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Volumn 6, Issue AUG, 2015, Pages

Plant-derived immunomodulators: An insight on their preclinical evaluation and clinical trials

Author keywords

Capsaicin; Colchicine; Curcumin; Epigallocatechol 3 gallate; Immunomodulation; Quercetin; Resveratrol

Indexed keywords


EID: 84940650582     PISSN: None     EISSN: 1664462X     Source Type: Journal    
DOI: 10.3389/fpls.2015.00655     Document Type: Review
Times cited : (310)

References (191)
  • 1
    • 79955837052 scopus 로고    scopus 로고
    • Effect of quercetin supplementation on repeated-sprint performance, xanthine oxidase activity, and inflammation
    • Abbey, E. L., and Rankin, J. W. (2011). Effect of quercetin supplementation on repeated-sprint performance, xanthine oxidase activity, and inflammation. Int. J. Sport Nutr. Exerc. Metab. 21, 91-96.
    • (2011) Int. J. Sport Nutr. Exerc. Metab , vol.21 , pp. 91-96
    • Abbey, E.L.1    Rankin, J.W.2
  • 2
    • 33750391774 scopus 로고    scopus 로고
    • Boswellic acids in chronic inflammatory diseases
    • Ammon, H. P. (2006). Boswellic acids in chronic inflammatory diseases. Planta Med. 72, 1100-1116. doi: 10.1055/s-2006-947227
    • (2006) Planta Med , vol.72 , pp. 1100-1116
    • Ammon, H.P.1
  • 3
    • 37549051274 scopus 로고    scopus 로고
    • Bioavailability of curcumin: Problems and promises
    • Anand, P., Kunnumakkara, A. B., Newman, R. A., and Aggarwal, B. B. (2007). Bioavailability of curcumin: problems and promises. Mol. Pharm. 4, 807-818. doi: 10.1021/mp700113r
    • (2007) Mol. Pharm , vol.4 , pp. 807-818
    • Anand, P.1    Kunnumakkara, A.B.2    Newman, R.A.3    Aggarwal, B.B.4
  • 4
    • 77951683909 scopus 로고    scopus 로고
    • Shikonin reduces oedema induced by phorbol ester by interfering with IκBα degradation thus inhibiting translocation of NF-κB to the nucleus
    • Andújar, I., Recio, M. C., Bacelli, T., Giner, R. M., and Rios, J. L. (2010). Shikonin reduces oedema induced by phorbol ester by interfering with IκBα degradation thus inhibiting translocation of NF-κB to the nucleus. Br. J. Pharmacol. 160, 376-388. doi: 10.1111/j.1476-5381.2010.00696.x
    • (2010) Br. J. Pharmacol , vol.160 , pp. 376-388
    • Andújar, I.1    Recio, M.C.2    Bacelli, T.3    Giner, R.M.4    Rios, J.L.5
  • 5
    • 84887606941 scopus 로고    scopus 로고
    • Levamisole: A common cocaine adulterant with life-threatening side effects
    • Auffenberg, C., Rosenthal, L. J., and Dresner, N. (2013). Levamisole: a common cocaine adulterant with life-threatening side effects. Psychosomatics 54, 590-593. doi: 10.1016/j.psym.2013.02.012
    • (2013) Psychosomatics , vol.54 , pp. 590-593
    • Auffenberg, C.1    Rosenthal, L.J.2    Dresner, N.3
  • 6
    • 79957982285 scopus 로고    scopus 로고
    • Chrysin suppresses mast cell-mediated allergic inflammation: Involvement of calcium, caspase-1 and nuclear factor-κB. Toxicol
    • Bae, Y., Lee, S., and Kim, S.-H. (2011). Chrysin suppresses mast cell-mediated allergic inflammation: involvement of calcium, caspase-1 and nuclear factor-κB. Toxicol. Appl. Pharmacol. 254, 56-64. doi: 10.1016/j.taap.2011.04.008
    • (2011) Appl. Pharmacol , vol.254 , pp. 56-64
    • Bae, Y.1    Lee, S.2    Kim, S.-H.3
  • 7
    • 77950493668 scopus 로고    scopus 로고
    • An antiinflammatory dietary mix modulates inflammation and oxidative and metabolic stress in overweight men: A nutrigenomics approach
    • Bakker, G. C., Van Erk, M. J., Pellis, L., Wopereis, S., Rubingh, C. M., Cnubben, N. H., et al. (2010). An antiinflammatory dietary mix modulates inflammation and oxidative and metabolic stress in overweight men: a nutrigenomics approach. Am. J. Clin. Nutr. 91, 1044-1059. doi: 10.3945/ajcn.2009.28822
    • (2010) Am. J. Clin. Nutr , vol.91 , pp. 1044-1059
    • Bakker, G.C.1    Van Erk, M.J.2    Pellis, L.3    Wopereis, S.4    Rubingh, C.M.5    Cnubben, N.H.6
  • 8
    • 43149124005 scopus 로고    scopus 로고
    • (-)-Epigallocatechin gallate, a major constituent of green tea, poisons human type II topoisomerases
    • Bandele, O. J., and Osheroff, N. (2008). (-)-Epigallocatechin gallate, a major constituent of green tea, poisons human type II topoisomerases. Chem. Res. Toxicol. 21, 936-943. doi: 10.1021/tx700434v
    • (2008) Chem. Res. Toxicol , vol.21 , pp. 936-943
    • Bandele, O.J.1    Osheroff, N.2
  • 9
    • 79953906254 scopus 로고    scopus 로고
    • Development of antidrug antibodies against adalimumab and association with disease activity and treatment failure during long-term follow-up
    • Bartelds, G. M., Krieckaert, C. L., Nurmohamed, M. T., Van Schouwenburg, P. A., Lems, W. F., Twisk, J. W., et al. (2011). Development of antidrug antibodies against adalimumab and association with disease activity and treatment failure during long-term follow-up. JAMA 305, 1460-1468. doi: 10.1001/jama.2011.406
    • (2011) JAMA , vol.305 , pp. 1460-1468
    • Bartelds, G.M.1    Krieckaert, C.L.2    Nurmohamed, M.T.3    Van Schouwenburg, P.A.4    Lems, W.F.5    Twisk, J.W.6
  • 10
    • 78650825302 scopus 로고    scopus 로고
    • Green tea minimally affects biomarkers of inflammation in obese subjects with metabolic syndrome
    • Basu, A., Du, M., Sanchez, K., Leyva, M. J., Betts, N. M., Blevins, S., et al. (2011). Green tea minimally affects biomarkers of inflammation in obese subjects with metabolic syndrome. Nutrition 27, 206-213. doi: 10.1016/j.nut.2010.01.015
    • (2011) Nutrition , vol.27 , pp. 206-213
    • Basu, A.1    Du, M.2    Sanchez, K.3    Leyva, M.J.4    Betts, N.M.5    Blevins, S.6
  • 11
    • 0041465794 scopus 로고    scopus 로고
    • Anaphylactic shock caused by immunoglobulin E sensitization after retreatment with the chimeric anti-interleukin-2 receptor monoclonal antibody basiliximab
    • Baudouin, V., Crusiaux, A., Haddad, E., Schandene, L., Goldman, M., Loirat, C., et al. (2003). Anaphylactic shock caused by immunoglobulin E sensitization after retreatment with the chimeric anti-interleukin-2 receptor monoclonal antibody basiliximab. Transplantation 76, 459-463. doi: 10.1097/01.TP.0000073809.65502.8F
    • (2003) Transplantation , vol.76 , pp. 459-463
    • Baudouin, V.1    Crusiaux, A.2    Haddad, E.3    Schandene, L.4    Goldman, M.5    Loirat, C.6
  • 12
    • 78650176358 scopus 로고    scopus 로고
    • Arzanol, a prenylated heterodimeric phloroglucinyl pyrone, inhibits eicosanoid biosynthesis and exhibits anti-inflammatory efficacy in vivo. Biochem
    • Bauer, J., Koeberle, A., Dehm, F., Pollastro, F., Appendino, G., Northoff, H., et al. (2011). Arzanol, a prenylated heterodimeric phloroglucinyl pyrone, inhibits eicosanoid biosynthesis and exhibits anti-inflammatory efficacy in vivo. Biochem. Pharmacol. 81, 259-268. doi: 10.1016/j.bcp.2010.09.025
    • (2011) Pharmacol , vol.81 , pp. 259-268
    • Bauer, J.1    Koeberle, A.2    Dehm, F.3    Pollastro, F.4    Appendino, G.5    Northoff, H.6
  • 13
    • 36949021817 scopus 로고    scopus 로고
    • Active and passive immunity, vaccine types, excipients and licensing. Occup
    • Baxter, D. (2007). Active and passive immunity, vaccine types, excipients and licensing. Occup. Med. 57, 552-556. doi: 10.1093/occmed/kqm110
    • (2007) Med , vol.57 , pp. 552-556
    • Baxter, D.1
  • 14
    • 73149085279 scopus 로고    scopus 로고
    • Monoclonal antibodies and progressive multifocal leukoencephalopathy
    • Berger, J. R., Houff, S. A., and Major, E. O. (2009). Monoclonal antibodies and progressive multifocal leukoencephalopathy. MAbs 1, 583-589. doi: 10.4161/mabs.1.6.9884
    • (2009) Mabs , vol.1 , pp. 583-589
    • Berger, J.R.1    Houff, S.A.2    Major, E.O.3
  • 15
    • 0041837596 scopus 로고    scopus 로고
    • In vivo vascular effects of genistein on a rat model of septic shock induced by lipopolysaccharide
    • Bermejo, A., Zarzuelo, A., and Duarte, J. (2003). In vivo vascular effects of genistein on a rat model of septic shock induced by lipopolysaccharide. J. Cardiovasc. Pharmacol. 42, 329-338. doi: 10.1097/00005344-200309000-00003
    • (2003) J. Cardiovasc. Pharmacol , vol.42 , pp. 329-338
    • Bermejo, A.1    Zarzuelo, A.2    Duarte, J.3
  • 16
    • 37249020371 scopus 로고    scopus 로고
    • Anti-mitotic activity of colchicine and the structural basis for its interaction with tubulin. Med. Res
    • Bhattacharyya, B., Panda, D., Gupta, S., and Banerjee, M. (2008). Anti-mitotic activity of colchicine and the structural basis for its interaction with tubulin. Med. Res. Rev. 28, 155-183. doi: 10.1002/med.20097
    • (2008) Rev , vol.28 , pp. 155-183
    • Bhattacharyya, B.1    Panda, D.2    Gupta, S.3    Banerjee, M.4
  • 17
    • 0034644797 scopus 로고    scopus 로고
    • Differential modulation of nitric oxide production by curcumin in host macrophages and NK cells
    • Bhaumik, S., Jyothi, M. D., and Khar, A. (2000). Differential modulation of nitric oxide production by curcumin in host macrophages and NK cells. FEBS Lett. 483, 78-82. doi: 10.1016/S0014-5793(00)02089-5
    • (2000) FEBS Lett , vol.483 , pp. 78-82
    • Bhaumik, S.1    Jyothi, M.D.2    Khar, A.3
  • 18
    • 10344228747 scopus 로고    scopus 로고
    • Resveratrol inhibits nitric oxide and TNF-α production by lipopolysaccharide-activated microglia
    • Bi, X. L., Yang, J. Y., Dong, Y. X., Wang, J. M., Cui, Y. H., Ikeshima, T., et al. (2005). Resveratrol inhibits nitric oxide and TNF-α production by lipopolysaccharide-activated microglia. Int. Immunopharmacol. 5, 185-193. doi: 10.1016/j.intimp.2004.08.008
    • (2005) Int. Immunopharmacol , vol.5 , pp. 185-193
    • Bi, X.L.1    Yang, J.Y.2    Dong, Y.X.3    Wang, J.M.4    Cui, Y.H.5    Ikeshima, T.6
  • 19
    • 79960691818 scopus 로고    scopus 로고
    • Quercetin reduces markers of oxidative stress and inflammation in sarcoidosis. Clin
    • Boots, A. W., Drent, M., De Boer, V. C., Bast, A., and Haenen, G. R. (2011). Quercetin reduces markers of oxidative stress and inflammation in sarcoidosis. Clin. Nutr. 30, 506-512. doi: 10.1016/j.clnu.2011.01.010
    • (2011) Nutr , vol.30 , pp. 506-512
    • Boots, A.W.1    Drent, M.2    De Boer, V.C.3    Bast, A.4    Haenen, G.R.5
  • 20
    • 43049176634 scopus 로고    scopus 로고
    • Health effects of quercetin: From antioxidant to nutraceutical
    • Boots, A. W., Haenen, G. R., and Bast, A. (2008). Health effects of quercetin: from antioxidant to nutraceutical. Eur. J. Pharmacol. 585, 325-337. doi: 10.1016/j.ejphar.2008.03.008
    • (2008) Eur. J. Pharmacol , vol.585 , pp. 325-337
    • Boots, A.W.1    Haenen, G.R.2    Bast, A.3
  • 21
    • 0014118455 scopus 로고
    • The mechanism of action of colchicine. Colchicine binding to sea urchin eggs and the mitotic apparatus
    • Borisy, G. G., and Taylor, E. W. (1967). The mechanism of action of colchicine. colchicine binding to sea urchin eggs and the mitotic apparatus. J. Cell Biol. 34, 535-548
    • (1967) J. Cell Biol , vol.34 , pp. 535-548
    • Borisy, G.G.1    Taylor, E.W.2
  • 22
    • 33847278423 scopus 로고    scopus 로고
    • Medicinal chemistry and pharmacology of genus Tripterygium (Celastraceae)
    • Brinker, A. M., Ma, J., Lipsky, P. E., and Raskin, I. (2007). Medicinal chemistry and pharmacology of genus Tripterygium (Celastraceae). Phytochemistry 68, 732-766. doi: 10.1016/j.phytochem.2006.11.029
    • (2007) Phytochemistry , vol.68 , pp. 732-766
    • Brinker, A.M.1    Ma, J.2    Lipsky, P.E.3    Raskin, I.4
  • 23
    • 67849121334 scopus 로고    scopus 로고
    • Efficacy of an Andrographis paniculata composition for the relief of rheumatoid arthritis symptoms: A prospective randomized placebo-controlled trial. Clin
    • Burgos, R. A., Hancke, J. L., Bertoglio, J. C., Aguirre, V., Arriagada, S., Calvo, M., et al. (2009). Efficacy of an Andrographis paniculata composition for the relief of rheumatoid arthritis symptoms: a prospective randomized placebo-controlled trial. Clin. Rheumatol. 28, 931-946. doi: 10.1007/s10067-009-1180-5
    • (2009) Rheumatol , vol.28 , pp. 931-946
    • Burgos, R.A.1    Hancke, J.L.2    Bertoglio, J.C.3    Aguirre, V.4    Arriagada, S.5    Calvo, M.6
  • 24
    • 84971500442 scopus 로고    scopus 로고
    • Topical herbal therapies for treating osteoarthritis
    • Cameron, M., and Chrubasik, S. (2013). Topical herbal therapies for treating osteoarthritis. Cochrane Database Syst. Rev. 5, CD010538. doi: 10.1002/14651858.CD010538
    • (2013) Cochrane Database Syst. Rev , vol.5
    • Cameron, M.1    Chrubasik, S.2
  • 25
    • 0023035484 scopus 로고
    • Inosine Pranobex
    • Campoli-Richards, D., Sorkin, E., and Heel, R. (1986). Inosine Pranobex. Drugs 32, 383-424. doi: 10.2165/00003495-198632050-00001
    • (1986) Drugs , vol.32 , pp. 383-424
    • Campoli-Richards, D.1    Sorkin, E.2    Heel, R.3
  • 26
    • 0030777012 scopus 로고    scopus 로고
    • The capsaicin receptor: A heat-activated ion channel in the pain pathway
    • Caterina, M. J., Schumacher, M. A., Tominaga, M., Rosen, T. A., Levine, J. D., and Julius, D. (1997). The capsaicin receptor: a heat-activated ion channel in the pain pathway. Nature 389, 816-824. doi: 10.1038/39807
    • (1997) Nature , vol.389 , pp. 816-824
    • Caterina, M.J.1    Schumacher, M.A.2    Tominaga, M.3    Rosen, T.A.4    Levine, J.D.5    Julius, D.6
  • 27
    • 33846816486 scopus 로고    scopus 로고
    • Anti-inflammatory effects of isoflavones are dependent on flow and human endothelial cell PPAR gamma
    • Chacko, B. K., Chandler, R. T., D’alessandro, T. L., Mundhekar, A., Khoo, N. K., Botting, N., et al. (2007). Anti-inflammatory effects of isoflavones are dependent on flow and human endothelial cell PPAR gamma. J. Nutr. 137, 351-356.
