-
1
-
-
0028963084
-
Requirement for phosphatidylinositol-3 kinase in the prevention of apoptosis by nerve growth factor
-
Yao R., Cooper G.M. Requirement for phosphatidylinositol-3 kinase in the prevention of apoptosis by nerve growth factor. Science. 267(5206):1995;2003- 2006.
-
(1995)
Science
, vol.267
, Issue.5206
, pp. 2003-2006
-
-
Yao, R.1
Cooper, G.M.2
-
2
-
-
0037205048
-
The phosphoinositide 3-kinase pathway
-
Cantley L.C. The phosphoinositide 3-kinase pathway. Science. 296(5573):2002;1655-1657.
-
(2002)
Science
, vol.296
, Issue.5573
, pp. 1655-1657
-
-
Cantley, L.C.1
-
3
-
-
0030913673
-
Matrix adhesion and Ras transformation both activate a phosphoinositide 3-OH kinase and protein kinase B/Akt cellular survival pathway
-
Khwaja A., Rodriguez-Viciana P., Wennstrom S., Warne P.H., Downward J. Matrix adhesion and Ras transformation both activate a phosphoinositide 3-OH kinase and protein kinase B/Akt cellular survival pathway. EMBO J. 16(10):1997;2783-2793.
-
(1997)
EMBO J.
, vol.16
, Issue.10
, pp. 2783-2793
-
-
Khwaja, A.1
Rodriguez-Viciana, P.2
Wennstrom, S.3
Warne, P.H.4
Downward, J.5
-
4
-
-
0031028730
-
Suppression of c-Myc-induced apoptosis by Ras signalling through PI(3)K and PKB
-
Kauffmann-Zeh A., Rodriguez-Viciana P., Ulrich E., Gilbert C., Coffer P., Downward J.et al. Suppression of c-Myc-induced apoptosis by Ras signalling through PI(3)K and PKB. Nature. 385(6616):1997;544-548.
-
(1997)
Nature
, vol.385
, Issue.6616
, pp. 544-548
-
-
Kauffmann-Zeh, A.1
Rodriguez-Viciana, P.2
Ulrich, E.3
Gilbert, C.4
Coffer, P.5
Downward, J.6
-
5
-
-
0031053586
-
Regulation of neuronal survival by the serine-threonine protein kinase Akt
-
Dudek H., Datta S.R., Franke T.F., Birnbaum M.J., Yao R., Cooper G.M.et al. Regulation of neuronal survival by the serine-threonine protein kinase Akt. Science. 275(5300):1997;661-665.
-
(1997)
Science
, vol.275
, Issue.5300
, pp. 661-665
-
-
Dudek, H.1
Datta, S.R.2
Franke, T.F.3
Birnbaum, M.J.4
Yao, R.5
Cooper, G.M.6
-
6
-
-
0030867904
-
Interleukin 3-dependent survival by the Akt protein kinase
-
Songyang Z., Baltimore D., Cantley L.C., Kaplan D.R., Franke T.F. Interleukin 3-dependent survival by the Akt protein kinase. Proc. Natl Acad. Sci. USA. 94(21):1997;11345-11350.
-
(1997)
Proc. Natl Acad. Sci. USA
, vol.94
, Issue.21
, pp. 11345-11350
-
-
Songyang, Z.1
Baltimore, D.2
Cantley, L.C.3
Kaplan, D.R.4
Franke, T.F.5
-
7
-
-
0031034574
-
Antiapoptotic signalling by the insulin-like growth factor I receptor, phosphatidylinositol 3-kinase, and Akt
-
Kulik G., Klippel A., Weber M.J. Antiapoptotic signalling by the insulin-like growth factor I receptor, phosphatidylinositol 3-kinase, and Akt. Mol. Cell. Biol. 17(3):1997;1595-1606.
-
(1997)
Mol. Cell. Biol.
, vol.17
, Issue.3
, pp. 1595-1606
-
-
Kulik, G.1
Klippel, A.2
Weber, M.J.3
-
8
-
-
0037862006
-
Unravelling the activation mechanisms of protein kinase B/Akt
-
Scheid M.P., Woodgett J.R. Unravelling the activation mechanisms of protein kinase B/Akt. FEBS Lett. 546(1):2003;108-112.
-
(2003)
FEBS Lett
, vol.546
, Issue.1
, pp. 108-112
-
-
Scheid, M.P.1
Woodgett, J.R.2
-
9
-
-
0036463405
-
A matter of life and death
-
Green D.R., Evan G.I. A matter of life and death. Cancer Cell. 1(1):2002;19-30.
