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Volumn 33, Issue 11, 2012, Pages 602-610

Target-based selection of flavonoids for neurodegenerative disorders

Author keywords

[No Author keywords available]

Indexed keywords

AUTACOID; BAICALIN; CATECHIN; CISPLATIN; CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; DELPHINIDIN; EPICATECHIN; EPIGALLOCATECHIN GALLATE; FISETIN; FLAVONOID; GENISTEIN; GENTAMICIN; GINKGO BILOBA EXTRACT; HESPERETIN; ISOQUERCITRIN; ISORHAMNETIN; LUTEOLIN; PHOSPHODIESTERASE; PHOSPHODIESTERASE IV; PHOSPHODIESTERASE IV INHIBITOR; PLACEBO; PROTEIN KINASE B; QUERCETIN; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE); REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; UNINDEXED DRUG; XANTHINE OXIDASE;

EID: 84867869761     PISSN: 01656147     EISSN: 18733735     Source Type: Journal    
DOI: 10.1016/j.tips.2012.08.002     Document Type: Review
Times cited : (97)

References (108)
  • 1
    • 33750347347 scopus 로고    scopus 로고
    • Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases
    • M.T. Lin, and M.F. Beal Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases Nature 443 2006 787 795
    • (2006) Nature , vol.443 , pp. 787-795
    • Lin, M.T.1    Beal, M.F.2
  • 2
    • 61649088435 scopus 로고    scopus 로고
    • PINK1-associated Parkinson's disease is caused by neuronal vulnerability to calcium-induced cell death
    • S. Gandhi PINK1-associated Parkinson's disease is caused by neuronal vulnerability to calcium-induced cell death Mol. Cell 33 2009 627 638
    • (2009) Mol. Cell , vol.33 , pp. 627-638
    • Gandhi, S.1
  • 3
    • 77956522541 scopus 로고    scopus 로고
    • Loss of the Parkinson's disease-linked gene DJ-1 perturbs mitochondrial dynamics
    • I. Irrcher Loss of the Parkinson's disease-linked gene DJ-1 perturbs mitochondrial dynamics Hum. Mol. Genet. 19 2010 3734 3746
    • (2010) Hum. Mol. Genet. , vol.19 , pp. 3734-3746
    • Irrcher, I.1
  • 4
    • 10644270716 scopus 로고    scopus 로고
    • Mitochondrial dysfunction in hearing loss
    • N. Fischel-Ghodsian Mitochondrial dysfunction in hearing loss Mitochondrion 4 2004 675 694
    • (2004) Mitochondrion , vol.4 , pp. 675-694
    • Fischel-Ghodsian, N.1
  • 5
    • 84859732716 scopus 로고    scopus 로고
    • Classic and new animal models of Parkinson's disease
    • J. Blesa Classic and new animal models of Parkinson's disease J. Biomed. Biotechnol. 2012 2012 1 10
    • (2012) J. Biomed. Biotechnol. , vol.2012 , pp. 1-10
    • Blesa, J.1
  • 6
    • 66049099678 scopus 로고    scopus 로고
    • The copper transporter Ctr1 contributes to cisplatin uptake by renal tubular cells during cisplatin nephrotoxicity
    • N. Pabla The copper transporter Ctr1 contributes to cisplatin uptake by renal tubular cells during cisplatin nephrotoxicity Am. J. Physiol. Renal Physiol. 296 2009 F505 F511
    • (2009) Am. J. Physiol. Renal Physiol. , vol.296
    • Pabla, N.1
  • 7
    • 77749273763 scopus 로고    scopus 로고
    • Organic cation transporter 2 mediates cisplatin-induced oto- and nephrotoxicity and is a target for protective interventions
    • G. Ciarimboli Organic cation transporter 2 mediates cisplatin-induced oto- and nephrotoxicity and is a target for protective interventions Am. J. Pathol. 176 2010 1169 1180
    • (2010) Am. J. Pathol. , vol.176 , pp. 1169-1180
    • Ciarimboli, G.1
  • 8
    • 84155167955 scopus 로고    scopus 로고
    • Mechanisms in cancer-chemotherapeutic drugs-induced peripheral neuropathy
    • A.S. Jaggi, and N. Singh Mechanisms in cancer-chemotherapeutic drugs-induced peripheral neuropathy Toxicology 291 2012 1 9
    • (2012) Toxicology , vol.291 , pp. 1-9
    • Jaggi, A.S.1    Singh, N.2
  • 9
    • 77949699981 scopus 로고    scopus 로고
    • Roles of NADPH oxidases in cisplatin-induced reactive oxygen species generation and ototoxicity
    • H.J. Kim Roles of NADPH oxidases in cisplatin-induced reactive oxygen species generation and ototoxicity J. Neurosci. 30 2010 3933 3946
    • (2010) J. Neurosci. , vol.30 , pp. 3933-3946
    • Kim, H.J.1
  • 10
    • 0028885057 scopus 로고
    • Comparative adverse effect profiles of platinum drugs
    • M.J. McKeage Comparative adverse effect profiles of platinum drugs Drug Saf. 13 1995 228 244
    • (1995) Drug Saf. , vol.13 , pp. 228-244
    • McKeage, M.J.1
  • 11
    • 0023867189 scopus 로고
    • Very high-dose cisplatin-induced ototoxicity: A preliminary report on early and long-term effects
    • C.F. Pollera Very high-dose cisplatin-induced ototoxicity: a preliminary report on early and long-term effects Cancer Chemother. Pharmacol. 21 1988 61 64
    • (1988) Cancer Chemother. Pharmacol. , vol.21 , pp. 61-64
    • Pollera, C.F.1
  • 12
    • 84861205340 scopus 로고    scopus 로고
    • Risk factors for cisplatin-associated ototoxicity in pediatric oncology patients
    • A. Yancey Risk factors for cisplatin-associated ototoxicity in pediatric oncology patients Pediatr. Blood Cancer 59 2012 144 148
    • (2012) Pediatr. Blood Cancer , vol.59 , pp. 144-148
    • Yancey, A.1
  • 13
    • 70649113052 scopus 로고    scopus 로고
    • Genetic variants in TPMT and COMT are associated with hearing loss in children receiving cisplatin chemotherapy
    • C.J. Ross Genetic variants in TPMT and COMT are associated with hearing loss in children receiving cisplatin chemotherapy Nat. Genet. 41 2009 1345 1349
