Dietary polyphenols protect dopamine neurons from oxidative insults and apoptosis: Investigations in primary rat mesencephalic cultures

Biochemical Pharmacology

Volumn 69, Issue 2, 2005, Pages 339-345

  Mercer, Linda D ^a,b   Kelly, Belinda L ^a,b   Horne, Malcolm K ^a,b   Beart, Philip M ^a,b  

^a MONASH UNIVERSITY   (Australia)

^b UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

Cultures; Flavonoids; Injury; Mesencephalic dopamine neurones; Neuroprotection; Oxidative stress

Indexed keywords

BENZYLOXYCARBONYLASPARTYLVALYLGLUTAMYLASPARTYLFLUOROMETHYLKETONE; CASPASE 3 INHIBITOR; CATECHIN; CHRYSIN; DNA FRAGMENT; GENISTEIN; NARINGENIN; POLYPHENOL; PUERARIN; QUERCETIN; TYROSINE 3 MONOOXYGENASE; UNCLASSIFIED DRUG; DOPAMINE; FLAVONOID; PHENOL DERIVATIVE; POLYPHENOLS;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL CULTURE; CELL VIABILITY; CONTROLLED STUDY; DIET; DOPAMINE UPTAKE; DOPAMINERGIC NERVE CELL; DRUG EFFECT; DRUG MECHANISM; ENZYME ACTIVITY; IMMUNOCYTOCHEMISTRY; MESENCEPHALON; NEUROPROTECTION; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT; ANIMAL; COMPARATIVE STUDY; CYTOLOGY; DOSE RESPONSE; METABOLISM; NERVE CELL; PHYSIOLOGY;

ANIMALS; APOPTOSIS; CELLS, CULTURED; DOPAMINE; DOSE-RESPONSE RELATIONSHIP, DRUG; FLAVONOIDS; MESENCEPHALON; NEURONS; OXIDATIVE STRESS; PHENOLS; RATS;

EID: 13844271390     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcp.2004.09.018     Document Type: Article

References (36)

