Generation of a conditional allele for the mouse endothelial nitric oxide synthase gene

Genesis

Volumn 50, Issue 9, 2012, Pages 685-692

  Jiang, Rosie ^a   Wang, Suwan ^a   Takahashi, Keiko ^a   Fujita, Hiroki ^b   Fruci, Christopher R ^a   Breyer, Matthew D ^a,c   Harris, Raymond C ^a   Takahashi, Takamune ^a  

^a VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

^b AKITA UNIVERSITY   (Japan)

^c ELI LILLY AND COMPANY   (United States)

Author keywords

Conditional; Cre recombinase; Endothelium; Gene targeting; Vasodilatator

Indexed keywords

CRE RECOMBINASE; ENDOTHELIAL NITRIC OXIDE SYNTHASE; NITRIC OXIDE;

ALLELE; ALLELISM; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; EXON; FEMALE; GENE ACTIVITY; GENE DELETION; GENE TARGETING; GENETIC RECOMBINATION; HEART RATE; HOMOZYGOSITY; HYPERTENSION; KIDNEY CIRCULATION; KIDNEY SCAR; KNOCKOUT MOUSE; LOXP SITE; LUNG BLOOD VESSEL; MALE; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL;

ALLELES; ANIMALS; BLOOD PRESSURE; EMBRYONIC STEM CELLS; ENDOTHELIUM; EXONS; FEMALE; GENE DELETION; GENE TARGETING; GENETIC ENGINEERING; HEART RATE; HOMOZYGOTE; HYPERTENSION; INTEGRASES; KIDNEY; LUNG; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MODELS, ANIMAL; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE III; PHENOTYPE; RECOMBINATION, GENETIC;

MUS;

EID: 84866597899     PISSN: 1526954X     EISSN: 1526968X     Source Type: Journal    
DOI: 10.1002/dvg.22026     Document Type: Article

References (22)

