-
1
-
-
7144248725
-
-
Wall, M. E.; Wani, M. C.; Cook, C. E.; Palmer, K. H.; McPhail, A. T.; Sim, G. A. J. Am. Chem. Soc. 1966, 88, 3888-3890.
-
(1966)
J. Am. Chem. Soc.
, vol.88
, pp. 3888-3890
-
-
Wall, M.E.1
Wani, M.C.2
Cook, C.E.3
Palmer, K.H.4
McPhail, A.T.5
Sim, G.A.6
-
2
-
-
0022340594
-
-
Hsiang, Y.-H.; Hertzberg, R.; Hecht, S.; Liu, L. J. Biol. Chem. 1985, 260, 14873-14878.
-
(1985)
J. Biol. Chem.
, vol.260
, pp. 14873-14878
-
-
Hsiang, Y.-H.1
Hertzberg, R.2
Hecht, S.3
Liu, L.4
-
3
-
-
0034727063
-
-
Saltz, L. B.; Cox, J. V.; Blanke, C.; Rosen, L. S.; Fehrenbacher, L.; Moore, M. J.; Maroun, J. A.; Ackland, S. P.; Locker, P. K.; Pirotta, N.; Elfring, G. L.; Miller, L. L. N. Engl. J. Med. 2000, 343, 905-914.
-
(2000)
N. Engl. J. Med.
, vol.343
, pp. 905-914
-
-
Saltz, L.B.1
Cox, J.V.2
Blanke, C.3
Rosen, L.S.4
Fehrenbacher, L.5
Moore, M.J.6
Maroun, J.A.7
Ackland, S.P.8
Locker, P.K.9
Pirotta, N.10
Elfring, G.L.11
Miller, L.L.12
-
4
-
-
0035300609
-
-
Gore, M.; ten Bokkel Huinink, W.; Carmichael, J.; Gordon, A.; Davidson, N.; Coleman, R.; Spaczynski, M.; Heron, J. F.; Bolis, G.; Malmstrom, H.; Malfetano, J.; Scarabelli, C.; Vennin, P.; Ross, G.; Fields, S. Z. J. Clin. Oncol. 2001, 19, 1893-1900.
-
(2001)
J. Clin. Oncol.
, vol.19
, pp. 1893-1900
-
-
Gore, M.1
Ten Bokkel Huinink, W.2
Carmichael, J.3
Gordon, A.4
Davidson, N.5
Coleman, R.6
Spaczynski, M.7
Heron, J.F.8
Bolis, G.9
Malmstrom, H.10
Malfetano, J.11
Scarabelli, C.12
Vennin, P.13
Ross, G.14
Fields, S.Z.15
-
5
-
-
0015211527
-
-
Wani, M. C.; Taylor, H. L.; Wall, M. E.; Coggin, P.; McPhail, A. T. J. Am. Chem. Soc. 1971, 93, 2325-2327.
-
(1971)
J. Am. Chem. Soc.
, vol.93
, pp. 2325-2327
-
-
Wani, M.C.1
Taylor, H.L.2
Wall, M.E.3
Coggin, P.4
McPhail, A.T.5
-
7
-
-
0018387446
-
-
Schiff, P. B.; Fant, J.; Horwitz, S. B. Nature 1979, 277, 665-667.
-
(1979)
Nature
, vol.277
, pp. 665-667
-
-
Schiff, P.B.1
Fant, J.2
Horwitz, S.B.3
-
8
-
-
0002630461
-
-
Suffness, M., Ed.; CRC Press: Boca Raton, FL
-
Suffness, M.; Wall, M. E. In Taxol: Science and Applications; Suffness, M., Ed.; CRC Press: Boca Raton, FL, 1995; pp 3-25.
-
(1995)
Taxol: Science and Applications
, pp. 3-25
-
-
Suffness, M.1
Wall, M.E.2
-
10
-
-
0017105425
-
-
Wall, M. E.; Wani, M. C.; Taylor, H. Cancer Treat. Rep. 1976, 60, 1011-1030.
-
(1976)
Cancer Treat. Rep.
