Anti-inflammatory effects of (Z)-ligustilide through suppression of Mitogen-activated protein kinases and nuclear factor-κB activation pathways

Archives of Pharmacal Research

Volumn 35, Issue 4, 2012, Pages 723-732

  Chung, Ji Won ^a   Choi, Ran Joo ^a   Seo, Eun Kyoung ^b   Nam, Joo Won ^b   Dong, Mi Sook ^c   Shin, Eun Myoung ^a   Guo, Lian Yu ^a   Kim, Yeong Shik ^a  

^a Seoul National University   (South Korea)

^b Ewha Womans University   (South Korea)

^c Korea University   (South Korea)

Author keywords

(Z) Ligustilide; Anti inflammation; Mitogen activated protein kinases; Nuclear factor B

Indexed keywords

CYCLOOXYGENASE 2; DEXAMETHASONE; I KAPPA B ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; LIGUSTILIDE; LIPOPOLYSACCHARIDE; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; NITRITE; PROSTAGLANDIN E2; STRESS ACTIVATED PROTEIN KINASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOWN REGULATION; DRUG CYTOTOXICITY; DRUG ISOLATION; DRUG MECHANISM; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME REPRESSION; GENE EXPRESSION REGULATION; MACROPHAGE; MALE; MOUSE; NONHUMAN; PAW EDEMA; PLANT ROOT; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; TRANSCRIPTION INITIATION; TRANSCRIPTION REGULATION;

4-BUTYROLACTONE; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; BLOTTING, WESTERN; CELL CULTURE TECHNIQUES; CELL LINE; CELL SURVIVAL; CYCLOOXYGENASE 2; DOSE-RESPONSE RELATIONSHIP, DRUG; DOWN-REGULATION; EDEMA; LIPOPOLYSACCHARIDES; MACROPHAGES; MALE; MICE; MICE, INBRED ICR; MITOGEN-ACTIVATED PROTEIN KINASES; MOLECULAR STRUCTURE; NF-KAPPA B; NITRIC OXIDE SYNTHASE TYPE II; PHOSPHORYLATION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION;

EID: 84862903681     PISSN: 02536269     EISSN: 19763786     Source Type: Journal    
DOI: 10.1007/s12272-012-0417-z     Document Type: Article

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