski P, Stoehr JD, Wenk GL. Chronic neuroinflammation in rats reproduces components of the neurobiology of Alzheimer's disease. Brain Res 1998;780:294-303 (Pubitemid 28082916)
    • (1998) Brain Research , vol.780 , Issue.2 , pp. 294-303
    • Hauss-Wegrzyniak, B.1    Dobrzanski, P.2    Stoehr, J.D.3    Wenk, G.L.4
  • 94
    • 0041884769 scopus 로고    scopus 로고
    • Protective effect of flavonoids against aging- And lipopolysaccharide- induced cognitive impairment in mice
    • DOI 10.1159/000072357
    • Patil CS, Singh VP, Satyanarayan PS, et al. Protective effect of flavonoids against aging- and lipopolysaccharide-induced cognitive impairment in mice. Pharmacology 2003;69:59-67 (Pubitemid 37034425)
    • (2003) Pharmacology , vol.69 , Issue.2 , pp. 59-67
    • Patil, C.S.1    Singh, V.P.2    Satyanarayan, P.S.V.3    Jain, N.K.4    Singh, A.5    Kulkarni, S.K.6
  • 95
    • 0031773020 scopus 로고    scopus 로고
    • Selective effects of peripheral lipopolysaccharide administration on contextual and auditory-cue fear conditioning
    • DOI 10.1006/brbi.1998.0524
    • Pugh CR, Kumagawa K, Fleshner M, et al. Selective effects of peripheral lipopolysaccharide administration on contextual and auditory-cue fear conditioning. Brain Behav Immun 1998;12:212-229 (Pubitemid 28520001)
    • (1998) Brain, Behavior, and Immunity , vol.12 , Issue.3 , pp. 212-229
    • Pugh, C.R.1    Kumagawa, K.2    Fleshner, M.3    Watkins, L.R.4    Maier, S.F.5    Rudy, J.W.6
  • 97
    • 0032531132 scopus 로고    scopus 로고
    • Penetration of cisplatin into mouse brain by lipopolysaccharide
    • DOI 10.1016/S0300-483X(98)00103-6, PII S0168945298001848
    • Minami T, Okazaki J, Kawabata A, et al. Penetration of cisplatin into mouse brain by lipopolysaccharide. Toxicology 1998;130:107-113 (Pubitemid 28488579)
    • (1998) Toxicology , vol.130 , Issue.2-3 , pp. 107-113
    • Minami, T.1    Okazaki, J.2    Kawabata, A.3    Kuroda, R.4    Okazaki, Y.5
  • 99
    • 45849117586 scopus 로고    scopus 로고
    • Quercetin relieves chronic lead exposure-induced impairment of synaptic plasticity in rat dentate gyrus in vivo
    • Hu P, Wang M, Chen WH, et al. Quercetin relieves chronic lead exposure-induced impairment of synaptic plasticity in rat dentate gyrus in vivo. Naunyn Schmiedebergs Arch Pharmacol 2008;378:43-51
    • (2008) Naunyn Schmiedebergs Arch Pharmacol , vol.378 , pp. 43-51
    • Hu, P.1    Wang, M.2    Chen, W.H.3
  • 100
    • 58549098084 scopus 로고    scopus 로고
    • Blood-brain barrier: Ageing and microvascular disease - Systematic review and meta-analysis
    • Farrall AJ, Wardlaw JM. Blood-brain barrier: ageing and microvascular disease - systematic review and meta-analysis. Neurobiol Aging 2009;30:337-352
    • (2009) Neurobiol Aging , vol.30 , pp. 337-352
    • Farrall, A.J.1    Wardlaw, J.M.2
  • 101
    • 33747368249 scopus 로고    scopus 로고
    • Blood-brain barrier: Structural components and function under physiologic and pathologic conditions
    • DOI 10.1007/s11481-006-9025-3
    • Persidsky Y, Ramirez SH, Haorah J, Kanmogne GD. Blood-brain barrier: structural components and function under physiologic and pathologic conditions. J Neuroimmune Pharmacol 2006;1:223-236 (Pubitemid 44244128)
    • (2006) Journal of Neuroimmune Pharmacology , vol.1 , Issue.3 , pp. 223-236
    • Persidsky, Y.1    Ramirez, S.H.2    Haorah, J.3    Kanmogne, G.D.4
  • 102
    • 33344464320 scopus 로고    scopus 로고
    • Mannosylated liposomal flavonoid in combating age-related ischemia-reperfusion induced oxidative damage in rat brain
    • DOI 10.1016/j.mad.2005.12.010, PII S0047637406000029
    • Sarkar S, Das N. Mannosylated liposomal flavonoid in combating age-related ischemia-reperfusion induced oxidative damage in rat brain. Mech Ageing Dev 2006;127:391-397 (Pubitemid 43290543)
    • (2006) Mechanisms of Ageing and Development , vol.127 , Issue.4 , pp. 391-397
    • Sarkar, S.1    Das, N.2
  • 103
    • 58049191302 scopus 로고    scopus 로고
