메뉴 건너뛰기




Volumn 56, Issue 4, 2012, Pages 558-569

Flavone deglycosylation increases their anti-inflammatory activity and absorption

Author keywords

Apigenin; Bioactive food components; Flavones; Inflammation; Macrophages

Indexed keywords

ANTIINFLAMMATORY AGENT; AUTACOID; FLAVONE DERIVATIVE; GLYCOSIDE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LIPOPOLYSACCHARIDE; PLANT EXTRACT; TUMOR NECROSIS FACTOR ALPHA;

EID: 84859736687     PISSN: 16134125     EISSN: 16134133     Source Type: Journal    
DOI: 10.1002/mnfr.201100596     Document Type: Article
Times cited : (81)

References (49)
  • 2
    • 30044438392 scopus 로고    scopus 로고
    • Dampening inflammation
    • Henson, P. M., Dampening inflammation. Nat. Immunol. 2005, 6, 1179-1181.
    • (2005) Nat. Immunol. , vol.6 , pp. 1179-1181
    • Henson, P.M.1
  • 3
    • 34548022149 scopus 로고    scopus 로고
    • Understanding the inflammatory cytokine response in pneumonia and sepsis: results of the Genetic and Inflammatory Markers of Sepsis (GenIMS) Study
    • Kellum, J. A., Kong, L., Fink, M. P., Weissfeld, L. A. et al., Understanding the inflammatory cytokine response in pneumonia and sepsis: results of the Genetic and Inflammatory Markers of Sepsis (GenIMS) Study. Arch. Intern. Med. 2007, 167, 1655-1663.
    • (2007) Arch. Intern. Med. , vol.167 , pp. 1655-1663
    • Kellum, J.A.1    Kong, L.2    Fink, M.P.3    Weissfeld, L.A.4
  • 4
    • 3142517968 scopus 로고    scopus 로고
    • Association between chronic obstructive pulmonary disease and systemic inflammation: a systematic review and a meta-analysis
    • Gan, W. Q., Man, S. F. P., Senthilselvan, A., Sin, D. D., Association between chronic obstructive pulmonary disease and systemic inflammation: a systematic review and a meta-analysis. Thorax 2004, 59, 574-580.
    • (2004) Thorax , vol.59 , pp. 574-580
    • Gan, W.Q.1    Man, S.F.P.2    Senthilselvan, A.3    Sin, D.D.4
  • 5
    • 0035908632 scopus 로고    scopus 로고
    • C-reactive protein, interleukin 6, and risk of developing type 2 diabetes mellitus
    • Pradhan, A. D., Manson, J. E., Rifai, N., Buring, J. E. et al., C-reactive protein, interleukin 6, and risk of developing type 2 diabetes mellitus. JAMA 2001, 286, 327-334.
    • (2001) JAMA , vol.286 , pp. 327-334
    • Pradhan, A.D.1    Manson, J.E.2    Rifai, N.3    Buring, J.E.4
  • 6
    • 0035932519 scopus 로고    scopus 로고
    • Cytokine pathways and joint inflammation in rheumatoid arthritis
    • Choy, E. H., Panayi, G. S., Cytokine pathways and joint inflammation in rheumatoid arthritis. N. Engl. J. Med. 2001, 344, 907-916.
    • (2001) N. Engl. J. Med. , vol.344 , pp. 907-916
    • Choy, E.H.1    Panayi, G.S.2
  • 7
    • 34248141100 scopus 로고    scopus 로고
    • A cytokine-mediated link between innate immunity, inflammation, and cancer
    • Lin, W.-W., Karin, M., A cytokine-mediated link between innate immunity, inflammation, and cancer. J. Clin. Invest. 2007, 117, 1175-1183.
    • (2007) J. Clin. Invest. , vol.117 , pp. 1175-1183
    • Lin, W.-W.1    Karin, M.2
  • 8
    • 17644412023 scopus 로고    scopus 로고
    • Inflammation, atherosclerosis, and coronary artery disease
    • Hansson, G. K., Inflammation, atherosclerosis, and coronary artery disease. N. Engl. J. Med. 2005, 352, 1685-1695.
