Decreased pro-inflammatory cytokine production by LPS-stimulated PBMC upon in vitro incubation with the flavonoids apigenin, luteolin or chrysin, due to selective elimination of monocytes/macrophages

Biochemical Pharmacology

Volumn 69, Issue 2, 2005, Pages 241-248

  Hougee, Sander ^a   Sanders, Annemarie ^a   Faber, Joyce ^a   Graus, Yvo M F ^a   Van Den Berg, Wim B ^b   Garssen, Johan ^a   Smit, H Friso ^a   Hoijer, Maarten A ^a  

^a NUMICO RESEARCH   (Netherlands)

^b RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

Apigenin; Flavonoids; Metabolic activity; PBMC; Pro inflammatory

Indexed keywords

APIGENIN; APIGENIN DERIVATIVE; BAICALEIN; CHRYSIN; COSMOSIIN; INTERLEUKIN 1BETA; INTERLEUKIN 6; KAEMPFEROL; LIPOPOLYSACCHARIDE; LUTEOLIN; MORIN; NARINGENIN; QUERCETIN; SCUTELLAREIN; SUCCINATE DEHYDROGENASE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; CYTOKINE; FLAVONOID;

ANTIINFLAMMATORY ACTIVITY; ARTICLE; B LYMPHOCYTE; CELL CULTURE; CELL DEATH; COMPARATIVE STUDY; CONTROLLED STUDY; CYTOKINE PRODUCTION; DOSE RESPONSE; DRUG INHIBITION; DRUG MECHANISM; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IN VITRO STUDY; MACROPHAGE; MONOCYTE; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; T LYMPHOCYTE; ADULT; BIOSYNTHESIS; DRUG ANTAGONISM; DRUG EFFECT; FEMALE; INFLAMMATION; METABOLISM; MIDDLE AGED; MONONUCLEAR CELL;

ADULT; APIGENIN; CYTOKINES; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; FLAVONOIDS; HUMANS; INFLAMMATION; LEUKOCYTES, MONONUCLEAR; LIPOPOLYSACCHARIDES; LUTEOLIN; MACROPHAGES; MIDDLE AGED;

EID: 13844299448     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcp.2004.10.002     Document Type: Article

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