-
(2002)
Cancer Cell
, vol.1
, Issue.1
, pp. 19-30
-
-
Green, D.R.1
Evan, G.I.2
-
10
-
-
0035957653
-
Proapoptotic BAX and BAK: A requisite gateway to mitochondrial dysfunction and death
-
Wei M.C., Zong W.X., Cheng E.H., Lindsten T., Panoutsakopoulou V., Ross A.J.et al. Proapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and death. Science. 292(5517):2001;727-730.
-
(2001)
Science
, vol.292
, Issue.5517
, pp. 727-730
-
-
Wei, M.C.1
Zong, W.X.2
Cheng, E.H.3
Lindsten, T.4
Panoutsakopoulou, V.5
Ross, A.J.6
-
11
-
-
0037427412
-
Mechanisms of cytochrome c release by proapoptotic BCL-2 family members
-
Scorrano L., Korsmeyer S.J. Mechanisms of cytochrome c release by proapoptotic BCL-2 family members. Biochem. Biophys. Res. Commun. 304(3):2003;437-444.
-
(2003)
Biochem. Biophys. Res. Commun.
, vol.304
, Issue.3
, pp. 437-444
-
-
Scorrano, L.1
Korsmeyer, S.J.2
-
12
-
-
0037427441
-
Mammalian mitochondrial IAP binding proteins
-
Vaux D.L., Silke J. Mammalian mitochondrial IAP binding proteins. Biochem. Biophys. Res. Commun. 304(3):2003;499-504.
-
(2003)
Biochem. Biophys. Res. Commun.
, vol.304
, Issue.3
, pp. 499-504
-
-
Vaux, D.L.1
Silke, J.2
-
13
-
-
0034983918
-
Inhibition of early apoptotic events by Akt/PKB is dependent on the first committed step of glycolysis and mitochondrial hexokinase
-
Gottlob K., Majewski N., Kennedy S., Kandel E., Robey R.B., Hay N. Inhibition of early apoptotic events by Akt/PKB is dependent on the first committed step of glycolysis and mitochondrial hexokinase. Genes. Dev. 15(11):2001;1406-1418.
-
(2001)
Genes. Dev.
, vol.15
, Issue.11
, pp. 1406-1418
-
-
Gottlob, K.1
Majewski, N.2
Kennedy, S.3
Kandel, E.4
Robey, R.B.5
Hay, N.6
-
14
-
-
0035936023
-
The protein kinase PKB/Akt regulates cell survival and apoptosis by inhibiting Bax conformational change
-
Yamaguchi H., Wang H.G. The protein kinase PKB/Akt regulates cell survival and apoptosis by inhibiting Bax conformational change. Oncogene. 20(53):2001;7779-7786.
-
(2001)
Oncogene
, vol.20
, Issue.53
, pp. 7779-7786
-
-
Yamaguchi, H.1
Wang, H.G.2
-
15
-
-
0032808154
-
Akt/protein kinase B inhibits cell death by preventing the release of cytochrome c from mitochondria
-
Kennedy S.G., Kandel E.S., Cross T.K., Hay N. Akt/protein kinase B inhibits cell death by preventing the release of cytochrome c from mitochondria. Mol. Cell. Biol. 19(8):1999;5800-5810.
-
(1999)
Mol. Cell. Biol.
, vol.19
, Issue.8
, pp. 5800-5810
-
-
Kennedy, S.G.1
Kandel, E.S.2
Cross, T.K.3
Hay, N.4
-
16
-
-
0038075338
-
Decision making by p53: Life, death and cancer
-
Oren M. Decision making by p53: life, death and cancer. Cell Death Differ. 10(4):2003;431-442.
-
(2003)
Cell Death Differ.
, vol.10
, Issue.4
, pp. 431-442
-
-
Oren, M.1
-
17
-
-
0030584088
-
Serine phosphorylation of death agonist BAD in response to survival factor results in binding to 14-3-3 not BCL-X(L)
-
Zha J., Harada H., Yang E., Jockel J., Korsmeyer S.J. Serine phosphorylation of death agonist BAD in response to survival factor results in binding to 14-3-3 not BCL-X(L). Cell. 87(4):1996;619-628.
