Resveratrol inhibits Porphyromonas gingivalis lipopolysaccharide-induced endothelial adhesion molecule expression by suppressing NF-κB activation

Archives of Pharmacal Research

Volumn 32, Issue 4, 2009, Pages 583-591

  Park, Hyun Joo ^a   Jeong, Seong Kyoon ^a   Kim, Su Ryun ^a   Bae, Soo Kyung ^b   Kim, Woo Sik ^a   Jin, Seong Deok ^a   Koo, Tae Hyeon ^c   Jang, Hye Ock ^a   Yun, Il ^a   Kim, Kyu Won ^d   Bae, Moon Kyoung ^a  

^a Pusan National University   (South Korea)

^b Pusan National University School of Medicine   (South Korea)

^c Korea Food and Drug Administration   (South Korea)

^d Seoul National University   (South Korea)

Author keywords

Cell adhesion molecules; Nuclear factor B; Porphyromonas gingivalis lipopolysaccharide; Resveratrol; Vascular endothelial cells

Indexed keywords

ALPHA TUBULIN; BETA ACTIN; CELL ADHESION MOLECULE; I KAPPA B ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERCELLULAR ADHESION MOLECULE 1; LIPOPOLYSACCHARIDE; RESVERATROL; TRANSCRIPTION FACTOR RELA; VASCULAR CELL ADHESION MOLECULE 1;

ANIMAL CELL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; DOWN REGULATION; DRUG MECHANISM; ENDOTHELIUM CELL; HUMAN; HUMAN CELL; INFLAMMATION; LEUKOCYTE ADHERENCE INHIBITION; MALE; MONOCYTE; NONHUMAN; NUCLEAR LOCALIZATION SIGNAL; PERIODONTITIS; PORPHYROMONAS GINGIVALIS; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT; VASCULAR ENDOTHELIUM;

ANIMALS; ANTI-INFLAMMATORY AGENTS; CELL ADHESION; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOTHELIAL CELLS; HUMANS; I-KAPPA B PROTEINS; INTERCELLULAR ADHESION MOLECULE-1; LEUKOCYTES; LIPOPOLYSACCHARIDES; MALE; PHOSPHORYLATION; PORPHYROMONAS GINGIVALIS; RATS; RATS, SPRAGUE-DAWLEY; RNA, MESSENGER; STILBENES; TRANSCRIPTION FACTOR RELA; TRANSCRIPTION, GENETIC; U937 CELLS; VASCULAR CELL ADHESION MOLECULE-1;

EID: 65549141740     PISSN: 02536269     EISSN: 19763786     Source Type: Journal    
DOI: 10.1007/s12272-009-1415-7     Document Type: Article

References (33)

