Dietary soy protein isolate ameliorates atherosclerotic lesions in apolipoprotein E-deficient mice potentially by inhibiting monocyte chemoattractant protein-1 expression

Journal of Nutrition

Volumn 138, Issue 2, 2008, Pages 332-337

  Nagarajan, Shanmugam ^a,b   Burris, Ramona L ^b   Stewart, Bradford W ^b   Wilkerson, James E ^b   Badger, Thomas M ^b  

^a UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

^b UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

APOLIPOPROTEIN E; BACTERIUM LIPOPOLYSACCHARIDE; CASEIN; DAIDZEIN; EQUOL; GENISTEIN; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LOW DENSITY LIPOPROTEIN CHOLESTEROL; MONOCYTE CHEMOTACTIC PROTEIN 1; SOYBEAN PROTEIN; TRIACYLGLYCEROL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AORTA SINUS; ARTICLE; ATHEROSCLEROSIS; CONCENTRATION RESPONSE; CONTROLLED STUDY; DESCENDING AORTA; DIET; FEMALE; HUMAN; HUMAN CELL; INFLAMMATION; KNOCKOUT MOUSE; LEUKOCYTE MIGRATION INHIBITION TEST; LIPID BLOOD LEVEL; MACROPHAGE; MOUSE; NONHUMAN; PROTEIN EXPRESSION; PROTEIN SECRETION; REAL TIME POLYMERASE CHAIN REACTION;

MUS;

EID: 38949148974     PISSN: 00223166     EISSN: 15416100     Source Type: Journal    
DOI: 10.1093/jn/138.2.332     Document Type: Article

References (29)