-
(1996)
Cell
, vol.87
, Issue.4
, pp. 619-628
-
-
Zha, J.1
Harada, H.2
Yang, E.3
Jockel, J.4
Korsmeyer, S.J.5
-
18
-
-
0030702123
-
Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery
-
Datta S.R., Dudek H., Tao X., Masters S., Fu H., Gotoh Y.et al. Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery. Cell. 91(2):1997;231-241.
-
(1997)
Cell
, vol.91
, Issue.2
, pp. 231-241
-
-
Datta, S.R.1
Dudek, H.2
Tao, X.3
Masters, S.4
Fu, H.5
Gotoh, Y.6
-
19
-
-
0033143385
-
How BAD phosphorylation is good for survival
-
Downward J. How BAD phosphorylation is good for survival. Nat. Cell. Biol. 1(2):1999;E33-E35.
-
(1999)
Nat. Cell. Biol.
, vol.1
, Issue.2
-
-
Downward, J.1
-
20
-
-
0042424706
-
Bad-deficient mice develop diffuse large B cell lymphoma
-
Ranger A.M., Zha J., Harada H., Datta S.R., Danial N.N., Gilmore A.P.et al. Bad-deficient mice develop diffuse large B cell lymphoma. Proc. Natl. Acad. Sci. USA. 100(16):2003;9324-9329.
-
(2003)
Proc. Natl. Acad. Sci. USA
, vol.100
, Issue.16
, pp. 9324-9329
-
-
Ranger, A.M.1
Zha, J.2
Harada, H.3
Datta, S.R.4
Danial, N.N.5
Gilmore, A.P.6
-
21
-
-
0036849192
-
Survival factor-mediated BAD phosphorylation raises the mitochondrial threshold for apoptosis
-
Datta S.R., Ranger A.M., Lin M.Z., Sturgill J.F., Ma Y.C., Cowan C.W.et al. Survival factor-mediated BAD phosphorylation raises the mitochondrial threshold for apoptosis. Dev. Cell. 3(5):2002;631-643.
-
(2002)
Dev. Cell.
, vol.3
, Issue.5
, pp. 631-643
-
-
Datta, S.R.1
Ranger, A.M.2
Lin, M.Z.3
Sturgill, J.F.4
Ma, Y.C.5
Cowan, C.W.6
-
22
-
-
0032515027
-
Regulation of cell death protease caspase-9 by phosphorylation
-
Cardone M.H., Roy N., Stennicke H.R., Salvesen G.S., Franke T.F., Stanbridge E.et al. Regulation of cell death protease caspase-9 by phosphorylation. Science. 282(5392):1998;1318-1321.
-
(1998)
Science
, vol.282
, Issue.5392
, pp. 1318-1321
-
-
Cardone, M.H.1
Roy, N.2
Stennicke, H.R.3
Salvesen, G.S.4
Franke, T.F.5
Stanbridge, E.6
-
23
-
-
0034735569
-
Akt regulates cell survival and apoptosis at a postmitochondrial level
-
Zhou H., Li X.M., Meinkoth J., Pittman R.N. Akt regulates cell survival and apoptosis at a postmitochondrial level. J. Cell. Biol. 151(3):2000;483-494.
-
(2000)
J. Cell. Biol.
, vol.151
, Issue.3
, pp. 483-494
-
-
Zhou, H.1
Li, X.M.2
Meinkoth, J.3
Pittman, R.N.4
-
24
-
-
0033582929
-
Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor
-
Brunet A., Bonni A., Zigmond M.J., Lin M.Z., Juo P., Hu L.S.et al. Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor. Cell. 96(6):1999;857-868.
-
(1999)
Cell
, vol.96
, Issue.6
, pp. 857-868
-
-
Brunet, A.1
Bonni, A.2
Zigmond, M.J.3
Lin, M.Z.4
Juo, P.5
Hu, L.S.6
-
25
-
-
0033560896
-
Direct control of the Forkhead transcription factor AFX by protein kinase B
-
Kops G.J., de Ruiter N.D., De Vries-Smits A.M., Powell D.R., Bos J.L., Burgering B.M. Direct control of the Forkhead transcription factor AFX by protein kinase B. Nature. 398(6728):1999;630-634.
-
(1999)
Nature
, vol.398
, Issue.6728
, pp. 630-634
-
-
Kops, G.J.1
De Ruiter, N.D.2
De Vries-Smits, A.M.3
Powell, D.R.4
Bos, J.L.5
Burgering, B.M.6
-
26
-
-
0033595011
-
Protein kinase B/Akt-mediated phosphorylation promotes nuclear exclusion of the winged helix transcription factor FKHR1
-
Biggs W.H. III, Meisenhelder J., Hunter T., Cavenee W.K., Arden K.C. Protein kinase B/Akt-mediated phosphorylation promotes nuclear exclusion of the winged helix transcription factor FKHR1. Proc. Natl. Acad. Sci. USA. 96(13):1999;7421-7426.