    • (2009) Nat. Genet. , vol.41 , pp. 1345-1349
    • Ross, C.J.1
  • 14
    • 52449121171 scopus 로고    scopus 로고
    • Mitochondrial iron accumulation with age and functional consequences
    • A.Y. Seo Mitochondrial iron accumulation with age and functional consequences Aging Cell 7 2008 706 716
    • (2008) Aging Cell , vol.7 , pp. 706-716
    • Seo, A.Y.1
  • 15
    • 69949091187 scopus 로고    scopus 로고
    • Response to the increase of oxidative stress and mutation of mitochondrial DNA in aging
    • Y.S. Ma Response to the increase of oxidative stress and mutation of mitochondrial DNA in aging Biochim. Biophys. Acta 1790 2009 1021 1029
    • (2009) Biochim. Biophys. Acta , vol.1790 , pp. 1021-1029
    • Ma, Y.S.1
  • 16
    • 84861854211 scopus 로고    scopus 로고
    • NADPH oxidases: Novel therapeutic targets for neurodegenerative diseases
    • H.M. Gao NADPH oxidases: novel therapeutic targets for neurodegenerative diseases Trends Pharmacol. Sci. 33 2012 295 303
    • (2012) Trends Pharmacol. Sci. , vol.33 , pp. 295-303
    • Gao, H.M.1
  • 17
    • 67649800742 scopus 로고    scopus 로고
    • NADPH oxidase is the primary source of superoxide induced by NMDA receptor activation
    • A.M. Brennan NADPH oxidase is the primary source of superoxide induced by NMDA receptor activation Nat. Neurosci. 12 2009 857 863
    • (2009) Nat. Neurosci. , vol.12 , pp. 857-863
    • Brennan, A.M.1
  • 18
    • 23244453929 scopus 로고    scopus 로고
    • Regulation of xanthine oxidoreductase protein expression by hydrogen peroxide and calcium
    • J.S. McNally Regulation of xanthine oxidoreductase protein expression by hydrogen peroxide and calcium Arterioscler. Thromb. Vasc. Biol. 25 2005 1623 1628
    • (2005) Arterioscler. Thromb. Vasc. Biol. , vol.25 , pp. 1623-1628
    • McNally, J.S.1
  • 19
    • 33846818524 scopus 로고    scopus 로고
    • Three distinct mechanisms generate oxygen free radicals in neurons and contribute to cell death during anoxia and reoxygenation
    • A.Y. Abramov Three distinct mechanisms generate oxygen free radicals in neurons and contribute to cell death during anoxia and reoxygenation J. Neurosci. 27 2007 1129 1138
    • (2007) J. Neurosci. , vol.27 , pp. 1129-1138
    • Abramov, A.Y.1
  • 20
    • 0042320316 scopus 로고    scopus 로고
    • Allopurinol improves cardiac dysfunction after ischemia-reperfusion via reduction of oxidative stress in isolated perfused rat hearts
    • Y. Kinugasa Allopurinol improves cardiac dysfunction after ischemia-reperfusion via reduction of oxidative stress in isolated perfused rat hearts Circ. J. 67 2003 781 787
    • (2003) Circ. J. , vol.67 , pp. 781-787
    • Kinugasa, Y.1
  • 21
    • 72049098893 scopus 로고    scopus 로고
    • Xanthine oxidase is one of the major sources of superoxide anion radicals in blood after reperfusion in rats with forebrain ischemia/reperfusion
    • T. Ono Xanthine oxidase is one of the major sources of superoxide anion radicals in blood after reperfusion in rats with forebrain ischemia/reperfusion Brain Res. 1305 2009 158 167
    • (2009) Brain Res. , vol.1305 , pp. 158-167
    • Ono, T.1
  • 22
    • 77954754161 scopus 로고    scopus 로고
    • Role of the copper transporter, CTR1, in platinum-induced ototoxicity
    • S.S. More Role of the copper transporter, CTR1, in platinum-induced ototoxicity J. Neurosci. 30 2010 9500 9509
    • (2010) J. Neurosci. , vol.30 , pp. 9500-9509
    • More, S.S.1
  • 23
    • 0025353691 scopus 로고
    • Cellular pharmacology of cisplatin: Perspectives on mechanisms of acquired resistance
    • P.A. Andrews, and S.B. Howell Cellular pharmacology of cisplatin: perspectives on mechanisms of acquired resistance Cancer Cells 2 1990 35 43
    • (1990) Cancer Cells , vol.2 , pp. 35-43
    • Andrews, P.A.1    Howell, S.B.2
  • 24
    • 0030933609 scopus 로고    scopus 로고
    • Cisplatin-induced nephrotoxicity in porcine proximal tubular cells: Mitochondrial dysfunction by inhibition of complexes i to IV of the respiratory chain
    • M. Kruidering Cisplatin-induced nephrotoxicity in porcine proximal tubular cells: mitochondrial dysfunction by inhibition of complexes I to IV of the respiratory chain J. Pharmacol. Exp. Ther. 280 1997 638 649
    • (1997) J. Pharmacol. Exp. Ther. , vol.280 , pp. 638-649
    • Kruidering, M.1
  • 25
    • 77949808915 scopus 로고    scopus 로고
    • The relationship between cisplatin-induced reactive oxygen species, glutathione, and BCL-2 and resistance to cisplatin
    • A. Brozovic The relationship between cisplatin-induced reactive oxygen species, glutathione, and BCL-2 and resistance to cisplatin Crit. Rev. Toxicol. 40 2010 347 359
    • (2010) Crit. Rev. Toxicol. , vol.40 , pp. 347-359
    • Brozovic, A.1
  • 26
    • 84855448154 scopus 로고    scopus 로고
    • Mitochondrial-targeted antioxidants represent a promising approach for prevention of cisplatin-induced nephropathy
    • P. Mukhopadhyay Mitochondrial-targeted antioxidants represent a promising approach for prevention of cisplatin-induced nephropathy Free Radic. Biol. Med. 52 2012 497 506
    • (2012) Free Radic. Biol. Med. , vol.52 , pp. 497-506
    • Mukhopadhyay, P.1
  • 27
    • 80052266526 scopus 로고    scopus 로고
    • Cross talk between mitochondria and NADPH oxidases
    • S. Dikalov Cross talk between mitochondria and NADPH oxidases Free Radic. Biol. Med. 51 2011 1289 1301