1. Aguirre J, Buttery L, O'Shaughnessy M, Afzal F, Fernandez de Marticorena I, Hukkanen M, Huang P, MacIntyre I, Polak J. 2001. Endothelial nitric oxide synthase gene-deficient mice demonstrate marked retardation in postnatal bone formation, reduced bone volume, and defects in osteoblast maturation and activity. Am J Pathol 158: 247-257.
2. Albrecht EW, Stegeman CA, Heeringa P, Henning RH, van Goor H. 2003. Protective role of endothelial nitric oxide synthase. J Pathol 199: 8-17.
3. Balasubramaniam V, Maxey AM, Morgan DB, Markham NE, Abman SH. 2006. Inhaled NO restores lung structure in eNOS-deficient mice recovering from neonatal hypoxia. Am J Physiol Lung Cell Mol Physiol 291: L119-L127.
4. Dudzinski DM, Igarashi J, Greif D, Michel T. 2006. The regulation and pharmacology of endothelial nitric oxide synthase. Annu Rev Pharmacol Toxicol 46: 235-276.
5. Duplain H, Burcelin R, Sartori C, Cook S, Egli M, Lepori M, Vollenweider P, Pedrazzini T, Nicod P, Thorens B, Scherrer U. 2001. Insulin resistance, hyperlipidemia, and hypertension in mice lacking endothelial nitric oxide synthase. Circulation 104: 342-345.
6. Feng Q, Song W, Lu X, Hamilton JA, Lei M, Peng T, Yee SP. 2002. Development of heart failure and congenital septal defects in mice lacking endothelial nitric oxide synthase. Circulation 106: 873-879.
7. Forbes MS, Thornhill BA, Park MH, Chevalier RL. 2007. Lack of endothelial nitric-oxide synthase leads to progressive focal renal injury. Am J Pathol 170: 87-99.
8. Han RN, Babaei S, Robb M, Lee T, Ridsdale R, Ackerley C, Post M, Stewart DJ. 2004. Defective lung vascular development and fatal respiratory distress in endothelial NO synthase-deficient mice: a model of alveolar capillary dysplasia? Circ Res 94: 1115-1123.
9. Hayashi S, Lewis P, Pevny L, McMahon AP. 2002. Efficient gene modulation in mouse epiblast using a Sox2Cre transgenic mouse strain. Mech Dev 119 ( Suppl 1): S97-S101.
10. Herrera M, Ortiz PA, Garvin JL. 2006. Regulation of thick ascending limb transport: Role of nitric oxide. Am J Physiol Renal Physiol 290: F1279-F1284.
11. Jones JR, Shelton KD, Magnuson MA. 2005. Strategies for the use of site-specific recombinases in genome engineering. Methods Mol Med 103: 245-257.
12. Kanetsuna Y, Takahashi K, Nagata M, Gannon MA, Breyer MD, Harris RC, Takahashi T. 2007. Deficiency of endothelial nitric-oxide synthase confers susceptibility to diabetic nephropathy in nephropathy-resistant inbred mice. Am J Pathol 170: 1473-1484.
13. Kleinbongard P, Schulz R, Rassaf T, Lauer T, Dejam A, Jax T, Kumara I, Gharini P, Kabanova S, Ozuyaman B, Schnurch HG, Godecke A, Weber AA, Robenek M, Robenek H, Bloch W, Rosen P, Kelm M. 2006. Red blood cells express a functional endothelial nitric oxide synthase. Blood 107: 2943-2951.
14. Koh EH, Kim M, Ranjan KC, Kim HS, Park HS, Oh KS, Park IS, Lee WJ, Kim MS, Park JY, Youn JH, Lee KU. 2010. eNOS plays a major role in adiponectin synthesis in adipocytes. Am J Physiol Endocrinol Metab 298: E846-E853.
15. Kojda G, Laursen JB, Ramasamy S, Kent JD, Kurz S, Burchfield J, Shesely EG, Harrison DG. 1999. Protein expression, vascular reactivity and soluble guanylate cyclase activity in mice lacking the endothelial cell nitric oxide synthase: Contributions of NOS isoforms to blood pressure and heart rate control. Cardiovasc Res 42: 206-213.
16. Lee TC, Zhao YD, Courtman DW, Stewart DJ. 2000. Abnormal aortic valve development in mice lacking endothelial nitric oxide synthase. Circulation 101: 2345-2348.
17. Lepic E, Burger D, Lu X, Song W, Feng Q. 2006. Lack of endothelial nitric oxide synthase decreases cardiomyocyte proliferation and delays cardiac maturation. Am J Physiol Cell Physiol 291: C1240-C1246.
18. Li W, Mital S, Ojaimi C, Csiszar A, Kaley G, Hintze TH. 2004. Premature death and age-related cardiac dysfunction in male eNOS-knockout mice. J Mol Cell Cardiol 37: 671-680.
19. Ortiz PA, Garvin JL. 2003. Cardiovascular and renal control in NOS-deficient mouse models. Am J Physiol Regul Integr Comp Physiol 284: R628-R638.
20. Shesely EG, Maeda N, Kim HS, Desai KM, Krege JH, Laubach VE, Sherman PA, Sessa WC, Smithies O. 1996. Elevated blood pressures in mice lacking endothelial nitric oxide synthase. Proc Natl Acad Sci USA 93: 13176-13181.
21. Yang XP, Liu YH, Shesely EG, Bulagannawar M, Liu F, Carretero OA. 1999. Endothelial nitric oxide gene knockout mice: cardiac phenotypes and the effect of angiotensin-converting enzyme inhibitor on myocardial ischemia/reperfusion injury. Hypertension 34: 24-30.
22. Zhao GQ, Deng K, Labosky PA, Liaw L, Hogan BL. 1996. The gene encoding bone morphogenetic protein 8B is required for the initiation and maintenance of spermatogenesis in the mouse. Genes Dev 10: 1657-1669.