-
(1999)
Proc. Natl. Acad. Sci. USA
, vol.96
, Issue.13
, pp. 7421-7426
-
-
Biggs III, W.H.1
Meisenhelder, J.2
Hunter, T.3
Cavenee, W.K.4
Arden, K.C.5
-
27
-
-
0030659557
-
The Fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. elegans
-
Ogg S., Paradis S., Gottlieb S., Patterson G.I., Lee L., Tissenbaum H.A.et al. The Fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. elegans. Nature. 389(6654):1997;994-999.
-
(1997)
Nature
, vol.389
, Issue.6654
, pp. 994-999
-
-
Ogg, S.1
Paradis, S.2
Gottlieb, S.3
Patterson, G.I.4
Lee, L.5
Tissenbaum, H.A.6
-
28
-
-
0030657540
-
Daf-16: An HNF-3/forkhead family member that can function to double the life-span of Caenorhabditis elegans
-
Lin K., Dorman J.B., Rodan A., Kenyon C. Daf-16: an HNF-3/forkhead family member that can function to double the life-span of Caenorhabditis elegans. Science. 278(5341):1997;1319-1322.
-
(1997)
Science
, vol.278
, Issue.5341
, pp. 1319-1322
-
-
Lin, K.1
Dorman, J.B.2
Rodan, A.3
Kenyon, C.4
-
29
-
-
0035135841
-
Protein kinase SGK mediates survival signals by phosphorylating the Forkhead transcription factor FKHRL1 (FOXO3a)
-
Brunet A., Park J., Tran H., Hu L.S., Hemmings B.A., Greenberg M.E. Protein kinase SGK mediates survival signals by phosphorylating the Forkhead transcription factor FKHRL1 (FOXO3a). Mol. Cell. Biol. 21(3):2001;952-965.
-
(2001)
Mol. Cell. Biol.
, vol.21
, Issue.3
, pp. 952-965
-
-
Brunet, A.1
Park, J.2
Tran, H.3
Hu, L.S.4
Hemmings, B.A.5
Greenberg, M.E.6
-
30
-
-
0034609737
-
Expression of the pro-apoptotic Bcl-2 family member Bim is regulated by the Forkhead transcription factor FKHR-L1
-
Dijkers P.F., Medema R.H., Lammers J.W., Koenderman L., Coffer P.J. Expression of the pro-apoptotic Bcl-2 family member Bim is regulated by the Forkhead transcription factor FKHR-L1. Curr. Biol. 10(19):2000;1201-1204.
-
(2000)
Curr. Biol.
, vol.10
, Issue.19
, pp. 1201-1204
-
-
Dijkers, P.F.1
Medema, R.H.2
Lammers, J.W.3
Koenderman, L.4
Coffer, P.J.5
-
31
-
-
0035949588
-
A phosphatidylinositol 3-kinase/Akt pathway promotes translocation of Mdm2 from the cytoplasm to the nucleus
-
Mayo L.D., Donner D.B. A phosphatidylinositol 3-kinase/Akt pathway promotes translocation of Mdm2 from the cytoplasm to the nucleus. Proc. Natl. Acad. Sci. USA. 98(20):2001;11598-11603.
-
(2001)
Proc. Natl. Acad. Sci. USA
, vol.98
, Issue.20
, pp. 11598-11603
-
-
Mayo, L.D.1
Donner, D.B.2
-
32
-
-
0035736487
-
HER-2/neu induces p53 ubiquitination via Akt-mediated MDM2 phosphorylation
-
Zhou B.P., Liao Y., Xia W., Zou Y., Spohn B., Hung M.C. HER-2/neu induces p53 ubiquitination via Akt-mediated MDM2 phosphorylation. Nat. Cell. Biol. 3(11):2001;973-982.
-
(2001)
Nat. Cell. Biol.
, vol.3
, Issue.11
, pp. 973-982
-
-
Zhou, B.P.1
Liao, Y.2
Xia, W.3
Zou, Y.4
Spohn, B.5
Hung, M.C.6
-
33
-
-
85047700501
-
Phosphorylation of HDM2 by Akt
-
Ashcroft M., Ludwig R.L., Woods D.B., Copeland T.D., Weber H.O., MacRae E.J.et al. Phosphorylation of HDM2 by Akt. Oncogene. 21(13):2002;1955-1962.