1. S. Amar X. Han 2003 The impact of periodontal infection on systemic diseases Med. Sci. Monit. 9 RA291 9 (Pubitemid 38009859)
2. S. R. Coats R. A. Reife B. W. Bainbridge T. T. Pham R. P. Darveau 2003 Porphyromonas gingivalis lipopolysaccharide antagonizes escherichia coli lipopolysaccharide at toll-like receptor 4 in human endothelial cells Infect. Immun. 71 6799 6807 (Pubitemid 37475308)
3. A. Csiszar K. Smith N. Labinskyy Z. Orosz A. Rivera Z. Ungvari 2006 Resveratrol attenuates TNF-alpha-induced activation of coronary arterial endothelial cells: Role of NF-kappaB inhibition Am. J. Physiol. Heart Circ. Physiol. 291 H1694 9 (Pubitemid 44497674)
4. V. Cucciolla A. Borriello A. Oliva P. Galletti V. Zappia F. Della Ragione 2007 Resveratrol: From basic science to the clinic Cell. Cycle 6 2495 2510 (Pubitemid 350058668)
5. S. Das D. K. Das 2007 Anti-Inflammatory Responses of Resveratrol Inflamm. Allergy Drug Targets 6 168 173 (Pubitemid 47455785)
6. R. T. Demmer M. Desvarieux 2006 Periodontal infections and cardiovascular disease: The heart of the matter J. Am. Dent. Assoc. 137 Suppl 14S 20S
7. Z. Dong 2003 Molecular Mechanism of the Chemopreventive Effect of Resveratrol Mutat. Res. 523-524 145 150 (Pubitemid 36293241)
8. J. Egelberg 1966 The Blood vessels of the dento-gingival junction J. Periodontal. Res. 1 163 179
9. P. J. Ford E. Gemmell P. Timms A. Chan F. M. Preston G. J. Seymour 2007 Anti-P. gingivalis response correlates with atherosclerosis J. Dent. Res. 86 35 40
10. F. C. Gibson H. Yumoto Y. Takahashi H. H. Chou C. A. Genco 2006 Innate immune signaling and porphyromonas gingivalis-accelerated atherosclerosis J. Dent. Res. 85 106 121
11. J. Gusman H. Malonne G. Atassi 2001 A reappraisal of the potential chemopreventive and chemotherapeutic properties of resveratrol Carcinogenesis 22 1111 1117 (Pubitemid 32737324)
12. H. D. Hao L. R. He 2004 Mechanisms of cardiovascular protection by resveratrol J. Med. Food 7 290 298 (Pubitemid 39299486)
13. M. Hirschfeld J. J. Weis V. Toshchakov C. A. Salkowski M. J. Cody D. C. Ward N. Qureshi S. M. Michalek S. N. Vogel 2001 Signaling by toll-like receptor 2 and 4 agonists results in differential gene expression in murine macrophages Infect. Immun. 69 1477 1482 (Pubitemid 32187597)
14. M. Holmes-McNary A. S. Baldwin Jr. 2000 Chemopreventive properties of trans-resveratrol are associated with inhibition of activation of the IkappaB kinase Cancer Res. 60 3477 3483 (Pubitemid 30482167)
15. M. Karin Y. Ben-Neriah 2000 Phosphorylation meets ubiquitination: The control of NF-[Kappa]B activity Annu. Rev. Immunol. 18 621 663 (Pubitemid 30365393)
16. S. R. Kim Y. H. Bae S. K. Bae K. S. Choi K. H. Yoon T. H. Koo H. O. Jang I. Yun K. W. Kim Y. G. Kwon 2008 Visfatin enhances ICAM-1 and VCAM-1 expression through ROS-dependent NF-kappaB activation in endothelial cells Biochim. Biophys. Acta 1783 886 895
17. J. K. Kundu Y. K. Shin S. H. Kim Y. J. Surh 2006 Resveratrol inhibits phorbol ester-induced expression of COX-2 and activation of NF-kappaB in mouse skin by blocking IkappaB kinase activity Carcinogenesis 27 1465 1474 (Pubitemid 43994860)
18. Kundu, J. K. and Surh, Y. J., Cancer chemopreventive and therapeutic potential of resveratrol: Mechanistic perspectives. Cancer Lett. (2008).
19. K. Ley C. Laudanna M. I. Cybulsky S. Nourshargh 2007 Getting to the site of inflammation: The leukocyte adhesion cascade updated Nat. Rev. Immunol. 7 678 689 (Pubitemid 47327397)
20. S. K. Manna A. Mukhopadhyay B. B. Aggarwal 2000 Resveratrol suppresses TNF-induced activation of nuclear transcription factors NF-kappa B, activator protein-1, and apoptosis: potential role of reactive oxygen intermediates and lipid peroxidation J. Immunol. 164 6509 6519 (Pubitemid 30408836)
21. S. Mao N. Maeno S. Matayoshi K. Yoshiie T. Fujimura H. Oda 2004 The induction of intercellular adhesion molecule-1 on human umbilical vein endothelial cells by a heat-stable component of porphyromonas gingivalis Curr. Microbiol. 48 108 112 (Pubitemid 38134083)
22. T. Minami W. C. Aird 2001 Thrombin stimulation of the vascular cell adhesion molecule-1 promoter in endothelial cells is mediated by tandem nuclear factor-kappa B and GATA motifs J. Biol. Chem. 276 47632 47641 (Pubitemid 37373150)
23. N. Nakamura M. Yoshida M. Umeda Y. Huang S. Kitajima Y. Inoue I. Ishikawa T. Iwai 2008 Extended exposure of lipopolysaccharide fraction from porphyromonas gingivalis facilitates mononuclear cell adhesion to vascular endothelium via toll-like receptor-2 dependent mechanism Atherosclerosis 196 59 67
24. R. C. Page H. E. Schroeder 1976 Pathogenesis of inflammatory periodontal disease. A summary of current work Lab. Invest. 34 235 249
25. I. Rahman S. K. Biswas P. A. Kirkham 2006 Regulation of inflammation and redox signaling by dietary polyphenols Biochem. Pharmacol. 72 1439 1452 (Pubitemid 44666744)
26. R. M. Rao L. Yang G. Garcia-Cardena F. W. Luscinskas 2007 Endothelial-dependent mechanisms of leukocyte recruitment to the vascular wall Circ. Res. 101 234 247 (Pubitemid 47344073)
27. J. Slots M. Ting 1999 Actinobacillus actinomycetemcomitans and porphyromonas gingivalis in human periodontal disease: Occurrence and treatment Periodontol. 2000 20 82 121
28. S. H. Tsai Y. C. Liang S. Y. Lin-Shiau J. K. Lin 1999 Suppression of TNFalpha-mediated NFkappaB activity by myricetin and other flavonoids through downregu=-lating the activity of IKK in ECV304 cells J. Cell Biochem. 74 606 615 (Pubitemid 29372500)
29. C. Walter J. Zahlten B. Schmeck C. Schaudinn S. Hippenstiel E. Frisch A. C. Hocke N. Pischon H. K. Kuramitsu J. P. Bernimoulin N. Suttorp M. Krull 2004 Porphyromonas gingivalis strain-dependent activation of human endothelial cells Infect. Immun. 72 5910 5918 (Pubitemid 39303704)
30. P. L. Wang K. Ohura 2002 Porphyromonas gingivalis lipopolysaccharide signaling in gingival fibroblasts-CD14 and toll-like receptors Crit. Rev. Oral Biol. Med. 13 132 142
31. P. L. Wang M. Oido-Mori T. Fujii Y. Kowashi M. Kikuchi Y. Suetsugu J. Tanaka Y. Azuma M. Shinohara K. Ohura 2001 Heterogeneous expression of toll-like receptor 4 and downregulation of toll-like receptor 4 expression on human gingival fibroblasts by porphyromonas gingivalis lipopolysaccharide Biochem. Biophys. Res. Commun. 288 863 867 (Pubitemid 33140962)
32. H. S. Youn J. Y. Lee K. A. Fitzgerald H. A. Young S. Akira D. H. Hwang 2005 Specific inhibitor of MyD88-indepent signaling pathways of TLR3 and TLR4 by resveratrol: molecular targets are TBK1 and RIP1 in TRIF complex J. Immunol. 175 3339 3346 (Pubitemid 41170555)
33. P. L. Yun A. A. Decarlo C. C. Chapple N. Hunter 2005 Functional implication of the hydrolysis of platelet endothelial cell adhesion molecule 1 (CD31) by gingipains of porphyromonas gingivalis for the pathology of periodontal disease Infect. Immun. 73 1386 1398 (Pubitemid 40470724)