In vitro and in vivo modulation of cartilage degradation by a standardized Centella asiatica fraction

Experimental Biology and Medicine

Volumn 234, Issue 6, 2009, Pages 617-623

  Hartog, Anita ^a,b   Smit, H Friso ^a   Van Der Kraan, Peter M ^c   Hoijer, Maarten A ^a   Garssen, Johan ^a,b  

^a DANONE RESEARCH   (Netherlands)

^b UTRECHT UNIVERSITY   (Netherlands)

^c RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

Arthritis; Cartilage; Centella asiatica; IL 1; Nitric oxide; Proteoglycan

Indexed keywords

AGLYCONE; ALGINIC ACID; ASIATICOSIDE; CENTELLA ASIATICA EXTRACT; INTERLEUKIN 1BETA; NITRIC OXIDE; PROTEOGLYCAN; ZYMOSAN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTHRITIS; ARTICLE; CARTILAGE CELL; CARTILAGE DEGENERATION; CELL CULTURE; CELL INFILTRATION; CELL PROLIFERATION; CENTELLA ASIATICA; CONTROLLED STUDY; DRUG EFFECT; DRUG INHIBITION; EXPLANT; FEMALE; IN VITRO STUDY; IN VIVO STUDY; INFLAMMATORY CELL; JOINT SWELLING; MOUSE; NONHUMAN; PROTECTION;

ANIMALS; CARTILAGE; CATTLE; CELL PROLIFERATION; CELLS, CULTURED; CENTELLA; CHONDROCYTES; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; INTERLEUKIN-1BETA; MICE; NITRIC OXIDE; OSTEOARTHRITIS, KNEE; PROTEOGLYCANS; TRITERPENES; ZYMOSAN;

BOVINAE; CENTELLA ASIATICA;

EID: 66449137250     PISSN: 15353702     EISSN: 15353699     Source Type: Journal    
DOI: 10.3181/0810-RM-298     Document Type: Article

References (37)