    • (2005) N. Engl. J. Med. , vol.352 , pp. 1685-1695
    • Hansson, G.K.1
  • 9
    • 0842265247 scopus 로고    scopus 로고
    • Guidelines for the appropriate use of non-steroidal anti-inflammatory drugs, cyclo-oxygenase-2-specific inhibitors and proton pump inhibitors in patients requiring chronic anti-inflammatory therapy
    • Dubois, R. W., Melmed, G. Y., Henning, J. M., Laine, L., Guidelines for the appropriate use of non-steroidal anti-inflammatory drugs, cyclo-oxygenase-2-specific inhibitors and proton pump inhibitors in patients requiring chronic anti-inflammatory therapy. Aliment. Pharmacol. Ther. 2004, 19, 197-208.
    • (2004) Aliment. Pharmacol. Ther. , vol.19 , pp. 197-208
    • Dubois, R.W.1    Melmed, G.Y.2    Henning, J.M.3    Laine, L.4
  • 11
    • 68449103573 scopus 로고    scopus 로고
    • Flavonoids as anti-inflammatory agents: implications in cancer and cardiovascular disease
    • García-Lafuente, A., Guillamón, E., Villares, A., Rostagno, M. A. et al., Flavonoids as anti-inflammatory agents: implications in cancer and cardiovascular disease. Inflamm. Res. 2009, 58, 537-552.
    • (2009) Inflamm. Res. , vol.58 , pp. 537-552
    • García-Lafuente, A.1    Guillamón, E.2    Villares, A.3    Rostagno, M.A.4
  • 12
    • 0020789120 scopus 로고
    • Acylhydrolases from parsley (Petroselinum hortense). Relative distribution and properties of four esterases hydrolyzing malonic acid hemiesters of flavonoid glucosides
    • Matern, U., Acylhydrolases from parsley (Petroselinum hortense). Relative distribution and properties of four esterases hydrolyzing malonic acid hemiesters of flavonoid glucosides. Arch. Biochem. Biophys. 1983, 224, 261-271.
    • (1983) Arch. Biochem. Biophys. , vol.224 , pp. 261-271
    • Matern, U.1
  • 13
    • 0033804796 scopus 로고    scopus 로고
    • Effect of variety, processing, and storage on the flavonoid glycoside content and composition of lettuce and endive
    • DuPont, M. S., Mondin, Z., Williamson, G., Price, K. R., Effect of variety, processing, and storage on the flavonoid glycoside content and composition of lettuce and endive. J. Agric. Food Chem. 2000, 48, 3957-3964.
    • (2000) J. Agric. Food Chem. , vol.48 , pp. 3957-3964
    • DuPont, M.S.1    Mondin, Z.2    Williamson, G.3    Price, K.R.4
  • 14
    • 3042567137 scopus 로고    scopus 로고
    • Identification and quantification of caffeoylquinic acids and flavonoids from artichoke (Cynara scolymus L.) heads, juice, and pomace by HPLC-DAD-ESI/MSn
    • Schutz, K., Kammerer, D., Carle, R., Schieber, A., Identification and quantification of caffeoylquinic acids and flavonoids from artichoke (Cynara scolymus L.) heads, juice, and pomace by HPLC-DAD-ESI/MSn. J. Agric. Food Chem. 2004, 52, 4090-4096.
    • (2004) J. Agric. Food Chem. , vol.52 , pp. 4090-4096
    • Schutz, K.1    Kammerer, D.2    Carle, R.3    Schieber, A.4
  • 15
    • 0037189860 scopus 로고    scopus 로고
    • Effect of processing techniques at industrial scale on orange juice antioxidant and beneficial health compounds
    • Gil-Izquierdo, A., Gil, M. I., Ferreres, F., Effect of processing techniques at industrial scale on orange juice antioxidant and beneficial health compounds. J. Agric. Food Chem. 2002, 50, 5107-5114.
    • (2002) J. Agric. Food Chem. , vol.50 , pp. 5107-5114
    • Gil-Izquierdo, A.1    Gil, M.I.2    Ferreres, F.3
  • 16
    • 32444451694 scopus 로고    scopus 로고
    • Bioavailability is improved by enzymatic modification of the citrus flavonoid hesperidin in humans: a randomized, double-blind, crossover trial
    • Nielsen, I. L. F., Chee, W. S. S., Poulsen, L., Offord-Cavin, E. et al., Bioavailability is improved by enzymatic modification of the citrus flavonoid hesperidin in humans: a randomized, double-blind, crossover trial. J. Nutr. 2006, 136, 404-408.