, vol.60
, pp. 1011-1030
-
-
Wall, M.E.1
Wani, M.C.2
Taylor, H.3
-
13
-
-
1442340405
-
-
May (for Camptosar, ca. $574 million)
-
The sales figures for the camptothecin analogues come from the 2002 Annual Report for GlaxoSmithKline (for Hycamtin, ca. $140 million) and the 2002 sales figures for the top 400 prescription drugs reported by Med. Ad. News in May 2003 (for Camptosar, ca. $574 million).
-
(2003)
Med. Ad. News
-
-
-
14
-
-
1442315839
-
-
Annals of the New York Academy of Sciences: New York
-
Liehr, J. G., Giovanella, B. C., Verschraegen, C. F., Eds. The Camptothecins: Unfolding Their Anticancer Potential; Annals of the New York Academy of Sciences: New York, 2000; p 362.
-
(2000)
The Camptothecins: Unfolding Their Anticancer Potential
, pp. 362
-
-
Liehr, J.G.1
Giovanella, B.C.2
Verschraegen, C.F.3
-
15
-
-
0004065291
-
-
CRC Press: Boca Raton, FL
-
Potmesil, M., Pinedo, H., Eds. Camptothecins: New Anticancer Agents; CRC Press: Boca Raton, FL, 1995; p 149.
-
(1995)
Camptothecins: New Anticancer Agents
, pp. 149
-
-
Potmesil, M.1
Pinedo, H.2
-
16
-
-
0004521324
-
-
Annals of the New York Academy of Sciences: New York
-
Pantazis, P., Giovanella, B. C., Rothenberg, M. L., Eds. The Camptothecins: From Discovery to the Patient; Annals of the New York Academy of Sciences: New York, 1996; p 335.
-
(1996)
The Camptothecins: From Discovery to the Patient
, pp. 335
-
-
Pantazis, P.1
Giovanella, B.C.2
Rothenberg, M.L.3
-
17
-
-
0142144344
-
-
Cambridge University Press: Cambridge, UK
-
Goodman, J.; Walsh, V. The Story of Taxol; Cambridge University Press: Cambridge, UK, 2001; p 282.
-
(2001)
The Story of Taxol
, pp. 282
-
-
Goodman, J.1
Walsh, V.2
-
19
-
-
1442315836
-
-
Symposium Series 583; American Chemical Society: Washington, DC
-
Georg, G. I., Chen, T. T., Ojima, I., Vyas, D. M., Eds. Taxane Anticancer Agents: Basic Science and Current Status; Symposium Series 583; American Chemical Society: Washington, DC, 1995; p 353.
-
(1995)
Taxane Anticancer Agents: Basic Science and Current Status
, pp. 353
-
-
Georg, G.I.1
Chen, T.T.2
Ojima, I.3
Vyas, D.M.4
-
20
-
-
77956791953
-
-
Bristol, J. A., Ed.; Academic Press: San Diego
-
Suffness, M. In Annual Reports in Medicinal Chemistry; Bristol, J. A., Ed.; Academic Press: San Diego, 1993; Vol. 28, pp 305-314.
-
(1993)
Annual Reports in Medicinal Chemistry
, vol.28
, pp. 305-314
-
-
Suffness, M.1
-
23
-
-
1442340405
-
-
May
-
According to Reuters Business Insight on Healthcare, their report of the "Cancer Market Outlook to 2008" estimates the global cytotoxics market in 2002 at $8.9 billion. Sales in 2002 for Taxotere, as reported by Med. Ad. News in May 2003 in "The Top 400 Prescription Drugs" totaled ca. $1.192 billion. The same report showed 2002 sales of Taxol to be ca. $857 million. As explained in ref 13, the combined sales of the camptothecin analogues represent nearly $750 million. Thus, the total sales of taxol, docetaxel (Taxotere), and camptothecin analogues represent more than $2.75 billion, or about one-third of the global antineoplastic agent market.
-
(2003)
Med. Ad. News
-
-
-
24
-
-
18044362891
-
-
Kozuch, P.; Grossbard, M. L.; Barzdins, A.; Araneo, M.; Robin, A.; Frager, D.; Homel, P.; Marino, J.; DeGregorio, P.; Bruckner, H. W. Oncologist 2001, 6, 488-495.
