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Volumn 46, Issue 8, 2012, Pages 1019-1028

Effect of quercetin and its glucuronide metabolite upon 6-hydorxydopamine-induced oxidative damage in Neuro-2a cells

Author keywords

6 hydroxydopamine; Oxidative stress; Parkinson disease; Quercetin; Quercetin 3 O d glucuronide

Indexed keywords

HYDROGEN PEROXIDE; OXIDOPAMINE; QUERCETIN; QUERCETIN 3BETA GLUCURONIDE; QUERCETIN AGLYCONE; UNCLASSIFIED DRUG;

EID: 84863918773     PISSN: 10715762     EISSN: 10292470     Source Type: Journal    
DOI: 10.3109/10715762.2012.673720     Document Type: Article
Times cited : (34)

References (30)
  • 1
    • 0034851475 scopus 로고    scopus 로고
    • Flavonoid (myricetin, quercetin, kaempferol, luteolin, and apigenin) content of edible tropical plants
    • Miean KH, Mohamed S. Flavonoid (myricetin, quercetin, kaempferol, luteolin, and apigenin) content of edible tropical plants. J Agric Food Chem 2001;49:3106-3112.
    • (2001) J Agric Food Chem , vol.49 , pp. 3106-3112
    • Miean, K.H.1    Mohamed, S.2
  • 2
    • 0033863355 scopus 로고    scopus 로고
    • Dietary intake and bioavailability of polyphenols
    • Scalbert A, Williamson G. Dietary intake and bioavailability of polyphenols. J Nutr 2000;130(8S Suppl):2073S-2085S.
    • (2000) J Nutr , vol.130 , Issue.8 SUPPL.
    • Scalbert, A.1    Williamson, G.2
  • 3
    • 0035692180 scopus 로고    scopus 로고
    • Human metabolism of dietary fl avonoids: Identifi cation of plasma metabolites of quercetin
    • Day AJ, Mellon F, Barron D, Sarrazin G, Morgan MR, Williamson G. Human metabolism of dietary fl avonoids: identifi cation of plasma metabolites of quercetin. Free Radic Res 2001;35:941-952.
    • (2001) Free Radic Res , vol.35 , pp. 941-952
    • Day, A.J.1    Mellon, F.2    Barron, D.3    Sarrazin, G.4    Morgan, M.R.5    Williamson, G.6
  • 4
    • 80052269348 scopus 로고    scopus 로고
    • Accumulation of orally administered quercetin in brain tissue and its antioxidative effects in rats
    • Ishisaka A, Ichikawa S, Sakakibara H, Piskula MK, Nakamura T, Kato Y, et al. Accumulation of orally administered quercetin in brain tissue and its antioxidative effects in rats. Free Radic Biol Med 2011;51:1329-1336.
    • (2011) Free Radic Biol Med , vol.51 , pp. 1329-1336
    • Ishisaka, A.1    Ichikawa, S.2    Sakakibara, H.3    Piskula, M.K.4    Nakamura, T.5    Kato, Y.6
  • 6
    • 7444253369 scopus 로고    scopus 로고
    • Flavonoids and the brain: Interactions at the blood-brain barrier and their physiological effects on the central nervous system
    • Youdim KA, Shukitt-Hale B, Joseph JA. Flavonoids and the brain: interactions at the blood-brain barrier and their physiological effects on the central nervous system. Free Radic Biol Med 2004;37:1683-1693.
    • (2004) Free Radic Biol Med , vol.37 , pp. 1683-1693
    • Youdim, K.A.1    Shukitt-Hale, B.2    Joseph, J.A.3
  • 8
    • 79959267565 scopus 로고    scopus 로고
    • Effect of quercetin and glucuronide metabolites on the monoamine oxidase-A reaction in mouse brain mitochondria
    • Yoshino S, Hara A, Sakakibara H, Kawabata K, Tokumura A, Ishisaka A, et al. Effect of quercetin and glucuronide metabolites on the monoamine oxidase-A reaction in mouse brain mitochondria. Nutrition 2011; 27:847-852.