    • (2006) J. Nutr. , vol.136 , pp. 404-408
    • Nielsen, I.L.F.1    Chee, W.S.S.2    Poulsen, L.3    Offord-Cavin, E.4
  • 17
    • 0036712527 scopus 로고    scopus 로고
    • Hydrolysis of isoflavone glycosides to aglycones by β-glycosidase does not alter plasma and urine isoflavone pharmacokinetics in postmenopausal women
    • Richelle, M., Pridmore-Merten, S., Bodenstab, S., Enslen, M. et al., Hydrolysis of isoflavone glycosides to aglycones by β-glycosidase does not alter plasma and urine isoflavone pharmacokinetics in postmenopausal women. J. Nutr. 2002, 132, 2587-2592.
    • (2002) J. Nutr. , vol.132 , pp. 2587-2592
    • Richelle, M.1    Pridmore-Merten, S.2    Bodenstab, S.3    Enslen, M.4
  • 18
    • 66749131330 scopus 로고    scopus 로고
    • The bioavailability of apigenin-7-glucoside is influenced by human intestinal microbiota in rats
    • Hanske, L., Loh, G., Sczesny, S., Blaut, M. et al., The bioavailability of apigenin-7-glucoside is influenced by human intestinal microbiota in rats. J. Nutr. 2009, 139, 1095-1102.
    • (2009) J. Nutr. , vol.139 , pp. 1095-1102
    • Hanske, L.1    Loh, G.2    Sczesny, S.3    Blaut, M.4
  • 19
    • 13844281685 scopus 로고    scopus 로고
    • Bioavailability and bioefficacy of polyphenols in humans. I. Review of 97 bioavailability studies
    • Manach, C., Williamson, G., Morand, C., Scalbert, A. et al., Bioavailability and bioefficacy of polyphenols in humans. I. Review of 97 bioavailability studies. Am. J. Clin. Nutr. 2005, 81, 230S-242S.
    • (2005) Am. J. Clin. Nutr. , vol.81
    • Manach, C.1    Williamson, G.2    Morand, C.3    Scalbert, A.4
  • 20
    • 13844271387 scopus 로고    scopus 로고
    • Bioavailability and bioefficacy of polyphenols in humans. II. Review of 93 intervention studies
    • Williamson, G., Manach, C., Bioavailability and bioefficacy of polyphenols in humans. II. Review of 93 intervention studies. Am. J. Clin. Nutr. 2005, 81, 243S-255S.
    • (2005) Am. J. Clin. Nutr. , vol.81
    • Williamson, G.1    Manach, C.2
  • 21
    • 38449107785 scopus 로고    scopus 로고
    • Apigenin blocks lipopolysaccharide-induced lethality in vivo and proinflammatory cytokines expression by inactivating NF-κB through the suppression of p65 phosphorylation
    • Nicholas, C., Batra, S., Vargo, M. A., Voss, O. H. et al., Apigenin blocks lipopolysaccharide-induced lethality in vivo and proinflammatory cytokines expression by inactivating NF-κB through the suppression of p65 phosphorylation. J. Immunol. 2007, 179, 7121-7127.
    • (2007) J. Immunol. , vol.179 , pp. 7121-7127
    • Nicholas, C.1    Batra, S.2    Vargo, M.A.3    Voss, O.H.4
  • 22
    • 33747188963 scopus 로고    scopus 로고
    • Apigenin-induced-apoptosis is mediated by the activation of PKCδ and caspases in leukemia cells
    • Vargo, M. A., Voss, O. H., Poustka, F., Cardounel, A. J. et al., Apigenin-induced-apoptosis is mediated by the activation of PKCδ and caspases in leukemia cells. Biochem. Pharmacol. 2006, 72, 681-692.
