Neuroprotective effects of quercetin and rutin on spatial memory impairment in an 8-arm radial maze task and neuronal death induced by repeated cerebral ischemia in rats

Journal of Pharmacological Sciences

Volumn 104, Issue 4, 2007, Pages 329-334

  Pu, Fengling ^a   Mishima, Kenichi ^a   Irie, Keiichi ^a   Motohashi, Kyouko ^a   Tanaka, Yurika ^a   Orito, Kensuke ^b   Egawa, Takashi ^a   Kitamura, Yoshihisa ^a   Egashira, Nobuaki ^a   Iwasaki, Katsunori ^a   Fujiwara, Michihiro ^a  

^a FUKUOKA UNIVERSITY   (Japan)

^b AZABU UNIVERSITY   (Japan)

Author keywords

( ) epigallocatechin gallate (EGCG); Catechin; Quercetin; Repeated cerebral ischemia model; Rutin

Indexed keywords

CATECHIN; EPIGALLOCATECHIN GALLATE; QUERCETIN; RUTOSIDE;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN ISCHEMIA; CONTROLLED STUDY; DRUG EFFECT; HIPPOCAMPUS; MALE; MAZE TEST; MEMORY DISORDER; NERVE CELL NECROSIS; NEUROPROTECTION; NONHUMAN; RAT; SPATIAL MEMORY;

EID: 34548471990     PISSN: 13478613     EISSN: 13478648     Source Type: Journal    
DOI: 10.1254/jphs.FP0070247     Document Type: Article

References (25)