    • (2011) Nutrition , vol.27 , pp. 847-852
    • Yoshino, S.1    Hara, A.2    Sakakibara, H.3    Kawabata, K.4    Tokumura, A.5    Ishisaka, A.6
  • 9
    • 0036884733 scopus 로고    scopus 로고
    • Pathogenesis of Parkinson's disease: Dopamine, vesicles and alpha-synuclein
    • Lotharius J, Brundin P. Pathogenesis of Parkinson's disease: dopamine, vesicles and alpha-synuclein. Nat Rev Neurosci 2002; 3:932-942.
    • (2002) Nat Rev Neurosci , vol.3 , pp. 932-942
    • Lotharius, J.1    Brundin, P.2
  • 10
    • 0032911488 scopus 로고    scopus 로고
    • Parkinson's disease is associated with oxidative damage to cytoplasmic DNA and RNA in substantia nigra neurons
    • Zhang J, Perry G, Smith MA, Robertson D, Olson SJ, Graham DG, et al. Parkinson's disease is associated with oxidative damage to cytoplasmic DNA and RNA in substantia nigra neurons. Am J Pathol 1999;154:1423-1429.
    • (1999) Am J Pathol , vol.154 , pp. 1423-1429
    • Zhang, J.1    Perry, G.2    Smith, M.A.3    Robertson, D.4    Olson, S.J.5    Graham, D.G.6
  • 12
    • 0034993599 scopus 로고    scopus 로고
    • Molecular pathways involved in the neurotoxicity of 6-OHDA, dopamine and MPTP: Contribution to the apoptotic theory in Parkinson's disease
    • Blum D, Torch S, Lambeng N, Nissou M, Benabid AL, Sadoul R, et al. Molecular pathways involved in the neurotoxicity of 6-OHDA, dopamine and MPTP: contribution to the apoptotic theory in Parkinson's disease. Prog Neurobiol 2001;65:135-172.
    • (2001) Prog Neurobiol , vol.65 , pp. 135-172
    • Blum, D.1    Torch, S.2    Lambeng, N.3    Nissou, M.4    Benabid, A.L.5    Sadoul, R.6
  • 13
    • 81455144664 scopus 로고    scopus 로고
    • Oxidation of DJ-1 induced by 6-hydroxydopamine decreasing intracellular glutathione
    • Miyama A, Saito Y, Yamanaka K, Hayashi K, Hamakubo T and Noguchi N. Oxidation of DJ-1 induced by 6-hydroxydopamine decreasing intracellular glutathione. PLoS One 2011;6:e27883.
    • (2011) PLoS One , vol.6
    • Miyama, A.1    Saito, Y.2    Yamanaka, K.3    Hayashi, K.4    Hamakubo, T.5    Noguchi, N.6
  • 14
    • 81255208412 scopus 로고    scopus 로고
    • Mutations in LRRK2 increase phosphorylation of peroxiredoxin 3 exacerbating oxidative stress-induced neuronal death
    • Angeles DC, Gan BH, Onstead L, Zhao Y, Lim KL, Dachsel J, et al. Mutations in LRRK2 increase phosphorylation of peroxiredoxin 3 exacerbating oxidative stress-induced neuronal death. Hum Mutat 2011;32:1390-1397.
    • (2011) Hum Mutat , vol.32 , pp. 1390-1397
    • Angeles, D.C.1    Gan, B.H.2    Onstead, L.3    Zhao, Y.4    Lim, K.L.5    Dachsel, J.6
  • 15
    • 0029751104 scopus 로고    scopus 로고
    • Oxidative stress and the pathogenesis of Parkinson's disease
    • Jenner P, Olanow CW. Oxidative stress and the pathogenesis of Parkinson's disease. Neurology 1996; 47(6 Suppl 3): S161-S170.
    • (1996) Neurology , vol.47 , Issue.6 SUPPL. 3
    • Jenner, P.1    Olanow, C.W.2
  • 16
    • 33749239851 scopus 로고    scopus 로고
    • Effect of a conjugated quercetin metabolite, quercetin 3-glucuronide, on lipid hydroperoxide-dependent formation of reactive oxygen species in differentiated PC-12 cells
