Anti-inflammatory, anti-proliferative and anti-atherosclerotic effects of quercetin in human in vitro and in vivo models

Atherosclerosis

Volumn 218, Issue 1, 2011, Pages 44-52

  Kleemann, Robert ^a   Verschuren, Lars ^a   Morrison, Martine ^a   Zadelaar, Susanne ^a   van Erk, Marjan J ^a   Wielinga, Peter Y ^a   Kooistra, Teake ^a  

^a TNO   (Netherlands)

Author keywords

Anti inflammatory; Atherosclerosis; Cholesterol; CRP; Inflammation; Polyphenol; Proliferation; Quercetin

Indexed keywords

C REACTIVE PROTEIN; ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; FIBRINOGEN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; QUERCETIN; VASCULAR CELL ADHESION MOLECULE 1;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; ATHEROSCLEROSIS; CARDIOVASCULAR RISK; CONTROLLED STUDY; DRUG ACTIVITY; DRUG BLOOD LEVEL; DRUG EFFECT; ENDOTHELIUM CELL; HUMAN; HUMAN CELL; INFLAMMATION; LIVER CELL; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RISK FACTOR; TRANSGENIC MOUSE;

ANIMALS; ANTI-INFLAMMATORY AGENTS; ANTIOXIDANTS; APOLIPOPROTEINS E; ATHEROSCLEROSIS; C-REACTIVE PROTEIN; CARDIOVASCULAR DISEASES; CELL PROLIFERATION; E-SELECTIN; HUMANS; INFLAMMATION; MICE; MICE, TRANSGENIC; OXIDATIVE STRESS; QUERCETIN; RISK FACTORS; TRANSGENES; VASCULAR CELL ADHESION MOLECULE-1;

EID: 80052273994     PISSN: 00219150     EISSN: 18791484     Source Type: Journal    
DOI: 10.1016/j.atherosclerosis.2011.04.023     Document Type: Article

References (48)