1. Pilorget A, Berthet V, Luis J, Moghrabi A, Annabi B, Beliveau R. Medulloblastoma cell invasion is inhibited by green tea (-)-epigallocatechin-3- gallate. J Cell Biochem. 2003;90:745-755.
2. Morimoto Y, Yasuhara T, Sugimoto A, Inoue A, Izumi H, Akiyama M, et al. Anti-allergic substances contained in the pollen of Cryptomeria japonica possess diverse effects on the degranulation of RBL-2H3 Cells. J Pharmacol Sci. 2003;92:291-295.
3. Novakovic A, Gojkovic-Bukarica L, Peric M, Nezic D, Djukanovic B, Markovic-Lipkovski J, et al. The mechanism of endothelium-independent relaxation induced by the wine polyphenol resveratrol in human internal mammary artery. J Pharmacol Sci. 2006;101:85-90.
4. Lee S, Suh S, Kim S. Protective effects of the green tea polyphenol (-)-epigallocatechin gallate against hippocampal neuronal damage after transient global ischemia in gerbils. Neurosci Lett. 2000;287:191-194.
5. Kim HP, Son KH, Chang HW, Kang SS. Anti-inflammatory plant flavonoids and cellular action mechanisms. J Pharmacol Sci. 2004;96:229-245.
6. Borbulevych OY, Jankun J, Selman SH, Skrzypczak-Jankun E. Lipoxygenase interactions with natural flavonoid, quercetin, reveal a complex with protocatechuic acid in its X-ray structure at 2.1 A resolution. Proteins. 2004;54:13-19.
7. Potapovich AI, Kostyuk VA. Comparative study of antioxidant properties and cytoprotective activity of flavonoids. Biochem (Mosc). 2003;68:514-519.
8. Yokozawa T, Rhyu DY, Cho EJ. (-)-Epicatechin 3-O-gallate ameliorates the damages related to peroxynitrite production by mechanisms distinct from those of other free radical inhibitors. J Pharm Pharmacol. 2004;56:231-239.
9. Guardia T, Rotelli AE, Juarez AO, Pelzer LE. Anti-inflammatory properties of plant flavonoids. Effects of rutin, quercetin and hesperidin on adjuvant arthritis in rat. Farmaco. 2001;56:683-687.
10. Pulsinelli WA, Brierley JB. A new model of bilateral hemispheric ischemia in the unanesthetized rat. Stroke. 1979;10:267-272.
11. Chung E, Iwasaki K, Mishima K, Egashira N, Fujiwara M. Repeated cerebral ischemia induced hippocampal cell death and impairments of spatial cognition in the rat. Life Sci. 2002;72:609-619.
12. Iwasaki K, Chung E, Egashira N, Hatip-Al-Khatib I, Mishima K, Egawa T, et al. Non-NMDA mechanism in the inhibition of cellular apoptosis and memory impairment induced by repeated ischemia in rats. Brain Res. 2004;995:131-139.
13. Iriea K, Mishima K, Ishibashia D, Egashira N, Iwasaki K, Fujiwara M. Involvement of bcl-family expression in the spatial memory impairment induced by repeated ischemia. Life Sci. 2002;72:621-629.
14. Hatip-Al-Khatib I, Iwasaki K, Egashira N, Ishibashi D, Mishima K, Fujiwara M. Comparison of single- and repeated-ischemia-induced changes in expression of flip and flop splice variants of AMPA receptor subtypes GluR1 and GluR2 in the rats hippocampus CA1 subregion. J Pharmacol Sci. 2007;103:83-91.
15. Pu F, Mishima K, Egashira N, Iwasaki K, Kaneko T, Uchida T, et al. Protective effect of buckwheat polyphenols against long-lasting impairment of spatial memory associated with hippocampal neuronal damage in rats subjected to repeated cerebral ischemia. J Pharmacol Sci. 2004;94:393-402.
16. Mastuoka Y, Hasegawa H, Okuda S, Muraki T, Uruno T, Kubota K. Ameliorative effects of tea catechins on active oxygen-related nerve cell in injuries. J Pharmacol Exp Ther. 1995;274:602-608.
17. Rahmana RMA, Nair SM, Helps SC, Shawa OM, Sims NR, Rosengren RJ, et al. (-)-Epigallocatechin gallate as an intervention for the acute treatment of cerebral ischemia. Neurosci Lett. 2005;382:227-230.
18. Furukawa A, Oikawa S, Murata M, Hiraku Y, Kawanishi S. (-)-Epigallocatechin gallate causes oxidative damage to isolated and cellular DNA. Biochem Pharma. 2003;66:1769-1778.
19. Goodin MG, Rosengren RJ. Epigallocatechin gallate modulates CYP450 isoforms in the female Swiss-Webster mouse. Toxicol Sci. 2003;76:262-270.
20. Inanami O, Watanabe Y, Syuto B, Nakano M, Tsuji M, Kuwabara M. Oral administration of (-)catechin protects against ischemia-reperfusion-induced neuronal death in the gerbil. Free Radic Res. 1998;29:359-365.
21. Xu YC, Leung SW, Yeung DK, Hu LH, Chen GH, Che CM, et al. Structure-activity relationships of flavonoids for vascular relaxation in porcine coronary artery. Phytochemistry. 2007:68;1179-1188.
22. Khlebnikov AI, Schepetkin IA, Domina NG, Kirpotina LN, Quinn MT. Improved quantitative structure-activity relationship models to predict antioxidant activity of flavonoids in chemical, enzymatic, and cellular systems. Bioorg Med Chem. 2007;15:1749-1770.
23. Maher P, Akaishi T, Abe K. Flavonoid fisetin promotes ERK-dependent long-term potentiation and enhances memory. Proc Natl Acad Sci U S A. 2006;103:16568-16573.
24. Prouillet C, Maziere JC, Maziere C, Wattel A, Brazier M, Kamel S. Stimulatory effect of naturally occurring flavonols quercetin and kaempferol on alkaline phosphatase activity in MG-63 human osteoblasts through ERK and estrogen receptor pathway. Biochem Pharmacol. 2004;67:1307-1313.
25. Rechner AR, Smith MA, Kuhnle G, Gibson GR, Debnam ES, Srai SK, et al. Colonic metabolism of dietary polyphenols: influence of structure on microbial fermentation products. Free Radic Biol Med. 2004;36:212-225.