-
(2001)
Oncologist
, vol.6
, pp. 488-495
-
-
Kozuch, P.1
Grossbard, M.L.2
Barzdins, A.3
Araneo, M.4
Robin, A.5
Frager, D.6
Homel, P.7
Marino, J.8
DeGregorio, P.9
Bruckner, H.W.10
-
26
-
-
0036499282
-
-
Dizon, D. S.; Hensley, M. L.; Poynor, E. A.; Sabbatini, P.; Aghajanian, C.; Hummer, A.; Venkatraman, E.; Spriggs, D. R. J. Clin. Oncol. 2002, 20, 1238-1247.
-
(2002)
J. Clin. Oncol.
, vol.20
, pp. 1238-1247
-
-
Dizon, D.S.1
Hensley, M.L.2
Poynor, E.A.3
Sabbatini, P.4
Aghajanian, C.5
Hummer, A.6
Venkatraman, E.7
Spriggs, D.R.8
-
29
-
-
0015150039
-
-
Horwitz, S. B.; Chang, C. K.; Grollman, A. P. Mol. Pharmacol. 1971, 7, 632-644.
-
(1971)
Mol. Pharmacol.
, vol.7
, pp. 632-644
-
-
Horwitz, S.B.1
Chang, C.K.2
Grollman, A.P.3
-
30
-
-
0018803120
-
-
Ross, W. E.; Glaubiger, D.; Kohn, K. W. Biochim. Biophys. Acta 1979, 562, 41-50.
-
(1979)
Biochim. Biophys. Acta
, vol.562
, pp. 41-50
-
-
Ross, W.E.1
Glaubiger, D.2
Kohn, K.W.3
-
32
-
-
0001534829
-
-
Sugino, A.; Peebles, C. L.; Kreuzer, K. N.; Cozzarelli, N. R. Proc. Natl. Acad. Sci. U.S.A. 1977, 74, 4767-4771.
-
(1977)
Proc. Natl. Acad. Sci. U.S.A.
, vol.74
, pp. 4767-4771
-
-
Sugino, A.1
Peebles, C.L.2
Kreuzer, K.N.3
Cozzarelli, N.R.4
-
33
-
-
0021151237
-
-
Tewey, K. M.; Rowe, T. C.; Yang, L.; Halligan, B. D.; Liu, L. F. Science 1984, 226, 466-468.
-
(1984)
Science
, vol.226
, pp. 466-468
-
-
Tewey, K.M.1
Rowe, T.C.2
Yang, L.3
Halligan, B.D.4
Liu, L.F.5
-
34
-
-
1442315840
-
-
Personal communication from T. C. Rowe to D. J. Kroll (Oct. 1989)
-
Personal communication from T. C. Rowe to D. J. Kroll (Oct. 1989).
-
-
-
-
35
-
-
0024420685
-
-
Hsiang, Y. H.; Lihou, M. G.; Liu, L. F. Cancer Res. 1989, 49, 5077-5082.
-
(1989)
Cancer Res.
, vol.49
, pp. 5077-5082
-
-
Hsiang, Y.H.1
Lihou, M.G.2
Liu, L.F.3
-
38
-
-
0036682284
-
-
Rapisarda, A.; Uranchimeg, B.; Scudiero, D. A.; Selby, M.; Sausville, E. A.; Shoemaker, R. H.; Melillo, G. Cancer Res. 2002, 62, 4316-4324.
-
(2002)
Cancer Res.
, vol.62
, pp. 4316-4324
-
-
Rapisarda, A.1
Uranchimeg, B.2
Scudiero, D.A.3
Selby, M.4
Sausville, E.A.5
Shoemaker, R.H.6
Melillo, G.7
-
39
-
-
0000568618
-
-
Perez, E. A.; Hillman, D. W.; Mailliard, J. A.; Ingle, J. N.; Ryan, J. M.; Fitch, T. R.; Rowland, J. K. M.; Kardinal, C. G.; Krook, J. E.; Kugler, J. W.; Dakhil, S. R. Proc. Am. Soc. Clin. Oncol. 2003, 21, 206.
-
(2003)
Proc. Am. Soc. Clin. Oncol.
, vol.21
, pp. 206
-
-
Perez, E.A.1
Hillman, D.W.2
Mailliard, J.A.3
Ingle, J.N.4
Ryan, J.M.5
Fitch, T.R.6
Rowland, J.K.M.7
Kardinal, C.G.8
Krook, J.E.9
Kugler, J.W.10
Dakhil, S.R.11
-
40
-
-
0035942226
-
-
Snyder, J. P.; Nettles, J. H.; Cornett, B.; Downing, K. H.; Nogales, E. Proc. Natl. Acad. Sci. U.S.A. 2001, 98, 5312-5316.
