Anti-inflammatory effects of sophocarpine in LPS-induced RAW 264.7 cells via NF-κB and MAPKs signaling pathways

Toxicology in Vitro

Volumn 26, Issue 1, 2012, Pages 1-6

  Gao, Yonglin ^a   Jiang, Wanglin ^b   Dong, Chaohua ^c   Li, Chunmei ^a   Fu, Xuejun ^a   Min, Li ^a   Tian, Jingwei ^a   Jin, Haizhu ^a   Shen, Jingyu ^a  

^a YANTAI UNIVERSITY   (China)

^b BINZHOU MEDICAL UNIVERSITY   (China)

^c QINGDAO AGRICULTURAL UNIVERSITY   (China)

Author keywords

Anti inflammatory activity; COX 2; INOS; Mitogen activated protein kinases; NF B; Sophocarpine

Indexed keywords

CYCLOOXYGENASE 2; I KAPPA B; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 6; LACTATE DEHYDROGENASE; LIPOPOLYSACCHARIDE; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; QUINOLIZIDINE DERIVATIVE; SOPHOCARPINE; STRESS ACTIVATED PROTEIN KINASE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CELL LINE; CELL STAIN RAW 264; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOTOXICITY; ENZYME PHOSPHORYLATION; IN VITRO STUDY; MACROPHAGE; MOUSE; NONHUMAN; PROTEIN EXPRESSION; PROTEIN INDUCTION; PROTEIN PHOSPHORYLATION;

ALKALOIDS; ANIMALS; ANTI-INFLAMMATORY AGENTS; CELL LINE; CELL SURVIVAL; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITORS; I-KAPPA B PROTEINS; INTERLEUKIN-6; L-LACTATE DEHYDROGENASE; LIPOPOLYSACCHARIDES; MICE; MITOGEN-ACTIVATED PROTEIN KINASES; NF-KAPPA B; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE II; SIGNAL TRANSDUCTION; TUMOR NECROSIS FACTOR-ALPHA;

ANIMALIA; SOPHORA ALOPECUROIDES;

EID: 84855343027     PISSN: 08872333     EISSN: 18793177     Source Type: Journal    
DOI: 10.1016/j.tiv.2011.09.019     Document Type: Article

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