Rhynchophylline attenuates LPS-induced pro-inflammatory responses through down-regulation of MAPK/NF-κB signaling pathways in primary microglia

Phytotherapy Research

Volumn 26, Issue 10, 2012, Pages 1528-1533

  Song, Yu ^a   Qu, Rong ^b   Zhu, Shenghua ^c   Zhang, Ruiguo ^c   Ma, Shiping ^a  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

^b NANJING UNIVERSITY OF CHINESE MEDICINE   (China)

^c UNIVERSITY OF MANITOBA   (Canada)

Author keywords

COX 2; iNOS; microglia; pro inflammatory mediators; rhynchophylline; signaling pathway

Indexed keywords

CYCLOOXYGENASE 2; I KAPPA B ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 1BETA; LIPOPOLYSACCHARIDE; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; MONOCYTE CHEMOTACTIC PROTEIN 1; NITRIC OXIDE; PROSTAGLANDIN E2; RHYNCHOPHYLLINE; STRESS ACTIVATED PROTEIN KINASE; TRANSCRIPTION FACTOR RELA; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CELL ACTIVATION; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DOWN REGULATION; DRUG EFFECT; DRUG MECHANISM; DRUG STRUCTURE; ENZYME PHOSPHORYLATION; GENE EXPRESSION REGULATION; INTRACELLULAR SIGNALING; MICROGLIA; MOLECULAR DYNAMICS; NERVE CELL STIMULATION; NERVOUS SYSTEM INFLAMMATION; NEWBORN; NONHUMAN; PROTEIN DEGRADATION; PROTEIN PHOSPHORYLATION; RAT; UPREGULATION;

ANIMALS; CELL SURVIVAL; CELLS, CULTURED; CHEMOKINE CCL2; CYCLOOXYGENASE 2; DINOPROSTONE; DOWN-REGULATION; I-KAPPA B PROTEINS; INDOLE ALKALOIDS; INFLAMMATION; INFLAMMATION MEDIATORS; INTERLEUKIN-1BETA; LIPOPOLYSACCHARIDES; MAP KINASE SIGNALING SYSTEM; MICROGLIA; MITOGEN-ACTIVATED PROTEIN KINASES; NF-KAPPA B; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE II; PHOSPHORYLATION; RATS; SIGNAL TRANSDUCTION; TUMOR NECROSIS FACTOR-ALPHA;

CARANGIDAE; UNCARIA RHYNCHOPHYLLA;

EID: 84867335978     PISSN: 0951418X     EISSN: 10991573     Source Type: Journal    
DOI: 10.1002/ptr.4614     Document Type: Article

References (26)