1. Nettleton J.A., Steffen L.M., Mayer-Davis E.J., et al. Dietary patterns are associated with biochemical markers of inflammation and endothelial activation in the Multi-Ethnic Study of Atherosclerosis (MESA). Am J Clin Nutr 2006, 83:1369-1379.
2. Nettleton J.A., Polak J.F., Tracy R., Burke G.L., Jacobs D.R. Dietary patterns and incident cardiovascular disease in the Multi-Ethnic Study of Atherosclerosis. Am J Clin Nutr 2009, 90:647-654.
3. Karakas M., Koenig W. CRP in cardiovascular disease. Herz 2009, 34:607-613.
4. Zern T.L., Fernandez M.L. Cardioprotective effects of dietary polyphenols. J Nutr 2005, 135:2291-2294.
5. Hollman P.C., Geelen A., Kromhout D. Dietary flavonol intake may lower stroke risk in men and women. J Nutr 2010, 140:600-604.
6. Konstantinidou V., Covas M.I., Munoz-Aguayo D., et al. In vivo nutrigenomic effects of virgin olive oil polyphenols within the frame of the Mediterranean diet: a randomized controlled trial. FASEB J 2010, 24:2546-2557.
7. Karlsen A., Paur I., Bohn S.K., et al. Bilberry juice modulates plasma concentration of NF-kappaB related inflammatory markers in subjects at increased risk of CVD. Eur J Nutr 2010, 49:345-355.
8. de Maat M.P., Pijl H., Kluft C., Princen H.M. Consumption of black and green tea had no effect on inflammation, haemostasis and endothelial markers in smoking healthy individuals. Eur J Clin Nutr 2000, 54:757-763.
9. Boots A.W., Haenen G.R., Bast A. Health effects of quercetin: from antioxidant to nutraceutical. Eur J Pharmacol 2008, 585:325-337.
10. Hirpara K.V., Aggarwal P., Mukherjee A.J., Joshi N., Burman A.C. Quercetin and its derivatives: synthesis, pharmacological uses with special emphasis on anti-tumor properties and prodrug with enhanced bio-availability. Anticancer Agents Med Chem 2009, 9:138-161.
11. Bischoff S.C. Quercetin: potentials in the prevention and therapy of disease. Curr Opin Clin Nutr Metab Care 2008, 11:733-740.
12. Zadelaar S., Kleemann R., Verschuren L., et al. Mouse models for atherosclerosis and pharmaceutical modifiers. Arterioscler Thromb Vasc Biol 2007, 27:1706-1721.
13. van Dam B., van H.V., Stehouwer C.D., et al. Vitamin E inhibits lipid peroxidation-induced adhesion molecule expression in endothelial cells and decreases soluble cell adhesion molecules in healthy subjects. Cardiovasc Res 2003, 57:563-571.
14. Kleemann R., Gervois P.P., Verschuren L., et al. Fibrates down-regulate IL-1-stimulated C-reactive protein gene expression in hepatocytes by reducing nuclear p50-NFkappa B-C/EBP-beta complex formation. Blood 2003, 101:545-551.
15. Haslinger B., Kleemann R., Toet K.H., Kooistra T. Simvastatin suppresses tissue factor expression and increases fibrinolytic activity in tumor necrosis factor-alpha-activated human peritoneal mesothelial cells. Kidney Int 2003, 63:2065-2074.
16. Verschuren L., Kleemann R., Offerman E.H., et al. Effect of low dose atorvastatin versus diet-induced cholesterol lowering on atherosclerotic lesion progression and inflammation in apolipoprotein E*3-Leiden transgenic mice. Arterioscler Thromb Vasc Biol 2005, 25:161-167.
17. Rein D., Schijlen E., Kooistra T., et al. Transgenic flavonoid tomato intake reduces C-reactive protein in human C-reactive protein transgenic mice more than wild-type tomato. J Nutr 2006, 136:2331-2337.
18. Kleemann R., Verschuren L., van Erk M.J., et al. Atherosclerosis and liver inflammation induced by increased dietary cholesterol intake: a combined transcriptomics and metabolomics analysis. Genome Biol 2007, 8:R200.
19. Kooistra T., Verschuren L., de Vries-van der Weij, et al. Fenofibrate reduces atherogenesis in ApoE*3Leiden mice: evidence for multiple antiatherogenic effects besides lowering plasma cholesterol. Arterioscler Thromb Vasc Biol 2006, 26:2322-2330.
20. Moon J.H., Nakata R., Oshima S., Inakuma T., Terao J. Accumulation of quercetin conjugates in blood plasma after the short-term ingestion of onion by women. Am J Physiol Regul Integr Comp Physiol 2000, 279:R461-R467.
21. Park K., de Oca G., Bonello P., Lee K.J., Dabrowski K. Determination of quercetin concentrations in fish tissues after feeding quercetin-containing diets. Aquacult Int 2009, 17:537-544.
22. de Boer V.C.J., Dihal A.A., van der Woude H., et al. Tissue distribution of quercetin in rats and pigs. J Nutr 2005, 135:1718-1725.
23. Bernhagen J., Krohn R., Lue H., et al. MIF is a noncognate ligand of CXC chemokine receptors in inflammatory and atherogenic cell recruitment. Nat Med 2007, 13:587-596.
24. Verschuren L., de Vries-van der Weij, Zadelaar S., Kleemann R., Kooistra T. LXR agonist suppresses atherosclerotic lesion growth and promotes lesion regression in apoE*3Leiden mice: time course and mechanisms. J Lipid Res 2009, 50:301-311.
25. Kleemann R., van E.M., Verschuren L., et al. Time-resolved and tissue-specific systems analysis of the pathogenesis of insulin resistance. PLoS ONE 2010, 5:e8817.
