Brain-targeted proanthocyanidin metabolites for Alzheimer's disease treatment

Journal of Neuroscience

Volumn 32, Issue 15, 2012, Pages 5144-5150

  Wang, Jun ^a,g   Ferruzzi, Mario G ^b   Ho, Lap ^a,g   Blount, Jack ^c   Janle, Elsa M ^b   Gong, Bing ^a   Pan, Yong ^a   Nagana Gowda, G A ^b   Raftery, Daniel ^b   Arrieta Cruz, Isabel ^a   Sharma, Vaishali ^c   Cooper, Bruce ^b   Lobo, Jessica ^b   Simon, James E ^e   Zhang, Chungfen ^c   Cheng, Alice ^a   Qian, Xianjuan ^a   Ono, Kenjiro ^f   Teplow, David B ^f   Pavlides, Constantine ^d   Dixon, Richard A ^c   Pasinetti, Giulio M ^a,g   more..

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^b PURDUE UNIVERSITY   (United States)

^c PLANT BIOLOGY DIVISION   (United States)

^d ROCKEFELLER UNIVERSITY   (United States)

^e RUTGERS UNIVERSITY   (United States)

^f UNIVERSITY OF CALIFORNIA   (United States)

^g VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN [1-40]; AMYLOID BETA PROTEIN [1-42]; CATECHIN; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; DRUG METABOLITE; EPICATECHIN; MITOGEN ACTIVATED PROTEIN KINASE KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE KINASE KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE KINASE KINASE 2; MONOMER; OLIGOMER; POLYMER; POLYPHENOL DERIVATIVE; PROANTHOCYANIDIN; S6 KINASE; STRESS ACTIVATED PROTEIN KINASE; SYNAPTOPHYSIN; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BEHAVIOR; COGNITION; CONTROLLED STUDY; DIET SUPPLEMENTATION; DRUG BIOAVAILABILITY; DRUG METABOLISM; ELECTROPHYSIOLOGY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; GRAPE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HIPPOCAMPUS; LEARNING; LONG TERM POTENTIATION; MALE; MAZE TEST; MEMORY; MOUSE; NERVE CELL PLASTICITY; NEUROPATHOLOGY; NONHUMAN; PRIORITY JOURNAL; RAT; SIGNAL TRANSDUCTION; SYNAPTIC TRANSMISSION; TRANSGENIC MOUSE; WESTERN BLOTTING;

ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; ANIMALS; ANTIOXIDANTS; BIOLOGICAL AVAILABILITY; BIOTRANSFORMATION; BLOTTING, WESTERN; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN; DIET; DRUG DELIVERY SYSTEMS; FEMALE; LONG-TERM POTENTIATION; MALE; MAZE LEARNING; MICE; MICE, TRANSGENIC; POLYPHENOLS; PROANTHOCYANIDINS; RATS; RATS, SPRAGUE-DAWLEY; SYNAPTIC TRANSMISSION; VITIS;

EID: 84859542836     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.6437-11.2012     Document Type: Article

References (20)