    • (2011) Free Radic. Biol. Med. , vol.51 , pp. 1289-1301
    • Dikalov, S.1
  • 28
    • 77954935934 scopus 로고    scopus 로고
    • Transtympanic administration of short interfering (si)RNA for the NOX3 isoform of NADPH oxidase protects against cisplatin-induced hearing loss in the rat
    • D. Mukherjea Transtympanic administration of short interfering (si)RNA for the NOX3 isoform of NADPH oxidase protects against cisplatin-induced hearing loss in the rat Antioxid. Redox Signal. 13 2010 589 598
    • (2010) Antioxid. Redox Signal. , vol.13 , pp. 589-598
    • Mukherjea, D.1
  • 29
    • 13844266756 scopus 로고    scopus 로고
    • Reduction of acute cisplatin ototoxicity and nephrotoxicity in rats by oral administration of allopurinol and ebselen
    • E.D. Lynch Reduction of acute cisplatin ototoxicity and nephrotoxicity in rats by oral administration of allopurinol and ebselen Hear. Res. 201 2005 81 89
    • (2005) Hear. Res. , vol.201 , pp. 81-89
    • Lynch, E.D.1
  • 30
    • 79960054388 scopus 로고    scopus 로고
    • Cisplatin ototoxicity involves cytokines and STAT6 signaling network
    • H.J. Kim Cisplatin ototoxicity involves cytokines and STAT6 signaling network Cell Res. 21 2011 944 956
    • (2011) Cell Res. , vol.21 , pp. 944-956
    • Kim, H.J.1
  • 31
    • 80051492646 scopus 로고    scopus 로고
    • Short interfering RNA against STAT1 attenuates cisplatin-induced ototoxicity in the rat by suppressing inflammation
    • T. Kaur Short interfering RNA against STAT1 attenuates cisplatin-induced ototoxicity in the rat by suppressing inflammation Cell Death Dis. 2 2011 e180
    • (2011) Cell Death Dis. , vol.2 , pp. 180
    • Kaur, T.1
  • 32
    • 0036738517 scopus 로고    scopus 로고
    • TNF-alpha mediates chemokine and cytokine expression and renal injury in cisplatin nephrotoxicity
    • G. Ramesh, and W.B. Reeves TNF-alpha mediates chemokine and cytokine expression and renal injury in cisplatin nephrotoxicity J. Clin. Invest. 110 2002 835 842
    • (2002) J. Clin. Invest. , vol.110 , pp. 835-842
    • Ramesh, G.1    Reeves, W.B.2
  • 33
    • 0035397409 scopus 로고    scopus 로고
    • Cisplatin ototoxicity: Involvement of iron and enhanced formation of superoxide anion radicals
    • N. Dehne Cisplatin ototoxicity: involvement of iron and enhanced formation of superoxide anion radicals Toxicol. Appl. Pharmacol. 174 2001 27 34
    • (2001) Toxicol. Appl. Pharmacol. , vol.174 , pp. 27-34
    • Dehne, N.1
  • 34
    • 38349008651 scopus 로고    scopus 로고
    • The interactions of flavonoids within neuronal signalling pathways
    • J.P. Spencer The interactions of flavonoids within neuronal signalling pathways Genes Nutr. 2 2007 257 273
    • (2007) Genes Nutr. , vol.2 , pp. 257-273
    • Spencer, J.P.1
  • 35
    • 34548656056 scopus 로고    scopus 로고
    • Dietary patterns and risk of dementia: The Three-City cohort study
    • P. Barberger-Gateau Dietary patterns and risk of dementia: the Three-City cohort study Neurology 69 2007 1921 1930
    • (2007) Neurology , vol.69 , pp. 1921-1930
    • Barberger-Gateau, P.1
  • 36
    • 84859313679 scopus 로고    scopus 로고
    • Dietary flavonoids and risk of stroke in women
    • A. Cassidy Dietary flavonoids and risk of stroke in women Stroke 43 2012 946 951
    • (2012) Stroke , vol.43 , pp. 946-951
    • Cassidy, A.1
  • 37
    • 0028920708 scopus 로고
    • Protective effect of fruits and vegetables on development of stroke in men
    • M.W. Gillman Protective effect of fruits and vegetables on development of stroke in men JAMA 273 1995 1113 1117
    • (1995) JAMA , vol.273 , pp. 1113-1117
    • Gillman, M.W.1
  • 38
    • 84860708402 scopus 로고    scopus 로고
    • Habitual intake of dietary flavonoids and risk of Parkinson disease
    • X. Gao Habitual intake of dietary flavonoids and risk of Parkinson disease Neurology 78 2012 1138 1145
    • (2012) Neurology , vol.78 , pp. 1138-1145
    • Gao, X.1
  • 39
    • 20444447208 scopus 로고    scopus 로고
    • Liquid chromatography-tandem mass spectroscopy assay for quercetin and conjugated quercetin metabolites in human plasma and urine
    • L. Wang, and M.E. Morris Liquid chromatography-tandem mass spectroscopy assay for quercetin and conjugated quercetin metabolites in human plasma and urine J. Chromatogr. B: Analyt. Technol. Biomed. Life Sci. 821 2005 194 201
    • (2005) J. Chromatogr. B: Analyt. Technol. Biomed. Life Sci. , vol.821 , pp. 194-201
    • Wang, L.1    Morris, M.E.2
  • 40
    • 13844281685 scopus 로고    scopus 로고
    • Bioavailability and bioefficacy of polyphenols in humans. I. Review of 97 bioavailability studies
    • C. Manach Bioavailability and bioefficacy of polyphenols in humans. I. Review of 97 bioavailability studies Am. J. Clin. Nutr. 81 2005 230S 242S
    • (2005) Am. J. Clin. Nutr. , vol.81
    • Manach, C.1
  • 41
    • 79959557659 scopus 로고    scopus 로고
    • Pharmacokinetic and chemoprevention studies on tea in humans
    • H.H. Chow, and I.A. Hakim Pharmacokinetic and chemoprevention studies on tea in humans Pharmacol. Res. 64 2011 105 112
    • (2011) Pharmacol. Res. , vol.64 , pp. 105-112
    • Chow, H.H.1    Hakim, I.A.2
  • 42
    • 77955284662 scopus 로고    scopus 로고
    • Oral bioavailability of quercetin from different quercetin glycosides in dogs
    • M. Reinboth Oral bioavailability of quercetin from different quercetin glycosides in dogs Br. J. Nutr. 104 2010 198 203
