Immunomodulatory activity of resveratrol: Suppression of lymphocyte proliferation, development of cell-mediated cytotoxicity, and cytokine production

Biochemical Pharmacology

Volumn 62, Issue 9, 2001, Pages 1299-1308

  Gao, Xiaohua ^a   Xu, Yong X ^a   Janakiraman, Nalini ^a   Chapman, Robert A ^a   Gautam, Subhash C ^a  

^a HENRY FORD HEALTH SYSTEM   (United States)

Author keywords

Cell mediated cytotoxicity; Cytokines; Immuno modulation; Lymphocyte proliferation; Resveratrol

Indexed keywords

ALLOANTIGEN; CONCANAVALIN A; GAMMA INTERFERON; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 12; INTERLEUKIN 2; MESSENGER RNA; RESVERATROL; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL TISSUE; ANTIGEN SPECIFICITY; ARTICLE; CELL MEDIATED CYTOTOXICITY; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOTOXIC T LYMPHOCYTE; DRUG EFFECT; IMMUNOMODULATION; LYMPHOCYTE PROLIFERATION; LYMPHOKINE ACTIVATED KILLER CELL; MALE; MOUSE; NONHUMAN; PERITONEUM MACROPHAGE; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN EXPRESSION; SPLEEN LYMPHOCYTE;

ADJUVANTS, IMMUNOLOGIC; ANIMALS; CELL DIVISION; CELLS, CULTURED; CYTOKINES; IMMUNITY, CELLULAR; INTERLEUKIN-2; LYMPHOCYTES; MALE; MICE; MICE, INBRED C3H; MICE, INBRED C57BL; NF-KAPPA B; RNA, MESSENGER; STILBENES;

EID: 0035503936     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-2952(01)00775-4     Document Type: Article

References (40)

1. Fruit, vegetables, and cancer prevention: A review of the epidemiological evidence
2. Diet and health: What should we eat?
3. Diet and cancer: A review
4. Inhibition of carcinogenesis by minor dietary constituents
5. Dietary fat intake and the risk of coronary heart disease in women
6. Dietary flavonoid and cancer prevention: Evidence and potential mechanism
7. Molecular mechanisms of chemopreventive effects of selected dietary and medicinal phenolic substances
8. Alcohol, ischemic heart disease, and the French paradox
9. Wine, alcohol, platelets, and the French paradox for coronary heart disease
10. Mortality associated with moderate intakes of wine, beer, or spirits
11. Interaction of transresveratrol with plasma lipoproteins
12. Inhibition of human LDL oxidation by resveratrol
13. The red wine phenolics trans-reversatrol and quercetin block human platelet aggregation and eicosanoid synthesis: Implications for protection against coronary heart disease
14. Effects of trans-resveratrol, a natural polyphenolic compound, on human polymorphonuclear leukocyte function
15. Effects of stilbenes on arachidonate metabolism in leukocytes
16. Resveratrol inhibits metal ion-dependent and independent peroxidation of porcine low-density lipoproteins
17. Antiplatelet activity of cis-resveratrol
18. Synergy between ethanol and grape polyphenols, quercetin, and resveratrol, in the inhibition of the inducible nitric oxide synthase pathway
19. Resveratrol modulates arachidonic acid release, prostaglandin synthesis, and 3T6 fibroblast growth factor
20. Cancer chemopreventive activity of resveratrol, a natural product derived from grapes
21. Antiproliferative effect of synthetic resveratrol on human breast epithelial cells
22. Resveratrol, a natural product derived from grape, exhibits antiestrogenic activity, and inhibits the growth of human breast cancer cells
23. Differential effects on growth, cell cycle arrest, and induction of apoptosis by resveratrol in human prostrate cancer cell lines
24. Anti-proliferative effect of resveratrol, a natural component of grapes, and wine, on human colonic cancer cells
25. Cardioprotective effect of resveratrol, a natural antioxidant derived from grapes
26. Partial neuroprotection of in vivo excitotoxic brain damage by chronic administration of the red wine antioxidant agent, trans-resveratrol in rats
27. Resveratrol selectively inhibits leukemia cells: A prospective agent for ex vivo bone marrow purging
28. Accurate transcription initiation by RNA polymerase II in a solute extract from isolated mammalian nuclei
29. Beyond alcohol: Beverage consumption and cardiovascular mortality
30. The production of resveratrol by Vitis-vinifera and other members of the vitaceae as a response to infection or injury
31. Resveratrol, a remarkable inhibitor of ribonucleotide reductase
32. DNA polymerase, and topoisomerase II inhibitors from Psoralea corylifolia
33. Resveratrol arrests the cell division cycle at S/G2 phase transition
34. Anti-oxidants as modulators of immune function
35. The role of reactive oxygen species in triggering proliferation and IL-2 secretion in T cells
36. NF-κB: A pleiotrophic mediator of inducible, and tissue-specific gene control
37. Constitutive nuclear factor-κB-RelA activation is required for proliferation and survival of Hodgkin's disease tumor cells
38. A requirement for NF-κB activation in Bcr-Abl-mediated transformation
39. Chemopreventive properties of trans-resveratrol are associated with inhibition of activation of the IκB kinase
40. Resveratrol suppresses TNF-induced activation of nuclear transcription factors NK-κB, activator protein-1, and apoptosis: Potential role of reactive oxygen intermediates and lipid peroxidation