-
(2001)
Proc. Natl. Acad. Sci. U.S.A.
, vol.98
, pp. 5312-5316
-
-
Snyder, J.P.1
Nettles, J.H.2
Cornett, B.3
Downing, K.H.4
Nogales, E.5
-
41
-
-
0033169231
-
-
Stewart, Z. A.; Mays, D.; Pietenpol, J. A. Cancer Res. 1999, 59, 3831-3837.
-
(1999)
Cancer Res.
, vol.59
, pp. 3831-3837
-
-
Stewart, Z.A.1
Mays, D.2
Pietenpol, J.A.3
-
42
-
-
0035889710
-
-
He, L.; Orr, G. A.; Horwitz, S. B. Drug Discovery Today 2001, 6, 1153-1164.
-
(2001)
Drug Discovery Today
, vol.6
, pp. 1153-1164
-
-
He, L.1
Orr, G.A.2
Horwitz, S.B.3
-
43
-
-
0030018666
-
-
Gerth, K.; Bedorf, N.; Hofie, G.; Irschik, H.; Reichenbach, H. J. Antibiot. 1996, 49, 560-563.
-
(1996)
J. Antibiot.
, vol.49
, pp. 560-563
-
-
Gerth, K.1
Bedorf, N.2
Hofie, G.3
Irschik, H.4
Reichenbach, H.5
-
44
-
-
0024373271
-
-
Mangatal, L.; Adeline, M. T.; Guenard, D.; Gueritte-Voegelein, F.; Potier, P. Tetrahedron 1989, 45, 4177-4190.
-
(1989)
Tetrahedron
, vol.45
, pp. 4177-4190
-
-
Mangatal, L.1
Adeline, M.T.2
Guenard, D.3
Gueritte-Voegelein, F.4
Potier, P.5
-
45
-
-
0025804190
-
-
Gueritte-Voegelein, F.; Guenard, D.; Lavelle, F.; Le Goff, M. T.; Mangatal, L.; Potier, P. J. Med. Chem. 1991, 34, 992-998.
-
(1991)
J. Med. Chem.
, vol.34
, pp. 992-998
-
-
Gueritte-Voegelein, F.1
Guenard, D.2
Lavelle, F.3
Le Goff, M.T.4
Mangatal, L.5
Potier, P.6
-
46
-
-
0036096946
-
-
Ibrahim, N. K.; Desai, N.; Legha, S.; Soon-Shiong, P.; Theriault, R. L.; Rivera, E.; Esmaeli, B.; Ring, S. E.; Bedikian, A.; Hortobagyi, G. N.; Ellerhorst, J. A. Clin. Cancer Res. 2002, 8, 1038-1044.
-
(2002)
Clin. Cancer Res.
, vol.8
, pp. 1038-1044
-
-
Ibrahim, N.K.1
Desai, N.2
Legha, S.3
Soon-Shiong, P.4
Theriault, R.L.5
Rivera, E.6
Esmaeli, B.7
Ring, S.E.8
Bedikian, A.9
Hortobagyi, G.N.10
Ellerhorst, J.A.11
-
47
-
-
0037451926
-
-
Park, S. J.; Shim, W. H.; Ho, D. S.; Raizner, A. E.; Park, S. W.; Hong, M. K.; Lee, C. W.; Choi, D.; Jang, Y.; Lam, R.; Weissman, N. J.; Mintz, G. S. N. Engl. J. Med. 2003, 348, 1537-1545.
-
(2003)
N. Engl. J. Med.
, vol.348
, pp. 1537-1545
-
-
Park, S.J.1
Shim, W.H.2
Ho, D.S.3
Raizner, A.E.4
Park, S.W.5
Hong, M.K.6
Lee, C.W.7
Choi, D.8
Jang, Y.9
Lam, R.10
Weissman, N.J.11
Mintz, G.S.12
-
50
-
-
1442266881
-
-
The cover of the January-June 2004 issues of the Journal of Natural Products shows a photograph of the plaque awarded by the American Chemical Society to Research Triangle Institute in connection with this National Historic Chemical Landmark.
-
(2004)
Journal of Natural Products
-
-
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