1. Jenner P, Olanow C. Oxidative stress and the pathogenesis of Parkinson's disease. Neurology 1996;47:161-70.
2. Olanow C, Tatton W. Etiology and pathogenesis of Parkinson's disease. Annu Rev Neurosci 1999;22:123-44.
3. Schapira A, Cooper J, Dexter D, Clark J, Jenner P, Marsden C. Mitochondrial complex I deficiency in Parkinson's disease. J Neurochem 1990;54:823-7.
4. Janetzky B, Hauck S, Youdim M, Riederer P, Jellinger K, Pantucek F, et al. Unaltered aconitase activity, but decreased complex I activity in substantia nigra pars compacta of patients with Parkinson's disease. Neurosci Lett 1994;169:126-8.
5. Foley P, Riederer P. Influence of neurotoxins and oxidative stress on the onset and progression of Parkinson's disease. J Neurol 2000;247(Suppl 2):II82-94.
6. Schapira A, Mann V, Cooper J, Dexter D, Daniel S, Jenner P, et al. Anatomic and disease specificity of NADH CoQ1 reductase (complex I) deficiency in Parkinson's disease. J Neurochem 1990;55:2142-5.
7. Greenamyre J, MacKenzie G, Peng T, Stephans S. Mitochondrial dysfunction in Parkinson's disease. Biochem Soc Symp 1999;66:85-97.
8. Greenamyre J, Betarbet R, Sherer T. The rotenone model of Parkinson's disease: genes, environment and mitochondria. Parkinsonism Relat Disorders 2003;9:59-64.
9. Giasson B, Duda J, Murray I, Chen Q, Souza J, Hurtig H, et al. Oxidative damage linked to neurodegeneration by selective alpha-synuclein nitration in synucleinopathy lesions. Science 2000;290: 985-9.
10. Xu J, Kao S, Lee F, Song W, Jin L, Yankner B. Dopamine-dependent neurotoxicity of alpha-synuclein: a mechanism for selective neurodegeneration in Parkinson disease. Nat Med 2002;8:600-6.
11. Bonifati V, Rizzu P, van Baren M, Schaap O, Breedveld G, Krieger E, et al. Mutations in the DJ-1 gene associated with autosomal recessive early-onset Parkinsonism. Science 2003;299:256-9.
12. Jenner P. Oxidative stress as a cause of Parkinson's disease. Acta Neurol Scand 1991;136:6-15.
13. Dauer W, Przedborski S. Parkinson's disease: mechanisms and models. Neuron 2003;39:889-909.
14. Tatton N. Increased caspase 3 and Bax immunoreactivity accompany nuclear GAPDH translocation and neuronal apoptosis in Parkinson's disease. Exp Neurol 2000;166:29-43.
15. Hartmann A, Michel P, Troadec J, Mouatt-Prigent A, Faucheux B, Ruberg M, et al. Is Bax a mitochondrial mediator in apoptotic death of dopaminergic neurons in Parkinson's disease? J Neurochem 2001;76:1785-93.
16. 10 in early Parkinson disease: evidence of slowing of the functional decline. Arch Neurol 2002;59:1541-50.
17. Youdim K, Joseph J. A possible emerging role of phytochemicals in improving age-related neurological dysfunctions: a multiplicity of effects. Free Radic Biol Med 2001;30:583-94.
18. Jiang F, Dusting G. Natural phenolic compounds as cardiovascular therapeutics: potential role of their anti-inflammatory effects. Curr Vasc Pharm 2003;1:135-56.
19. Paganga G, Miller N, Rice-Evans C. The polyphenolic content of fruit and vegetables and their antioxidant activities. What does a serving constitute? Free Radic Res 1999;30:153-62.
20. Mandel S, Weinreb O, Amit T, Youdim M. Cell signaling pathways in the neuroprotective actions of the green tea polyphenol (-)-epigallocatechin-3- gallate: implications for neurodegenerative diseases. J Neurochem 2004;88:1555.
21. Cheung N, Hickling Y, Beart P. Development and survival of rat embryonic mesencephalic dopaminergic neurones in serum-free, antioxidant-rich primary cultures. Neurosci Lett 1997;233:13-6.
22. Cheung N, Pascoe C, Giardina S, John C, Beart P. Micromolar L-glutamate induces extensive apoptosis in an apoptotic-necrotic continuum of insult-dependent, excitotoxic injury in cultured cortical neurones. Neuropharmacology 1998;37:1419-29.
23. Malecki A, Garrido R, Mattson M, Hennig B, Toborek M. 4-Hydroxynonenal induces oxidative stress and death of cultured spinal cord neurons. J Neurochem 2000;74:2278-87.
24. +-induced dopamine neuron injury. Life Sci 2003;72:1073-83.
25. Ahmadi F, Linseman D, Grammatopoulos T, Jones S, Bouchard R, Freed C, et al. The pesticide rotenone induces caspase-3-mediated apoptosis in ventral mesencephalic dopaminergic neurons. J Neurochem 2003;87:914-21.
26. Kikuchi S, Kim S. Glutamate neurotoxicity in mesencephalic dopaminergic neurons in culture. J Neurosci Res 1993;36:558-69.
27. Kaul S, Kanthasamy A, Kitazawa M, Anantharam V, Kanthasamy A. Caspase-3 dependent proteolytic activation of protein kinase C delta mediates and regulates 1-methyl-4-phenylpyridinium (MPP+)-induced apoptotic cell death in dopaminergic cells: relevance to oxidative stress in dopaminergic degeneration. Eur J Neurosci 2003;18:1387-401.
28. Schroeter H, Williams RJ, Matin R, Iversen L, Rice-Evans CA. Phenolic antioxidants attenuate neuronal cell death following uptake of oxidized low-density lipoprotein. Free Radic Biol Med 2000;29:1222-33.
29. van Meeteren ME, Hendriks JJA, Dijkstra CD, van Tol EAF. Dietary compounds prevent oxidative damage and nitric oxide production by cells involved in demyelinating disease. Biochem Pharmacol 2004;67:967-75.
30. Prasad K, Cole W, Kumar B. Multiple antioxidants in the prevention and treatment of Parkinson's disease. J Am Coll Nutr 1999;18:413-23.
31. Tatton W, Chalmers-Redman R. Mitochondria in neurodegenerative apoptosis: an opportunity for therapy? Ann Neurol 1998;44:134-41.
32. Mercer L, Lim M, Horne M, Nagley P, Beart P. Mitochondria, apoptosis and mesencephalic dopamine neurones. Fed Eur Neurosci Soc 2004;2: [Abstr. AO53.9].
33. Overstreet D, Lee Y, Rezvani A, Pei Y, Criswell H, Janowsky D. Suppression of alcohol intake after administration of the Chinese herbal medicine, NPI-028, and its derivatives. Alcohol Clin Exp Res 1996;20:221-7.
34. Levites Y, Weinreb O, Maor G, Youdim M, Mandel S. Green tea polyphenol (-)-epigallocatechin-3-gallate prevents N-methyl-4-phenyl-1,2,36- tetrahydropyridine-induced dopaminergic neurodegeneration. J Neurochem 2001;78:1073-82.
35. Chen C, Yu R, Owuor E, Kong A. Activation of antioxidant-response element (ARE), mitogen-activated protein kinases (MAPKs) and caspases by major green tea polyphenol components during cell survival and death. Arch Pharm Res 2000;23:605-12.
36. Abd El Mohsen MM, Kuhnle G, Rechner AR, Schroeter H, Rose S, Jenner P, et al. Uptake and metabolism of epicatechin and its access to the brain after oral ingestion. Free Radic Biol Med 2002;33:1693-702.