1. Adlercreutz H. Western diet and Western diseases: some hormonal and biochemical mechanisms and associations. Scand J Clin Lab Invest. 1990;50:3-23.
2. Kolonel LN. Variability in diet and its relation to risk in ethnic and migration groups. Basic Life Sci. 1988;43:129-35.
3. Ni W, Tsuda Y, Sakono M, Imaizumi K. Dietary soy protein isolate, compared with casein, reduces atherosclerotic lesion area in apolipoprotein E-deficient mice. J Nutr. 1998;128:1884-9.
4. Adams MR, Golden DL, Register TC, Anthony MS, Hodgin JB, Maeda N, Williams JK. The atheroprotective effect of dietary soy isoflavones in apolipoprotein E-/- mice requires the presence of estrogen receptoralpha. Arterioscler Thromb Vasc Biol. 2002;22:1859-64.
5. Libby P. Inflammation in atherosclerosis. Nature. 2002;420:868-74.
6. Lusis AJ. Atherosclerosis. Nature. 2000;407:233-41.
7. Boring L, Gosling J, Cleary M, Charo IF. Decreased lesion formation in CCR2-/- mice reveals a role for chemokines in the initiation of atherosclerosis. Nature. 1998;394:894-7.
8. Gosling J, Slaymaker S, Gu L, Tseng S, Zlot CH, Young SG, Rollins BJ, Charo IF. MCP-1 deficiency reduces susceptibility to atherosclerosis inmice that overexpress human apolipoprotein B. J Clin Invest. 1999;103:773-8.
9. Weber KS, Draude G, Erl W, de Martin R, Weber C. Monocyte arrest and transmigration on inflamed endothelium in shear flow is inhibited by adenovirus-mediated gene transfer of IkappaB-alpha. Blood. 1999;93:3685-93.
10. Kowala MC, Recce R, Beyer S, Gu C, Valentine M. Characterization of atherosclerosis in LDL receptor knockout mice: macrophage accumulation correlates with rapid and sustained expression of aortic MCP-1/JE. Atherosclerosis. 2000;149:323-30.
11. Zhang SH, Reddick RL, Piedrahita JA, Maeda N. Spontaneous hypercholesterolemia and arterial lesions in mice lacking apolipoprotein E. Science. 1992;258:468-71.
12. Reeves PG, Nielsen FH, Fahey GC Jr. AIN-93 purified diets for laboratory rodents: final report of the American Institute of Nutrition ad hoc writing committee on the reformulation of the AIN-76A rodent diet. J Nutr. 1993;123:1939-51.
13. Rowlands JC, He L, Hakkak R, Ronis MJ, Badger TM. Soy and whey proteins downregulate DMBA-induced liver and mammary gland CYP1 expression in female rats. J Nutr. 2001;131:3281-7.
14. Paigen B, Holmes PA, Mitchell D, Albee D. Comparison of atherosclerotic lesions and HDL-lipid levels in male, female, and testosterone-treated female mice from strains C57BL/6, BALB/c and C3H. Atherosclerosis. 1987;64:215-21.
15. Thampi P, Stewart BW, Joseph L, Melnyk SB, Hennings LJ, Nagarajan S. Dietary homocysteine promotes atherosclerosis in apoE-deficient mice by inducing scavenger receptors expression. Atherosclerosis. 2007; 10.1016/j. atherosclerosis.2007.09.014.
16. Friedewald WT, Levy RI, Fredrickson DS. Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of preparative ultracentrifuge. Clin Chem. 1972;18:499-502.
17. Enkhmaa B, Shiwaku K, Katsube T, Kitajima K, Anuurad E, Yamasaki M, Yamane Y. Mulberry (Morus alba L.) leaves and their major flavonol quercetin 3-(6-malonylglucoside) attenuate atherosclerotic lesion development in LDL receptor-deficient mice. J Nutr. 2005;135:729-34.
18. Nagarajan S. Anti-OxLDL IgG blocks OxLDL interaction with CD36, but promotes FcgammaR, CD32A-dependent inflammatory cell adhesion. Immunol Lett. 2007;108:52-61.
19. Anthony MS, Clarkson TB, Bullock BC, Wagner JD. Soy protein versus soy phytoestrogens in the prevention of diet-induced coronary artery atherosclerosis of male cynomolgus monkeys. Arterioscler Thromb Vasc Biol. 1997;17:2524-31.
20. Chacko BK, Chandler RT, Mundhekar A, Khoo N, Pruitt HM, Kucik DF, Parks DA, Kevil CG, Barnes S, et al. Revealing anti-inflammatory mechanisms of soy isoflavones by flow: modulation of leukocyte-endothelial cell interactions. Am J Physiol Heart Circ Physiol. 2005;289:H908-15.
21. Chacko BK, Chandler RT, D'Alessandro TL, Mundhekar A, Khoo NK, Botting N, Barnes S, Patel RP. Anti-inflammatory effects of isoflavones are dependent on flow and human endothelial cell PPARgamma. J Nutr. 2007;137:351-6.
22. Nagarajan S, Stewart BW, Badger TM. Soy isoflavones attenuate human monocyte adhesion to endothelial cell-specific CD54 by inhibiting monocyte CD11a. J Nutr. 2006;136:2384-90.
23. Sirtori CR, Gianazza E, Manzoni C, Lovati MR, Murphy PA. Role of isoflavones in the cholesterol reduction by soy proteins in the clinic. Am J Clin Nutr. 1997;65:166-7.
24. Sirtori CR, Even R, Lovati MR. Soybean protein diet and plasma cholesterol: from therapy to molecular mechanisms. Ann N Y Acad Sci. 1993;676:188-201.
25. Lovati MR, Manzoni C, Gianazza E, Arnoldi A, Kurowska E, Carroll KK, Sirtori CR. Soy protein peptides regulate cholesterol homeostasis in Hep G2 cells. J Nutr. 2000;130:2543-9.
26. Adams MR, Golden DL, Franke AA, Potter SM, Smith HS, Anthony MS. Dietary soy beta-conglycinin (7S globulin) inhibits atherosclerosis in mice. J Nutr. 2004;134:511-6.
27. Ueda A, Ishigatsubo Y, Okubo T, Yoshimura T. Transcriptional regulation of the human monocyte chemoattractant protein-1 gene. Cooperation of two NF-kappaB sites and NF-kappaB/Rel subunit specificity. J Biol Chem. 1997;272:31092-9.
28. Setchell KD, Brown NM, Desai P, Zimmer-Nechemias L, Wolfe BE, Brashear WT, Kirschner AS, Cassidy A, Heubi JE. Bioavailability of pure isoflavones in healthy humans and analysis of commercial soy isoflavone supplements. J Nutr. 2001;131:S1362-75.
29. Gu L, House SE, Prior RL, Fang N, Ronis MJ, Clarkson TB, Wilson ME, Badger TM. Metabolic phenotype of isoflavones differ among female rats, pigs, monkeys, and women. J Nutr. 2006;136:1215-21.