    • (2010) Br. J. Nutr. , vol.104 , pp. 198-203
    • Reinboth, M.1
  • 43
    • 0028793218 scopus 로고
    • Absorption of dietary quercetin glycosides and quercetin in healthy ileostomy volunteers
    • P.C. Hollman Absorption of dietary quercetin glycosides and quercetin in healthy ileostomy volunteers Am. J. Clin. Nutr. 62 1995 1276 1282
    • (1995) Am. J. Clin. Nutr. , vol.62 , pp. 1276-1282
    • Hollman, P.C.1
  • 44
    • 30744477453 scopus 로고    scopus 로고
    • Characteristics of (+)-catechin and (-)-epicatechin transport across pig intestinal brush border membranes
    • C. Starp Characteristics of (+)-catechin and (-)-epicatechin transport across pig intestinal brush border membranes Ann. Nutr. Metab. 50 2006 59 65
    • (2006) Ann. Nutr. Metab. , vol.50 , pp. 59-65
    • Starp, C.1
  • 45
    • 0034672514 scopus 로고    scopus 로고
    • Conjugation position of quercetin glucuronides and effect on biological activity
    • A.J. Day Conjugation position of quercetin glucuronides and effect on biological activity Free Radic. Biol. Med. 29 2000 1234 1243
    • (2000) Free Radic. Biol. Med. , vol.29 , pp. 1234-1243
    • Day, A.J.1
  • 46
    • 0032566518 scopus 로고    scopus 로고
    • Deglycosylation of flavonoid and isoflavonoid glycosides by human small intestine and liver beta-glucosidase activity
    • A.J. Day Deglycosylation of flavonoid and isoflavonoid glycosides by human small intestine and liver beta-glucosidase activity FEBS Lett. 436 1998 71 75
    • (1998) FEBS Lett. , vol.436 , pp. 71-75
    • Day, A.J.1
  • 47
    • 84859736687 scopus 로고    scopus 로고
    • Flavone deglycosylation increases their anti-inflammatory activity and absorption
    • G. Hostetler Flavone deglycosylation increases their anti-inflammatory activity and absorption Mol. Nutr. Food Res. 56 2012 558 569
    • (2012) Mol. Nutr. Food Res. , vol.56 , pp. 558-569
    • Hostetler, G.1
  • 48
    • 1042290475 scopus 로고    scopus 로고
    • Cellular uptake and metabolism of flavonoids and their metabolites: Implications for their bioactivity
    • J.P. Spencer Cellular uptake and metabolism of flavonoids and their metabolites: implications for their bioactivity Arch. Biochem. Biophys. 423 2004 148 161
    • (2004) Arch. Biochem. Biophys. , vol.423 , pp. 148-161
    • Spencer, J.P.1
  • 49
    • 85027942097 scopus 로고    scopus 로고
    • The flavonoid paradox: Conjugation and deconjugation as key steps for the biological activity of flavonoids
    • F. Perez-Vizcaino The flavonoid paradox: conjugation and deconjugation as key steps for the biological activity of flavonoids J. Sci. Food Agric. 92 2012 1822 1825
    • (2012) J. Sci. Food Agric. , vol.92 , pp. 1822-1825
    • Perez-Vizcaino, F.1
  • 50
    • 30144432225 scopus 로고    scopus 로고
    • Glucuronidase deconjugation in inflammation
    • K. Shimoi, and T. Nakayama Glucuronidase deconjugation in inflammation Methods Enzymol. 400 2005 263 272
    • (2005) Methods Enzymol. , vol.400 , pp. 263-272
    • Shimoi, K.1    Nakayama, T.2
  • 51
    • 0035839129 scopus 로고    scopus 로고
    • Flavonoid glucuronides are substrates for human liver beta-glucuronidase
    • K.A. O'Leary Flavonoid glucuronides are substrates for human liver beta-glucuronidase FEBS Lett. 503 2001 103 106
    • (2001) FEBS Lett. , vol.503 , pp. 103-106
    • O'Leary, K.A.1
  • 52
    • 77958534784 scopus 로고    scopus 로고
    • Plasma levels and distribution of flavonoids in rat brain after single and repeated doses of standardized Ginkgo biloba extract EGb 761(R)
    • L. Rangel-Ordonez Plasma levels and distribution of flavonoids in rat brain after single and repeated doses of standardized Ginkgo biloba extract EGb 761(R) Planta Med. 76 2010 1683 1690
    • (2010) Planta Med. , vol.76 , pp. 1683-1690
    • Rangel-Ordonez, L.1
  • 53
    • 49449084484 scopus 로고    scopus 로고
    • Tissue distribution of quercetin in pigs after long-term dietary supplementation
    • J. Bieger Tissue distribution of quercetin in pigs after long-term dietary supplementation J. Nutr. 138 2008 1417 1420
    • (2008) J. Nutr. , vol.138 , pp. 1417-1420
    • Bieger, J.1
  • 54
    • 35848966547 scopus 로고    scopus 로고
    • Quercetin reduces blood pressure in hypertensive subjects
    • R.L. Edwards Quercetin reduces blood pressure in hypertensive subjects J. Nutr. 137 2007 2405 2411
    • (2007) J. Nutr. , vol.137 , pp. 2405-2411
    • Edwards, R.L.1
  • 55
    • 0034987459 scopus 로고    scopus 로고
    • Antihypertensive effects of the flavonoid quercetin in spontaneously hypertensive rats
    • J. Duarte Antihypertensive effects of the flavonoid quercetin in spontaneously hypertensive rats Br. J. Pharmacol. 133 2001 117 124
    • (2001) Br. J. Pharmacol. , vol.133 , pp. 117-124
    • Duarte, J.1
  • 56
    • 84858052503 scopus 로고    scopus 로고
    • Glucuronidated quercetin lowers blood pressure in spontaneously hypertensive rats via deconjugation
    • P. Galindo Glucuronidated quercetin lowers blood pressure in spontaneously hypertensive rats via deconjugation PLoS ONE 7 2012 e32673
    • (2012) PLoS ONE , vol.7 , pp. 32673
    • Galindo, P.1
  • 57
    • 44049084958 scopus 로고    scopus 로고
    • Macrophage as a target of quercetin glucuronides in human atherosclerotic arteries: Implication in the anti-atherosclerotic mechanism of dietary flavonoids
