Protective effects of onion-derived quercetin on glutamate-mediated hippocampal neuronal cell death

Pharmacognosy Magazine

Volumn 9, Issue 36, 2013, Pages 302-308

  Yang, Eun Ju ^a   Kim, Geum Soog ^b   Kim, Jeong ^b   Song, Kyung Sik ^a  

^a Kyungpook National University   (South Korea)

^b Rural Development Administration   (South Korea)

Author keywords

Glutamate; neuroprotective effects; onion; oxidative stress; quercetin

Indexed keywords

CALPAIN; CYTOCHROME C; GLUTAMIC ACID; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN BAX; PROTEIN BCL 2; PROTEIN BID; QUERCETIN; REACTIVE OXYGEN METABOLITE; SPECTRIN;

ANIMAL CELL; APOPTOSIS; ARTICLE; CONTROLLED STUDY; DRUG ISOLATION; DRUG STRUCTURE; ENZYME PHOSPHORYLATION; HIPPOCAMPUS; MITOCHONDRIAL MEMBRANE POTENTIAL; MOUSE; NERVE CELL CULTURE; NERVE CELL NECROSIS; NEUROPROTECTION; NONHUMAN; ONION; OXIDATIVE STRESS; PROTEIN EXPRESSION; PROTEIN SECRETION; RECEPTOR DOWN REGULATION; WESTERN BLOTTING;

EID: 84884635948     PISSN: 09731296     EISSN: 09764062     Source Type: Journal    
DOI: 10.4103/0973-1296.117824     Document Type: Article

References (31)