-
(2002)
Oncogene
, vol.21
, Issue.13
, pp. 1955-1962
-
-
Ashcroft, M.1
Ludwig, R.L.2
Woods, D.B.3
Copeland, T.D.4
Weber, H.O.5
MacRae, E.J.6
-
34
-
-
85047699328
-
Cross-talk between Akt, p53 and Mdm2: Possible implications for the regulation of apoptosis
-
Gottlieb T.M., Leal J.F., Seger R., Taya Y., Oren M. Cross-talk between Akt, p53 and Mdm2: possible implications for the regulation of apoptosis. Oncogene. 21(8):2002;1299-1303.
-
(2002)
Oncogene
, vol.21
, Issue.8
, pp. 1299-1303
-
-
Gottlieb, T.M.1
Leal, J.F.2
Seger, R.3
Taya, Y.4
Oren, M.5
-
35
-
-
0034680838
-
Peptide and protein library screening defines optimal substrate motifs for AKT/PKB
-
Obata T., Yaffe M.B., Leparc G.G., Piro E.T., Maegawa H., Kashiwagi A.et al. Peptide and protein library screening defines optimal substrate motifs for AKT/PKB. J. Biol. Chem. 275(46):2000;36108-36115.
-
(2000)
J. Biol. Chem.
, vol.275
, Issue.46
, pp. 36108-36115
-
-
Obata, T.1
Yaffe, M.B.2
Leparc, G.G.3
Piro, E.T.4
Maegawa, H.5
Kashiwagi, A.6
-
36
-
-
0036710512
-
The PTEN, Mdm2, p53 tumor suppressor-oncoprotein network
-
Mayo L.D., Donner D.B. The PTEN, Mdm2, p53 tumor suppressor-oncoprotein network. Trends Biochem. Sci. 27(9):2002;462-467.
-
(2002)
Trends Biochem. Sci.
, vol.27
, Issue.9
, pp. 462-467
-
-
Mayo, L.D.1
Donner, D.B.2
-
37
-
-
0035805487
-
Physical interaction with Yes-associated protein enhances p73 transcriptional activity
-
Strano S., Munarriz E., Rossi M., Castagnoli L., Shaul Y., Sacchi A.et al. Physical interaction with Yes-associated protein enhances p73 transcriptional activity. J. Biol. Chem. 276(18):2001;15164-15173.
-
(2001)
J. Biol. Chem.
, vol.276
, Issue.18
, pp. 15164-15173
-
-
Strano, S.1
Munarriz, E.2
Rossi, M.3
Castagnoli, L.4
Shaul, Y.5
Sacchi, A.6
-
38
-
-
0037249343
-
Akt phosphorylates the Yes-associated protein, YAP, to induce interaction with 14-3-3 and attenuation of p73-mediated apoptosis
-
Basu S., Totty N.F., Irwin M.S., Sudol M., Downward J. Akt phosphorylates the Yes-associated protein, YAP, to induce interaction with 14-3-3 and attenuation of p73-mediated apoptosis. Mol. Cell. 11(1):2003;11-23.
-
(2003)
Mol. Cell.
, vol.11
, Issue.1
, pp. 11-23
-
-
Basu, S.1
Totty, N.F.2
Irwin, M.S.3
Sudol, M.4
Downward, J.5
-
39
-
-
0032562682
-
The activation of p38 and apoptosis by the inhibition of Erk is antagonized by the phosphoinositide 3-kinase/Akt pathway
-
Berra E., Diaz-Meco M.T., Moscat J. The activation of p38 and apoptosis by the inhibition of Erk is antagonized by the phosphoinositide 3-kinase/Akt pathway. J. Biol. Chem. 273(17):1998;10792-10797.
-
(1998)
J. Biol. Chem.
, vol.273
, Issue.17
, pp. 10792-10797
-
-
Berra, E.1
Diaz-Meco, M.T.2
Moscat, J.3
-
40
-
-
0031770118
-
Role of Akt and c-Jun N-terminal kinase 2 in apoptosis induced by interleukin-4 deprivation
-
Cerezo A., Martinez A.C., Lanzarot D., Fischer S., Franke T.F., Rebollo A. Role of Akt and c-Jun N-terminal kinase 2 in apoptosis induced by interleukin-4 deprivation. Mol. Biol. Cell. 9(11):1998;3107-3118.