1. Abd El Mohsen MM, Kuhnle G, Rechner AR, Schroeter H, Rose S, Jenner P, Rice-Evans CA (2002) Uptake and metabolism of epicatechin and its access to the brain after oral ingestion. Free Radic Biol Med 33:1693-1702.
2. Abd El-Mohsen M, Bayele H, Kuhnle G, Gibson G, Debnam E, Kaila Srai S, Rice-Evans C, Spencer JP (2006) Distribution of [3H]trans-resveratrol in rat tissues following oral administration. Br J Nutr 96:62-70.
3. Bartsch D, Casadio A, Karl KA, Serodio P, Kandel ER (1998) CREB1 encodes a nuclear activator, a repressor, and a cytoplasmic modulator that form a regulatory unit critical for long-term facilitation. Cell 95:211-223.
4. Bliss TV, Collingridge GL (1993) A synaptic model of memory: long-term potentiation in the hippocampus. Nature 361:31-39.
5. Chapman PF, White GL, Jones MW, Cooper-Blacketer D, Marshall VJ, Irizarry M, Younkin L, Good MA, Bliss TV, Hyman BT, Younkin SG, Hsiao KK (1999) Impaired synaptic plasticity and learning in aged amyloid precursor protein transgenic mice. Nat Neurosci 2:271-276.
6. Chrivia JC, Kwok RP, Lamb N, Hagiwara M, Montminy MR, Goodman RH (1993) Phosphorylated CREB binds specifically to the nuclear protein CBP. Nature 365:855-859.
7. Feng WY (2006) Metabolism of green tea catechins: an overview. Curr Drug Metab 7:755-809.
8. Funke SA, Birkmann E, Henke F, Görtz P, Lange-Asschenfeldt C, Riesner D, Willbold D (2007) Single particle detection of Abeta aggregates associated with Alzheimer's disease. Biochem Biophys Res Commun 364:902-907.
9. Gong B, Vitolo OV, Trinchese F, Liu S, Shelanski M, Arancio O (2004) Persistent improvement in synaptic and cognitive functions in an Alzheimer mouse model after rolipram treatment. J Clin Invest 114:1624-1634.
10. Hartman RE, Shah A, Fagan AM, Schwetye KE, Parsadanian M, Schulman RN, Finn MB, Holtzman DM (2006) Pomegranate juice decreases amyloid load and improves behavior in a mouse model of Alzheimer's disease. Neurobiol Dis 24:506-515.
11. Milbury PE, KaltW (2010) Xenobiotic metabolism and berry flavonoid transport across the blood-brain barrier. J Agric Food Chem 58:3950-3956.
12. Rezai-Zadeh K, Shytle D, Sun N, Mori T, Hou H, Jeanniton D, Ehrhart J, Townsend K, Zeng J, Morgan D, Hardy J, Town T, Tan J (2005) Green tea epigallocatechin-3-gallate (EGCG) modulates amyloid precursor protein cleavage and reduces cerebral amyloidosis in Alzheimer transgenic mice. J Neurosci 25:8807-8814.
13. Roura E, Andrés-Lacueva C, Jáuregui O, Badia E, Estruch R, Izquierdo-Pulido M, Lamuela-Raventós RM (2005) Rapid liquid chromatography tandem mass spectrometry assay to quantify plasma (-)-epicatechin metabolites after ingestion of a standard portion of cocoa beverage in humans. J Agric Food Chem 53:6190-6194.
14. Selkoe DJ (2008) Soluble oligomers of the amyloid beta-protein impair synaptic plasticity and behavior. Behav Brain Res 192:106-113.
15. Sharma V, Zhang C, Pasinetti G, Dixon R (2011) Fractionation of grape seed proanthocyanidins for bioactivity assessment. In: The biological activity of phytochemicals (Gang DR, ed), pp 33-46. NY: Springer.
16. Tsang C, Auger C, Mullen W, Bornet A, Rouanet JM, Crozier A, Teissedre PL (2005) The absorption, metabolism and excretion of flavan-3-ols and procyanidins following the ingestion of a grape seed extract by rats. Br J Nutr 94:170-181.
17. van Praag H, Lucero MJ, Yeo GW, Stecker K, Heivand N, Zhao C, Yip E, Afanador M, Schroeter H, Hammerstone J, Gage FH (2007) Plantderived flavanol (-)epicatechin enhances angiogenesis and retention of spatial memory in mice. J Neurosci 27:5869-5878.
18. Wang J, Ho L, Qin W, Rocher AB, Seror I, Humala N, Maniar K, Dolios G, Wang R, Hof PR, Pasinetti GM (2005) Caloric restriction attenuates beta-amyloid neuropathology in a mouse model of Alzheimer's disease. FASEB J 19:659-661.
19. Wang J, Ho L, Chen L, Zhao Z, Zhao W, Qian X, Humala N, Seror I, Bartholomew S, Rosendorff C, Pasinetti GM (2007) Valsartan lowers brain beta-amyloid protein levels and improves spatial learning in a mouse model of Alzheimer disease. J Clin Invest 117:3393-3402.
20. Wang J, Ho L, Zhao W, Ono K, Rosensweig C, Chen L, Humala N, Teplow DB, Pasinetti GM (2008) Grape-derived polyphenolics prevent Abeta oligomerization and attenuate cognitive deterioration in a mouse model of Alzheimer's disease. J Neurosci 28:6388-6392