    • (2006) Biochem. Pharmacol. , vol.72 , pp. 681-692
    • Vargo, M.A.1    Voss, O.H.2    Poustka, F.3    Cardounel, A.J.4
  • 23
    • 33947359919 scopus 로고    scopus 로고
    • Cancer chemopreventive properties of orally bioavailable flavonoids-methylated versus unmethylated flavones
    • Walle, T., Ta, N., Kawamori, T., Wen, X. et al., Cancer chemopreventive properties of orally bioavailable flavonoids-methylated versus unmethylated flavones. Biochem. Pharmacol. 2007, 73, 1288-1296.
    • (2007) Biochem. Pharmacol. , vol.73 , pp. 1288-1296
    • Walle, T.1    Ta, N.2    Kawamori, T.3    Wen, X.4
  • 24
    • 33748580218 scopus 로고    scopus 로고
    • Inhibition of pro-inflammatory markers in primary bone marrow-derived mouse macrophages by naturally occurring flavonoids: analysis of the structure-activity relationship
    • Comalada, M., Ballester, I., Bailón, E., Sierra, S. et al., Inhibition of pro-inflammatory markers in primary bone marrow-derived mouse macrophages by naturally occurring flavonoids: analysis of the structure-activity relationship. Biochem. Pharmacol. 2006, 72, 1010-1021.
    • (2006) Biochem. Pharmacol. , vol.72 , pp. 1010-1021
    • Comalada, M.1    Ballester, I.2    Bailón, E.3    Sierra, S.4
  • 25
    • 0141655182 scopus 로고    scopus 로고
    • Modulation of lipopolysaccharide-induced proinflammatory cytokine production in vitro and in vivo by the herbal constituents apigenin (chamomile), ginsenoside Rb(1) (ginseng) and parthenolide (feverfew)
    • Smolinski, A. T., Pestka, J. J., Modulation of lipopolysaccharide-induced proinflammatory cytokine production in vitro and in vivo by the herbal constituents apigenin (chamomile), ginsenoside Rb(1) (ginseng) and parthenolide (feverfew). Food Chem. Toxicol. 2003, 41, 1381-1390.
    • (2003) Food Chem. Toxicol. , vol.41 , pp. 1381-1390
    • Smolinski, A.T.1    Pestka, J.J.2
  • 26
    • 48649094823 scopus 로고    scopus 로고
    • Plant-derived polyphenols attenuate lipo-polysaccharide-induced nitric oxide and tumour necrosis factor production in murine microglia and macrophages
    • Shanmugam, K., Holmquist, L., Steele, M., Stuchbury, G. et al., Plant-derived polyphenols attenuate lipo-polysaccharide-induced nitric oxide and tumour necrosis factor production in murine microglia and macrophages. Mol. Nutr. Food Res. 2008, 52, 427-438.
    • (2008) Mol. Nutr. Food Res. , vol.52 , pp. 427-438
    • Shanmugam, K.1    Holmquist, L.2    Steele, M.3    Stuchbury, G.4
  • 27
    • 33645081458 scopus 로고    scopus 로고
    • Determination and assay validation of luteolin and apigenin in human urine after oral administration of tablet of Chrysanthemum morifolium extract by HPLC
    • Li, L.-P., Jiang, H.-D., Determination and assay validation of luteolin and apigenin in human urine after oral administration of tablet of Chrysanthemum morifolium extract by HPLC. J. Pharm. Biomed. Anal. 2006, 41, 261-265.
    • (2006) J. Pharm. Biomed. Anal. , vol.41 , pp. 261-265
    • Li, L.-P.1    Jiang, H.-D.2
  • 28
    • 0037174140 scopus 로고    scopus 로고
    • High-throughput quantification of soy isoflavones in human and rodent blood using liquid chromatography with electrospray mass spectrometry and tandem mass spectrometry detection
    • Twaddle, N. C., Churchwell, M. I., Doerge, D. R., High-throughput quantification of soy isoflavones in human and rodent blood using liquid chromatography with electrospray mass spectrometry and tandem mass spectrometry detection. J. Chromatogr. B 2002, 777, 139-145.