-
(1998)
Mol. Biol. Cell.
, vol.9
, Issue.11
, pp. 3107-3118
-
-
Cerezo, A.1
Martinez, A.C.2
Lanzarot, D.3
Fischer, S.4
Franke, T.F.5
Rebollo, A.6
-
41
-
-
0032476032
-
Insulin-like growth factor-I inhibits the stress-activated protein kinase/c-Jun N-terminal kinase
-
Okubo Y., Blakesley V.A., Stannard B., Gutkind S., Le Roith D. Insulin-like growth factor-I inhibits the stress-activated protein kinase/c-Jun N-terminal kinase. J. Biol. Chem. 273(40):1998;25961-25966.
-
(1998)
J. Biol. Chem.
, vol.273
, Issue.40
, pp. 25961-25966
-
-
Okubo, Y.1
Blakesley, V.A.2
Stannard, B.3
Gutkind, S.4
Le Roith, D.5
-
42
-
-
0035133227
-
Akt phosphorylates and negatively regulates apoptosis signal-regulating kinase 1
-
Kim A.H., Khursigara G., Sun X., Franke T.F., Chao M.V. Akt phosphorylates and negatively regulates apoptosis signal-regulating kinase 1. Mol. Cell. Biol. 21(3):2001;893-901.
-
(2001)
Mol. Cell. Biol.
, vol.21
, Issue.3
, pp. 893-901
-
-
Kim, A.H.1
Khursigara, G.2
Sun, X.3
Franke, T.F.4
Chao, M.V.5
-
43
-
-
0037423289
-
Negative regulation of mixed lineage kinase 3 by protein kinase B/AKT leads to cell survival
-
Barthwal M.K., Sathyanarayana P., Kundu C.N., Rana B., Pradeep A., Sharma C.et al. Negative regulation of mixed lineage kinase 3 by protein kinase B/AKT leads to cell survival. J. Biol. Chem. 278(6):2003;3897-3902.
-
(2003)
J. Biol. Chem.
, vol.278
, Issue.6
, pp. 3897-3902
-
-
Barthwal, M.K.1
Sathyanarayana, P.2
Kundu, C.N.3
Rana, B.4
Pradeep, A.5
Sharma, C.6
-
44
-
-
0034614606
-
Akt protein kinase inhibits Rac1-GTP binding through phosphorylation at serine 71 of Rac1
-
Kwon T., Kwon D.Y., Chun J., Kim J.H., Kang S.S. Akt protein kinase inhibits Rac1-GTP binding through phosphorylation at serine 71 of Rac1. J. Biol. Chem. 275(1):2000;423-428.
-
(2000)
J. Biol. Chem.
, vol.275
, Issue.1
, pp. 423-428
-
-
Kwon, T.1
Kwon, D.Y.2
Chun, J.3
Kim, J.H.4
Kang, S.S.5
-
45
-
-
0033519453
-
Induction of NF-kappaB by the Akt/PKB kinase
-
Kane L.P., Shapiro V.S., Stokoe D., Weiss A. Induction of NF-kappaB by the Akt/PKB kinase. Curr. Biol. 9(11):1999;601-604.
-
(1999)
Curr. Biol.
, vol.9
, Issue.11
, pp. 601-604
-
-
Kane, L.P.1
Shapiro, V.S.2
Stokoe, D.3
Weiss, A.4
-
46
-
-
0033517189
-
NF-kappaB activation by tumour necrosis factor requires the Akt serine-threonine kinase
-
Ozes O.N., Mayo L.D., Gustin J.A., Pfeffer S.R., Pfeffer L.M., Donner D.B. NF-kappaB activation by tumour necrosis factor requires the Akt serine-threonine kinase. Nature. 401(6748):1999;82-85.
-
(1999)
Nature
, vol.401
, Issue.6748
, pp. 82-85
-
-
Ozes, O.N.1
Mayo, L.D.2
Gustin, J.A.3
Pfeffer, S.R.4
Pfeffer, L.M.5
Donner, D.B.6
-
47
-
-
0033517190
-
NF-kappaB is a target of AKT in anti-apoptotic PDGF signalling
-
Romashkova J.A., Makarov S.S. NF-kappaB is a target of AKT in anti-apoptotic PDGF signalling. Nature. 401(6748):1999;86-90.