    • Shirai M, Kawai Y, Yamanishi R, Kinoshita T, Chuman H, Terao J. Effect of a conjugated quercetin metabolite, quercetin 3-glucuronide, on lipid hydroperoxide-dependent formation of reactive oxygen species in differentiated PC-12 cells. Free Radic Res 2006;40:1047-1053.
    • (2006) Free Radic Res , vol.40 , pp. 1047-1053
    • Shirai, M.1    Kawai, Y.2    Yamanishi, R.3    Kinoshita, T.4    Chuman, H.5    Terao, J.6
  • 17
    • 0035370769 scopus 로고    scopus 로고
    • Identifi cation of quercetin 3-O-beta-D-glucuronide as an antioxidative metabolite in rat plasma after oral administration of quercetin
    • Moon JH, Tsushida T, Nakahara K, Terao J. Identifi cation of quercetin 3-O-beta-D-glucuronide as an antioxidative metabolite in rat plasma after oral administration of quercetin. Free Radic Biol Med 2001;30:1274-1285.
    • (2001) Free Radic Biol Med , vol.30 , pp. 1274-1285
    • Moon, J.H.1    Tsushida, T.2    Nakahara, K.3    Terao, J.4
  • 18
    • 0017184389 scopus 로고
    • A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
    • Bradford MM. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 1976;72:248-254.
    • (1976) Anal Biochem , vol.72 , pp. 248-254
    • Bradford, M.M.1
  • 19
    • 0016378870 scopus 로고
    • The generation of hydrogen peroxide, superoxide radical, and hydroxyl radical by 6-hydroxydopamine, dialuric acid, and related cytotoxic agents
    • Cohen G, Heikkila RE. The generation of hydrogen peroxide, superoxide radical, and hydroxyl radical by 6-hydroxydopamine, dialuric acid, and related cytotoxic agents. J Biol Chem 1974;249:2447-2452.
    • (1974) J Biol Chem , vol.249 , pp. 2447-2452
    • Cohen, G.1    Heikkila, R.E.2
  • 20
    • 38949217989 scopus 로고    scopus 로고
    • Genipin exhibits neurotrophic effects through a common signaling pathway in nitric oxide synthaseexpressing cells
    • Yamazaki M, Chiba K. Genipin exhibits neurotrophic effects through a common signaling pathway in nitric oxide synthaseexpressing cells. Eur J Pharmacol 2008;581:255-261.
    • (2008) Eur J Pharmacol , vol.581 , pp. 255-261
    • Yamazaki, M.1    Chiba, K.2
  • 21
    • 33846828453 scopus 로고    scopus 로고
    • Molecular mechanisms of 6-hydroxydopamine-induced cytotoxicity in PC12 cells: Involvement of hydrogen peroxidedependent and-independent action
    • Saito Y, Nishio K, Ogawa Y, Kinumi T, Yoshida Y, Masuo Y, et al. Molecular mechanisms of 6-hydroxydopamine-induced cytotoxicity in PC12 cells: Involvement of hydrogen peroxidedependent and-independent action. Free Radic Biol Med 2007;42:675-685.
    • (2007) Free Radic Biol Med , vol.42 , pp. 675-685
    • Saito, Y.1    Nishio, K.2    Ogawa, Y.3    Kinumi, T.4    Yoshida, Y.5    Masuo, Y.6
  • 22
    • 16444364285 scopus 로고    scopus 로고
    • P-Quinone mediates 6-hydroxydopamine-induced dopaminergic neuronal death and ferrous iron accelerates the conversion of p-quinone into melanin extracellularly
    • Izumi Y, Sawada H, Sakka N, Yamamoto N, Kume T, Katsuki H, et al. p-Quinone mediates 6-hydroxydopamine-induced dopaminergic neuronal death and ferrous iron accelerates the conversion of p-quinone into melanin extracellularly. J Neurosci Res 2005;79:849-860.
    • (2005) J Neurosci Res , vol.79 , pp. 849-860