    • (2002) J. Chromatogr. B , vol.777 , pp. 139-145
    • Twaddle, N.C.1    Churchwell, M.I.2    Doerge, D.R.3
  • 29
    • 0032513281 scopus 로고    scopus 로고
    • Quantitative analysis of flavonols, flavones, and flavanones in fruits, vegetables and beverages by high-performance liquid chromatography with photo-diode array and mass spectrometric detection
    • Justesen, U., Knuthsen, P., Leth, T., Quantitative analysis of flavonols, flavones, and flavanones in fruits, vegetables and beverages by high-performance liquid chromatography with photo-diode array and mass spectrometric detection. J. Chromatogr. A 1998, 799, 101-110.
    • (1998) J. Chromatogr. A , vol.799 , pp. 101-110
    • Justesen, U.1    Knuthsen, P.2    Leth, T.3
  • 30
    • 34147192203 scopus 로고    scopus 로고
    • Absorption and metabolism of bioactive molecules after oral consumption of cooked edible heads of Cynara scolymus L. (cultivar Violetto di Provenza) in human subjects: a pilot study
    • Azzini, E., Bugianesi, R., Romano, F., Di Venere, D. et al., Absorption and metabolism of bioactive molecules after oral consumption of cooked edible heads of Cynara scolymus L. (cultivar Violetto di Provenza) in human subjects: a pilot study. Br. J. Nutr. 2007, 97, 963-969.
    • (2007) Br. J. Nutr. , vol.97 , pp. 963-969
    • Azzini, E.1    Bugianesi, R.2    Romano, F.3    Di Venere, D.4
  • 31
    • 0037471608 scopus 로고    scopus 로고
    • Simultaneous determination of all polyphenols in vegetables, fruits, and teas
    • Sakakibara, H., Honda, Y., Nakagawa, S., Ashida, H. et al., Simultaneous determination of all polyphenols in vegetables, fruits, and teas. J. Agric. Food Chem. 2003, 51, 571-581.
    • (2003) J. Agric. Food Chem. , vol.51 , pp. 571-581
    • Sakakibara, H.1    Honda, Y.2    Nakagawa, S.3    Ashida, H.4
  • 32
    • 0034984690 scopus 로고    scopus 로고
    • Flavonoid accumulation patterns of transparent testa mutants of arabidopsis
    • Peer, W. A., Brown, D. E., Tague, B. W., Muday, G. K. et al., Flavonoid accumulation patterns of transparent testa mutants of arabidopsis. Plant Physiol. 2001, 126, 536-548.
    • (2001) Plant Physiol. , vol.126 , pp. 536-548
    • Peer, W.A.1    Brown, D.E.2    Tague, B.W.3    Muday, G.K.4
  • 33
    • 34447518702 scopus 로고    scopus 로고
    • Antioxidant activity and phenolic compounds in 32 selected herbs
    • Wojdylo, A., Oszmianski, J., Czemerys, R., Antioxidant activity and phenolic compounds in 32 selected herbs. Food Chem. 2007, 105, 940-949.
    • (2007) Food Chem. , vol.105 , pp. 940-949
    • Wojdylo, A.1    Oszmianski, J.2    Czemerys, R.3
  • 34
    • 70349332586 scopus 로고    scopus 로고
    • Mechanism of action of flavonoids as anti-inflammatory agents: a review
    • Rathee, P., Chaudhary, H., Rathee, S., Rathee, D. et al., Mechanism of action of flavonoids as anti-inflammatory agents: a review. Inflamm. Allergy Drug Targets 2009, 8, 229-235.
    • (2009) Inflamm. Allergy Drug Targets , vol.8 , pp. 229-235
    • Rathee, P.1    Chaudhary, H.2    Rathee, S.3    Rathee, D.4
  • 35
    • 0032941919 scopus 로고    scopus 로고
    • Polymethoxylated flavones derived from citrus suppress tumor necrosis factor-α expression by human monocytes
    • Manthey, J. A., Grohmann, K., Montanari, A., Ash, K. et al., Polymethoxylated flavones derived from citrus suppress tumor necrosis factor-α expression by human monocytes. J. Nat. Prod. 1999, 62, 441-444.