1. Houghton PJ, Howes MJ. Natural products and derivatives affecting neurotransmission relevant to Alzheimer's and Parkinson's disease. Neurosignals 2005;14:6-22.
2. Coyle JT, Puttfarcken P. Oxidative stress, glutamate, and neurodegenerative disorders. Science 1993;262:689-95.
3. Greenwood SM, Connolly CN. Dendritic and mitochondrial changes during glutamate excitotoxicity. Neuropharmacology 2007;53:891-8.
4. Mattson MP. Apoptosis in neurodegenerative disorders. Nat Rev Mol Cell Biol 2000;1:120-9.
5. Murphy TH, Miyamoto M, Sastre A, Schnaar RL, Coyle JT. Glutamate toxicity in a neuronal cell line involves inhibition of cystine transport leading to oxidative stress. Neuron 1989;2:1547-58.
6. Maher P, Schubert D. Signaling by reactive oxygen species in the nervous system. Cell Mol Life Sci 2000;57:1287-305.
7. Duchen MR. Mitochondria and calcium: from cell signaling to cell death. J Physiol 2000;529:57-68.
8. Squìer MK, Miller AC, Malkinson AM, Cohen JJ. Calpain activation in apoptosis. J Cell Physiol 1994;159:229-37.
9. Pearson G, Robinson F, Gibson TB, Xu B, Karandikar M, Berman K, et al. Mitogen-activated protein (MAP) kinase pathway: regulation and physiological functions. Endocr Rev 2001;22:153-83.
10. Chu CT, Levinthal DJ, Kulich SM, Chalovich EM, DeFranco DB. Oxidative neuronal injury. The dark side of ERK1/2. Eur J Biochem 2004;271:2060-6.
11. Chang L, Karin M. Mammalian MAP kinase signaling cascades. Nature 2001;410:37-40.
12. World Health Organization. (Chapter: Bulbus Allii Cepae). WHO Monographs on Selected Medicinal Plants. Volume WHO: Geneva; 1999; p. 5-15
13. Wu XJ, Stahl T, Hu Y, Kassie F, Mersch-Sundermann V. The production of reactive oxygen species and the mitochondrial membrane potential are modulated during onion oil-induced cell cycle arrest and apoptosis in A549 cells. J Nutr 2006;136:608-13.
14. Park S, Kim MY, Lee DH, Lee SH, Baik EJ, Moon CH, et al. Methanolic extract of onion (Allium cepa) attenuates ischemia/hypoxia-induced apoptosis in cardiomyocytes via antioxidant effect. Eur J Nutr 2009;48:235-42.
15. Li W, Tang C, Jin H, Du J. Effects of onion extract on endogenous vascular H2S and adrenomedulin in rat atherosclerosis. Curr Pharm Biotechnol 2011;12:1427-39.
16. Islam MS, Choi H, Loots du T. Effects of dietary onion (Allium cepa L.) in a high-fat diet streptozotocin-induced diabetes rodent model. Ann Nutr Metab 2008;53:6-12.
17. Shri R, Singh Bora K. Neuroprotective effect of methanolic extracts of Allium cepa on ischemia and reperfusion-induced cerebral injury. Fitoterapia 2008;79:86-96.
18. Lee BY, Ban JY, Seong YH. Chronic stimulation of GABAA receptor with muscimol reduces amyloid beta protein (25-35)-induced neurotoxicity in cultured rat cortical cells. Neurosci Res 2005;52:347-56.
19. Kolárová H, Bajgar R, Tománková K, Krest?n E, Dolezal L, Hálek J. In vitro study of reactive oxygen species production during photodynamic therapy in ultrasound-pretreated cancer cells. Physiol Res 2007;56:S27-32.
20. Grohm J, Plesnila N, Culmsee C. Bid mediates fi ssion, membrane permeabilization and peri-nuclear accumulation of mitochondria as a prerequisite for oxidative neuronal cell death. Brain Behav Immun 2010;24:831-8.
21. Bradford MM. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of proteindye binding. Anal Biochem 1976;72:248-54.
22. Fossen T, Pedersen AT, Andersen ∅M. Flavonoids from red onion (Allium cepa). Phytochemistry 1998;47:281-5.
23. Zhang Y, Bhavnani BR. Glutamate-induced apoptosis in primary cortical neurons is inhibited by equine estrogens via down-regulation of caspase-3 and prevention of mitochondrial cytochrome c release. BMC Neurosci 2005;6:13.
24. Desagher S, Osen-Sand A, Nichols A, Eskes R, Montessuit S, Lauper S, et al. Bid-induced conformational change of Bax is responsible for mitochondrial cytochrome c release during apoptosis. J Cell Biol 1999;144:891-901.
25. Isaev NK, Zorov DB, Stelmashook EV, Uzbekov RE, Kozhemyakin MB, Victorov IV. Neurotoxic glutamate treatment of cultured cerebellar granule cells induces Ca2+-dependent collapse of mitochondrial membrane potential and ultrastructural alterations of mitochondria. FEBS Lett 1996;392:143-7.
26. Scorrano L, Korsmeyer SJ. Mechanisms of cytochrome C release by proapoptotic Bcl-2 family members. Biochem Biophys Res Commun 2003;304:437-44.
27. Kao TK, Ou YC, Raung SL, Lai CY, Liao SL, Chen CJ. Inhibition of nitric oxide production by quercetin in endotoxin/cytokinestimulated microglia. Life Sci 2010;86:315-21.
28. Senthilkumar K, Elumalai P, Arunkumar R, Banudevi S, Gunadharini ND, Sharmila G, et al. Quercetin regulates insulin like growth factor signaling and induces intrinsic and extrinsic pathway mediated apoptosis in androgen independent prostate cancer cells (PC-3). Mol Cell Biochem 2010;344:173-84.
29. Ahn J, Lee H, Kim S, Park J, Ha T. The anti-obesity effect of quercetin is mediated by the AMPK and MAPK signaling pathways. Biochem Biophys Res Commun 2008;373:545-9.
30. Torres-Piedra M, Ortiz-Andrade R, Villalobos-Molina R, Singh N, Medina-Franco JL, Webster SP, et al. A comparative study of fl avonoid analogues on streptozotocin-nicotinamide induced diabetic rats: Quercetin as a potential antidiabetic agent acting via 11beta-hydroxysteroid dehydrogenase type 1 inhibition. Eur J Med Chem 2010;45:2606-12.
31. Ishige K, Schubert D, Sagara Y. Flavonoids protect neuronal cells from oxidative stress by three distinct mechanisms. Free Radic Biol Med 2001;30:433-46.