Andrographolide acts as an anti-inflammatory agent in LPS-stimulated RAW264.7 macrophages by inhibiting STAT3-mediated suppression of the NF-κB pathway

Journal of Ethnopharmacology

Volumn 135, Issue 3, 2011, Pages 678-684

  Lee, Ko Chen ^a,b   Chang, Hen Hong ^a,b   Chung, Ying Hui ^a,b   Lee, Tzung Yan ^a  

^a CHANG GUNG UNIVERSITY   (Taiwan)

^b CHANG GUNG MEMORIAL HOSPITAL   (Taiwan)

Author keywords

Andrographolide; Apoptosis; Inflammation; iNOS; NF B; STAT3

Indexed keywords

ANDROGRAPHOLIDE; CCAAT ENHANCER BINDING PROTEIN DELTA; CYCLOOXYGENASE 2; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LIPOPOLYSACCHARIDE; NITRIC OXIDE SYNTHASE; STAT3 PROTEIN; SUPPRESSOR OF CYTOKINE SIGNALING 1; SUPPRESSOR OF CYTOKINE SIGNALING 3;

ANTIINFLAMMATORY ACTIVITY; ARTICLE; CELL STIMULATION; DNA BINDING; DOWN REGULATION; DOWNSTREAM PROCESSING; DRUG EFFECT; DRUG STRUCTURE; GENE EXPRESSION; MACROPHAGE; MITOCHONDRIAL MEMBRANE POTENTIAL; NONHUMAN; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION;

ANDROGRAPHIS; ANIMALS; ANTI-INFLAMMATORY AGENTS; APOPTOSIS; CCAAT-ENHANCER-BINDING PROTEIN-DELTA; CYCLOOXYGENASE 2; DISEASE MODELS, ANIMAL; DITERPENES; DOWN-REGULATION; GENE EXPRESSION REGULATION; INFLAMMATION; INFLAMMATION MEDIATORS; LIPOPOLYSACCHARIDES; MACROPHAGES; MEMBRANE POTENTIAL, MITOCHONDRIAL; MICE; NF-KAPPA B; PHOSPHORYLATION; PHYTOTHERAPY; PLANT EXTRACTS; RNA, MESSENGER; SIGNAL TRANSDUCTION; STAT3 TRANSCRIPTION FACTOR; SUPPRESSOR OF CYTOKINE SIGNALING PROTEINS; TRANSCRIPTION FACTOR AP-1;

EID: 79957500051     PISSN: 03788741     EISSN: 18727573     Source Type: Journal    
DOI: 10.1016/j.jep.2011.03.068     Document Type: Article

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