-
(1999)
Nature
, vol.401
, Issue.6748
, pp. 86-90
-
-
Romashkova, J.A.1
Makarov, S.S.2
-
48
-
-
0032484019
-
CREB is a regulatory target for the protein kinase Akt/PKB
-
Du K., Montminy M. CREB is a regulatory target for the protein kinase Akt/PKB. J. Biol. Chem. 273(49):1998;32377-32379.
-
(1998)
J. Biol. Chem.
, vol.273
, Issue.49
, pp. 32377-32379
-
-
Du, K.1
Montminy, M.2
-
49
-
-
0029587224
-
Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B
-
Cross D.A., Alessi D.R., Cohen P., Andjelkovich M., Hemmings B.A. Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B. Nature. 378(6559):1995;785-789.
-
(1995)
Nature
, vol.378
, Issue.6559
, pp. 785-789
-
-
Cross, D.A.1
Alessi, D.R.2
Cohen, P.3
Andjelkovich, M.4
Hemmings, B.A.5
-
50
-
-
0037383322
-
GSK-3: Tricks of the trade for a multi-tasking kinase
-
Doble B.W., Woodgett J.R. GSK-3: tricks of the trade for a multi-tasking kinase. J. Cell. Sci. 116(Pt 7):2003;1175-1186.
-
(2003)
J. Cell. Sci.
, vol.116
, Issue.PT 7
, pp. 1175-1186
-
-
Doble, B.W.1
Woodgett, J.R.2
-
51
-
-
0032493729
-
Role of glycogen synthase kinase-3 in the phosphatidylinositol 3-kinase/Akt cell survival pathway
-
Pap M., Cooper G.M. Role of glycogen synthase kinase-3 in the phosphatidylinositol 3-kinase/Akt cell survival pathway. J. Biol. Chem. 273(32):1998;19929-19932.
-
(1998)
J. Biol. Chem.
, vol.273
, Issue.32
, pp. 19929-19932
-
-
Pap, M.1
Cooper, G.M.2
-
52
-
-
0033635249
-
In the absence of extrinsic signals, nutrient utilization by lymphocytes is insufficient to maintain either cell size or viability
-
Rathmell J.C., Vander Heiden M.G., Harris M.H., Frauwirth K.A., Thompson C.B. In the absence of extrinsic signals, nutrient utilization by lymphocytes is insufficient to maintain either cell size or viability. Mol. Cell. 6(3):2000;683-692.
-
(2000)
Mol. Cell.
, vol.6
, Issue.3
, pp. 683-692
-
-
Rathmell, J.C.1
Vander Heiden, M.G.2
Harris, M.H.3
Frauwirth, K.A.4
Thompson, C.B.5
-
53
-
-
0036320205
-
Akt maintains cell size and survival by increasing mTOR-dependent nutrient uptake
-
Edinger A.L., Thompson C.B. Akt maintains cell size and survival by increasing mTOR-dependent nutrient uptake. Mol. Biol. Cell. 13(7):2002;2276- 2288.
-
(2002)
Mol. Biol. Cell.
, vol.13
, Issue.7
, pp. 2276-2288
-
-
Edinger, A.L.1
Thompson, C.B.2
-
54
-
-
0035853833
-
Akt and Bcl-xL promote growth factor-independent survival through distinct effects on mitochondrial physiology
-
Plas D.R., Talapatra S., Edinger A.L., Rathmell J.C., Thompson C.B. Akt and Bcl-xL promote growth factor-independent survival through distinct effects on mitochondrial physiology. J. Biol. Chem. 276(15):2001;12041-12048.
-
(2001)
J. Biol. Chem.
, vol.276
, Issue.15
, pp. 12041-12048
-
-
Plas, D.R.1
Talapatra, S.2
Edinger, A.L.3
Rathmell, J.C.4
Thompson, C.B.5
-
55
-
-
0034904776
-
Growth factors can influence cell growth and survival through effects on glucose metabolism
-
Vander Heiden M.G., Plas D.R., Rathmell J.C., Fox C.J., Harris M.H., Thompson C.B. Growth factors can influence cell growth and survival through effects on glucose metabolism. Mol. Cell. Biol. 21(17):2001;5899-5912.
-
(2001)
Mol. Cell. Biol.
, vol.21
, Issue.17
, pp. 5899-5912
-
-
Vander Heiden, M.G.1
Plas, D.R.2
Rathmell, J.C.3
Fox, C.J.4
Harris, M.H.5
Thompson, C.B.6
-
56
-
-
0141863388
-
Akt-directed glucose metabolism can prevent Bax conformation change and promote growth factor-independent survival
-
Rathmell J.C., Fox C.J., Plas D.R., Hammerman P.S., Cinalli R.M., Thompson C.B. Akt-directed glucose metabolism can prevent Bax conformation change and promote growth factor-independent survival. Mol. Cell. Biol. 23(20):2003;7315-7328.