    • (2007) J. Nutr , vol.137 , pp. 351-356
    • Chacko, B.K.1    Chandler, R.T.2    D’Alessandro, T.L.3    Mundhekar, A.4    Khoo, N.K.5    Botting, N.6
  • 28
    • 84860518210 scopus 로고    scopus 로고
    • Baicalein inhibits pulmonary carcinogenesis-associated inflammation and interferes with COX-2, MMP-2 and MMP-9 expressions in-vivo
    • Chandrashekar, N., Selvamani, A., Subramanian, R., Pandi, A., and Thiruvengadam, D. (2012). Baicalein inhibits pulmonary carcinogenesis-associated inflammation and interferes with COX-2, MMP-2 and MMP-9 expressions in-vivo. Toxicol. Appl. Pharmacol. 261, 10-21. doi: 10.1016/j.taap.2012.02.004
    • (2012) Toxicol. Appl. Pharmacol , vol.261 , pp. 10-21
    • Chandrashekar, N.1    Selvamani, A.2    Subramanian, R.3    Pandi, A.4    Thiruvengadam, D.5
  • 29
    • 36148988399 scopus 로고    scopus 로고
    • Luteolin suppresses inflammation-associated gene expression by blocking NF-κB and AP-1 activation pathway in mouse alveolar macrophages
    • Chen, C. Y., Peng, W. H., Tsai, K. D., and Hsu, S. L. (2007). Luteolin suppresses inflammation-associated gene expression by blocking NF-κB and AP-1 activation pathway in mouse alveolar macrophages. Life Sci. 81, 1602-1614. doi: 10.1016/j.lfs.2007.09.028
    • (2007) Life Sci , vol.81 , pp. 1602-1614
    • Chen, C.Y.1    Peng, W.H.2    Tsai, K.D.3    Hsu, S.L.4
  • 30
    • 84890859996 scopus 로고    scopus 로고
    • Luteolin exhibits anti-inflammatory effects by blocking the activity of heat shock protein 90 in macrophages. Biochem. Biophys. Res
    • Chen, D., Bi, A., Dong, X., Jiang, Y., Rui, B., Liu, J., et al. (2014). Luteolin exhibits anti-inflammatory effects by blocking the activity of heat shock protein 90 in macrophages. Biochem. Biophys. Res. Commun. 443, 326-332. doi: 10.1016/j.bbrc.2013.11.122
    • (2014) Commun , vol.443 , pp. 326-332
    • Chen, D.1    Bi, A.2    Dong, X.3    Jiang, Y.4    Rui, B.5    Liu, J.6
  • 31
    • 80052026371 scopus 로고    scopus 로고
    • Anti-inflammatory activities of Chinese herbal medicine sinomenine and Liang Miao San on tumor necrosis factor-alpha-activated human fibroblast-like synoviocytes in rheumatoid arthritis
    • Chen, D. P., Wong, C. K., Leung, P. C., Fung, K. P., Lau, C. B., Lau, C. P., et al. (2011). Anti-inflammatory activities of Chinese herbal medicine sinomenine and Liang Miao San on tumor necrosis factor-alpha-activated human fibroblast-like synoviocytes in rheumatoid arthritis. J. Ethnopharmacol. 137, 457-468. doi: 10.1016/j.jep.2011.05.048
    • (2011) J. Ethnopharmacol , vol.137 , pp. 457-468
    • Chen, D.P.1    Wong, C.K.2    Leung, P.C.3    Fung, K.P.4    Lau, C.B.5    Lau, C.P.6
  • 32
    • 0034213030 scopus 로고    scopus 로고
    • Oroxylin A inhibition of lipopolysaccharide-induced iNOS and COX-2 gene expression via suppression of nuclear factor-κB activation
    • Chen, Y.-C., Yang, L. L., and Lee, T. J. F. (2000). Oroxylin A inhibition of lipopolysaccharide-induced iNOS and COX-2 gene expression via suppression of nuclear factor-κB activation. Biochem. Pharmacol. 59, 1445-1457. doi: 10.1016/S0006-2952(00)00255-0
    • (2000) Biochem. Pharmacol , vol.59 , pp. 1445-1457
    • Chen, Y.-C.1    Yang, L.L.2    Lee, T.J.F.3
  • 33
    • 0034001308 scopus 로고    scopus 로고
    • Mechanisms of suppression of inducible nitric oxide synthase (INOS) expression in RAW 264.7 cells by andrographolide
    • Chiou, W. F., Chen, C. F., and Lin, J. J. (2000). Mechanisms of suppression of inducible nitric oxide synthase (iNOS) expression in RAW 264.7 cells by andrographolide. Br. J. Pharmacol. 129, 1553-1560. doi: 10.1038/sj.bjp.0703191
    • (2000) Br. J. Pharmacol , vol.129 , pp. 1553-1560
    • Chiou, W.F.1    Chen, C.F.2    Lin, J.J.3
  • 34
    • 84862109622 scopus 로고    scopus 로고
    • Antioxidative and anti-inflammatory effect of quercetin and its glycosides isolated from mampat (Cratoxylum formosum). Food Sci
    • Choi, S. J., Tai, B., Cuong, N., Kim, Y. H., and Jang, H. D. (2012). Antioxidative and anti-inflammatory effect of quercetin and its glycosides isolated from mampat (Cratoxylum formosum). Food Sci. Biotechnol. 21, 587-595. doi: 10.1007/s10068-012-0075-4
    • (2012) Biotechnol , vol.21 , pp. 587-595
    • Choi, S.J.1    Tai, B.2    Cuong, N.3    Kim, Y.H.4    Jang, H.D.5
  • 35
    • 84862903681 scopus 로고    scopus 로고
    • Anti-inflammatory effects of (Z)-ligustilide through suppression of mitogen-activated protein kinases and nuclear factor-κB activation pathways. Arch. Pharm
    • Chung, J., Choi, R., Seo, E.-K., Nam, J.-W., Dong, M.-S., Shin, E., et al. (2012). Anti-inflammatory effects of (Z)-ligustilide through suppression of mitogen-activated protein kinases and nuclear factor-κB activation pathways. Arch. Pharm. Res. 35, 723-732. doi: 10.1007/s12272-012-0417-z
    • (2012) Res , vol.35 , pp. 723-732
    • Chung, J.1    Choi, R.2    Seo, E.-K.3    Nam, J.-W.4    Dong, M.-S.5    Shin, E.6
  • 36
    • 0035461363 scopus 로고    scopus 로고
    • Mechanisms of inhibition of the Ras-MAP kinase signaling pathway in 30.7b Ras 12 cells by tea polyphenols (-)-epigallocatechin-3-gallate and theaflavin-3,3’-digallate
    • Chung, J. Y., Park, J. O., Phyu, H., Dong, Z., and Yang, C. S. (2001). Mechanisms of inhibition of the Ras-MAP kinase signaling pathway in 30.7b Ras 12 cells by tea polyphenols (-)-epigallocatechin-3-gallate and theaflavin-3,3’-digallate. FASEB J. 15, 2022-2024. doi: 10.1096/fj.01-0031fje
    • (2001) FASEB J , vol.15 , pp. 2022-2024
    • Chung, J.Y.1    Park, J.O.2    Phyu, H.3    Dong, Z.4    Yang, C.S.5
  • 37
    • 0029745336 scopus 로고    scopus 로고
    • Tyrosine kinase inhibitors prevent cytokine-induced expression of iNOS and COX-2 by human islets
    • Corbett, J. A., Kwon, G., Marino, M. H., Rodi, C. P., Sullivan, P. M., Turk, J., et al. (1996). Tyrosine kinase inhibitors prevent cytokine-induced expression of iNOS and COX-2 by human islets. Am. J. Physiol. 270, C1581-C1587
    • (1996) Am. J. Physiol , vol.270 , pp. C1581-C1587
    • Corbett, J.A.1    Kwon, G.2    Marino, M.H.3    Rodi, C.P.4    Sullivan, P.M.5    Turk, J.6
  • 38
    • 20344402268 scopus 로고    scopus 로고
    • Antiallergic agents from natural sources 9. Inhibition of nitric oxide production by novel chalcone derivatives from Mallotus philippinensis (Euphorbiaceae)
    • Daikonya, A., Katsuki, S., and Kitanaka, S. (2004). Antiallergic agents from natural sources 9. Inhibition of nitric oxide production by novel chalcone derivatives from Mallotus philippinensis (Euphorbiaceae). Chem. Pharm. Bull. 52, 1326-1329. doi: 10.1248/cpb.52.1326
    • (2004) Chem. Pharm. Bull , vol.52 , pp. 1326-1329
    • Daikonya, A.1    Katsuki, S.2    Kitanaka, S.3
  • 39
    • 84867890410 scopus 로고    scopus 로고
    • Colchicine for prevention of early atrial fibrillation recurrence after pulmonary vein isolation: A randomized controlled study
    • Deftereos, S., Giannopoulos, G., Kossyvakis, C., Efremidis, M., Panagopoulou, V., Kaoukis, A., et al. (2012). Colchicine for prevention of early atrial fibrillation recurrence after pulmonary vein isolation: a randomized controlled study. J. Am. Coll. Cardiol. 60, 1790-1796. doi: 10.1016/j.jacc.2012.07.031
    • (2012) J. Am. Coll. Cardiol , vol.60 , pp. 1790-1796
    • Deftereos, S.1    Giannopoulos, G.2    Kossyvakis, C.3    Efremidis, M.4    Panagopoulou, V.5    Kaoukis, A.6
  • 40
    • 79955128316 scopus 로고    scopus 로고
    • Evidence for the efficacy of complementary and alternative medicines in the management of osteoarthritis: A systematic review
    • De Silva, V., El-Metwally, A., Ernst, E., Lewith, G., and Macfarlane, G. J. (2011). Evidence for the efficacy of complementary and alternative medicines in the management of osteoarthritis: a systematic review. Rheumatology 50, 911-920. doi: 10.1093/rheumatology/keq379
    • (2011) Rheumatology , vol.50 , pp. 911-920
    • De Silva, V.1    El-Metwally, A.2    Ernst, E.3    Lewith, G.4    Macfarlane, G.J.5
  • 41
    • 34347221946 scopus 로고    scopus 로고
    • Curcumin suppresses growth and chemoresistance of human glioblastoma cells via AP-1 and NFκB transcription factors
    • Dhandapani, K. M., Mahesh, V. B., and Brann, D. W. (2007). Curcumin suppresses growth and chemoresistance of human glioblastoma cells via AP-1 and NFκB transcription factors. J. Neurochem. 102, 522-538. doi: 10.1111/j.1471-4159.2007.04633.x
    • (2007) J. Neurochem , vol.102 , pp. 522-538
    • Dhandapani, K.M.1    Mahesh, V.B.2    Brann, D.W.3
  • 43
    • 84888205018 scopus 로고    scopus 로고
    • Anti-inflammatory activity of baicalein in LPS-stimulated RAW264.7 macrophages via estrogen receptor and Nf-κB-dependent pathways
    • Fan, G. W., Zhang, Y., Jiang, X., Zhu, Y., Wang, B., Su, L., et al. (2013). Anti-inflammatory activity of baicalein in LPS-stimulated RAW264.7 macrophages via estrogen receptor and Nf-κB-dependent pathways. Inflammation 36, 1584-1591. doi: 10.1007/s10753-013-9703-2
    • (2013) Inflammation , vol.36 , pp. 1584-1591
    • Fan, G.W.1    Zhang, Y.2    Jiang, X.3    Zhu, Y.4    Wang, B.5    Su, L.6
  • 44
    • 0028895694 scopus 로고
    • Genistein, a dietary ingested isoflavonoid, inhibits cell proliferation and in vitro angiogenesis
    • Fotsis, T., Pepper, M., Adlercreutz, H., Hase, T., Montesano, R., and Schweigerer, L. (1995). Genistein, a dietary ingested isoflavonoid, inhibits cell proliferation and in vitro angiogenesis. J. Nutr. 125, 790S-797S.
    • (1995) J. Nutr , vol.125 , pp. 790S-797S
    • Fotsis, T.1    Pepper, M.2    Adlercreutz, H.3    Hase, T.4    Montesano, R.5    Schweigerer, L.6
  • 45
    • 2942624044 scopus 로고    scopus 로고
    • Immunomodulatory activity of curcumin: Suppression of lymphocyte proliferation, development of cell-mediated cytotoxicity, and cytokine production in vitro
    • Gao, X., Kuo, J., Jiang, H., Deeb, D., Liu, Y., Divine, G., et al. (2004). Immunomodulatory activity of curcumin: suppression of lymphocyte proliferation, development of cell-mediated cytotoxicity, and cytokine production in vitro. Biochem. Pharmacol. 68, 51-61. doi: 10.1016/j.bcp.2004.03.015
    • (2004) Biochem. Pharmacol , vol.68 , pp. 51-61
    • Gao, X.1    Kuo, J.2    Jiang, H.3    Deeb, D.4    Liu, Y.5    Divine, G.6
  • 46
    • 0035503936 scopus 로고    scopus 로고
    • Immunomodulatory activity of resveratrol: Suppression of lymphocyte proliferation, development of cell-mediated cytotoxicity, and cytokine production
    • Gao, X., Xu, Y. X., Janakiraman, N., Chapman, R. A., and Gautam, S. C. (2001). Immunomodulatory activity of resveratrol: suppression of lymphocyte proliferation, development of cell-mediated cytotoxicity, and cytokine production. Biochem. Pharmacol. 62, 1299-1308. doi: 10.1016/S0006-2952(01)00775-4
    • (2001) Biochem. Pharmacol , vol.62 , pp. 1299-1308
    • Gao, X.1    Xu, Y.X.2    Janakiraman, N.3    Chapman, R.A.4    Gautam, S.C.5
  • 47
    • 84855343027 scopus 로고    scopus 로고
    • Anti-inflammatory effects of sophocarpine in LPS-induced RAW 264.7 cells via NF-κB and MAPKs signaling pathways. Toxicol
    • Gao, Y., Jiang, W., Dong, C., Li, C., Fu, X., Min, L., et al. (2012). Anti-inflammatory effects of sophocarpine in LPS-induced RAW 264.7 cells via NF-κB and MAPKs signaling pathways. Toxicol. In Vitro 26, 1-6
    • (2012) Vitro , vol.26 , pp. 1-6
    • Gao, Y.1    Jiang, W.2    Dong, C.3    Li, C.4    Fu, X.5    Min, L.6
  • 48
    • 84858975166 scopus 로고    scopus 로고
    • San Diego LaJolla, CA: Professor of Pharmacology & Medicine University of California
    • Gilman’s, G. (2008). Manual of Pharmacology and Therapeutics. San Diego LaJolla, CA: Professor of Pharmacology & Medicine University of California.
