Glucuronidated quercetin lowers blood pressure in spontaneously hypertensive rats via deconjugation

PLoS ONE

Volumn 7, Issue 3, 2012, Pages

  Galindo, Pilar ^a   Rodriguez Gómez, Isabel ^a   González Manzano, Susana ^b   Dueñas, Montserrat ^b   Jiménez, Rosario ^a   Menéndez, Carmen ^c,d   Vargas, Félix ^a   Tamargo, Juan ^c   Santos Buelga, Celestino ^b   Pérez Vizcaíno, Francisco ^c,d   Duarte, Juan ^a  

^a UNIVERSITY OF GRANADA   (Spain)

^b UNIVERSITY OF SALAMANCA   (Spain)

^c SCHOOL OF MEDICINE   (Spain)

^d INSTITUTO DE SALUD CARLOS III   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCURONIDE; ISORHAMNETIN; ISORHAMNETIN 3 GLUCURONIDE; PHENYLEPHRINE; QUERCETIN; QUERCETIN 3 GLUCURONIDE; QUERCETIN 3' SULFATE; SACCHAROLACTONE; UNCLASSIFIED DRUG; BETA GLUCURONIDASE; LACTONE; SACCHARIC ACID; SACCHARIC ACID-1,4-LACTONE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIHYPERTENSIVE ACTIVITY; ARTICLE; BLOOD PRESSURE REGULATION; CONTROLLED STUDY; DISEASE COURSE; DRUG DETERMINATION; DRUG EFFICACY; DRUG STRUCTURE; ENZYME INHIBITION; HYPERTENSION; IN VITRO STUDY; IN VIVO STUDY; INCUBATION TIME; MALE; MESENTERIC ARTERY; NONHUMAN; RAT; SPONTANEOUSLY HYPERTENSIVE RAT; TREATMENT RESPONSE; VASODILATATION; ANIMAL; BLOOD PRESSURE; CHEMICAL STRUCTURE; CHEMISTRY; DRUG ANTAGONISM; DRUG DETOXIFICATION; DRUG EFFECT; METABOLISM; ORAL DRUG ADMINISTRATION; PHYSIOLOGY;

ANIMALIA; RATTUS;

ADMINISTRATION, ORAL; ANIMALS; BLOOD PRESSURE; GLUCARIC ACID; GLUCURONIDASE; LACTONES; MALE; METABOLIC DETOXICATION, PHASE II; MOLECULAR STRUCTURE; QUERCETIN; RATS; RATS, INBRED SHR; VASODILATION;

EID: 84858052503     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0032673     Document Type: Article

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