    • (1999) J. Nat. Prod. , vol.62 , pp. 441-444
    • Manthey, J.A.1    Grohmann, K.2    Montanari, A.3    Ash, K.4
  • 36
    • 0032814249 scopus 로고    scopus 로고
    • Effects of naturally occurring flavonoids on nitric oxide production in the macrophage cell line RAW 264.7 and their structure-activity relationships
    • Kim, H. K., Cheon, B. S., Kim, Y. H., Kim, S. Y. et al., Effects of naturally occurring flavonoids on nitric oxide production in the macrophage cell line RAW 264.7 and their structure-activity relationships. Biochem. Pharmacol. 1999, 58, 759-765.
    • (1999) Biochem. Pharmacol. , vol.58 , pp. 759-765
    • Kim, H.K.1    Cheon, B.S.2    Kim, Y.H.3    Kim, S.Y.4
  • 37
    • 34447300768 scopus 로고    scopus 로고
    • An extract of Apium graveolens var. dulce leaves: structure of the major constituent, apiin, and its anti-inflammatory properties
    • Mencherini, T., Cau, A., Bianco, G., Della Loggia, R. et al., An extract of Apium graveolens var. dulce leaves: structure of the major constituent, apiin, and its anti-inflammatory properties. J. Pharm. Pharmacol. 2007, 59, 891-897.
    • (2007) J. Pharm. Pharmacol. , vol.59 , pp. 891-897
    • Mencherini, T.1    Cau, A.2    Bianco, G.3    Della Loggia, R.4
  • 38
    • 70449517239 scopus 로고    scopus 로고
    • Subcellular localization of flavonol aglycone in hepatocytes visualized by confocal laser scanning fluorescence microscope
    • Mukai, R., Shirai, Y., Saito, N., Yoshida, K. et al., Subcellular localization of flavonol aglycone in hepatocytes visualized by confocal laser scanning fluorescence microscope. Cytotechnology 2009, 59, 177-182.
    • (2009) Cytotechnology , vol.59 , pp. 177-182
    • Mukai, R.1    Shirai, Y.2    Saito, N.3    Yoshida, K.4
  • 39
    • 33750728052 scopus 로고    scopus 로고
    • Bioavailable flavonoids to suppress the formation of 8-OHdG in HepG2 cells
    • Kanazawa, K., Uehara, M., Yanagitani, H., Hashimoto, T., Bioavailable flavonoids to suppress the formation of 8-OHdG in HepG2 cells. Arch. Biochem. Biophys. 2006, 455, 197-203.
    • (2006) Arch. Biochem. Biophys. , vol.455 , pp. 197-203
    • Kanazawa, K.1    Uehara, M.2    Yanagitani, H.3    Hashimoto, T.4
  • 40
    • 0036024242 scopus 로고    scopus 로고
    • Inhibition of LPS-stimulated pathways in macrophages by the flavonoid luteolin
    • Xagorari, A., Roussos, C., Papapetropoulos, A., Inhibition of LPS-stimulated pathways in macrophages by the flavonoid luteolin. Br. J. Pharmacol. 2002, 136, 1058-1064.
    • (2002) Br. J. Pharmacol. , vol.136 , pp. 1058-1064
    • Xagorari, A.1    Roussos, C.2    Papapetropoulos, A.3
  • 41
    • 0033734729 scopus 로고    scopus 로고
    • Intestinal transport of quercetin glycosides in rats involves both deglycosylation and interaction with the hexose transport pathway
    • Gee, J. M., DuPont, M. S., Day, A. J., Plumb, G. W. et al., Intestinal transport of quercetin glycosides in rats involves both deglycosylation and interaction with the hexose transport pathway. J. Nutr. 2000, 130, 2765-2771.
    • (2000) J. Nutr. , vol.130 , pp. 2765-2771
    • Gee, J.M.1    DuPont, M.S.2    Day, A.J.3    Plumb, G.W.4
  • 42
    • 0032524982 scopus 로고    scopus 로고
    • Transport of quercetin and its glucosides across human intestinal epithelial Caco-2 cells
    • Walgren, R. A., Walle, U. K., Walle, T., Transport of quercetin and its glucosides across human intestinal epithelial Caco-2 cells. Biochem. Pharmacol. 1998, 55, 1721-1727.