    • Nanoencapsulation of quercetin enhances its dietary efficacy in combating arsenic-induced oxidative damage in liver and brain of rats
    • Ghosh A, Mandal AK, Sarkar S, et al. Nanoencapsulation of quercetin enhances its dietary efficacy in combating arsenic-induced oxidative damage in liver and brain of rats. Life Sci 2009;84:75-80
    • (2009) Life Sci , vol.84 , pp. 75-80
    • Ghosh, A.1    Mandal, A.K.2    Sarkar, S.3
  • 104
    • 2442430353 scopus 로고    scopus 로고
    • Polyphenols: Food sources and bioavailability
    • Manach C, Scalbert A, Morand C, et al. Polyphenols: food sources and bioavailability. Am J Clin Nutr 2004;79:727-747
    • (2004) Am J Clin Nutr , vol.79 , pp. 727-747
    • Manach, C.1    Scalbert, A.2    Morand, C.3
  • 106
    • 34548812546 scopus 로고    scopus 로고
    • A critical review of the data related to the safety of quercetin and lack of evidence of in vivo toxicity, including lack of genotoxic/carcinogenic properties
    • DOI 10.1016/j.fct.2007.05.015, PII S0278691507001780
    • Harwood M, Danielewska-Nikiel B, Borzelleca JF, et al. A critical review of the data related to the safety of quercetin and lack of evidence of in vivo toxicity, including lack of genotoxic/carcinogenic properties. Food Chem Toxicol 2007;45:2179-2205 (Pubitemid 47451573)
    • (2007) Food and Chemical Toxicology , vol.45 , Issue.11 , pp. 2179-2205
    • Harwood, M.1    Danielewska-Nikiel, B.2    Borzelleca, J.F.3    Flamm, G.W.4    Williams, G.M.5    Lines, T.C.6
  • 107
    • 46649092119 scopus 로고    scopus 로고
    • Evaluation of the potential in vivo genotoxicity of quercetin
    • Utesch D, Feige K, Dasenbrock J, et al. Evaluation of the potential in vivo genotoxicity of quercetin. Mutat Res 2008;654:38-44
    • (2008) Mutat Res , vol.654 , pp. 38-44
    • Utesch, D.1    Feige, K.2    Dasenbrock, J.3
  • 108
    • 2442710045 scopus 로고    scopus 로고
    • Anti- And pro-oxidant effects of quercetin in copper-induced low density lipoprotein oxidation: Quercetin as an effective antioxidant against pro-oxidant effects of urate
    • DOI 10.1111/j.1432-1033.2004.04111.x
    • Filipe P, Haigle J, Silva JN, et al. Anti- and pro-oxidant effects of quercetin in copper-induced low density lipoprotein oxidation. Quercetin as an effective antioxidant against pro-oxidant effects of urate. Eur J Biochem 2004;271:1991-1999 (Pubitemid 38657351)
    • (2004) European Journal of Biochemistry , vol.271 , Issue.10 , pp. 1991-1999
    • Filipe, P.1    Haigle, J.2    Silva, J.N.3    Freitas, J.4    Fernandes, A.5    Maziere, J.-C.6    Maziere, C.7    Santus, R.8    Morliere, P.9
  • 109
    • 59349101941 scopus 로고    scopus 로고
    • Synergistic neurotoxicity induced by methylmercury and quercetin in mice
    • Martins Rde P, Braga Hde C, da Silva AP, et al. Synergistic neurotoxicity induced by methylmercury and quercetin in mice. Food Chem Toxicol 2009;47:645-649
    • (2009) Food Chem Toxicol , vol.47 , pp. 645-649
    • Martins Rde, P.1    Braga Hde, C.2    Da Silva, A.P.3
  • 110
    • 38149107696 scopus 로고    scopus 로고
    • Mercurial-induced hydrogen peroxide generation in mouse brain mitochondria: Protective effects of quercetin
    • Franco JL, Braga HC, Stringari J, et al. Mercurial-induced hydrogen peroxide generation in mouse brain mitochondria: protective effects of quercetin. Chem Res Toxicol 2007;20:1919-1926
    • (2007) Chem Res Toxicol , vol.20 , pp. 1919-1926
    • Franco, J.L.1    Braga, H.C.2    Stringari, J.3
  • 111
    • 0242363191 scopus 로고    scopus 로고
    • Pro-inflammatory effect of quercetin by dual blockade of angiotensin converting-enzyme and neutral endopeptidase in vivo
    • DOI 10.1080/10284150310001595609
    • Nicolau M, Dovichi SS, Cuttle G. Pro-inflammatory effect of quercetin by dual blockade of angiotensin converting-enzyme and neutral endopeptidase in vivo. Nutr Neurosci 2003;6:309-316 (Pubitemid 37361913)
    • (2003) Nutritional Neuroscience , vol.6 , Issue.5 , pp. 309-316
    • Nicolau, M.1    Dovichi, S.S.2    Cuttle, G.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.