    • Y. Kawai Macrophage as a target of quercetin glucuronides in human atherosclerotic arteries: implication in the anti-atherosclerotic mechanism of dietary flavonoids J. Biol. Chem. 283 2008 9424 9434
    • (2008) J. Biol. Chem. , vol.283 , pp. 9424-9434
    • Kawai, Y.1
  • 58
    • 32244448638 scopus 로고    scopus 로고
    • Determination of St. John's wort flavonoid-metabolites in rat brain through high performance liquid chromatography coupled with fluorescence detection
    • A. Paulke Determination of St. John's wort flavonoid-metabolites in rat brain through high performance liquid chromatography coupled with fluorescence detection J. Chromatogr. B: Analyt. Technol. Biomed. Life Sci. 832 2006 109 113
    • (2006) J. Chromatogr. B: Analyt. Technol. Biomed. Life Sci. , vol.832 , pp. 109-113
    • Paulke, A.1
  • 59
    • 20844456273 scopus 로고    scopus 로고
    • Anthocyanin metabolism in rats and their distribution to digestive area, kidney, and brain
    • S. Talavera Anthocyanin metabolism in rats and their distribution to digestive area, kidney, and brain J. Agric. Food Chem. 53 2005 3902 3908
    • (2005) J. Agric. Food Chem. , vol.53 , pp. 3902-3908
    • Talavera, S.1
  • 60
    • 0037115062 scopus 로고    scopus 로고
    • Uptake and metabolism of epicatechin and its access to the brain after oral ingestion
    • M.M. Abd El Mohsen Uptake and metabolism of epicatechin and its access to the brain after oral ingestion Free Radic. Biol. Med. 33 2002 1693 1702
    • (2002) Free Radic. Biol. Med. , vol.33 , pp. 1693-1702
    • Abd El Mohsen, M.M.1
  • 61
    • 46749123053 scopus 로고    scopus 로고
    • Grape-derived polyphenolics prevent Abeta oligomerization and attenuate cognitive deterioration in a mouse model of Alzheimer's disease
    • J. Wang Grape-derived polyphenolics prevent Abeta oligomerization and attenuate cognitive deterioration in a mouse model of Alzheimer's disease J. Neurosci. 28 2008 6388 6392
    • (2008) J. Neurosci. , vol.28 , pp. 6388-6392
    • Wang, J.1
  • 62
    • 25444500410 scopus 로고    scopus 로고
    • Green tea epigallocatechin-3-gallate (EGCG) modulates amyloid precursor protein cleavage and reduces cerebral amyloidosis in Alzheimer transgenic mice
    • K. Rezai-Zadeh Green tea epigallocatechin-3-gallate (EGCG) modulates amyloid precursor protein cleavage and reduces cerebral amyloidosis in Alzheimer transgenic mice J. Neurosci. 25 2005 8807 8814
    • (2005) J. Neurosci. , vol.25 , pp. 8807-8814
    • Rezai-Zadeh, K.1
  • 63
    • 84859542836 scopus 로고    scopus 로고
    • Brain-targeted proanthocyanidin metabolites for Alzheimer's disease treatment
    • J. Wang Brain-targeted proanthocyanidin metabolites for Alzheimer's disease treatment J. Neurosci. 32 2012 5144 5150
    • (2012) J. Neurosci. , vol.32 , pp. 5144-5150
    • Wang, J.1
  • 64
    • 1542605222 scopus 로고    scopus 로고
    • Flavonoids: Antioxidants or signalling molecules?
    • R.J. Williams Flavonoids: antioxidants or signalling molecules? Free Radic. Biol. Med. 36 2004 838 849
    • (2004) Free Radic. Biol. Med. , vol.36 , pp. 838-849
    • Williams, R.J.1
  • 65
    • 71949107443 scopus 로고    scopus 로고
    • Flavonoids and brain health: Multiple effects underpinned by common mechanisms
    • J.P. Spencer Flavonoids and brain health: multiple effects underpinned by common mechanisms Genes Nutr. 4 2009 243 250
    • (2009) Genes Nutr. , vol.4 , pp. 243-250
    • Spencer, J.P.1
  • 66
    • 33749999530 scopus 로고    scopus 로고
    • Suppression of reactive oxygen species and neurodegeneration by the PGC-1 transcriptional coactivators
    • J. St-Pierre Suppression of reactive oxygen species and neurodegeneration by the PGC-1 transcriptional coactivators Cell 127 2006 397 408
    • (2006) Cell , vol.127 , pp. 397-408
    • St-Pierre, J.1
  • 67
    • 82255170572 scopus 로고    scopus 로고
    • Neurotrophic effect of citrus 5-hydroxy-3,6,7,8,3′,4′- hexamethoxyflavone: Promotion of neurite outgrowth via cAMP/PKA/CREB pathway in PC12 cells
    • H.C. Lai Neurotrophic effect of citrus 5-hydroxy-3,6,7,8,3′, 4′-hexamethoxyflavone: promotion of neurite outgrowth via cAMP/PKA/CREB pathway in PC12 cells PLoS ONE 6 2011 e28280
    • (2011) PLoS ONE , vol.6 , pp. 28280
    • Lai, H.C.1
  • 68
    • 0034306450 scopus 로고    scopus 로고
    • Specificity and mechanism of action of some commonly used protein kinase inhibitors
    • S.P. Davies Specificity and mechanism of action of some commonly used protein kinase inhibitors Biochem. J. 351 2000 95 105
    • (2000) Biochem. J. , vol.351 , pp. 95-105
    • Davies, S.P.1
  • 69
    • 74949110261 scopus 로고    scopus 로고
    • Stimulation of neurogenesis and synaptogenesis by bilobalide and quercetin via common final pathway in hippocampal neurons
    • F. Tchantchou Stimulation of neurogenesis and synaptogenesis by bilobalide and quercetin via common final pathway in hippocampal neurons J. Alzheimers Dis. 18 2009 787 798
    • (2009) J. Alzheimers Dis. , vol.18 , pp. 787-798
    • Tchantchou, F.1
  • 70
    • 79951971885 scopus 로고    scopus 로고
    • The flavonoid baicalein promotes NMDA receptor-dependent long-term potentiation and enhances memory
    • W. Wang The flavonoid baicalein promotes NMDA receptor-dependent long-term potentiation and enhances memory Br. J. Pharmacol. 162 2011 1364 1379