    • (2008) Manual of Pharmacology and Therapeutics
    • Gilman’S, G.1
  • 50
    • 33847642568 scopus 로고    scopus 로고
    • Anti-hepatitis B virus activity of wogonin in vitro and in vivo
    • Guo, Q., Zhao, L., You, Q., Yang, Y., Gu, H., Song, G., et al. (2007). Anti-hepatitis B virus activity of wogonin in vitro and in vivo. Antiviral Res. 74, 16-24. doi: 10.1016/j.antiviral.2007.01.002
    • (2007) Antiviral Res , vol.74 , pp. 16-24
    • Guo, Q.1    Zhao, L.2    You, Q.3    Yang, Y.4    Gu, H.5    Song, G.6
  • 51
    • 84866953951 scopus 로고    scopus 로고
    • Capsaicin for neuropathic pain: Linking traditional medicine and molecular biology
    • Haanpaa, M., and Treede, R. D. (2012). Capsaicin for neuropathic pain: linking traditional medicine and molecular biology. Eur. Neurol. 68, 264-275. doi: 10.1159/000339944
    • (2012) Eur. Neurol , vol.68 , pp. 264-275
    • Haanpaa, M.1    Treede, R.D.2
  • 52
    • 34548562078 scopus 로고    scopus 로고
    • Anti-inflammatory effects of flavonoids: Genistein, kaempferol, quercetin, and daidzein inhibit STAT-1 and NF-κB activations, whereas flavone, isorhamnetin, naringenin, and pelargonidin inhibit only NF-κB
    • Hamalainen, M., Nieminen, R., Vuorela, P., Heinonen, M., and Moilanen, E. (2007). Anti-inflammatory effects of flavonoids: genistein, kaempferol, quercetin, and daidzein inhibit STAT-1 and NF-κB activations, whereas flavone, isorhamnetin, naringenin, and pelargonidin inhibit only NF-κB activation along with their inhibitory effect on iNOS expression and NO production in activated macrophages. Mediators Inflamm. 2007:45673. doi: 10.1155/2007/45673
    • (2007) Mediators Inflamm , vol.2007
    • Hamalainen, M.1    Nieminen, R.2    Vuorela, P.3    Heinonen, M.4    Moilanen, E.5
  • 54
    • 33750613612 scopus 로고    scopus 로고
    • The reduction of hypoxia-induced and reoxygenation-induced apoptosis in rat islets by epigallocatechin gallate. Transplant
    • Hara, Y., Fujino, M., Adachi, K., and Li, X. K. (2006). The reduction of hypoxia-induced and reoxygenation-induced apoptosis in rat islets by epigallocatechin gallate. Transplant. Proc. 38, 2722-2725. doi: 10.1016/j.transproceed.2006.08.010
    • (2006) Proc , vol.38 , pp. 2722-2725
    • Hara, Y.1    Fujino, M.2    Adachi, K.3    Li, X.K.4
  • 55
    • 66449137250 scopus 로고    scopus 로고
    • In vitro and in vivo modulation of cartilage degradation by a standardized Centella asiatica fraction
    • Hartog, A., Smit, H. F., Van Der Kraan, P. M., Hoijer, M. A., and Garssen, J. (2009). In vitro and in vivo modulation of cartilage degradation by a standardized Centella asiatica fraction. Exp. Biol. Med. 234, 617-623. doi: 10.3181/0810-RM-298
    • (2009) Exp. Biol. Med , vol.234 , pp. 617-623
    • Hartog, A.1    Smit, H.F.2    Van Der Kraan, P.M.3    Hoijer, M.A.4    Garssen, J.5
  • 56
    • 77957252267 scopus 로고    scopus 로고
    • A 12-week supplementation with quercetin does not affect natural killer cell activity, granulocyte oxidative burst activity or granulocyte phagocytosis in female human subjects
    • Heinz, S. A., Henson, D. A., Nieman, D. C., Austin, M. D., and Jin, F. (2010). A 12-week supplementation with quercetin does not affect natural killer cell activity, granulocyte oxidative burst activity or granulocyte phagocytosis in female human subjects. Br. J. Nutr. 104, 849-857. doi: 10.1017/S000711451000156X
    • (2010) Br. J. Nutr , vol.104 , pp. 849-857
    • Heinz, S.A.1    Henson, D.A.2    Nieman, D.C.3    Austin, M.D.4    Jin, F.5
  • 57
    • 15944409586 scopus 로고    scopus 로고
    • Andrographolide interferes with binding of nuclear factor-kappaB to DNA in HL-60-derived neutrophilic cells
    • Hidalgo, M. A., Romero, A., Figueroa, J., Cortes, P., Concha, I. I., Hancke, J. L., et al. (2005). Andrographolide interferes with binding of nuclear factor-kappaB to DNA in HL-60-derived neutrophilic cells. Br. J. Pharmacol. 144, 680-686. doi: 10.1038/sj.bjp.0706105
    • (2005) Br. J. Pharmacol , vol.144 , pp. 680-686
    • Hidalgo, M.A.1    Romero, A.2    Figueroa, J.3    Cortes, P.4    Concha, I.I.5    Hancke, J.L.6
  • 58
    • 43049159523 scopus 로고    scopus 로고
    • Phorbol ester-stimulated NF-κB-dependent transcription: Roles for isoforms of novel protein kinase C
    • Holden, N. S., Squires, P. E., Kaur, M., Bland, R., Jones, C. E., and Newton, R. (2008). Phorbol ester-stimulated NF-κB-dependent transcription: roles for isoforms of novel protein kinase C. Cell. Signal. 20, 1338-1348. doi: 10.1016/j.cellsig.2008.03.001
    • (2008) Cell. Signal , vol.20 , pp. 1338-1348
    • Holden, N.S.1    Squires, P.E.2    Kaur, M.3    Bland, R.4    Jones, C.E.5    Newton, R.6
  • 59
    • 0034234254 scopus 로고    scopus 로고
    • Chemopreventive properties of trans-resveratrol are associated with inhibition of activation of the IκB kinase
    • Holmes-McNary, M., and Baldwin, A. S. Jr. (2000). Chemopreventive properties of trans-resveratrol are associated with inhibition of activation of the IκB kinase. Cancer Res. 60, 3477-3483
    • (2000) Cancer Res , vol.60 , pp. 3477-3483
    • Holmes-McNary, M.1    Baldwin, A.S.2
  • 60
    • 34247114295 scopus 로고    scopus 로고
    • (-)-Epigallocatechin-3-gallate inhibits monocyte chemotactic protein-1 expression in endothelial cells via blocking NF-κB signaling
    • Hong, M. H., Kim, M. H., Chang, H. J., Kim, N. H., Shin, B. A., Ahn, B. W., et al. (2007). (-)-Epigallocatechin-3-gallate inhibits monocyte chemotactic protein-1 expression in endothelial cells via blocking NF-κB signaling. Life Sci. 80, 1957-1965. doi: 10.1016/j.lfs.2007.02.024
    • (2007) Life Sci , vol.80 , pp. 1957-1965
    • Hong, M.H.1    Kim, M.H.2    Chang, H.J.3    Kim, N.H.4    Shin, B.A.5    Ahn, B.W.6
  • 61
    • 34547653779 scopus 로고    scopus 로고
    • Genistein reduces the production of proinflammatory molecules in human chondrocytes
    • Hooshmand, S., Soung Do, Y., Lucas, E. A., Madihally, S. V., Levenson, C. W., and Arjmandi, B. H. (2007). Genistein reduces the production of proinflammatory molecules in human chondrocytes. J. Nutr. Biochem. 18, 609-614. doi: 10.1016/j.jnutbio.2006.11.006
    • (2007) J. Nutr. Biochem , vol.18 , pp. 609-614
    • Hooshmand, S.1    Soung Do, Y.2    Lucas, E.A.3    Madihally, S.V.4    Levenson, C.W.5    Arjmandi, B.H.6
  • 62
    • 13844299448 scopus 로고    scopus 로고
    • Decreased pro-inflammatory cytokine production by LPS-stimulated PBMC upon in vitro incubation with the flavonoids apigenin, luteolin or chrysin, due to selective elimination of monocytes/macrophages
    • Hougee, S., Sanders, A., Faber, J., Graus, Y. M. F., Van Den Berg, W. B., Garssen, J., et al. (2005). Decreased pro-inflammatory cytokine production by LPS-stimulated PBMC upon in vitro incubation with the flavonoids apigenin, luteolin or chrysin, due to selective elimination of monocytes/macrophages. Biochem. Pharmacol. 69, 241-248. doi: 10.1016/j.bcp.2004.10.002
    • (2005) Biochem. Pharmacol , vol.69 , pp. 241-248
    • Hougee, S.1    Sanders, A.2    Faber, J.3    Graus, Y.M.F.4    Van Den Berg, W.B.5    Garssen, J.6
  • 63
    • 84870861356 scopus 로고    scopus 로고
    • Tetramethylpyrazine accelerates the function recovery of traumatic spinal cord in rat model by attenuating inflammation
    • Hu, J.-Z., Huang, J. H., Xiao, Z. M., Li, J. H., Li, X. M., and Lu, H. B. (2013). Tetramethylpyrazine accelerates the function recovery of traumatic spinal cord in rat model by attenuating inflammation. J. Neurol. Sci. 324, 94-99. doi: 10.1016/j.jns.2012.10.009
    • (2013) J. Neurol. Sci , vol.324 , pp. 94-99
    • Hu, J.-Z.1    Huang, J.H.2    Xiao, Z.M.3    Li, J.H.4    Li, X.M.5    Lu, H.B.6
  • 64
    • 25444478136 scopus 로고    scopus 로고
    • Colchicine in addition to conventional therapy for acute pericarditis: Results of the colchicine for acute PEricarditis (COPE) trial
    • Imazio, M., Bobbio, M., Cecchi, E., Demarie, D., Demichelis, B., Pomari, F., et al. (2005a). Colchicine in addition to conventional therapy for acute pericarditis: results of the colchicine for acute PEricarditis (COPE) trial. Circulation 112, 2012-2016. doi: 10.1161/CIRCULATIONAHA.105.542738
    • (2005) Circulation , vol.112 , pp. 2012-2016
    • Imazio, M.1    Bobbio, M.2    Cecchi, E.3    Demarie, D.4    Demichelis, B.5    Pomari, F.6
  • 65
    • 25444510637 scopus 로고    scopus 로고
    • Colchicine as first-choice therapy for recurrent pericarditis: Results of the CORE (Colchicine for REcurrent pericarditis) trial
    • Imazio, M., Bobbio, M., Cecchi, E., Demarie, D., Pomari, F., Moratti, M., et al. (2005b). Colchicine as first-choice therapy for recurrent pericarditis: results of the CORE (Colchicine for REcurrent pericarditis) trial. Arch. Intern. Med. 165, 1987-1991. doi: 10.1001/archinte.165.17.1987
    • (2005) Arch. Intern. Med , vol.165 , pp. 1987-1991
    • Imazio, M.1    Bobbio, M.2    Cecchi, E.3    Demarie, D.4    Pomari, F.5    Moratti, M.6
  • 66
    • 80053504821 scopus 로고    scopus 로고
    • Colchicine for recurrent pericarditis (CORP): A randomized trial
    • Imazio, M., Brucato, A., Cemin, R., Ferrua, S., Belli, R., Maestroni, S., et al. (2011). Colchicine for recurrent pericarditis (CORP): a randomized trial. Ann. Intern. Med. 155, 409-414. doi: 10.7326/0003-4819-155-7-201110040-00359
    • (2011) Ann. Intern. Med , vol.155 , pp. 409-414
    • Imazio, M.1    Brucato, A.2    Cemin, R.3    Ferrua, S.4    Belli, R.5    Maestroni, S.6
  • 68
    • 77958548721 scopus 로고    scopus 로고
    • Colchicine for the prevention of the post-pericardiotomy syndrome (COPPS): A multicentre, randomized, double-blind, placebo-controlled trial
    • Imazio, M., Trinchero, R., Brucato, A., Rovere, M. E., Gandino, A., Cemin, R., et al. (2010). Colchicine for the prevention of the post-pericardiotomy syndrome (COPPS): a multicentre, randomized, double-blind, placebo-controlled trial. Eur. Heart J. 31, 2749-2754. doi: 10.1093/eurheartj/ehq319
    • (2010) Eur. Heart J , vol.31 , pp. 2749-2754
    • Imazio, M.1    Trinchero, R.2    Brucato, A.3    Rovere, M.E.4    Gandino, A.5    Cemin, R.6
  • 69
    • 11844268084 scopus 로고    scopus 로고
    • Andrographolide interferes with T cell activation and reduces experimental autoimmune encephalomyelitis in the mouse
    • Iruretagoyena, M. I., Tobar, J. A., Gonzalez, P. A., Sepulveda, S. E., Figueroa, C. A., Burgos, R. A., et al. (2005). Andrographolide interferes with T cell activation and reduces experimental autoimmune encephalomyelitis in the mouse. J. Pharmacol. Exp. Ther. 312, 366-372. doi: 10.1124/jpet.104.072512
    • (2005) J. Pharmacol. Exp. Ther , vol.312 , pp. 366-372
    • Iruretagoyena, M.I.1    Tobar, J.A.2    Gonzalez, P.A.3    Sepulveda, S.E.4    Figueroa, C.A.5    Burgos, R.A.6
  • 70
    • 68849103758 scopus 로고    scopus 로고
    • Resveratrol attenuates C5a-induced inflammatory responses in vitro and in vivo by inhibiting phospholipase D and sphingosine kinase activities
    • Issuree, P. D., Pushparaj, P. N., Pervaiz, S., and Melendez, A. J. (2009). Resveratrol attenuates C5a-induced inflammatory responses in vitro and in vivo by inhibiting phospholipase D and sphingosine kinase activities. FASEB J. 23, 2412-2424. doi: 10.1096/fj.09-130542
    • (2009) FASEB J , vol.23 , pp. 2412-2424
    • Issuree, P.D.1    Pushparaj, P.N.2    Pervaiz, S.3    Melendez, A.J.4
  • 71
    • 0033584927 scopus 로고    scopus 로고
    • Protein synthesis inhibition by flavonoids: Roles of eukaryotic initiation factor 2alpha kinases. Biochem. Biophys. Res
    • Ito, T., Warnken, S. P., and May, W. S. (1999). Protein synthesis inhibition by flavonoids: roles of eukaryotic initiation factor 2alpha kinases. Biochem. Biophys. Res. Commun. 265, 589-594. doi: 10.1006/bbrc.1999.1727
    • (1999) Commun , vol.265 , pp. 589-594
    • Ito, T.1    Warnken, S.P.2    May, W.S.3
  • 73
    • 0031056998 scopus 로고    scopus 로고
    • Presence of an acidic glycoprotein in the serum of arthritic rats: Modulation by capsaicin and curcumin
    • Joe, B., Rao, U. J., and Lokesh, B. R. (1997). Presence of an acidic glycoprotein in the serum of arthritic rats: modulation by capsaicin and curcumin. Mol. Cell. Biochem. 169, 125-134. doi: 10.1023/a:1006877928703
    • (1997) Mol. Cell. Biochem , vol.169 , pp. 125-134
    • Joe, B.1    Rao, U.J.2    Lokesh, B.R.3
  • 74
    • 67650973761 scopus 로고    scopus 로고
    • Anti-inflammatory properties of curcumin, a major constituent of Curcuma longa: A review of preclinical and clinical research
    • Jurenka, J. S. (2009). Anti-inflammatory properties of curcumin, a major constituent of Curcuma longa: a review of preclinical and clinical research. Altern. Med. Rev. 14, 141-153.