-
(2003)
Mol. Cell. Biol.
, vol.23
, Issue.20
, pp. 7315-7328
-
-
Rathmell, J.C.1
Fox, C.J.2
Plas, D.R.3
Hammerman, P.S.4
Cinalli, R.M.5
Thompson, C.B.6
-
58
-
-
0347986675
-
Akt inhibits apoptosis downstream of BID cleavage via a glucose-dependent mechanism involving mitochondrial hexokinases
-
Majewski N., Nogueira V., Robey R.B., Hay N. Akt inhibits apoptosis downstream of BID cleavage via a glucose-dependent mechanism involving mitochondrial hexokinases. Mol. Cell. Biol. 24(2):2004;730-740.
-
(2004)
Mol. Cell. Biol.
, vol.24
, Issue.2
, pp. 730-740
-
-
Majewski, N.1
Nogueira, V.2
Robey, R.B.3
Hay, N.4
-
59
-
-
0042860122
-
Cell biology: Metabolism meets death
-
Downward J. Cell biology: metabolism meets death. Nature. 424(6951):2003;896-897.
-
(2003)
Nature
, vol.424
, Issue.6951
, pp. 896-897
-
-
Downward, J.1
-
60
-
-
0036510541
-
Mitochondrial binding of hexokinase II inhibits Bax-induced cytochrome c release and apoptosis
-
Pastorino J.G., Shulga N., Hoek J.B. Mitochondrial binding of hexokinase II inhibits Bax-induced cytochrome c release and apoptosis. J. Biol. Chem. 277(9):2002;7610-7618.
-
(2002)
J. Biol. Chem.
, vol.277
, Issue.9
, pp. 7610-7618
-
-
Pastorino, J.G.1
Shulga, N.2
Hoek, J.B.3
-
61
-
-
0041357164
-
BAD and glucokinase reside in a mitochondrial complex that integrates glycolysis and apoptosis
-
Danial N.N., Gramm C.F., Scorrano L., Zhang C.Y., Krauss S., Ranger A.M.et al. BAD and glucokinase reside in a mitochondrial complex that integrates glycolysis and apoptosis. Nature. 424(6951):2003;952-956.
-
(2003)
Nature
, vol.424
, Issue.6951
, pp. 952-956
-
-
Danial, N.N.1
Gramm, C.F.2
Scorrano, L.3
Zhang, C.Y.4
Krauss, S.5
Ranger, A.M.6
-
62
-
-
0035499454
-
Ten years of protein kinase B signalling: A hard Akt to follow
-
Brazil D.P., Hemmings B.A. Ten years of protein kinase B signalling: a hard Akt to follow. Trends Biochem. Sci. 26(11):2001;657-664.
-
(2001)
Trends Biochem. Sci.
, vol.26
, Issue.11
, pp. 657-664
-
-
Brazil, D.P.1
Hemmings, B.A.2
-
63
-
-
0041696635
-
Keeping p27(Kip1) in the cytoplasm: A second front in cancer's war on p27
-
Reed S.I. Keeping p27(Kip1) in the cytoplasm: a second front in cancer's war on p27. Cell. Cycle. 1(6):2002;389-390.
-
(2002)
Cell. Cycle
, vol.1
, Issue.6
, pp. 389-390
-
-
Reed, S.I.1
-
64
-
-
0642378387
-
The role of cyclin-dependent kinases in apoptosis
-
Borgne A., Golsteyn R.M. The role of cyclin-dependent kinases in apoptosis. Prog. Cell. Cycle Res. 5:2003;453-459.
-
(2003)
Prog. Cell. Cycle Res.
, vol.5
, pp. 453-459
-
-
Borgne, A.1
Golsteyn, R.M.2
-
65
-
-
0035502498
-
A new molecular target of insulin action: Regulating the pivotal PDK1
-
Wick K.L., Liu F. A new molecular target of insulin action: regulating the pivotal PDK1. Curr. Drug Targets Immune Endocr. Metabol. Disord. 1(3):2001;209-221.
-
(2001)
Curr. Drug Targets Immune Endocr. Metabol. Disord.
, vol.1
, Issue.3
, pp. 209-221
-
-
Wick, K.L.1
Liu, F.2
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