    • (2011) Br. J. Pharmacol. , vol.162 , pp. 1364-1379
    • Wang, W.1
  • 71
    • 50249116131 scopus 로고    scopus 로고
    • Inhibitory effects of quercetin derivatives on phosphodiesterase isozymes and high-affinity [(3) H]-rolipram binding in guinea pig tissues
    • A.L. Chan Inhibitory effects of quercetin derivatives on phosphodiesterase isozymes and high-affinity [(3) H]-rolipram binding in guinea pig tissues Invest. New Drugs 26 2008 417 424
    • (2008) Invest. New Drugs , vol.26 , pp. 417-424
    • Chan, A.L.1
  • 72
    • 11944259107 scopus 로고    scopus 로고
    • Suppressive effects of 3-O-methylquercetin on ovalbumin-induced airway hyperresponsiveness
    • W.C. Ko Suppressive effects of 3-O-methylquercetin on ovalbumin-induced airway hyperresponsiveness Planta Med. 70 2004 1123 1127
    • (2004) Planta Med. , vol.70 , pp. 1123-1127
    • Ko, W.C.1
  • 73
    • 56349110884 scopus 로고    scopus 로고
    • Control of mitochondria dynamics and oxidative metabolism by cAMP, AKAPs and the proteasome
    • A. Carlucci Control of mitochondria dynamics and oxidative metabolism by cAMP, AKAPs and the proteasome Trends Cell Biol. 18 2008 604 613
    • (2008) Trends Cell Biol. , vol.18 , pp. 604-613
    • Carlucci, A.1
  • 74
    • 33748324543 scopus 로고    scopus 로고
    • Flavonoids attenuate cardiovascular disease, inhibit phosphodiesterase, and modulate lipid homeostasis in adipose tissue and liver
    • M.R. Peluso Flavonoids attenuate cardiovascular disease, inhibit phosphodiesterase, and modulate lipid homeostasis in adipose tissue and liver Exp. Biol. Med. (Maywood) 231 2006 1287 1299
    • (2006) Exp. Biol. Med. (Maywood) , vol.231 , pp. 1287-1299
    • Peluso, M.R.1
  • 75
    • 84863011114 scopus 로고    scopus 로고
    • Resveratrol ameliorates aging-related metabolic phenotypes by inhibiting cAMP phosphodiesterases
    • S.J. Park Resveratrol ameliorates aging-related metabolic phenotypes by inhibiting cAMP phosphodiesterases Cell 148 2012 421 433
    • (2012) Cell , vol.148 , pp. 421-433
    • Park, S.J.1
  • 76
    • 5144221343 scopus 로고    scopus 로고
    • Inhibitory effects of flavonoids on phosphodiesterase isozymes from guinea pig and their structure-activity relationships
    • W.C. Ko Inhibitory effects of flavonoids on phosphodiesterase isozymes from guinea pig and their structure-activity relationships Biochem. Pharmacol. 68 2004 2087 2094
    • (2004) Biochem. Pharmacol. , vol.68 , pp. 2087-2094
    • Ko, W.C.1
  • 77
    • 0026802030 scopus 로고
    • Effects of flavonoids on cyclic AMP phosphodiesterase and lipid mobilization in rat adipocytes
    • U.R. Kuppusamy, and N.P. Das Effects of flavonoids on cyclic AMP phosphodiesterase and lipid mobilization in rat adipocytes Biochem. Pharmacol. 44 1992 1307 1315
    • (1992) Biochem. Pharmacol. , vol.44 , pp. 1307-1315
    • Kuppusamy, U.R.1    Das, N.P.2
  • 78
    • 79960896132 scopus 로고    scopus 로고
    • Phosphodiesterase inhibitors: Factors that influence potency, selectivity, and action
    • S.H. Francis Phosphodiesterase inhibitors: factors that influence potency, selectivity, and action Handb. Exp. Pharmacol. 204 2011 47 84
    • (2011) Handb. Exp. Pharmacol. , vol.204 , pp. 47-84
    • Francis, S.H.1
  • 79
    • 84863270633 scopus 로고    scopus 로고
    • Hesperetin, a selective phosphodiesterase 4 inhibitor, effectively suppresses ovalbumin-induced airway hyperresponsiveness without influencing xylazine/ketamine-induced anesthesia
    • C.H. Shih Hesperetin, a selective phosphodiesterase 4 inhibitor, effectively suppresses ovalbumin-induced airway hyperresponsiveness without influencing xylazine/ketamine-induced anesthesia Evid. Based Complement. Alternat. Med. 2012 2012 472897
    • (2012) Evid. Based Complement. Alternat. Med. , vol.2012 , pp. 472897
    • Shih, C.H.1
  • 80
    • 73449123347 scopus 로고    scopus 로고
    • Luteolin, a non-selective competitive inhibitor of phosphodiesterases 1-5, displaced [3H]-rolipram from high-affinity rolipram binding sites and reversed xylazine/ketamine-induced anesthesia
    • M.C. Yu Luteolin, a non-selective competitive inhibitor of phosphodiesterases 1-5, displaced [3H]-rolipram from high-affinity rolipram binding sites and reversed xylazine/ketamine-induced anesthesia Eur. J. Pharmacol. 627 2010 269 275
    • (2010) Eur. J. Pharmacol. , vol.627 , pp. 269-275
    • Yu, M.C.1
  • 81
    • 61749093429 scopus 로고    scopus 로고
    • Phosphodiesterases in the central nervous system
    • T. Kleppisch Phosphodiesterases in the central nervous system Handb. Exp. Pharmacol. 191 2009 71 92
    • (2009) Handb. Exp. Pharmacol. , vol.191 , pp. 71-92
    • Kleppisch, T.1
  • 82
    • 78650891913 scopus 로고    scopus 로고
    • Phosphodiesterase-4D knock-out and RNA interference-mediated knock-down enhance memory and increase hippocampal neurogenesis via increased cAMP signaling
    • Y.F. Li Phosphodiesterase-4D knock-out and RNA interference-mediated knock-down enhance memory and increase hippocampal neurogenesis via increased cAMP signaling J. Neurosci. 31 2011 172 183
    • (2011) J. Neurosci. , vol.31 , pp. 172-183
    • Li, Y.F.1
  • 83
    • 79952164540 scopus 로고    scopus 로고
    • Mitochondrial dysfunction in Parkinson's disease: Pathogenesis and neuroprotection
    • R.B. Mounsey, and P. Teismann Mitochondrial dysfunction in Parkinson's disease: pathogenesis and neuroprotection Parkinsons Dis. 2011 2010 617472