    • (1998) Biochem. Pharmacol. , vol.55 , pp. 1721-1727
    • Walgren, R.A.1    Walle, U.K.2    Walle, T.3
  • 43
    • 43149123621 scopus 로고    scopus 로고
    • Osteoarthritis and nutrition. From nutraceuticals to functional foods: a systematic review of the scientific evidence
    • Ameye, L. G., Chee, W. S., Osteoarthritis and nutrition. From nutraceuticals to functional foods: a systematic review of the scientific evidence. Arthritis Res. Ther. 2006, 8, R127-R127.
    • (2006) Arthritis Res. Ther. , vol.8
    • Ameye, L.G.1    Chee, W.S.2
  • 44
    • 0037219688 scopus 로고    scopus 로고
    • Deglycosylation by small intestinal epithelial cell β-glucosidases is a critical step in the absorption and metabolism of dietary flavonoid glycosides in humans
    • Németh, K., Plumb, G. W., Berrin, J.-G., Juge, N. et al., Deglycosylation by small intestinal epithelial cell β-glucosidases is a critical step in the absorption and metabolism of dietary flavonoid glycosides in humans. Eur. J. Nutr. 2003, 42, 29-42.
    • (2003) Eur. J. Nutr. , vol.42 , pp. 29-42
    • Németh, K.1    Plumb, G.W.2    Berrin, J.-G.3    Juge, N.4
  • 45
    • 78049257884 scopus 로고    scopus 로고
    • Relative contribution of small and large intestine to deglycosylation and absorption of flavonoids from Chrysanthemun morifolium extract
    • Lu, X.-Y., Sun, D.-L., Chen, Z.-J., Chen, T. et al., Relative contribution of small and large intestine to deglycosylation and absorption of flavonoids from Chrysanthemun morifolium extract. J. Agric. Food Chem. 2010, 58, 10661-10667.
    • (2010) J. Agric. Food Chem. , vol.58 , pp. 10661-10667
    • Lu, X.-Y.1    Sun, D.-L.2    Chen, Z.-J.3    Chen, T.4
  • 46
    • 0036201358 scopus 로고    scopus 로고
    • Absorption and metabolism of flavonoids in the caco-2 cell culture model and a perused rat intestinal model
    • Liu, Y., Hu, M., Absorption and metabolism of flavonoids in the caco-2 cell culture model and a perused rat intestinal model. Drug Metab. Dispos. 2002, 30, 370-377.
    • (2002) Drug Metab. Dispos. , vol.30 , pp. 370-377
    • Liu, Y.1    Hu, M.2
  • 47
    • 34248350462 scopus 로고    scopus 로고
    • Tissue distribution in mice and metabolism in murine and human liver of apigenin and tricin, flavones with putative cancer chemopreventive properties
    • Cai, H., Boocock, D., Steward, W., Gescher, A., Tissue distribution in mice and metabolism in murine and human liver of apigenin and tricin, flavones with putative cancer chemopreventive properties. Cancer Chemother. Pharm. 2007, 60, 257-266.
    • (2007) Cancer Chemother. Pharm. , vol.60 , pp. 257-266
    • Cai, H.1    Boocock, D.2    Steward, W.3    Gescher, A.4
  • 48
    • 38549159900 scopus 로고    scopus 로고
    • Intestinal absorption of luteolin from peanut hull extract is more efficient than that from individual pure luteolin
    • Zhou, P., Li, L.-P., Luo, S.-Q., Jiang, H.-D. et al., Intestinal absorption of luteolin from peanut hull extract is more efficient than that from individual pure luteolin. J. Agric. Food Chem. 2008, 56, 296-300.
    • (2008) J. Agric. Food Chem. , vol.56 , pp. 296-300
    • Zhou, P.1    Li, L.-P.2    Luo, S.-Q.3    Jiang, H.-D.4
  • 49
    • 34047225839 scopus 로고    scopus 로고
    • Absorption and excretion of luteolin and apigenin in rats after oral administration of Chrysanthemum morifolium extract
    • Chen, T., Li, L.-P., Lu, X.-Y., Jiang, H.-D. et al., Absorption and excretion of luteolin and apigenin in rats after oral administration of Chrysanthemum morifolium extract. J. Agric. Food Chem. 2007, 55, 273-277.
    • (2007) J. Agric. Food Chem. , vol.55 , pp. 273-277
    • Chen, T.1    Li, L.-P.2    Lu, X.-Y.3    Jiang, H.-D.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.