Isoquercetin protects cortical neurons from oxygen-glucose deprivation-reperfusion induced injury via suppression of TLR4-NF-kB signal pathway

Neurochemistry International

Volumn 63, Issue 8, 2013, Pages 741-749

  Wang, Cai Ping ^a   Li, Jian Long ^a   Zhang, Lu Zhong ^a   Zhang, Xiao Chuan ^a   Yu, Shu ^a   Liang, Xin Miao ^a,b   Ding, Fei ^a   Wang, Zhi Wei ^a,c  

^a NANTONG UNIVERSITY   (China)

^b DALIAN INSTITUTE OF CHEMICAL PHYSICS   (China)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Apoptosis; Inflammation; Ischemia; Isoquercetin; Oxygen glucose deprivation followed by reperfusion (OGD R)

Indexed keywords

CALCIUM ION; CASPASE 3; GLUCOSE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 6; ISOQUERCETIN; LACTATE DEHYDROGENASE; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; OXYGEN; QUERCETIN DERIVATIVE; TOLL LIKE RECEPTOR 4; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BRAIN NERVE CELL; CALCIUM CELL LEVEL; CELL VIABILITY; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INHIBITION; GENE EXPRESSION; IN VITRO STUDY; NEUROPROTECTION; NONHUMAN; PRIMARY CULTURE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REPERFUSION INJURY; SIGNAL TRANSDUCTION;

RATTUS;

3-(4,5-DIMETHYLTHIAZOL-2-YL)-2,5-DIPHENYLTETRAZOLIUM BROMIDE; APOPTOSIS; DMEM; DULBECCO'S MODIFIED EAGLE'S MEDIUM; ERK; EXTRACELLULAR-REGULATED KINASE; FBS; FETAL BOVINE SERUM; I/R; INFLAMMATION; INTRACELLULAR CALCIUM CONCENTRATIONS; ISCHEMIA; ISCHEMIA/REPERFUSION; ISOQUERCETIN; JNK; JUN KINASE; LACTATE DEHYDROGENASE; LDH; MAP; MCAO; MIDDLE CEREBRAL ARTERY OCCLUSION; MITOGEN-ACTIVATED PROTEIN; MTT; NF-ΚB; NUCLEAR FACTOR-KAPPA B; OGD/R; OXYGEN-GLUCOSE DEPRIVATION FOLLOWED BY REPERFUSION; OXYGEN-GLUCOSE DEPRIVATION FOLLOWED BY REPERFUSION (OGD/R); PI; PROPIDIUM IODIDE; REVERSE TRANSCRIPTION-POLYMERASE CHAIN REACTION; RT-PCR; SD; SPRAGUE-DAWLEY; TLR4; TLRS; TOLL-LIKE RECEPTOR 4; TOLL-LIKE RECEPTORS; [CA(2+)](I);

ANIMALS; BASE SEQUENCE; CELLS, CULTURED; CEREBRAL CORTEX; DNA PRIMERS; GLUCOSE; NEURONS; NF-KAPPA B; OXYGEN; QUERCETIN; RATS; RATS, SPRAGUE-DAWLEY; REAL-TIME POLYMERASE CHAIN REACTION; REPERFUSION INJURY; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTOR 4;

EID: 84887137678     PISSN: 01970186     EISSN: 18729754     Source Type: Journal    
DOI: 10.1016/j.neuint.2013.09.018     Document Type: Article

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