    • (2010) Parkinsons Dis. , vol.2011 , pp. 617472
    • Mounsey, R.B.1    Teismann, P.2
  • 84
    • 80054863077 scopus 로고    scopus 로고
    • Ototoxicity: Mechanisms of cochlear impairment and its prevention
    • K. Tabuchi Ototoxicity: mechanisms of cochlear impairment and its prevention Curr. Med. Chem. 18 2011 4866 4871
    • (2011) Curr. Med. Chem. , vol.18 , pp. 4866-4871
    • Tabuchi, K.1
  • 85
    • 81155128482 scopus 로고    scopus 로고
    • Complex i and cytochrome c are molecular targets of flavonoids that inhibit hydrogen peroxide production by mitochondria
    • R. Lagoa Complex I and cytochrome c are molecular targets of flavonoids that inhibit hydrogen peroxide production by mitochondria Biochim. Biophys. Acta 1807 2011 1562 1572
    • (2011) Biochim. Biophys. Acta , vol.1807 , pp. 1562-1572
    • Lagoa, R.1
  • 86
    • 77951498353 scopus 로고    scopus 로고
    • Mitochondria accumulate large amounts of quercetin: Prevention of mitochondrial damage and release upon oxidation of the extramitochondrial fraction of the flavonoid
    • M. Fiorani Mitochondria accumulate large amounts of quercetin: prevention of mitochondrial damage and release upon oxidation of the extramitochondrial fraction of the flavonoid J. Nutr. Biochem. 21 2010 397 404
    • (2010) J. Nutr. Biochem. , vol.21 , pp. 397-404
    • Fiorani, M.1
  • 87
    • 84863091436 scopus 로고    scopus 로고
    • Inhibition of mitochondrial complex i by various non-steroidal anti-inflammatory drugs and its protection by quercetin via a coenzyme Q-like action
    • C. Sandoval-Acuna Inhibition of mitochondrial complex I by various non-steroidal anti-inflammatory drugs and its protection by quercetin via a coenzyme Q-like action Chem. Biol. Interact. 199 2012 18 28
    • (2012) Chem. Biol. Interact. , vol.199 , pp. 18-28
    • Sandoval-Acuna, C.1
  • 88
    • 37549011857 scopus 로고    scopus 로고
    • Mono-O-methylated flavanols and other flavonoids as inhibitors of endothelial NADPH oxidase
    • Y. Steffen Mono-O-methylated flavanols and other flavonoids as inhibitors of endothelial NADPH oxidase Arch. Biochem. Biophys. 469 2008 209 219
    • (2008) Arch. Biochem. Biophys. , vol.469 , pp. 209-219
    • Steffen, Y.1
  • 89
    • 0031886669 scopus 로고    scopus 로고
    • Structure-activity relationship and classification of flavonoids as inhibitors of xanthine oxidase and superoxide scavengers
    • P. Cos Structure-activity relationship and classification of flavonoids as inhibitors of xanthine oxidase and superoxide scavengers J. Nat. Prod. 61 1998 71 76
    • (1998) J. Nat. Prod. , vol.61 , pp. 71-76
    • Cos, P.1
  • 90
    • 0027492737 scopus 로고
    • Antioxidant and iron-chelating activities of the flavonoids catechin, quercetin and diosmetin on iron-loaded rat hepatocyte cultures
    • I. Morel Antioxidant and iron-chelating activities of the flavonoids catechin, quercetin and diosmetin on iron-loaded rat hepatocyte cultures Biochem. Pharmacol. 45 1993 13 19
    • (1993) Biochem. Pharmacol. , vol.45 , pp. 13-19
    • Morel, I.1
  • 91
    • 41849117298 scopus 로고    scopus 로고
    • Flavonoids-induced accumulation of hypoxia-inducible factor (HIF)-1alpha/2alpha is mediated through chelation of iron
    • S.S. Park Flavonoids-induced accumulation of hypoxia-inducible factor (HIF)-1alpha/2alpha is mediated through chelation of iron J. Cell. Biochem. 103 2008 1989 1998
    • (2008) J. Cell. Biochem. , vol.103 , pp. 1989-1998
    • Park, S.S.1
  • 92
    • 34347334632 scopus 로고    scopus 로고
    • Quercetin activates an angiogenic pathway, hypoxia inducible factor (HIF)-1-vascular endothelial growth factor, by inhibiting HIF-prolyl hydroxylase: A structural analysis of quercetin for inhibiting HIF-prolyl hydroxylase
    • H. Jeon Quercetin activates an angiogenic pathway, hypoxia inducible factor (HIF)-1-vascular endothelial growth factor, by inhibiting HIF-prolyl hydroxylase: a structural analysis of quercetin for inhibiting HIF-prolyl hydroxylase Mol. Pharmacol. 71 2007 1676 1684
    • (2007) Mol. Pharmacol. , vol.71 , pp. 1676-1684
    • Jeon, H.1
  • 93
    • 58849166492 scopus 로고    scopus 로고
    • Green tea epigallocatechin 3-gallate accumulates in mitochondria and displays a selective antiapoptotic effect against inducers of mitochondrial oxidative stress in neurons
    • E.K. Schroeder Green tea epigallocatechin 3-gallate accumulates in mitochondria and displays a selective antiapoptotic effect against inducers of mitochondrial oxidative stress in neurons Antioxid. Redox Signal. 11 2009 469 480
    • (2009) Antioxid. Redox Signal. , vol.11 , pp. 469-480
    • Schroeder, E.K.1
  • 94
    • 34548246598 scopus 로고    scopus 로고
    • Ginkgo biloba extract (EGb 761) protects against cisplatin-induced ototoxicity in rats
    • X. Huang Ginkgo biloba extract (EGb 761) protects against cisplatin-induced ototoxicity in rats Otol. Neurotol. 28 2007 828 833
    • (2007) Otol. Neurotol. , vol.28 , pp. 828-833
    • Huang, X.1
  • 95
    • 64849117650 scopus 로고    scopus 로고
    • Cisplatin-induced hair cell death requires STAT1 and is attenuated by epigallocatechin gallate
    • N.C. Schmitt Cisplatin-induced hair cell death requires STAT1 and is attenuated by epigallocatechin gallate J. Neurosci. 29 2009 3843 3851
    • (2009) J. Neurosci. , vol.29 , pp. 3843-3851