1. Dieppe PA, Lohmander LS. Pathogenesis and management of pain in osteoarthritis. Lancet 365:965-973, 2005.
2. Felson DT, Lawrence RC, Dieppe PA, Hirsch R, Helmick CG, Jordan JM, Kington RS, Lane NE, Nevitt MC, Zhang Y, Sowers M, McAlindon T, Spector TD, Poole AR, Yanovski SZ, Ateshian G, Sharma L, Buckwalter JA, Brandt KD, Fries JF. Osteoarthritis: new insights. Part 1: the disease and its risk factors. Ann Intern Med 133: 635-646, 2000.
3. Martel-Pelletier J, Boileau C, Pelletier JP, Roughley PJ. Cartilage in normal and osteoarthritis conditions. Best Pract Res Clin Rheumatol 22:351-384, 2008.
4. Pelletier JP, DiBattista JA, Roughley P, McCollum R, Martel-Pelletier J. Cytokines and inflammation in cartilage degradation. Rheum Dis Clin North Am 19:545-568, 1993. (Pubitemid 23258909)
5. Shinmei M, Masuda K, Kikuchi T, Shimomura Y, Okada Y. Production of cytokines by chondrocytes and its role in proteoglycan degradation. J Rheumatol Suppl 27:89-91, 1991.
6. Stove J, Huch K, Gunther KP, Scharf HP. Interleukin-1beta induces different gene expression of stromelysin, aggrecan and tumor-necrosis-factor- stimulated gene 6 in human osteoarthritic chondrocytes in vitro. Pathobiology 68:144-149, 2000. (Pubitemid 32110323)
7. Mengshol JA, Vincenti MP, Coon CI, Barchowsky A, Brinckerhoff CE. Interleukin-1 induction of collagenase 3 (matrix metalloproteinase 13) gene expression in chondrocytes requires p38, c-Jun N-terminal kinase, and nuclear factor kappaB: differential regulation of collagenase 1 and collagenase 3. Arthritis Rheum 43:801-811, 2000.
8. Attur MG, Patel IR, Patel RN, Abramson SB, Amin AR. Autocrine production of IL-1 beta by human osteoarthritis-affected cartilage and differential regulation of endogenous nitric oxide, IL-6, prostaglandin E2, and IL-8. Proc Assoc Am Physicians 110:65-72, 1998. (Pubitemid 28051639)
9. Pelletier JP, Jovanovic DV, Lascau-Coman V, Fernandes JC, Manning PT, Connor JR, Currie MG, Martel-Pelletier J. Selective inhibition of inducible nitric oxide synthase reduces progression of experimental osteoarthritis in vivo: possible link with the reduction in chondrocyte apoptosis and caspase 3 level. Arthritis Rheum 43:1290-1299, 2000. (Pubitemid 30416313)
10. Blom AB, van der Kraan PM, van den Berg WB. Cytokine targeting in osteoarthritis. Curr Drug Targets 8:283-292, 2007. (Pubitemid 46299676)
11. Hungin AP, Kean WF. Nonsteroidal anti-inflammatory drugs: overused or underused in osteoarthritis? Am J Med 110:8S-11S, 2001.
12. Ding C. Do NSAIDs affect the progression of osteoarthritis? Inflammation 26:139-142, 2002.
13. Pelletier JP, Martel-Pelletier J. DMOAD developments: present and future. Bull NYU Hosp Jt Dis 65:242-248, 2007.
14. Pei M, Yu C, Qu M. Expression of collagen type I, II and III in loose body of osteoarthritis. J Orthop Sci 5:288-293, 2000. (Pubitemid 30431806)
15. Nimni M, Deshmukh K. Differences in collagen metabolism between normal and osteoarthritic human articular cartilage. Science 181:751-752, 1973.
16. Schnabel M, Marlovits S, Eckhoff G, Fichtel I, Gotzen L, Vecsei V, Schlegel J. Dedifferentiation-associated changes in morphology and gene expression in primary human articular chondrocytes in cell culture. Osteoarthritis Cartilage 10:62-70, 2002. (Pubitemid 34110791)
17. Brinkhaus B, Lindner M, Schuppan D, Hahn EG. Chemical, pharmacological and clinical profile of the East Asian medical plant Centella asiatica. Phytomedicine 7:427-448, 2000.
18. Lee J, Jung E, Kim Y, Park J, Hong S, Kim J, Hyun C, Kim YS, Park D. Asiaticoside induces human collagen I synthesis through TGF-beta receptor I kinase (TbetaRI kinase)-independent Smad signaling. Planta Med 72:324-328, 2006.
19. Shukla A, Rasik AM, Jain GK, Shankar R, Kulshrestha DK, Dhawan BN. In vitro and in vivo wound healing activity of asiaticoside isolated from Centella asiatica. J Ethnopharmacol 65:1-11, 1999.
20. Suguna L, Sivakumar P, Chandrakasan G. Effects of Centella asiatica extract on dermal wound healing in rats. Indian J Exp Biol 34:1208-1211, 1996. (Pubitemid 26411242)