1. Albazzaz MK, Pal C, Berman P, Shale DJ,. 1994. Inflammatory markers of lower respiratory tract infection in elderly people. Age Ageing 23: 299-302.
2. Bal-Price A, Brown GC,. 2001. Inflammatory neurodegeneration mediated by nitric oxide from activated glia-inhibiting neuronal respiration, causing glutamate release and excitotoxicity. J Neurosci 21: 6480-6491.
3. Banati RB, Gehrmann J, Schubert P, Kreutzberg GW,. 1993. Cytotoxicity of microglia. Glia 7: 111-118.
4. Barger SW, Harmon AD,. 1997. Microglial activation by Alzheimer amyloid precursor protein and modulation by apolipoprotein E. Nature 388: 878-881.
5. Bauer MKA, Lieb K, Schulze-Osthoff K, et al. 1997. Expression and regulation of cyclooxygenase-2 in rat microglia. Eur J Biochem 243: 726-731.
6. Chen CX, Jin RM, Li YK, et al. 1992. Inhibitory effect of rhynchophylline on platelet aggregation and thrombosis. Zhongguo Yaoli Xuebao 13: 126-130.
7. Chew LJ, Takanohashi A, Bell M,. 2006. Microglia and inflammation: impact on developmental brain injuries. Ment Retard Dev Disabil Res Rev 12: 105-112.
8. Comalada M, Ballester I, Bailón E, Sierra S, Xaus J, Gálvez J,. 2006. Inhibition of pro-inflammatory markers in primary bone marrow-derived mouse macrophages by naturally occurring flavonoids: analysis of the structure-activity relationship. Biochem Pharmacol 72: 1010-1021.
9. Gao HM, Jiang J, Wilson B, Zhang W, Hong JS, Liu B,. 2002. Microglial activation-mediated delayed and progressive degeneration of rat nigral dopaminergic neurons: relevance to Parkinson's disease. J Neurochem 81: 1285-1297.
10. Gao HM, Liu B, Zhang W, Hong JS,. 2003. Novel anti-inflammatory therapy for Parkinson's disease. Trends Pharmacol Sci 24: 395-401.
11. Hu S, Peterson PK, Chao CC,. 1997. Cytokine-mediated neuronal apoptosis. Neurochem Int 30: 427-431.
12. Karunakaran S, Ravindranath V,. 2009. Activation of p38 MAPK in the substantia nigra leads to nuclear translocation of NF-kappaB in MPTP-treated mice: implication in Parkinson's disease. J Neurochem 109: 1791-1799.
13. Lim H, Lee JG, Lee SH, Kim YS, Kim HP,. 2008. Anti-inflammatory activity of phylligenin, a lignan from the fruits of Forsythia koreana, and its cellular mechanism of action. J Ethnopharmacol 118: 113-117.
14. Liu B, Hong JS,. 2003. Role of microglia in inflammation-mediated neurodegenerative diseases: mechanisms and strategies for therapeutic intervention. J Pharmacol Exp Ther 304: 1-7.
15. Luo SF, Lin WN, Yang CM, et al. 2006. Induction of cytosolic phospholipase A2 by lipopolysaccharide in canine tracheal smooth muscle cells: involvement of MAPKs and NF-kappaB pathways. Cell Signal 18: 1201-1211.
16. McGeer PL, Kawamata T, Walker DG, Akiyama H, Tooyama I, McGeer EG,. 1993. Microglia in degenerative neurological disease. Glia 7: 84-92.
17. Nelson PT, Soma LA, Lavi E,. 2002. Microglia in diseases of the central nervous system. Ann Med 34: 491-500.
18. Ozaki Y,. 1989. Pharmacological studies of indole alkaloids obtained from domestic plants, Uncaria rhynchophylla Miq. and Amsonia elliptica Roem. et Schult. Nippon Yakurigaku Zasshi 94: 17-26.
19. Shen S, Yu S, Binek J,. 2005. Distinct signaling pathways for induction of type II NOS by IFN-γ and LPS in BV-2 microglial cells. Neuroscience 22: 3352-3358.
20. Shi JS, Kenneth HG,. 2002. Effect of rhynchophylline on apoptosis induced by dopamine in NT2 cells. Acta Pharmacol Sin 23: 445-449.
21. Shimada Y, Goto H, Itoh T, et al. 1999. Evaluation of the protective effects of alkaloids isolated from the hooks and stems of Uncaria sinensis on glutamate-induced neuronal death in cultured cerebellar granule cells from rats. J Pharm Pharmacol 51: 715-722.
22. Smith WL, Langenbach R,. 2001. Why there are two cyclooxygenase isozymes. J Clin Invest 107: 1491-1495.
23. Suk K, Kim SY, Leem K, et al. 2002. Neuroprotection by methanol extract of Uncaria rhynchophylla against global cerebral ischemia in rats. Life Sci 70: 2467-2480.
24. Tang W, Eisenbrand G,. 1992. Chinese Drugs of Plant Origin: Chemistry, Pharmacology, and Use in Traditional and Modern Medicine. Springer-Verlag: Berlin.
25. Watanabe H, Zhao Q, Matsumoto K, et al. 2003. Pharmacological evidence for antidementia effect of Choto-san (Gouteng-san), a traditional Kampo medicine. Pharmacol Biochem Behav 75: 635-643
26. Xiong S, She H, Takeuchi H, et al. 2003. Signaling role of intracellular iron in NF-kappaB activation. J Biol Chem 278: 17646-17654.