    • (2009) Altern. Med. Rev , vol.14 , pp. 141-153
    • Jurenka, J.S.1
  • 75
    • 65849187567 scopus 로고    scopus 로고
    • Apigenin, a non-mutagenic dietary flavonoid, suppresses lupus by inhibiting autoantigen presentation for expansion of autoreactive Th1 and Th17 cells
    • Kang, H.-K., Ecklund, D., Liu, M., and Datta, S. K. (2009). Apigenin, a non-mutagenic dietary flavonoid, suppresses lupus by inhibiting autoantigen presentation for expansion of autoreactive Th1 and Th17 cells. Arthritis Res. Ther. 11, R59. doi: 10.1186/ar2682
    • (2009) Arthritis Res. Ther , vol.11
    • Kang, H.-K.1    Ecklund, D.2    Liu, M.3    Datta, S.K.4
  • 76
    • 84856102254 scopus 로고    scopus 로고
    • Lycorine inhibits lipopolysaccharide-induced iNOS and COX-2 up-regulation in RAW264.7 cells through suppressing P38 and STATs activation and increases the survival rate of mice after LPS challenge
    • Kang, J., Zhang, Y., Cao, X., Fan, J., Li, G., Wang, Q., et al. (2012). Lycorine inhibits lipopolysaccharide-induced iNOS and COX-2 up-regulation in RAW264.7 cells through suppressing P38 and STATs activation and increases the survival rate of mice after LPS challenge. Int. Immunopharmacol. 12, 249-256. doi: 10.1016/j.intimp.2011.11.018
    • (2012) Int. Immunopharmacol , vol.12 , pp. 249-256
    • Kang, J.1    Zhang, Y.2    Cao, X.3    Fan, J.4    Li, G.5    Wang, Q.6
  • 77
    • 80051785668 scopus 로고    scopus 로고
    • Anti-inflammatory effect of flavonoids isolated from Korea Citrus aurantium L. On lipopolysaccharide-induced mouse macrophage RAW 264.7 cells by blocking of nuclear factor-kappa B (NF-κB) and mitogen-activated protein kinase (MAPK) signalling pathways
    • Kang, S. R., Park, K. I., Park, H. S., Lee, D. H., Kim, J. A., Nagappan, A., et al. (2011). Anti-inflammatory effect of flavonoids isolated from Korea Citrus aurantium L. on lipopolysaccharide-induced mouse macrophage RAW 264.7 cells by blocking of nuclear factor-kappa B (NF-κB) and mitogen-activated protein kinase (MAPK) signalling pathways. Food Chem. 129, 1721-1728. doi: 10.1016/j.foodchem.2011.06.039
    • (2011) Food Chem , vol.129 , pp. 1721-1728
    • Kang, S.R.1    Park, K.I.2    Park, H.S.3    Lee, D.H.4    Kim, J.A.5    Nagappan, A.6
  • 78
    • 79951853010 scopus 로고    scopus 로고
    • Molecular targets of celastrol derived from Thunder of God Vine: Potential role in the treatment of inflammatory disorders and cancer
    • Kannaiyan, R., Shanmugam, M. K., and Sethi, G. (2011). Molecular targets of celastrol derived from Thunder of God Vine: potential role in the treatment of inflammatory disorders and cancer. Cancer Lett. 303, 9-20. doi: 10.1016/j.canlet.2010.10.025
    • (2011) Cancer Lett , vol.303 , pp. 9-20
    • Kannaiyan, R.1    Shanmugam, M.K.2    Sethi, G.3
  • 80
    • 0035846326 scopus 로고    scopus 로고
    • Tuberculosis associated with infliximab, a tumor necrosis factor alpha-neutralizing agent
    • Keane, J., Gershon, S., Wise, R. P., Mirabile-Levens, E., Kasznica, J., Schwieterman, W. D., et al. (2001). Tuberculosis associated with infliximab, a tumor necrosis factor alpha-neutralizing agent. N. Engl. J. Med. 345, 1098-1104. doi: 10.1056/NEJMoa011110
    • (2001) N. Engl. J. Med , vol.345 , pp. 1098-1104
    • Keane, J.1    Gershon, S.2    Wise, R.P.3    Mirabile-Levens, E.4    Kasznica, J.5    Schwieterman, W.D.6
  • 81
    • 33847027186 scopus 로고    scopus 로고
    • Immunomodulatory effects of two sapogenins 1 and 2 isolated from Luffa cylindrica in Balb/C mice
    • Khajuria, A., Gupta, A., Garai, S., and Wakhloo, B. P. (2007). Immunomodulatory effects of two sapogenins 1 and 2 isolated from Luffa cylindrica in Balb/C mice. Bioorg. Med. Chem. Lett. 17, 1608-1612. doi: 10.1016/j.bmcl.2006.12.091
    • (2007) Bioorg. Med. Chem. Lett , vol.17 , pp. 1608-1612
    • Khajuria, A.1    Gupta, A.2    Garai, S.3    Wakhloo, B.P.4
  • 82
    • 0037346879 scopus 로고    scopus 로고
    • Capsaicin exhibits anti-inflammatory property by inhibiting IkB-a degradation in LPS-stimulated peritoneal macrophages
    • Kim, C. S., Kawada, T., Kim, B. S., Han, I. S., Choe, S. Y., Kurata, T., et al. (2003). Capsaicin exhibits anti-inflammatory property by inhibiting IkB-a degradation in LPS-stimulated peritoneal macrophages. Cell. Signal. 15, 299-306. doi: 10.1016/S0898-6568(02)00086-4
    • (2003) Ignal , vol.15 , pp. 299-306
    • Kim, C.S.1    Kawada, T.2    Kim, B.S.3    Han, I.S.4    Choe, S.Y.5    Kurata, T.6
  • 83
    • 20444402292 scopus 로고    scopus 로고
    • Curcumin inhibits immunostimulatory function of dendritic cells: MAPKs and translocation of NF-κB as potential targets
    • Kim, G. Y., Kim, K. H., Lee, S. H., Yoon, M. S., Lee, H. J., Moon, D. O., et al. (2005). Curcumin inhibits immunostimulatory function of dendritic cells: MAPKs and translocation of NF-κB as potential targets. J. Immunol. 174, 8116-8124. doi: 10.4049/jimmunol.174.12.8116
    • (2005) J. Immunol , vol.174 , pp. 8116-8124
    • Kim, G.Y.1    Kim, K.H.2    Lee, S.H.3    Yoon, M.S.4    Lee, H.J.5    Moon, D.O.6
  • 84
    • 84859953055 scopus 로고    scopus 로고
    • Anti-inflammatory effects of apocynin, an inhibitor of NADPH oxidase, in airway inflammation
    • Kim, S. Y., Moon, K. A., Jo, H. Y., Jeong, S., Seon, S. H., Jung, E., et al. (2012). Anti-inflammatory effects of apocynin, an inhibitor of NADPH oxidase, in airway inflammation. Immunol. Cell Biol. 90, 441-448. doi: 10.1038/icb.2011.60
    • (2012) Immunol. Cell Biol , vol.90 , pp. 441-448
    • Kim, S.Y.1    Moon, K.A.2    Jo, H.Y.3    Jeong, S.4    Seon, S.H.5    Jung, E.6
  • 85
    • 2942529395 scopus 로고    scopus 로고
    • Genistein enhances expression of genes involved in fatty acid catabolism through activation of PPARalpha
    • Kim, S., Shin, H. J., Kim, S. Y., Kim, J. H., Lee, Y. S., Kim, D. H., et al. (2004). Genistein enhances expression of genes involved in fatty acid catabolism through activation of PPARalpha. Mol. Cell. Endocrinol. 220, 51-58. doi: 10.1016/j.mce.2004.03.011
    • (2004) Mol. Cell. Endocrinol , vol.220 , pp. 51-58
    • Kim, S.1    Shin, H.J.2    Kim, S.Y.3    Kim, J.H.4    Lee, Y.S.5    Kim, D.H.6
  • 86
    • 80052273994 scopus 로고    scopus 로고
    • Anti-inflammatory, anti-proliferative and anti-atherosclerotic effects of quercetin in human in vitro and in vivo models
    • Kleemann, R., Verschuren, L., Morrison, M., Zadelaar, S., Van Erk, M. J., Wielinga, P. Y., et al. (2011). Anti-inflammatory, anti-proliferative and anti-atherosclerotic effects of quercetin in human in vitro and in vivo models. Atherosclerosis 218, 44-52. doi: 10.1016/j.atherosclerosis.2011.04.023
    • (2011) Atherosclerosis , vol.218 , pp. 44-52
    • Kleemann, R.1    Verschuren, L.2    Morrison, M.3    Zadelaar, S.4    Van Erk, M.J.5    Wielinga, P.Y.6
  • 87
    • 0032862903 scopus 로고    scopus 로고
    • Quercetin inhibits inducible ICAM-1 expression in human endothelial cells through the JNK pathway
    • Kobuchi, H., Roy, S., Sen, C. K., Nguyen, H. G., and Packer, L. (1999). Quercetin inhibits inducible ICAM-1 expression in human endothelial cells through the JNK pathway. Am. J. Physiol. 277, C403-C411.
    • (1999) Am. J. Physiol , vol.277 , pp. C403-C411
    • Kobuchi, H.1    Roy, S.2    Sen, C.K.3    Nguyen, H.G.4    Packer, L.5
  • 88
    • 67650628023 scopus 로고    scopus 로고
    • Myrtucommulone, a natural acylphloroglucinol, inhibits microsomal prostaglandin E(2) synthase-1
    • Koeberle, A., Pollastro, F., Northoff, H., and Werz, O. (2009). Myrtucommulone, a natural acylphloroglucinol, inhibits microsomal prostaglandin E(2) synthase-1. Br. J. Pharmacol. 156, 952-961. doi: 10.1111/j.1476-5381.2009.00070.x
    • (2009) Br. J. Pharmacol , vol.156 , pp. 952-961
    • Koeberle, A.1    Pollastro, F.2    Northoff, H.3    Werz, O.4
  • 89
    • 84880899192 scopus 로고    scopus 로고
    • The anti-inflammatory effect of kaempferol on early atherosclerosis in high cholesterol fed rabbits
    • Kong, L., Luo, C., Li, X., Zhou, Y., and He, H. (2013). The anti-inflammatory effect of kaempferol on early atherosclerosis in high cholesterol fed rabbits. Lipids Health Dis. 12, 112-115. doi: 10.1186/1476-511X-12-115
    • (2013) Lipids Health Dis , vol.12 , pp. 112-115
    • Kong, L.1    Luo, C.2    Li, X.3    Zhou, Y.4    He, H.5
  • 90
    • 22744459004 scopus 로고    scopus 로고
    • Effect of apigenin, kaempferol and resveratrol on the expression of interleukin-1beta and tumor necrosis factor-alpha genes in J774.2 macrophages
    • Kowalski, J., Samojedny, A., Paul, M., Pietsz, G., and Wilczok, T. (2005). Effect of apigenin, kaempferol and resveratrol on the expression of interleukin-1beta and tumor necrosis factor-alpha genes in J774.2 macrophages. Pharmacol. Rep. 57, 390-394.
