Andrographis paniculata extract (HMPL-004) for active ulcerative colitis

American Journal of Gastroenterology

Volumn 108, Issue 1, 2013, Pages 90-98

  Sandborn, William J ^a   Targan, Stephan R ^b   Byers, Vera S ^c   Rutty, Dean A ^d   Mu, Hua ^e   Zhang, Xun ^e   Tang, Tom ^e  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b CEDARS SINAI MEDICAL CENTER   (United States)

^c Immunology Inc   (United States)

^d Everest Clinical Research Services Inc   (Canada)

^e Hutchison Medipharma Ltd   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ANDROGRAPHIS PANICULATA EXTRACT; BALSALAZIDE; HMPL 004; MESALAZINE; OLSALAZINE; PLACEBO; SALAZOSULFAPYRIDINE; UNCLASSIFIED DRUG;

ABDOMINAL PAIN; ADULT; AGEUSIA; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ALKALINE PHOSPHATASE BLOOD LEVEL; ANDROGRAPHIS PANICULATA; ANEMIA; ARTICLE; BACKACHE; BASOPHILIA; CLINICAL EVALUATION; CONTROLLED STUDY; DIARRHEA; DISEASE SEVERITY; DOUBLE BLIND PROCEDURE; DRUG DOSE COMPARISON; DRUG EFFICACY; DRUG ERUPTION; DRUG INDUCED HEADACHE; DRUG SAFETY; DRUG WITHDRAWAL; DYSGEUSIA; DYSPEPSIA; FATIGUE; FEMALE; FLATULENCE; GAMMA GLUTAMYL TRANSFERASE BLOOD LEVEL; GLUCOSE BLOOD LEVEL; HUMAN; INFLUENZA; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY; NAUSEA; PILOT STUDY; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; REMISSION; RHINOPHARYNGITIS; SIDE EFFECT; TREATMENT DURATION; TREATMENT OUTCOME; TREATMENT RESPONSE; ULCERATIVE COLITIS;

ADMINISTRATION, ORAL; ADULT; ANDROGRAPHIS; ANTI-INFLAMMATORY AGENTS; COLITIS, ULCERATIVE; DOSE-RESPONSE RELATIONSHIP, DRUG; DOUBLE-BLIND METHOD; DRUG ADMINISTRATION SCHEDULE; FEMALE; HUMANS; KAPLAN-MEIER ESTIMATE; LOGISTIC MODELS; MALE; MIDDLE AGED; PHYTOTHERAPY; PLANT EXTRACTS; PROPORTIONAL HAZARDS MODELS; SEVERITY OF ILLNESS INDEX; TREATMENT OUTCOME;

EID: 84872012274     PISSN: 00029270     EISSN: 15720241     Source Type: Journal    
DOI: 10.1038/ajg.2012.340     Document Type: Article

References (14)

1. Baumgart DC, Sandborn WJ. Inflammatory bowel disease: clinical aspects and established and evolving therapies. Lancet 2007; 369: 1641-57.
2. Kornbluth A, Sachar DB. Ulcerative colitis practice guidelines in adults: American College Of Gastroenterology, Practice Parameters Committee. Am J Gastroenterol 2010; 105: 501-23; quiz 24.
3. Travis SPL, Stange EF, Lémann M et al. European evidence-based consensus on the management of ulcerative colitis: current management. J Crohn ′?s Colitis 2008; 2: 24-62.
4. Lichtenstein GR, Abreu MT, Cohen R et al. American Gastroenterological Association Institute technical review on corticosteroids, immunomodulators, and infliximab in inflammatory bowel disease. Gastroenterology 2006; 130: 940-87.
5. Poolsup N, Suthisisang C, Prathanturarug S et al. Andrographis paniculata in the symptomatic treatment of uncomplicated upper respiratory tract infection: systematic review of randomized controlled trials. J Clin Pharm Ther 2004; 29: 37-45.
6. Coon JT, Ernst E. Andrographis paniculata in the treatment of upper respiratory tract infections: a systematic review of safety and efficacy. Planta Med 2004; 70: 293-8.
7. Saxena RC, Singh R, Kumar P et al. A randomized double blind placebo controlled clinical evaluation of extract of Andrographis paniculata (KalmCold) in patients with uncomplicated upper respiratory tract infection. Phytomedicine 2010; 17: 178-85.
8. Chao WW, Kuo YH, Lin BF. Anti-inflammatory activity of new compounds from Andrographis paniculata by NF-kappaB transactivation inhibition. J Agric Food Chem 2010; 58: 2505-12.
9. Parichatikanond W, Suthisisang C, Dhepakson P et al. Study of anti-inflammatory activities of the pure compounds from Andrographis paniculata (burm. f.) Nees and their effects on gene expression. Int Immunopharmacol 2010; 10: 1361-73.
10. Tang T, Targan S, Li ZS et al. Randomised clinical trial: herbal extract HMPL-004 in active ulcerative colitis: a double blind comparison with sustained release mesalazine. Aliment Pharmacol Ther 2011; 33: 194-202.
11. Schroeder KW, Tremaine WJ, Ilstrup DM. Coated oral 5-aminosalicylic acid therapy for mildly to moderately active ulcerative colitis. a randomized study. N Engl J Med 1987; 317: 1625-9.
12. Rutgeerts P, Sandborn WJ, Feagan BG et al. Infliximab induction and maintenance therapy for ulcerative colitis. N Engl J Med 2005; 353: 2462-76.
13. D'Haens G, Sandborn WJ, Feagan BG et al. A review of activity indices and efficacy endpoints for clinical trials of medical therapy in adults with ulcerative colitis. Gastroenterology 2007; 132: 763-86.
14. Sandborn W, Targan S, Byers V et al. Randomized, double-blind, placebocontrolled trial of Andrographis paniculata extract (HMPL-004) in patients with moderately active Crohn's Disease. Am J Gastroenterol 2010; 105 (Suppl 1): S429 Abstract 1180.