21. Maquart FX, Chastang F, Simeon A, Birembaut P, Gillery P, Wegrowski Y. Triterpenes from Centella asiatica stimulate extracellular matrix accumulation in rat experimental wounds. Eur J Dermatol 9: 289-296, 1999. (Pubitemid 29272069)
22. Zheng CJ, Qin LP. Chemical components of Centella asiatica and their bioactivities. Zhong Xi Yi Jie He Xue Bao 5:348-351, 2007.
23. Farndale RW, Sayers CA, Barrett AJ. A direct spectrophotometric microassay for sulfated glycosaminoglycans in cartilage cultures. Connect Tissue Res 9:247-248, 1982. (Pubitemid 12009669)
24. Green LC, Wagner DA, Glogowski J, Skipper PL, Wishnok JS, Tannenbaum SR. Analysis of nitrate, nitrite, and [15N]nitrate in biological fluids. Anal Biochem 126:131-138, 1982. (Pubitemid 13203451)
25. Kruijsen MW, van den Berg WB, van de Putte LB, van den Broek WJ. Detection and quantification of experimental joint inflammation in mice by measurement of 99mTc-pertechnetate uptake. Agents Actions 11: 640-642, 1981.
26. Lens JW, van den Berg WB, van de Putte LB. Quantitation of arthritis by 99mTc-uptake measurements in the mouse knee-joint: correlation with histological joint inflammation scores. Agents Actions 14:723-728, 1984. (Pubitemid 14087181)
27. van den Berg WB, Kruijsen MW, van de Putte LB, van Beusekom HJ, van der Sluis-van der Pol M, Zwarts WA. Antigen-induced and zymosan-induced arthritis in mice: studies on in vivo cartilage proteoglycan synthesis and chondrocyte death. Br J Exp Pathol 62: 308-316, 1981. (Pubitemid 11044272)
28. van der Kraan PM, de Lange J, Vitters EL, van Beuningen HM, van Osch GJ, van Lent PL, van den Berg WB. Analysis of changes in proteoglycan content in murine articular cartilage using image analysis. Osteoarthritis Cartilage 2:207-214, 1994. (Pubitemid 24265339)
29. Farrell AJ, Blake DR, Palmer RM, Moncada S. Increased concentrations of nitrite in synovial fluid and serum samples suggest increased nitric oxide synthesis in rheumatic diseases. Ann Rheum Dis 51:1219-1222, 1992.
30. Melchiorri C, Meliconi R, Frizziero L, Silvestri T, Pulsatelli L, Mazzetti I, Borzi RM, Uguccioni M, Facchini A. Enhanced and coordinated in vivo expression of inflammatory cytokines and nitric oxide synthase by chondrocytes from patients with osteoarthritis. Arthritis Rheum 41:2165-2174, 1998. (Pubitemid 29009374)
31. Vuolteenaho K, Moilanen T, Knowles RG, Moilanen E. The role of nitric oxide in osteoarthritis. Scand J Rheumatol 36:247-258, 2007.
32. van de Loo FA, Arntz OJ, van Enckevort FH, van Lent PL, van den Berg WB. Reduced cartilage proteoglycan loss during zymosan-induced gonarthritis in NOS2-deficient mice and in anti-interleukin-1- treated wild-type mice with unabated joint inflammation. Arthritis Rheum 41:634-646, 1998. (Pubitemid 28214981)
33. Guo JS, Cheng CL, Koo MW. Inhibitory effects of Centella asiatica water extract and asiaticoside on inducible nitric oxide synthase during gastric ulcer healing in rats. Planta Med 70:1150-1154, 2004. (Pubitemid 40101095)
34. Yun KJ, Kim JY, Kim JB, Lee KW, Jeong SY, Park HJ, Jung HJ, Cho YW, Yun K, Lee KT. Inhibition of LPS-induced NO and PGE(2) production by asiatic acid via NF-kappaB inactivation in RAW 264.7 macrophages: possible involvement of the IKK and MAPK pathways. Int Immunopharmacol 8:431-441, 2008.
35. Punturee K, Wild CP, Vinitketkumneun U. Thai medicinal plants modulate nitric oxide and tumor necrosis factor-alpha in J774.2 mouse macrophages. J Ethnopharmacol 95:183-189, 2004. (Pubitemid 39422668)
36. Aigner T, Rose J, Martin J, Buckwalter J. Aging theories of primary osteoarthritis: from epidemiology to molecular biology. Rejuvenation Res 7:134-145, 2004. (Pubitemid 39150064)
37. Aigner T, Hemmel M, Neureiter D, Gebhard PM, Zeiler G, Kirchner T, McKenna L. Apoptotic cell death is not a widespread phenomenon in normal aging and osteoarthritis human articular knee cartilage: a study of proliferation, programmed cell death (apoptosis), and viability of chondrocytes in normal and osteoarthritic human knee cartilage. Arthritis Rheum 44:1304-1312, 2001. (Pubitemid 32537528)