    • (2005) Pharmacol. Rep , vol.57 , pp. 390-394
    • Kowalski, J.1    Samojedny, A.2    Paul, M.3    Pietsz, G.4    Wilczok, T.5
  • 91
    • 0032520716 scopus 로고    scopus 로고
    • Curcumin (Diferuloylmethane) inhibition of tumor necrosis factor (TNF)-mediated adhesion of monocytes to endothelial cells by suppression of cell surface expression of adhesion molecules and of nuclear factor-kappa B activation. Biochem
    • Kumar, A., Dhawan, S., Hardegen, N. J., and Aggarwal, B. B. (1998). Curcumin (Diferuloylmethane) inhibition of tumor necrosis factor (TNF)-mediated adhesion of monocytes to endothelial cells by suppression of cell surface expression of adhesion molecules and of nuclear factor-kappa B activation. Biochem. Pharmacol. 55, 775-783. doi: 10.1016/S0006-2952(97)00557-1
    • (1998) Pharmacol , vol.55 , pp. 775-783
    • Kumar, A.1    Dhawan, S.2    Hardegen, N.J.3    Aggarwal, B.B.4
  • 92
    • 2342550564 scopus 로고    scopus 로고
    • Anticancer and immunostimulatory compounds from Andrographis paniculata
    • Kumar, R. A., Sridevi, K., Kumar, N. V., Nanduri, S., and Rajagopal, S. (2004). Anticancer and immunostimulatory compounds from Andrographis paniculata. J. Ethnopharmacol. 92, 291-295. doi: 10.1016/j.jep.2004.03.004
    • (2004) J. Ethnopharmacol , vol.92 , pp. 291-295
    • Kumar, R.A.1    Sridevi, K.2    Kumar, N.V.3    Nanduri, S.4    Rajagopal, S.5
  • 93
  • 94
    • 84878435205 scopus 로고    scopus 로고
    • Mechanisms by which licochalcone e exhibits potent anti-inflammatory properties: Studies with phorbol ester-treated mouse skin and lipopolysaccharide-stimulated murine macrophages
    • Lee, H. N., Cho, H. J., Lim, D. Y., Kang, Y.-H., Lee, K. W., and Park, J. H. Y. (2013a). Mechanisms by which licochalcone e exhibits potent anti-inflammatory properties: studies with phorbol ester-treated mouse skin and lipopolysaccharide-stimulated murine macrophages. Int. J. Mol. Sci. 14, 10926-10943. doi: 10.3390/ijms140610926
    • (2013) Int. J. Mol. Sci , vol.14 , pp. 10926-10943
    • Lee, H.N.1    Cho, H.J.2    Lim, D.Y.3    Kang, Y.-H.4    Lee, K.W.5    Park, J.H.Y.6
  • 95
    • 84870434847 scopus 로고    scopus 로고
    • Protective effects of (-)-epigallocatechin-3-gallate against TNF-α-induced lung inflammation via ROS-dependent ICAM-1 inhibition
    • Lee, I. T., Lin, C. C., Lee, C. Y., Hsieh, P. W., and Yang, C. M. (2013b). Protective effects of (-)-epigallocatechin-3-gallate against TNF-α-induced lung inflammation via ROS-dependent ICAM-1 inhibition. J. Nutr. Biochem. 24, 124-136. doi: 10.1016/j.jnutbio.2012.03.009
    • (2013) J. Nutr. Biochem , vol.24 , pp. 124-136
    • Lee, I.T.1    Lin, C.C.2    Lee, C.Y.3    Hsieh, P.W.4    Yang, C.M.5
  • 96
    • 79957500051 scopus 로고    scopus 로고
    • Andrographolide acts as an anti-inflammatory agent in LPS-stimulated RAW264.7 macrophages by inhibiting STAT3-mediated suppression of the NF-κB pathway
    • Lee, K. C., Chang, H. H., Chung, Y. H., and Lee, T. Y. (2011). Andrographolide acts as an anti-inflammatory agent in LPS-stimulated RAW264.7 macrophages by inhibiting STAT3-mediated suppression of the NF-κB pathway. J. Ethnopharmacol. 135, 678-684. doi: 10.1016/j.jep.2011.03.068
    • (2011) J. Ethnopharmacol , vol.135 , pp. 678-684
    • Lee, K.C.1    Chang, H.H.2    Chung, Y.H.3    Lee, T.Y.4
  • 97
    • 84925491117 scopus 로고    scopus 로고
    • Anti-inflammatory effects of Baicalin, Baicalein, and Wogonin in vitro and in vivo
    • Lee, W., Ku, S.-K., and Bae, J.-S. (2015). Anti-inflammatory effects of Baicalin, Baicalein, and Wogonin in vitro and in vivo. Inflammation 38, 110-125. doi: 10.1007/s10753-014-0013-0
    • (2015) Inflammation , vol.38 , pp. 110-125
    • Lee, W.1    Ku, S.-K.2    Bae, J.-S.3
  • 98
    • 25144507259 scopus 로고    scopus 로고
    • Mechanisms for the inhibition of DNA methyltransferases by tea catechins and bioflavonoids
    • Lee, W. J., Shim, J. Y., and Zhu, B. T. (2005). Mechanisms for the inhibition of DNA methyltransferases by tea catechins and bioflavonoids. Mol. Pharmacol. 68, 1018-1030. doi: 10.1124/mol.104.008367
    • (2005) Mol. Pharmacol , vol.68 , pp. 1018-1030
    • Lee, W.J.1    Shim, J.Y.2    Zhu, B.T.3
  • 99
    • 55249091877 scopus 로고    scopus 로고
    • Protective effects of genistein on proinflammatory pathways in human brain microvascular endothelial cells
    • Lee, Y. W., and Lee, W. H. (2008). Protective effects of genistein on proinflammatory pathways in human brain microvascular endothelial cells. J. Nutr. Biochem. 19, 819-825. doi: 10.1016/j.jnutbio.2007.10.006
    • (2008) J. Nutr. Biochem , vol.19 , pp. 819-825
    • Lee, Y.W.1    Lee, W.H.2
  • 100
    • 67349229123 scopus 로고    scopus 로고
    • Madecassoside attenuates inflammatory response on collagen-induced arthritis in DBA/1 mice
    • Li, H., Gong, X., Zhang, L., Zhang, Z., Luo, F., Zhou, Q., et al. (2009). Madecassoside attenuates inflammatory response on collagen-induced arthritis in DBA/1 mice. Phytomedicine 16, 538-546. doi: 10.1016/j.phymed.2008.11.002
    • (2009) Phytomedicine , vol.16 , pp. 538-546
    • Li, H.1    Gong, X.2    Zhang, L.3    Zhang, Z.4    Luo, F.5    Zhou, Q.6
  • 101
    • 34249827735 scopus 로고    scopus 로고
    • Amino acids and immune function
    • Li, P., Yin, Y. L., Li, D., Kim, S. W., and Wu, G. (2007). Amino acids and immune function. Br. J. Nutr. 98, 237-252. doi: 10.1017/S000711450769936X
    • (2007) Br. J. Nutr , vol.98 , pp. 237-252
    • Li, P.1    Yin, Y.L.2    Li, D.3    Kim, S.W.4    Wu, G.5
  • 102
    • 81855201902 scopus 로고    scopus 로고
    • Berberine down-regulates the Th1/Th2 cytokine gene expression ratio in mouse primary splenocytes in the absence or presence of lipopolysaccharide in a preventive manner
    • Lin, W. C., and Lin, J. Y. (2011). Berberine down-regulates the Th1/Th2 cytokine gene expression ratio in mouse primary splenocytes in the absence or presence of lipopolysaccharide in a preventive manner. Int. Immunopharmacol. 11, 1984-1990. doi: 10.1016/j.intimp.2011.08.008
    • (2011) Int. Immunopharmacol , vol.11 , pp. 1984-1990
    • Lin, W.C.1    Lin, J.Y.2
  • 103
    • 77953355877 scopus 로고    scopus 로고
    • Tetramethylpyrazine inhibits production of nitric oxide and inducible nitric oxide synthase in lipopolysaccharide-induced N9 microglial cells through blockade of MAPK and PI3K/Akt signaling pathways, and suppression of intracellular reactive oxygen species
    • Liu, H.-T., Du, Y.-G., He, J.-L., Chen, W.-J., Li, W.-M., Yang, Z., et al. (2010). Tetramethylpyrazine inhibits production of nitric oxide and inducible nitric oxide synthase in lipopolysaccharide-induced N9 microglial cells through blockade of MAPK and PI3K/Akt signaling pathways, and suppression of intracellular reactive oxygen species. J. Ethnopharmacol. 129, 335-343. doi: 10.1016/j.jep.2010.03.037
    • (2010) J. Ethnopharmacol , vol.129 , pp. 335-343
    • Liu, H.-T.1    Du, Y.-G.2    He, J.-L.3    Chen, W.-J.4    Li, W.-M.5    Yang, Z.6
  • 104
    • 84893688702 scopus 로고    scopus 로고
    • The unexpected side effects and safety of therapeutic monoclonal antibodies
    • Liu, L., and Li, Y. (2014). The unexpected side effects and safety of therapeutic monoclonal antibodies. Drugs Today 50, 33-50. doi: 10.1358/dot.2014.50.1.2076506
    • (2014) Drugs Today , vol.50 , pp. 33-50
    • Liu, L.1    Li, Y.2
  • 105
    • 84892760529 scopus 로고    scopus 로고
    • Puerarin partly counteracts the inflammatory response after cerebral ischemia/reperfusion via activating the cholinergic anti-inflammatory pathway
    • Liu, X., Mei, Z., Qian, J., Zeng, Y., and Wang, M. (2013). Puerarin partly counteracts the inflammatory response after cerebral ischemia/reperfusion via activating the cholinergic anti-inflammatory pathway. Neural Regen. Res. 8, 3203. doi: 10.3969/j.issn.1673-5374.2013.34.004
    • (2013) Neural Regen. Res , vol.8
    • Liu, X.1    Mei, Z.2    Qian, J.3    Zeng, Y.4    Wang, M.5
  • 106
    • 84862787904 scopus 로고    scopus 로고
    • Leonurine attenuates lipopolysaccharide-induced inflammatory responses in human endothelial cells: Involvement of reactive oxygen species and NF-κB pathways
    • Liu, X. H., Pan, L. L., Yang, H. B., Gong, Q. H., and Zhu, Y. Z. (2012). Leonurine attenuates lipopolysaccharide-induced inflammatory responses in human endothelial cells: involvement of reactive oxygen species and NF-κB pathways. Eur. J. Pharmacol 680, 108-114. doi: 10.1016/j.ejphar.2012.01.012
    • (2012) Eur. J. Pharmacol , vol.680 , pp. 108-114
    • Liu, X.H.1    Pan, L.L.2    Yang, H.B.3    Gong, Q.H.4    Zhu, Y.Z.5
  • 108
    • 33645038314 scopus 로고    scopus 로고
    • Therapeutic potentials of andrographolide from Andrographis paniculata: A review
    • Maiti, K., Gantait, A., Mukherjee, K., Saha, B., and Mukherjee, P. K. (2006). Therapeutic potentials of andrographolide from Andrographis paniculata: a review. J. Nat. Remed. 6, 1-13.
    • (2006) J. Nat. Remed , vol.6 , pp. 1-13
    • Maiti, K.1    Gantait, A.2    Mukherjee, K.3    Saha, B.4    Mukherjee, P.K.5
  • 109
    • 0034660659 scopus 로고    scopus 로고
    • Resveratrol suppresses TNF-induced activation of nuclear transcription factors NF-κB, activator protein-1, and apoptosis: Potential role of reactive oxygen intermediates and lipid peroxidation
    • Manna, S. K., Mukhopadhyay, A., and Aggarwal, B. B. (2000). Resveratrol suppresses TNF-induced activation of nuclear transcription factors NF-κB, activator protein-1, and apoptosis: potential role of reactive oxygen intermediates and lipid peroxidation. J. Immunol. 164, 6509-6519. doi: 10.4049/jimmunol.164.12.6509
    • (2000) J. Immunol , vol.164 , pp. 6509-6519
    • Manna, S.K.1    Mukhopadhyay, A.2    Aggarwal, B.B.3
  • 110
    • 0027337210 scopus 로고
    • Genistein induces apoptosis in immature human thymocytes by inhibiting topoisomerase-II
    • Mccabe, M. J. Jr., and Orrenius, S. (1993). Genistein induces apoptosis in immature human thymocytes by inhibiting topoisomerase-II. Biochem. Biophys. Res. Commun. 194, 944-950. doi: 10.1006/bbrc.1993.1912
    • (1993) Biochem. Biophys. Res. Commun , vol.194 , pp. 944-950
    • McCabe, M.J.1    Orrenius, S.2
  • 111
    • 0033637140 scopus 로고    scopus 로고
    • The effects of plant flavonoids on mammalian cells: Implications for inflammation, heart disease, and cancer
    • Middleton, E. Jr., Kandaswami, C., and Theoharides, T. C. (2000). The effects of plant flavonoids on mammalian cells: implications for inflammation, heart disease, and cancer. Pharmacol. Rev. 52, 673-751.
    • (2000) Pharmacol. Rev , vol.52 , pp. 673-751
    • Middleton, E.1    Kandaswami, C.2    Theoharides, T.C.3
  • 112
    • 34247354967 scopus 로고    scopus 로고
    • Immunomodulating and anticancer agents in the realm of macromycetes fungi (Macrofungi)
    • Moradali, M. F., Mostafavi, H., Ghods, S., and Hedjaroude, G. A. (2007). Immunomodulating and anticancer agents in the realm of macromycetes fungi (macrofungi). Int. Immunopharmacol. 7, 701-724. doi: 10.1016/j.intimp.2007.01.008
    • (2007) Int. Immunopharmacol , vol.7 , pp. 701-724
    • Moradali, M.F.1    Mostafavi, H.2    Ghods, S.3    Hedjaroude, G.A.4
  • 113
    • 0035999066 scopus 로고    scopus 로고
    • Flavonoids exert diverse inhibitory effects on the activation of NF-κB
    • Muraoka, K., Shimizu, K., Sun, X., Tani, T., Izumi, R., Miwa, K., et al. (2002). Flavonoids exert diverse inhibitory effects on the activation of NF-κB. Transplant. Proc. 34, 1335-1340. doi: 10.1016/S0041-1345(02)02795-1
    • (2002) Transplant. Proc , vol.34 , pp. 1335-1340
    • Muraoka, K.1    Shimizu, K.2    Sun, X.3    Tani, T.4    Izumi, R.5    Miwa, K.6
  • 114
    • 2942750305 scopus 로고    scopus 로고
    • Effect of cyclophosphamide pretreatment on hematological indices of Indian Bonnet monkeys
    • Mythili, M., Nair, S., and Gunasekaran, S. (2004). Effect of cyclophosphamide pretreatment on hematological indices of Indian Bonnet monkeys. Indian J. Pharmacol. 36, 175
    • (2004) Indian J. Pharmacol , vol.36
    • Mythili, M.1    Nair, S.2    Gunasekaran, S.3
  • 115
    • 38949148974 scopus 로고    scopus 로고
    • Dietary soy protein isolate ameliorates atherosclerotic lesions in apolipoprotein E-deficient mice potentially by inhibiting monocyte chemoattractant protein-1 expression
    • Nagarajan, S., Burris, R. L., Stewart, B. W., Wilkerson, J. E., and Badger, T. M. (2008). Dietary soy protein isolate ameliorates atherosclerotic lesions in apolipoprotein E-deficient mice potentially by inhibiting monocyte chemoattractant protein-1 expression. J. Nutr. 138, 332-337.