26. Kleemann R., Verschuren L., De Rooij B.J., et al. Evidence for anti-inflammatory activity of statins and PPARalpha activators in human C-reactive protein transgenic mice in vivo and in cultured human hepatocytes in vitro. Blood 2004, 103:4188-4194.
27. Johnson B.D., Kip K.E., Marroquin O.C., et al. Serum amyloid A as a predictor of coronary artery disease and cardiovascular outcome in women: the National Heart, Lung, and Blood Institute-Sponsored Women's Ischemia Syndrome Evaluation (WISE). Circulation 2004, 109:726-732.
28. Blake G.J., Ridker P.M. C-reactive protein and other inflammatory risk markers in acute coronary syndromes. J Am Coll Cardiol 2003, 41:S37-S42.
29. Ridker P.M., Cannon C.P., Morrow D., et al. C-reactive protein levels and outcomes after statin therapy. N Engl J Med 2005, 352:20-28.
30. O'Brian K.D., McDonald T.O., Kunjathoor V., et al. Serum amyloid A and lipoprotein retention in murine models of atherosclerosis. Arterioscler Thromb Vasc Biol 2005, 25:785-790.
31. Pasceri V., Willerson J.T., Yeh E.T. Direct proinflammatory effect of C-reactive protein on human endothelial cells. Circulation 2000, 102:2165-2168.
32. Ridker P.M., Danielson E., Fonseca F.A., et al. Rosuvastatin to prevent vascular events in men and women with elevated C-reactive protein. N Engl J Med 2008, 20(359):2195-2207.
33. Basu A., Devaraj S., Jialal I. Dietary factors that promote or retard inflammation. Arterioscler Thromb Vasc Biol 2006, 26:995-1001.
34. Chun O.K., Chung S.J., Claycombe K.J., Song W.O. Serum C-reactive protein concentrations are inversely associated with dietary flavonoid intake in U.S. adults. J Nutr 2008, 138:753-760.
35. Sacanella E., Vazquez-Agell M., Mena M.P., et al. Down-regulation of adhesion molecules and other inflammatory biomarkers after moderate wine consumption in healthy women: a randomized trial. Am J Clin Nutr 2007, 86:1463-1469.
36. Granado-Serrano A.B., Martin M.A., Bravo L., Goya L., Ramos S. Quercetin modulates NF-kappa B and AP-1/JNK pathways to induce cell death in human hepatoma cells. Nutr Cancer 2010, 62:390-401.
37. Kim B.H., Lee I.J., Lee H.Y., et al. Quercetin 3-O-beta-(2" -galloyl)-glucopyranoside inhibits endotoxin LPS-induced IL-6 expression and NF-kappa B activation in macrophages. Cytokine 2007, 39:207-215.
38. Yang J.Y., la-Fera M.A., Rayalam S., et al. Enhanced inhibition of adipogenesis and induction of apoptosis in 3T3-L1 adipocytes with combinations of resveratrol and quercetin. Life Sci 2008, 82:1032-1039.
39. Noe V., Penuelas S., Lamuela-Raventos R.M., et al. Epicatechin and a cocoa polyphenolic extract modulate gene expression in human Caco-2 cells. J Nutr 2004, 134:2509-2516.
40. Mora S., Rifai N., Buring J.E., Ridker P.M. Additive value of immunoassay-measured fibrinogen and high-sensitivity C-reactive protein levels for predicting incident cardiovascular events. Circulation 2006, 114:381-387.
41. Loke W.M., Proudfoot J.M., Hodgson J.M., et al. Specific dietary polyphenols attenuate atherosclerosis in apolipoprotein E-knockout mice by alleviating inflammation and endothelial dysfunction. Arterioscler Thromb Vasc Biol 2010, 30:749-757.
42. Hayek T., Fuhrman B., Vaya J., et al. Reduced progression of atherosclerosis in apolipoprotein E-deficient mice following consumption of red wine, or its polyphenols quercetin or catechin, is associated with reduced susceptibility of LDL to oxidation and aggregation. Arterioscler Thromb Vasc Biol 1997, 17:2744-2752.
43. Zern T.L., Wood R.J., Greene C., et al. Grape polyphenols exert a cardioprotective effect in pre- and postmenopausal women by lowering plasma lipids and reducing oxidative stress. J Nutr 2005, 135:1911-1917.
44. Rivera L., Moron R., Sanchez M., Zarzuelo A., Galisteo M. Quercetin ameliorates metabolic syndrome and improves the inflammatory status in obese Zucker rats. Obesity (Silver Spring) 2008, 16:2081-2087.
45. Choi J.S., Choi Y.J., Park S.H., Kang J.S., Kang Y.H. Flavones mitigate tumor necrosis factor-alpha-induced adhesion molecule upregulation in cultured human endothelial cells: role of nuclear factor-kappa B. J Nutr 2004, 134:1013-1019.
46. Lotito S.B., Frei B. Dietary flavonoids attenuate tumor necrosis factor alpha-induced adhesion molecule expression in human aortic endothelial cells. Structure-function relationships and activity after first pass metabolism. J Biol Chem 2006, 281:37102-37110.
47. Boesch-Saadatmandi C., Loboda A., Wagner A.E., et al. Effect of quercetin and its metabolites isorhamnetin and quercetin-3-glucuronide on inflammatory gene expression: role of miR-155. J Nutr Biochem 2011, 22:293-299.
48. Damas J.K., Waehre T., Yndestad A., et al. Interleukin-7-mediated inflammation in unstable angina: possible role of chemokines and platelets. Circulation 2003, 107:2670-2676.