    • Schmitt, N.C.1
  • 96
    • 49349114072 scopus 로고    scopus 로고
    • Epicatechin protects auditory cells against cisplatin-induced death
    • C.H. Kim Epicatechin protects auditory cells against cisplatin-induced death Apoptosis 13 2008 1184 1194
    • (2008) Apoptosis , vol.13 , pp. 1184-1194
    • Kim, C.H.1
  • 97
    • 78650516788 scopus 로고    scopus 로고
    • Epicatechin protects the auditory organ by attenuating cisplatin-induced ototoxicity through inhibition of ERK
    • J.S. Lee Epicatechin protects the auditory organ by attenuating cisplatin-induced ototoxicity through inhibition of ERK Toxicol. Lett. 199 2010 308 316
    • (2010) Toxicol. Lett. , vol.199 , pp. 308-316
    • Lee, J.S.1
  • 98
    • 33746010873 scopus 로고    scopus 로고
    • Polyphenols enhance platelet nitric oxide by inhibiting protein kinase C-dependent NADPH oxidase activation: Effect on platelet recruitment
    • P. Pignatelli Polyphenols enhance platelet nitric oxide by inhibiting protein kinase C-dependent NADPH oxidase activation: effect on platelet recruitment FASEB J. 20 2006 1082 1089
    • (2006) FASEB J. , vol.20 , pp. 1082-1089
    • Pignatelli, P.1
  • 99
    • 58649117965 scopus 로고    scopus 로고
    • Targeting STAT1 by myricetin and delphinidin provides efficient protection of the heart from ischemia/reperfusion-induced injury
    • T.M. Scarabelli Targeting STAT1 by myricetin and delphinidin provides efficient protection of the heart from ischemia/reperfusion-induced injury FEBS Lett. 583 2009 531 541
    • (2009) FEBS Lett. , vol.583 , pp. 531-541
    • Scarabelli, T.M.1
  • 100
    • 84857061670 scopus 로고    scopus 로고
    • Reduction of cisplatin ototoxicity in rats by oral administration of pomegranate extract
    • Z.M. Yazici Reduction of cisplatin ototoxicity in rats by oral administration of pomegranate extract Eur. Arch. Otorhinolaryngol. 269 2012 45 52
    • (2012) Eur. Arch. Otorhinolaryngol. , vol.269 , pp. 45-52
    • Yazici, Z.M.1
  • 101
    • 53249087817 scopus 로고    scopus 로고
    • Determination of baicalin in rat cerebrospinal fluid and blood using microdialysis coupled with ultra-performance liquid chromatography-tandem mass spectrometry
    • H. Huang Determination of baicalin in rat cerebrospinal fluid and blood using microdialysis coupled with ultra-performance liquid chromatography-tandem mass spectrometry J. Chromatogr. B: Analyt. Technol. Biomed. Life Sci. 874 2008 77 83
    • (2008) J. Chromatogr. B: Analyt. Technol. Biomed. Life Sci. , vol.874 , pp. 77-83
    • Huang, H.1
  • 102
    • 73649141996 scopus 로고    scopus 로고
    • Effect of baicalein from Scutellaria baicalensis on prevention of noise-induced hearing loss
    • T.H. Kang Effect of baicalein from Scutellaria baicalensis on prevention of noise-induced hearing loss Neurosci. Lett. 469 2010 298 302
    • (2010) Neurosci. Lett. , vol.469 , pp. 298-302
    • Kang, T.H.1
  • 103
    • 79251634664 scopus 로고    scopus 로고
    • Efficacy and safety of flavocoxid compared with naproxen in subjects with osteoarthritis of the knee- A subset analysis
    • R. Levy Efficacy and safety of flavocoxid compared with naproxen in subjects with osteoarthritis of the knee- a subset analysis Adv. Ther. 27 2010 953 962
    • (2010) Adv. Ther. , vol.27 , pp. 953-962
    • Levy, R.1
  • 104
    • 73449117855 scopus 로고    scopus 로고
    • Luteolin promotes long-term potentiation and improves cognitive functions in chronic cerebral hypoperfused rats
    • B. Xu Luteolin promotes long-term potentiation and improves cognitive functions in chronic cerebral hypoperfused rats Eur. J. Pharmacol. 627 2010 99 105
    • (2010) Eur. J. Pharmacol. , vol.627 , pp. 99-105
    • Xu, B.1
  • 105
    • 46749119052 scopus 로고    scopus 로고
    • Luteolin suppresses cisplatin-induced apoptosis in auditory cells: Possible mediation through induction of heme oxygenase-1 expression
    • B.M. Choi Luteolin suppresses cisplatin-induced apoptosis in auditory cells: possible mediation through induction of heme oxygenase-1 expression J. Med. Food 11 2008 230 236
    • (2008) J. Med. Food , vol.11 , pp. 230-236
    • Choi, B.M.1
  • 106
    • 80955136983 scopus 로고    scopus 로고
    • Ginkgo biloba extract in the treatment of tinnitus: A systematic review
    • A. von Boetticher Ginkgo biloba extract in the treatment of tinnitus: a systematic review Neuropsychiatr. Dis. Treat. 7 2011 441 447
    • (2011) Neuropsychiatr. Dis. Treat. , vol.7 , pp. 441-447
    • Von Boetticher, A.1
  • 107
    • 0033873786 scopus 로고    scopus 로고
    • Flavonoids apigenin and quercetin inhibit melanoma growth and metastatic potential
    • S. Caltagirone Flavonoids apigenin and quercetin inhibit melanoma growth and metastatic potential Int. J. Cancer 87 2000 595 600
    • (2000) Int. J. Cancer , vol.87 , pp. 595-600
    • Caltagirone, S.1
  • 108
    • 35348928702 scopus 로고    scopus 로고
    • The effect of monohydroxyethylrutoside on doxorubicin-induced cardiotoxicity in patients treated for metastatic cancer in a phase II study
    • A.M. Bruynzeel The effect of monohydroxyethylrutoside on doxorubicin-induced cardiotoxicity in patients treated for metastatic cancer in a phase II study Br. J. Cancer 97 2007 1084 1089
    • (2007) Br. J. Cancer , vol.97 , pp. 1084-1089
    • Bruynzeel, A.M.1


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