    • (2008) J. Nutr , vol.138 , pp. 332-337
    • Nagarajan, S.1    Burris, R.L.2    Stewart, B.W.3    Wilkerson, J.E.4    Badger, T.M.5
  • 116
    • 38449107785 scopus 로고    scopus 로고
    • Apigenin blocks lipopolysaccharide-induced lethality in vivo and proinflammatory cytokines expression by inactivating NF-κB through the suppression of p65 phosphorylation
    • Nicholas, C., Batra, S., Vargo, M. A., Voss, O. H., Gavrilin, M. A., Wewers, M. D., et al. (2007). Apigenin blocks lipopolysaccharide-induced lethality in vivo and proinflammatory cytokines expression by inactivating NF-κB through the suppression of p65 phosphorylation. J. Immunol. 179, 7121-7127. doi: 10.4049/jimmunol.179.10.7121
    • (2007) J. Immunol , vol.179 , pp. 7121-7127
    • Nicholas, C.1    Batra, S.2    Vargo, M.A.3    Voss, O.H.4    Gavrilin, M.A.5    Wewers, M.D.6
  • 117
    • 79955469916 scopus 로고    scopus 로고
    • Effects of chelerythrine, a specific inhibitor of cyclooxygenase-2, on acute inflammation in mice
    • Niu, X. F., Zhou, P., Li, W. F., and Xu, H. B. (2011). Effects of chelerythrine, a specific inhibitor of cyclooxygenase-2, on acute inflammation in mice. Fitoterapia 82, 620-625. doi: 10.1016/j.fitote.2011.01.020
    • (2011) Fitoterapia , vol.82 , pp. 620-625
    • Niu, X.F.1    Zhou, P.2    Li, W.F.3    Xu, H.B.4
  • 118
    • 51449124322 scopus 로고    scopus 로고
    • Colchicine: Its mechanism of action and efficacy in crystal-induced inflammation
    • Nuki, G. (2008). Colchicine: its mechanism of action and efficacy in crystal-induced inflammation. Curr. Rheumatol. Rep. 10, 218-227. doi: 10.1007/s11926-008-0036-3
    • (2008) Curr. Rheumatol. Rep , vol.10 , pp. 218-227
    • Nuki, G.1
  • 119
    • 1442334562 scopus 로고    scopus 로고
    • Camptothecin and taxol: Historic achievements in natural products research
    • Oberlies, N. H., and Kroll, D. J. (2004). Camptothecin and taxol: historic achievements in natural products research. J. Nat. Prod. 67, 129-135. doi: 10.1021/np030498t
    • (2004) J. Nat. Prod , vol.67 , pp. 129-135
    • Oberlies, N.H.1    Kroll, D.J.2
  • 120
    • 0033871177 scopus 로고    scopus 로고
    • Effects of triterpenoids from Pueraria lobata on immunohemolysis: Beta-D-glucuronic acid plays an active role in anticomplementary activity in vitro
    • Oh, S. R., Kinjo, J., Shii, Y., Ikeda, T., Nohara, T., Ahn, K. S., et al. (2000). Effects of triterpenoids from Pueraria lobata on immunohemolysis: beta-D-glucuronic acid plays an active role in anticomplementary activity in vitro. Planta Med. 66, 506-510. doi: 10.1055/s-2000-8614
    • (2000) Planta Med , vol.66 , pp. 506-510
    • Oh, S.R.1    Kinjo, J.2    Shii, Y.3    Ikeda, T.4    Nohara, T.5    Ahn, K.S.6
  • 121
    • 84867932436 scopus 로고    scopus 로고
    • Anti-inflammatory effect of sinomenine by inhibition of pro-inflammatory mediators in PMA plus A23187-stimulated HMC-1 Cells
    • Oh, Y. C., Kang, O. H., Kim, S. B., Mun, S. H., Park, C. B., Kim, Y. G., et al. (2012). Anti-inflammatory effect of sinomenine by inhibition of pro-inflammatory mediators in PMA plus A23187-stimulated HMC-1 Cells. Eur. Rev. Med. Pharmacol. Sci. 16, 1184-1191.
    • (2012) Eur. Rev. Med. Pharmacol. Sci , vol.16 , pp. 1184-1191
    • Oh, Y.C.1    Kang, O.H.2    Kim, S.B.3    Mun, S.H.4    Park, C.B.5    Kim, Y.G.6
  • 122
    • 84867095636 scopus 로고    scopus 로고
    • Unravelling the mystery of capsaicin: A tool to understand and treat pain. Pharmacol
    • O’Neill, J., Brock, C., Olesen, A. E., Andresen, T., Nilsson, M., and Dickenson, A. H. (2012). Unravelling the mystery of capsaicin: a tool to understand and treat pain. Pharmacol. Rev. 64, 939-971. doi: 10.1124/pr.112.006163
    • (2012) Rev , vol.64 , pp. 939-971
    • O’Neill, J.1    Brock, C.2    Olesen, A.E.3    Resen, T.4    Nilsson, M.5    Dickenson, A.H.6
  • 123
    • 55149102265 scopus 로고    scopus 로고
    • Flavonoids inhibit histamine release and expressionof proinflammatory cytokines in mast cells
    • Park, H. H., Lee, S., Son, H. Y., Park, S. B., Kim, M. S., Choi, E. J., et al. (2008). Flavonoids inhibit histamine release and expressionof proinflammatory cytokines in mast cells. Arch. Pharm. Res. 31, 1303-1311. doi: 10.1007/s12272-001-2110-5
    • (2008) Arch. Pharm. Res , vol.31 , pp. 1303-1311
    • Park, H.H.1    Lee, S.2    Son, H.Y.3    Park, S.B.4    Kim, M.S.5    Choi, E.J.6
  • 124
    • 65549141740 scopus 로고    scopus 로고
    • Resveratrol inhibits Porphyromonas gingivalis lipopolysaccharide-induced endothelial adhesion molecule expression by suppressing NF-κB activation
    • Park, H. J., Jeong, S. K., Kim, S. R., Bae, S. K., Kim, W. S., Jin, S. D., et al. (2009). Resveratrol inhibits Porphyromonas gingivalis lipopolysaccharide-induced endothelial adhesion molecule expression by suppressing NF-κB activation. Arch. Pharm. Res. 32, 583-591. doi: 10.1007/s12272-009-1415-7
    • (2009) Arch. Pharm. Res , vol.32 , pp. 583-591
    • Park, H.J.1    Jeong, S.K.2    Kim, S.R.3    Bae, S.K.4    Kim, W.S.5    Jin, S.D.6
  • 125
    • 33646084601 scopus 로고    scopus 로고
    • Epigallocatechin gallate reduces hypoxia-induced apoptosis in human hepatoma cells
    • Park, H. J., Shin, D. H., Chung, W. J., Leem, K., Yoon, S. H., Hong, M. S., et al. (2006). Epigallocatechin gallate reduces hypoxia-induced apoptosis in human hepatoma cells. Life Sci. 78, 2826-2832. doi: 10.1016/j.lfs.2005.11.001
    • (2006) Life Sci , vol.78 , pp. 2826-2832
    • Park, H.J.1    Shin, D.H.2    Chung, W.J.3    Leem, K.4    Yoon, S.H.5    Hong, M.S.6
  • 126
    • 0034634270 scopus 로고    scopus 로고
    • Capsaicin protects against ethanol-induced oxidative injury in the gastric mucosa of rats
    • Park, J. S., Choi, M. A., Kim, B. S., Han, I. S., Kurata, T., and Yu, R. (2000). Capsaicin protects against ethanol-induced oxidative injury in the gastric mucosa of rats. Life Sci. 67, 3087-3093. doi: 10.1016/S0024-3205(00)00890-0
    • (2000) Life Sci , vol.67 , pp. 3087-3093
    • Park, J.S.1    Choi, M.A.2    Kim, B.S.3    Han, I.S.4    Kurata, T.5    Yu, R.6
  • 127
    • 0035795985 scopus 로고    scopus 로고
    • An overview of the immune system
    • Parkin, J., and Cohen, B. (2001). An overview of the immune system. Lancet 357, 1777-1789. doi: 10.1016/S0140-6736(00)04904-7
    • (2001) Lancet , vol.357 , pp. 1777-1789
    • Parkin, J.1    Cohen, B.2
  • 129
    • 84876813600 scopus 로고    scopus 로고
    • Effect of quercetin on traits of the metabolic syndrome, endothelial function and inflammation in men with different APOE isoforms
    • Pfeuffer, M., Auinger, A., Bley, U., Kraus-Stojanowic, I., Laue, C., Winkler, P., et al. (2013). Effect of quercetin on traits of the metabolic syndrome, endothelial function and inflammation in men with different APOE isoforms. Nutr. Metab. Cardiovasc. Dis. 23, 403-409. doi: 10.1016/j.numecd.2011.08.010
    • (2013) Nutr. Metab. Cardiovasc. Dis , vol.23 , pp. 403-409
    • Pfeuffer, M.1    Auinger, A.2    Bley, U.3    Kraus-Stojanowic, I.4    Laue, C.5    Winkler, P.6
  • 131
    • 32044450554 scopus 로고    scopus 로고
    • Andrographolide inhibits the production of TNF-alpha and interleukin-12 in lipopolysaccharide-stimulated macrophages: Role of mitogen-activated protein kinases
    • Qin, L. H., Kong, L., Shi, G. J., Wang, Z. T., and Ge, B. X. (2006). Andrographolide inhibits the production of TNF-alpha and interleukin-12 in lipopolysaccharide-stimulated macrophages: role of mitogen-activated protein kinases. Biol. Pharm. Bull. 29, 220-224. doi: 10.1248/bpb.29.220
    • (2006) Biol. Pharm. Bull , vol.29 , pp. 220-224
    • Qin, L.H.1    Kong, L.2    Shi, G.J.3    Wang, Z.T.4    Ge, B.X.5
  • 132
    • 0141457852 scopus 로고    scopus 로고
    • Andrographolide, a potential cancer therapeutic agent isolated from Andrographis paniculata
    • Rajagopal, S., Kumar, R. A., Deevi, D. S., Satyanarayana, C., and Rajagopalan, R. (2003). Andrographolide, a potential cancer therapeutic agent isolated from Andrographis paniculata. J. Exp. Ther. Oncol. 3, 147-158. doi: 10.1046/j.1359-4117.2003.01090.x
    • (2003) J. Exp. Ther. Oncol , vol.3 , pp. 147-158
    • Rajagopal, S.1    Kumar, R.A.2    Deevi, D.S.3    Satyanarayana, C.4    Rajagopalan, R.5
  • 136
    • 34247872831 scopus 로고    scopus 로고
    • Quercetin inhibits TNF-induced NF-κB transcription factor recruitment to proinflammatory gene promoters in murine intestinal epithelial cells
    • Ruiz, P. A., Braune, A., Holzlwimmer, G., Quintanilla-Fend, L., and Haller, D. (2007). Quercetin inhibits TNF-induced NF-κB transcription factor recruitment to proinflammatory gene promoters in murine intestinal epithelial cells. J. Nutr. 137, 1208-1215.
    • (2007) J. Nutr , vol.137 , pp. 1208-1215
    • Ruiz, P.A.1    Braune, A.2    Holzlwimmer, G.3    Quintanilla-Fend, L.4    Haller, D.5
  • 137
    • 34347251957 scopus 로고    scopus 로고
    • The green tea polyphenol, epigallocatechin-3-gallate inhibits telomerase and induces apoptosis in drug-resistant lung cancer cells
    • Sadava, D., Whitlock, E., and Kane, S. E. (2007). The green tea polyphenol, epigallocatechin-3-gallate inhibits telomerase and induces apoptosis in drug-resistant lung cancer cells. Biochem. Biophys. Res. Commun. 360, 233-237. doi: 10.1016/j.bbrc.2007.06.030
    • (2007) Biochem. Biophys. Res. Commun , vol.360 , pp. 233-237
    • Sadava, D.1    Whitlock, E.2    Kane, S.E.3
  • 138
    • 85015407547 scopus 로고    scopus 로고
    • Randomized, double-blind, placebo controlled trial of Andrographis paniculata extract (HMPL-004) in patients with moderately active Crohn’s disease
    • Sandborn, W., Targan, S., Byers, V., and Tang, T. (2010). Randomized, double-blind, placebo controlled trial of Andrographis paniculata extract (HMPL-004) in patients with moderately active Crohn’s disease. Am. J. Gastroenterol. 105(Suppl. 1), s429-s430.
    • (2010) Am. J. Gastroenterol , vol.105 , pp. s429-s430
    • Sandborn, W.1    Targan, S.2    Byers, V.3    Tang, T.4
  • 139
    • 84872012274 scopus 로고    scopus 로고
    • Andrographis paniculata extract (HMPL-004) for active ulcerative colitis
    • Sandborn, W. J., Targan, S. R., Byers, V. S., Rutty, D. A., Mu, H., Zhang, X., et al. (2013). Andrographis paniculata extract (HMPL-004) for active ulcerative colitis. Am. J. Gastroenterol. 108, 90-98. doi: 10.1038/ajg.2012.340
    • (2013) Am. J. Gastroenterol , vol.108 , pp. 90-98
    • Sandborn, W.J.1    Targan, S.R.2    Byers, V.S.3    Rutty, D.A.4    Mu, H.5    Zhang, X.6
  • 140
    • 67650898932 scopus 로고    scopus 로고
    • Oral treatment with genistein reduces the expression of molecular and biochemical markers of inflammation in a rat model of chronic TNBS-induced colitis
    • Seibel, J., Molzberger, A. F., Hertrampf, T., Laudenbach-Leschowski, U., and Diel, P. (2009). Oral treatment with genistein reduces the expression of molecular and biochemical markers of inflammation in a rat model of chronic TNBS-induced colitis. Eur. J. Nutr. 48, 213-220. doi: 10.1007/s00394-009-0004-3
    • (2009) Eur. J. Nutr , vol.48 , pp. 213-220
    • Seibel, J.1    Molzberger, A.F.2    Hertrampf, T.3    Laudenbach-Leschowski, U.4    Diel, P.5
  • 141
    • 0029565168 scopus 로고    scopus 로고
    • Medical Pharmacology. New Delhi: CBS Publisher. Sgro, C. (1995). Side-effects of a monoclonal antibody, muromonab CD3/orthoclone OKT3: Bibliographic review
    • Sengupta, P. R. (2009). Medical Pharmacology. New Delhi: CBS Publisher. Sgro, C. (1995). Side-effects of a monoclonal antibody, muromonab CD3/orthoclone OKT3: bibliographic review. Toxicology 105, 23-29. doi: 10.1016/0300-483X(95)03123-W
    • (2009) Toxicology , vol.105 , pp. 23-29
    • Sengupta, P.R.1
  • 143
    • 0036181416 scopus 로고    scopus 로고
    • Andrographolide prevents oxygen radical production by human neutrophils: Possible mechanism(s) involved in its anti-inflammatory effect
    • Shen, Y. C., Chen, C. F., and Chiou, W. F. (2002). Andrographolide prevents oxygen radical production by human neutrophils: possible mechanism(s) involved in its anti-inflammatory effect. Br. J. Pharmacol. 135, 399-406. doi: 10.1038/sj.bjp.0704493
    • (2002) Br. J. Pharmacol , vol.135 , pp. 399-406
    • Shen, Y.C.1    Chen, C.F.2    Chiou, W.F.3
  • 144
    • 62649118631 scopus 로고    scopus 로고
    • Chrysin, a natural flavone, improves murine inflammatory bowel diseases
    • Shin, E. K., Kwon, H. S., Kim, Y. H., Shin, H. K., and Kim, J. K. (2009). Chrysin, a natural flavone, improves murine inflammatory bowel diseases. Biochem. Biophys. Res. Commun. 381, 502-507. doi: 10.1016/j.bbrc.2009.02.071
    • (2009) Biochem. Biophys. Res. Commun , vol.381 , pp. 502-507
    • Shin, E.K.1    Kwon, H.S.2    Kim, Y.H.3    Shin, H.K.4    Kim, J.K.5
  • 145
    • 35548980921 scopus 로고    scopus 로고
    • Phytochemical genistein in the regulation of vascular function: New insights
    • Si, H., and Liu, D. (2007). Phytochemical genistein in the regulation of vascular function: new insights. Curr. Med. Chem 14, 2581-2589. doi: 10.2174/092986707782023325
    • (2007) Curr. Med. Chem , vol.14 , pp. 2581-2589
    • Si, H.1    Liu, D.2
  • 146
    • 80555123045 scopus 로고    scopus 로고
    • Green tea catechin, epigallocatechin-3-gallate (EGCG): Mechanisms, perspectives and clinical applications
    • Singh, B. N., Shankar, S., and Srivastava, R. K. (2011). Green tea catechin, epigallocatechin-3-gallate (EGCG): mechanisms, perspectives and clinical applications. Biochem. Pharmacol. 82, 1807-1821. doi: 10.1016/j.bcp.2011.07.093
    • (2011) Biochem. Pharmacol , vol.82 , pp. 1807-1821
    • Singh, B.N.1    Shankar, S.2    Srivastava, R.K.3
  • 147
    • 0028867742 scopus 로고
    • Activation of transcription factor NF-κB is suppressed by curcumin (Diferuloylmethane) [corrected]
    • Singh, S., and Aggarwal, B. B. (1995). Activation of transcription factor NF-κB is suppressed by curcumin (diferuloylmethane) [corrected]. J. Biol. Chem. 270, 24995-25000. doi: 10.1074/jbc.270.42.24995
    • (1995) J. Biol. Chem , vol.270 , pp. 24995-25000
    • Singh, S.1    Aggarwal, B.B.2
  • 149
    • 84927172907 scopus 로고    scopus 로고
    • Piperine inhibits the activities of platelet cytosolic phospholipase A2 and thromboxane A2 synthase without affecting cyclooxygenase-1 activity: Different mechanisms of action are involved in the inhibition of platelet aggregation and macrophage inflammatory response