    • Izumi, Y.1    Sawada, H.2    Sakka, N.3    Yamamoto, N.4    Kume, T.5    Katsuki, H.6
  • 23
    • 43049176634 scopus 로고    scopus 로고
    • Health effects of quercetin: From antioxidant to nutraceutical
    • Boots AW, Haenen GR, Bast A. Health effects of quercetin: from antioxidant to nutraceutical. Eur J Pharmacol 2008;585:325-337.
    • (2008) Eur J Pharmacol , vol.585 , pp. 325-337
    • Boots, A.W.1    Haenen, G.R.2    Bast, A.3
  • 24
    • 0345148810 scopus 로고    scopus 로고
    • Quercetin may act as a cytotoxic prooxidant after its metabolic activation to semiquinone and quinoidal product
    • Metodiewa D, Jaiswal AK, Cenas N, Dickancaite E, Segura-Aguilar J. Quercetin may act as a cytotoxic prooxidant after its metabolic activation to semiquinone and quinoidal product. Free Radic Biol Med 1999;26: 107-116.
    • (1999) Free Radic Biol Med , vol.26 , pp. 107-116
    • Metodiewa, D.1    Jaiswal, A.K.2    Cenas, N.3    Dickancaite, E.4    Segura-Aguilar, J.5
  • 25
    • 47849085831 scopus 로고    scopus 로고
    • Timedependent protective and harmful effects of quercetin on 6-OHDA-induced toxicity in neuronal SH-SY5Y cells
    • Ossola B, Kaarainen TM, Raasmaja A, Mannisto PT. Timedependent protective and harmful effects of quercetin on 6-OHDA-induced toxicity in neuronal SH-SY5Y cells. Toxicology 2008;250:1-8.
    • (2008) Toxicology , vol.250 , pp. 1-8
    • Ossola, B.1    Kaarainen, T.M.2    Raasmaja, A.3    Mannisto, P.T.4
  • 26
    • 49449084484 scopus 로고    scopus 로고
    • Tissue distribution of quercetin in pigs after long-term dietary supplementation
    • Bieger J, Cermak R, Blank R, de Boer VC, Hollman PC, Kamphues J, et al. Tissue distribution of quercetin in pigs after long-term dietary supplementation. J Nutr 2008;138: 1417-1420.
    • (2008) J Nutr , vol.138 , pp. 1417-1420
    • Bieger, J.1    Cermak, R.2    Blank, R.3    De Boer, V.C.4    Hollman, P.C.5    Kamphues, J.6
  • 27
  • 28
    • 22244458574 scopus 로고    scopus 로고
    • Neuroscience Brain under surveillance: The microglia patrol
    • Fetler L, Amigorena S. Neuroscience. Brain under surveillance: the microglia patrol. Science 2005;309:392-393.
    • (2005) Science , vol.309 , pp. 392-393
    • Fetler, L.1    Amigorena, S.2
  • 29
    • 0023789193 scopus 로고
    • Reactive microglia are positive for HLA-DR in the substantia nigra of Parkinson's and Alzheimer's disease brains
    • McGeer PL, Itagaki S, Boyes BE, McGeer EG. Reactive microglia are positive for HLA-DR in the substantia nigra of Parkinson's and Alzheimer's disease brains. Neurology 1988;38:1285-1291.
    • (1988) Neurology , vol.38 , pp. 1285-1291
    • McGeer, P.L.1    Itagaki, S.2    Boyes, B.E.3    McGeer, E.G.4
  • 30
    • 52049120648 scopus 로고    scopus 로고
    • Predominant release of lysosomal enzymes by newborn rat microglia after LPS treatment revealed by proteomic studies
    • Liu J, Hong Z, Ding J, Zhang J, Chen S. Predominant release of lysosomal enzymes by newborn rat microglia after LPS treatment revealed by proteomic studies. J Proteome Res 2008;7:2033-2049.
    • (2008) J Proteome Res , vol.7 , pp. 2033-2049
    • Liu, J.1    Hong, Z.2    Ding, J.3    Zhang, J.4    Chen, S.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.