Lycorine inhibits lipopolysaccharide-induced iNOS and COX-2 up-regulation in RAW264.7 cells through suppressing P38 and STATs activation and increases the survival rate of mice after LPS challenge

International Immunopharmacology

Volumn 12, Issue 1, 2012, Pages 249-256

  Kang, Jingjing ^a   Zhang, Yushun ^a   Cao, Xiang ^a   Fan, Jie ^a   Li, Guilan ^a   Wang, Qi ^a   Diao, Ying ^a   Zhao, Zhihui ^a   Luo, Lan ^b   Yin, Zhimin ^a  

^a NANJING NORMAL UNIVERSITY   (China)

^b NANJING UNIVERSITY   (China)

Author keywords

COX 2; iNOS; Lipopolysaccharide; Lycorine; P38; STATs

Indexed keywords

CYCLOOXYGENASE 2; DEXAMETHASONE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; LIPOPOLYSACCHARIDE; LYCORINE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; NITRIC OXIDE; PROSTAGLANDIN E2; STAT PROTEIN; STRESS ACTIVATED PROTEIN KINASE; SYNAPTOPHYSIN; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL MODEL; ARTICLE; CELL CULTURE; CONTROLLED STUDY; ENZYME ACTIVATION; GENE EXPRESSION; MALE; MORTALITY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SURVIVAL; UPREGULATION;

AMARYLLIDACEAE ALKALOIDS; ANIMALS; ANTI-INFLAMMATORY AGENTS; CELL LINE; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITORS; DINOPROSTONE; INTERLEUKIN-6; LIPOPOLYSACCHARIDES; MALE; MICE; MICE, INBRED ICR; MITOGEN-ACTIVATED PROTEIN KINASES; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE II; PHENANTHRIDINES; RNA, MESSENGER; SHOCK, SEPTIC; STAT1 TRANSCRIPTION FACTOR; STAT3 TRANSCRIPTION FACTOR; TUMOR NECROSIS FACTOR-ALPHA; UP-REGULATION;

EID: 84856102254     PISSN: 15675769     EISSN: 18781705     Source Type: Journal    
DOI: 10.1016/j.intimp.2011.11.018     Document Type: Article

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