    •  Son, D. J., Akiba, S., Hong, J. T., Yun, Y. P., Hwang, S. Y., Park, Y. H., et al. (2014). Piperine inhibits the activities of platelet cytosolic phospholipase A2 and thromboxane A2 synthase without affecting cyclooxygenase-1 activity: different mechanisms of action are involved in the inhibition of platelet aggregation and macrophage inflammatory response. Nutrients 6, 3336-3352. doi: 10.3390/nu6083336
    • (2014) Nutrients , vol.6 , pp. 3336-3352
    • So, D.J.1    Akib, S.2    Hon, J.T.3    Yu, Y.P.4    Hwan, S.Y.5    Par, Y.H.6
  • 150
    • 0036310091 scopus 로고    scopus 로고
    • Induction of secretory and tumoricidal activities in peritoneal macrophages by ginsan
    • Song, J. Y., Han, S. K., Son, E. H., Pyo, S. N., Yun, Y. S., and Yi, S. Y. (2002). Induction of secretory and tumoricidal activities in peritoneal macrophages by ginsan. Int. Immunopharmacol. 2, 857-865. doi: 10.1016/S1567-5769(01)00211-9
    • (2002) Int. Immunopharmacol , vol.2 , pp. 857-865
    • Song, J.Y.1    Han, S.K.2    Son, E.H.3    Pyo, S.N.4    Yun, Y.S.5    Yi, S.Y.6
  • 151
    • 84964237769 scopus 로고    scopus 로고
    • Leonurine exerts anti-inflammatory effect by regulating inflammatory signaling pathways and cytokines in lps-induced mouse mastitis
    • Song, X., Wang, T., Zhang, Z., Jiang, H., Wang, W., Cao, Y., et al. (2015). Leonurine exerts anti-inflammatory effect by regulating inflammatory signaling pathways and cytokines in lps-induced mouse mastitis. Inflammation 38, 79-88. doi: 10.1007/s10753-014-0009-9
    • (2015) Inflammation , vol.38 , pp. 79-88
    • Song, X.1    Wang, T.2    Zhang, Z.3    Jiang, H.4    Wang, W.5    Cao, Y.6
  • 152
    • 84867335978 scopus 로고    scopus 로고
    • Rhynchophylline attenuates LPS-induced pro-inflammatory responses through down-regulation of MAPK/NF-κB signaling pathways in primary microglia
    • Song, Y., Qu, R., Zhu, S., Zhang, R., and Ma, S. (2012). Rhynchophylline attenuates LPS-induced pro-inflammatory responses through down-regulation of MAPK/NF-κB signaling pathways in primary microglia. Phytother. Res. 26, 1528-1533. doi: 10.1002/ptr.4614
    • (2012) Phytother. Res , vol.26 , pp. 1528-1533
    • Song, Y.1    Qu, R.2    Zhu, S.3    Zhang, R.4    Ma, S.5
  • 153
    • 0035134439 scopus 로고    scopus 로고
    • Type 1/Type 2 immunity in infectious diseases
    • Spellberg, B., and Edwards, J. E. Jr. (2001). Type 1/Type 2 immunity in infectious diseases. Clin. Infect. Dis 32, 76-102. doi: 10.1086/317537
    • (2001) Clin. Infect. Dis , vol.32 , pp. 76-102
    • Spellberg, B.1    Edwards, J.E.2
  • 154
    • 79953299183 scopus 로고    scopus 로고
    • Drugs that target dynamic microtubules: A new molecular perspective
    • Stanton, R. A., Gernert, K. M., Nettles, J. H., and Aneja, R. (2011). Drugs that target dynamic microtubules: a new molecular perspective. Med. Res. Rev. 31, 443-481. doi: 10.1002/med.20242
    • (2011) Med. Res. Rev , vol.31 , pp. 443-481
    • Stanton, R.A.1    Gernert, K.M.2    Nettles, J.H.3    Aneja, R.4
  • 155
    • 58149163406 scopus 로고    scopus 로고
    • Apocynin: Molecular aptitudes
    • 106507
    • Stefanska, J., and Pawliczak, R. (2008). Apocynin: molecular aptitudes. Mediators Inflamm. 2008:106507. doi: 10.1155/2008/106507
    • (2008) Mediators Inflamm , pp. 2008
    • Stefanska, J.1    Pawliczak, R.2
  • 156
    • 84857853991 scopus 로고    scopus 로고
    • Recombinant and natural human interferons: Analysis of the incidence and clinical impact of neutralizing antibodies
    • Strayer, D. R., and Carter, W. A. (2012). Recombinant and natural human interferons: analysis of the incidence and clinical impact of neutralizing antibodies. J. Interferon Cytokine Res. 32, 95-102. doi: 10.1089/jir.2011.0069
    • (2012) J. Interferon Cytokine Res , vol.32 , pp. 95-102
    • Strayer, D.R.1    Carter, W.A.2
  • 157
    • 0035451363 scopus 로고    scopus 로고
    • Molecular mechanisms underlying chemopreventive activities of anti-inflammatory phytochemicals: Down-regulation of COX-2 and iNOS through suppression of NF-κB activation
    • Surh, Y. J., Chun, K. S., Cha, H. H., Han, S. S., Keum, Y. S., Park, K. K., et al. (2001). Molecular mechanisms underlying chemopreventive activities of anti-inflammatory phytochemicals: down-regulation of COX-2 and iNOS through suppression of NF-κB activation. Mutat. Res. 481, 243-268. doi: 10.1016/S0027-5107(01)00183-X
    • (2001) Mutat. Res , vol.481 , pp. 243-268
    • Surh, Y.J.1    Chun, K.S.2    Cha, H.H.3    Han, S.S.4    Keum, Y.S.5    Park, K.K.6
  • 158
    • 78650259671 scopus 로고    scopus 로고
    • Randomised clinical trial: Herbal extract HMPL-004 in active ulcerative colitis -a double-blind comparison with sustained release mesalazine
    • Tang, T., Targan, S. R., Li, Z. S., Xu, C., Byers, V. S., and Sandborn, W. J. (2011). Randomised clinical trial: herbal extract HMPL-004 in active ulcerative colitis -a double-blind comparison with sustained release mesalazine. Aliment. Pharmacol. Ther. 33, 194-202. doi: 10.1111/j.1365-2036.2010.04515.x
    • (2011) Aliment. Pharmacol. Ther , vol.33 , pp. 194-202
    • Tang, T.1    Targan, S.R.2    Li, Z.S.3    Xu, C.4    Byers, V.S.5    Sandborn, W.J.6
  • 159
    • 84877002108 scopus 로고    scopus 로고
    • One-year supplementation with a grape extract containing resveratrol modulates inflammatory-related microRNAs and cytokines expression in peripheral blood mononuclear cells of type 2 diabetes and hypertensive patients with coronary artery disease
    • Tome-Carneiro, J., Larrosa, M., Yanez-Gascon, M. J., Davalos, A., Gil-Zamorano, J., Gonzalvez, M., et al. (2013). One-year supplementation with a grape extract containing resveratrol modulates inflammatory-related microRNAs and cytokines expression in peripheral blood mononuclear cells of type 2 diabetes and hypertensive patients with coronary artery disease. Pharmacol. Res. 72, 69-82. doi: 10.1016/j.phrs.2013.03.011
    • (2013) Pharmacol. Res , vol.72 , pp. 69-82
    • Tome-Carneiro, J.1    Larrosa, M.2    Yanez-Gascon, M.J.3    Davalos, A.4    Gil-Zamorano, J.5    Gonzalvez, M.6
  • 161
    • 4444376879 scopus 로고    scopus 로고
    • Andrographolide acts through inhibition of ERK1/2 and Akt phosphorylation to suppress chemotactic migration
    • Tsai, H. R., Yang, L. M., Tsai, W. J., and Chiou, W. F. (2004). Andrographolide acts through inhibition of ERK1/2 and Akt phosphorylation to suppress chemotactic migration. Eur. J. Pharmacol 498, 45-52. doi: 10.1016/j.ejphar.2004.07.077
    • (2004) Eur. J. Pharmacol , vol.498 , pp. 45-52
    • Tsai, H.R.1    Yang, L.M.2    Tsai, W.J.3    Chiou, W.F.4
  • 162
    • 84863481787 scopus 로고    scopus 로고
    • Piperine suppresses cerebral ischemia-reperfusion-induced inflammation through the repression of COX-2, NOS-2, and NF-κB in middle cerebral artery occlusion rat model
    • Vaibhav, K., Shrivastava, P., Javed, H., Khan, A., Ahmed, M. E., Tabassum, R., et al. (2012). Piperine suppresses cerebral ischemia-reperfusion-induced inflammation through the repression of COX-2, NOS-2, and NF-κB in middle cerebral artery occlusion rat model. Mol. Cell. Biochem. 367, 73-84. doi: 10.1007/s11010-012-1321-z
    • (2012) Mol. Cell. Biochem , vol.367 , pp. 73-84
    • Vaibhav, K.1    Shrivastava, P.2    Javed, H.3    Khan, A.4    Ahmed, M.E.5    Tabassum, R.6
  • 163
    • 78651296775 scopus 로고    scopus 로고
    • Elucidation of molecular mechanisms underlying the protective effects of thymoquinone against rheumatoid arthritis
    • Vaillancourt, F., Silva, P., Shi, Q., Fahmi, H., Fernandes, J. C., and Benderdour, M. (2011). Elucidation of molecular mechanisms underlying the protective effects of thymoquinone against rheumatoid arthritis. J. Cell. Biochem. 112, 107-117. doi: 10.1002/jcb.22884
    • (2011) J. Cell. Biochem , vol.112 , pp. 107-117
    • Vaillancourt, F.1    Silva, P.2    Shi, Q.3    Fahmi, H.4    Fernandes, J.C.5    Benderdour, M.6
  • 164
    • 73649131216 scopus 로고    scopus 로고
    • Estradiol or genistein prevent Alzheimer’s disease-associated inflammation correlating with an increase PPAR gamma expression in cultured astrocytes
    • Valles, S. L., Dolz-Gaiton, P., Gambini, J., Borras, C., Lloret, A., Pallardo, F. V., et al. (2010). Estradiol or genistein prevent Alzheimer’s disease-associated inflammation correlating with an increase PPAR gamma expression in cultured astrocytes. Brain Res. 2, 138-144. doi: 10.1016/j.brainres.2009.11.044
    • (2010) Brain Res , vol.2 , pp. 138-144
    • Valles, S.L.1    Dolz-Gaiton, P.2    Gambini, J.3    Borras, C.4    Lloret, A.5    Pallardo, F.V.6
  • 165
    • 79959261445 scopus 로고    scopus 로고
    • What is new for an old molecule? Systematic review and recommendations on the use of resveratrol
    • Vang, O., Ahmad, N., Baile, C. A., Baur, J. A., Brown, K., Csiszar, A., et al. (2011). What is new for an old molecule? Systematic review and recommendations on the use of resveratrol. PLoS ONE 6:e19881. doi: 10.1371/journal.pone.0019881
    • (2011) Plos ONE , vol.6
    • Vang, O.1    Ahmad, N.2    Baile, C.A.3    Baur, J.A.4    Brown, K.5    Csiszar, A.6
  • 166
    • 79953059789 scopus 로고    scopus 로고
    • Natural innate and adaptive immunity to cancer
    • Vesely, M. D., Kershaw, M. H., Schreiber, R. D., and Smyth, M. J. (2011). Natural innate and adaptive immunity to cancer. Annu. Rev. Immunol. 29, 235-271. doi: 10.1146/annurev-immunol-031210-101324
    • (2011) Annu. Rev. Immunol , vol.29 , pp. 235-271
    • Vesely, M.D.1    Kershaw, M.H.2    Schreiber, R.D.3    Smyth, M.J.4
  • 167
    • 45449120990 scopus 로고    scopus 로고
    • Genistein modulate immune responses in collagen-induced rheumatoid arthritis model
    • Wang, J., Zhang, Q., Jin, S., He, D., Zhao, S., and Liu, S. (2008). Genistein modulate immune responses in collagen-induced rheumatoid arthritis model. Maturitas 59, 405-412. doi: 10.1016/j.maturitas.2008.04.003
    • (2008) Maturitas , vol.59 , pp. 405-412
    • Wang, J.1    Zhang, Q.2    Jin, S.3    He, D.4    Zhao, S.5    Liu, S.6
  • 168
    • 1342323332 scopus 로고    scopus 로고
    • Andrographolide reduces inflammation-mediated dopaminergic neurodegeneration in mesencephalic neuron-glia cultures by inhibiting microglial activation
    • Wang, T., Liu, B., Zhang, W., Wilson, B., and Hong, J. S. (2004). Andrographolide reduces inflammation-mediated dopaminergic neurodegeneration in mesencephalic neuron-glia cultures by inhibiting microglial activation. J. Pharmacol. Exp. Ther. 308, 975-983. doi: 10.1124/jpet.103.059683
    • (2004) J. Pharmacol. Exp. Ther , vol.308 , pp. 975-983
    • Wang, T.1    Liu, B.2    Zhang, W.3    Wilson, B.4    Hong, J.S.5
  • 169
    • 14944340012 scopus 로고    scopus 로고
    • Genistein protects dopaminergic neurons by inhibiting microglial activation
    • Wang, X., Chen, S., Ma, G., Ye, M., and Lu, G. (2005). Genistein protects dopaminergic neurons by inhibiting microglial activation. Neuroreport 16, 267-270. doi: 10.1097/00001756-200502280-00013
    • (2005) Neuroreport , vol.16 , pp. 267-270
    • Wang, X.1    Chen, S.2    Ma, G.3    Ye, M.4    Lu, G.5
  • 170
    • 84901906412 scopus 로고    scopus 로고
    • Inhibition of adipocyte inflammation and macrophage chemotaxis by butein
    • Wang, Z., Lee, Y., Eun, J. S., and Bae, E. J. (2014). Inhibition of adipocyte inflammation and macrophage chemotaxis by butein. Eur. J. Pharmacol. 738, 40-48. doi: 10.1016/j.ejphar.2014.05.031
    • (2014) Eur. J. Pharmacol , vol.738 , pp. 40-48
    • Wang, Z.1    Lee, Y.2    Eun, J.S.3    Bae, E.J.4
  • 171
    • 82655184204 scopus 로고    scopus 로고
    • Tetrandrine down-regulates ERK/NF-κB signaling and inhibits activation of mesangial cells
    • Wu, C. J., Wang, Y. H., Lin, C. J., Chen, H. H., and Chen, Y. J. (2011). Tetrandrine down-regulates ERK/NF-κB signaling and inhibits activation of mesangial cells. Toxicol In Vitro 25, 1834-1840. doi: 10.1016/j.tiv.2011.09.024
    • (2011) Toxicol in Vitro , vol.25 , pp. 1834-1840
    • Wu, C.J.1    Wang, Y.H.2    Lin, C.J.3    Chen, H.H.4    Chen, Y.J.5
  • 172
    • 27744438212 scopus 로고    scopus 로고
    • Resveratrol suppresses IL-6-induced ICAM-1 gene expression in endothelial cells: Effects on the inhibition of STAT3 phosphorylation
    • Wung, B. S., Hsu, M. C., Wu, C. C., and Hsieh, C. W. (2005). Resveratrol suppresses IL-6-induced ICAM-1 gene expression in endothelial cells: effects on the inhibition of STAT3 phosphorylation. Life Sci. 78, 389-397. doi: 10.1016/j.lfs.2005.04.052
    • (2005) Life Sci , vol.78 , pp. 389-397
    • Wung, B.S.1    Hsu, M.C.2    Wu, C.C.3    Hsieh, C.W.4
  • 173
    • 4644241127 scopus 로고    scopus 로고
    • Andrographolide attenuates inflammation by inhibition of NF-κB activation through covalent modification of reduced cysteine 62 of p50
    • Xia, Y. F., Ye, B. Q., Li, Y. D., Wang, J. G., He, X. J., Lin, X., et al. (2004). Andrographolide attenuates inflammation by inhibition of NF-κB activation through covalent modification of reduced cysteine 62 of p50. J. Immunol. 173, 4207-4217. doi: 10.4049/jimmunol.173.6.4207
    • (2004) J. Immunol , vol.173 , pp. 4207-4217
    • Xia, Y.F.1    Ye, B.Q.2    Li, Y.D.3    Wang, J.G.4    He, X.J.5    Lin, X.6
  • 174
    • 79251521851 scopus 로고    scopus 로고
    • Emodin-8-O-beta-D-glucoside from Polygonum amplexicaule D. Don var. Sinense Forb. Promotes proliferation and differentiation of osteoblastic MC3T3-E1 cells
    • Xiang, M. X., Xu, Z., Su, H. W., Hu, J., and Yan, Y. J. (2011). Emodin-8-O-beta-D-glucoside from Polygonum amplexicaule D. Don var. sinense Forb. promotes proliferation and differentiation of osteoblastic MC3T3-E1 cells. Molecules 16, 728-737. doi: 10.3390/molecules16010728
    • (2011) Molecules , vol.16 , pp. 728-737
    • Xiang, M.X.1    Xu, Z.2    Su, H.W.3    Hu, J.4    Yan, Y.J.5
  • 175
    • 84863983972 scopus 로고    scopus 로고
    • Gelsemium alkaloids, immunosuppressive agents from Gelsemium elegans
    • Xu, Y.-K., Liao, S.-G., Na, Z., Hu, H.-B., Li, Y., and Luo, H.-R. (2012). Gelsemium alkaloids, immunosuppressive agents from Gelsemium elegans. Fitoterapia 83, 1120-1124. doi: 10.1016/j.fitote.2012.04.023
    • (2012) Fitoterapia , vol.83 , pp. 1120-1124
    • Xu, Y.-K.1    Liao, S.-G.2    Na, Z.3    Hu, H.-B.4    Li, Y.5    Luo, H.-R.6
  • 176
    • 0031439994 scopus 로고    scopus 로고
    • Curcumin inhibits IL1 alpha and TNF-alpha induction of AP-1 and NF-kB DNA-binding activity in bone marrow stromal cells
    • Xu, Y. X., Pindolia, K. R., Janakiraman, N., Chapman, R. A., and Gautam, S. C. (1997). Curcumin inhibits IL1 alpha and TNF-alpha induction of AP-1 and NF-kB DNA-binding activity in bone marrow stromal cells. Hematopathol. Mol. Hematol. 11, 49-62.
    • (1997) Hematopathol. Mol. Hematol , vol.11 , pp. 49-62
    • Xu, Y.X.1    Pindolia, K.R.2    Janakiraman, N.3    Chapman, R.A.4    Gautam, S.C.5
  • 177
    • 34948848563 scopus 로고    scopus 로고
    • Preventive role of genistein in an experimental non-alcoholic steatohepatitis model
    • Yalniz, M., Bahcecioglu, I. H., Kuzu, N., Poyrazoglu, O. K., Bulmus, O., Celebi, S., et al. (2007). Preventive role of genistein in an experimental non-alcoholic steatohepatitis model. J. Gastroenterol. Hepatol. 22, 2009-2014. doi: 10.1111/j.1440-1746.2006.04681
    • (2007) J. Gastroenterol. Hepatol , vol.22 , pp. 2009-2014
    • Yalniz, M.1    Bahcecioglu, I.H.2    Kuzu, N.3    Poyrazoglu, O.K.4    Bulmus, O.5    Celebi, S.6
  • 178
    • 49149090463 scopus 로고    scopus 로고
    • Epigallocatechin gallate inhibits endothelial exocytosis
    • Yamakuchi, M., Bao, C., Ferlito, M., and Lowenstein, C. J. (2008). Epigallocatechin gallate inhibits endothelial exocytosis. Biol. Chem. 389, 935-941. doi: 10.1515/BC.2008.095
    • (2008) Biol. Chem , vol.389 , pp. 935-941
    • Yamakuchi, M.1    Bao, C.2    Ferlito, M.3    Lowenstein, C.J.4
  • 179
    • 79959556771 scopus 로고    scopus 로고
    • Cancer prevention by tea: Evidence from laboratory studies
    • Yang, C. S., Wang, H., Li, G. X., Yang, Z., Guan, F., and Jin, H. (2011a). Cancer prevention by tea: evidence from laboratory studies. Pharmacol. Res. 64, 113-122. doi: 10.1016/j.phrs.2011.03.001
    • (2011) Pharmacol. Res , vol.64 , pp. 113-122
    • Yang, C.S.1    Wang, H.2    Li, G.X.3    Yang, Z.4    Guan, F.5    Jin, H.6
  • 180
    • 79951710144 scopus 로고    scopus 로고
    • Green tea polyphenols as proteasome inhibitors: Implication in chemoprevention
    • Yang, H., Landis-Piwowar, K., Chan, T. H., and Dou, Q. P. (2011b). Green tea polyphenols as proteasome inhibitors: implication in chemoprevention. Curr. Cancer Drug Targets 11, 296-306. doi: 10.2174/156800911794519743
    • (2011) Curr. Cancer Drug Targets , vol.11 , pp. 296-306
    • Yang, H.1    Landis-Piwowar, K.2    Chan, T.H.3    Dou, Q.P.4
  • 181
    • 84910010311 scopus 로고    scopus 로고
    • Oroxylin A exerts anti-inflammatory activity on lipopolysaccharide-induced mouse macrophage via Nrf2/ARE activation
    • Ye, M., Wang, Q., Zhang, W., Li, Z., Wang, Y., and Hu, R. (2014). Oroxylin A exerts anti-inflammatory activity on lipopolysaccharide-induced mouse macrophage via Nrf2/ARE activation. Biochem. Cell Biol. 92, 337-348. doi: 10.1139/bcb-2014-0030
    • (2014) Biochem. Cell Biol , vol.92 , pp. 337-348
    • Ye, M.1    Wang, Q.2    Zhang, W.3    Li, Z.4    Wang, Y.5    Hu, R.6
  • 182
    • 84894493999 scopus 로고    scopus 로고
    • Anti-inflammatory effects of rutin on HMGB1-induced inflammatory responses in vitro and in vivo
    • Yoo, H., Ku, S.-K., Baek, Y.-D., and Bae, J.-S. (2014). Anti-inflammatory effects of rutin on HMGB1-induced inflammatory responses in vitro and in vivo. Inflam. Res. 63, 197-206. doi: 10.1007/s00011-013-0689-x
    • (2014) Inflam. Res , vol.63 , pp. 197-206
    • Yoo, H.1    Ku, S.-K.2    Baek, Y.-D.3    Bae, J.-S.4
  • 183
    • 84872608286 scopus 로고    scopus 로고
    • Epigallocatechin-3-gallate improves acne in humans by modulating intracellular molecular targets and inhibiting Pacnes
    • Yoon, J. Y., Kwon, H. H., Min, S. U., Thiboutot, D. M., and Suh, D. H. (2013). Epigallocatechin-3-gallate improves acne in humans by modulating intracellular molecular targets and inhibiting Pacnes. J. Invest. Dermatol. 133, 429-440. doi: 10.1038/jid.2012.292
    • (2013) J. Invest. Dermatol , vol.133 , pp. 429-440
    • Yoon, J.Y.1    Kwon, H.H.2    Min, S.U.3    Thiboutot, D.M.4    Suh, D.H.5
  • 184
    • 77952482590 scopus 로고    scopus 로고
    • Resveratrol and piceatannol inhibit iNOS expression and NF-κB activation in dextran sulfate sodium-induced mouse colitis
    • Youn, J., Lee, J. S., Na, H. K., Kundu, J. K., and Surh, Y. J. (2009). Resveratrol and piceatannol inhibit iNOS expression and NF-κB activation in dextran sulfate sodium-induced mouse colitis. Nutr. Cancer 61, 847-854. doi: 10.1080/01635580903285072
    • (2009) Nutr. Cancer , vol.61 , pp. 847-854
    • Youn, J.1    Lee, J.S.2    Na, H.K.3    Kundu, J.K.4    Surh, Y.J.5
  • 185
    • 35148848289 scopus 로고    scopus 로고
    • Comparison of effects of epigallocatechin-3-gallate on hypoxia injury to human umbilical vein, RF/6A, and ECV304 cells induced by Na(2)S(2)O(4)
    • Yu, H. N., Ma, X. L., Yang, J. G., Shi, C. C., Shen, S. R., and He, G. Q. (2007). Comparison of effects of epigallocatechin-3-gallate on hypoxia injury to human umbilical vein, RF/6A, and ECV304 cells induced by Na(2)S(2)O(4). Endothelium 14, 227-231. doi: 10.1080/10623320701547299
    • (2007) Endothelium , vol.14 , pp. 227-231
    • Yu, H.N.1    Ma, X.L.2    Yang, J.G.3    Shi, C.C.4    Shen, S.R.5    He, G.Q.6
  • 186
    • 70249145062 scopus 로고    scopus 로고
    • Quaternary alkaloid, pseudocoptisine isolated from tubers of Corydalis turtschaninovi inhibits LPS-induced nitric oxide, PGE2, and pro-inflammatory cytokines production via the down-regulation of NF-κB in RAW 264.7 murine macrophage cells
    • Yun, K. J., Shin, J. S., Choi, J. H., Back, N. I., Chung, H. G., and Lee, K. T. (2009). Quaternary alkaloid, pseudocoptisine isolated from tubers of Corydalis turtschaninovi inhibits LPS-induced nitric oxide, PGE2, and pro-inflammatory cytokines production via the down-regulation of NF-κB in RAW 264.7 murine macrophage cells. Int. Immunopharmacol. 9, 1323-1331. doi: 10.1016/j.intimp.2009.08.001
    • (2009) Int. Immunopharmacol , vol.9 , pp. 1323-1331
    • Yun, K.J.1    Shin, J.S.2    Choi, J.H.3    Back, N.I.4    Chung, H.G.5    Lee, K.T.6
  • 187
    • 82155175654 scopus 로고    scopus 로고
    • Antiinflammatory effects of matrine in LPS-induced acute lung injury in mice
    • Zhang, B., Liu, Z. Y., Li, Y. Y., Luo, Y., Liu, M. L., Dong, H. Y., et al. (2011). Antiinflammatory effects of matrine in LPS-induced acute lung injury in mice. Eur. J. Pharm. Sci. 44, 573-579. doi: 10.1016/j.ejps.2011.09.020
    • (2011) Eur. J. Pharm. Sci , vol.44 , pp. 573-579
    • Zhang, B.1    Liu, Z.Y.2    Li, Y.Y.3    Luo, Y.4    Liu, M.L.5    Dong, H.Y.6
  • 188
    • 84897054558 scopus 로고    scopus 로고
    • Andrographolide suppress tumor growth by inhibiting TLR4/NF-κB signaling activation in insulinoma
    • Zhang, Q. Q., Ding, Y., Lei, Y., Qi, C. L., He, X. D., Lan, T., et al. (2014). Andrographolide suppress tumor growth by inhibiting TLR4/NF-κB signaling activation in insulinoma. Int. J. Biol. Sci. 10, 404-414. doi: 10.7150/ijbs.7723
    • (2014) Int. J. Biol. Sci , vol.10 , pp. 404-414
    • Zhang, Q.Q.1    Ding, Y.2    Lei, Y.3    Qi, C.L.4    He, X.D.5    Lan, T.6
  • 189
    • 55249100081 scopus 로고    scopus 로고
    • Sophocarpine and matrine inhibit the production of TNF-α and IL-6 in murine macrophages and prevent cachexia-related symptoms induced by colon26 adenocarcinoma in mice
    • Zhang, Y., Wang, S., Li, Y., Xiao, Z., Hu, Z., and Zhang, J. (2008). Sophocarpine and matrine inhibit the production of TNF-α and IL-6 in murine macrophages and prevent cachexia-related symptoms induced by colon26 adenocarcinoma in mice. Int. Immunopharmacol. 8, 1767-1772. doi: 10.1016/j.intimp.2008.08.008
    • (2008) Int. Immunopharmacol , vol.8 , pp. 1767-1772
    • Zhang, Y.1    Wang, S.2    Li, Y.3    Xiao, Z.4    Hu, Z.5    Zhang, J.6
  • 190
    • 0038721155 scopus 로고    scopus 로고
    • Inhibitors of nitric oxide production from hops (Humulus lupulus L.)
    • Zhao, F., Nozawa, H., Daikonnya, A., Kondo, K., and Kitanaka, S. (2003). Inhibitors of nitric oxide production from hops (Humulus lupulus L.). Biol. Pharm. Bull. 26, 61-65. doi: 10.1248/bpb.26.61
    • (2003) Biol. Pharm. Bull , vol.26 , pp. 61-65
    • Zhao, F.1    Nozawa, H.2    Daikonnya, A.3    Kondo, K.4    Kitanaka, S.5
  • 191
    • 34250317826 scopus 로고    scopus 로고
    • Evaluation of the anti-inflammatory activity of luteolin in experimental animal models
    • Ziyan, L., Yongmei, Z., Nan, Z., Ning, T., and Baolin, L. (2007). Evaluation of the anti-inflammatory activity of luteolin in experimental animal models. Planta Med. 73, 221-226. doi: 10.1055/s-2007-967122
    • (2007) Planta Med , vol.73 , pp. 221-226
    • Ziyan, L.1    Yongmei, Z.2    Nan, Z.3    Ning, T.4    Baolin, L.5


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