A randomized trial of colchicine for acute pericarditis

New England Journal of Medicine

Volumn 369, Issue 16, 2013, Pages 1522-1528

  Imazio, Massimo ^a   Brucato, Antonio ^b   Cemin, Roberto ^c   Ferrua, Stefania ^d   Maggiolini, Stefano ^e   Beqaraj, Federico ^a   Demarie, Daniela ^a   Forno, Davide ^h   Ferro, Silvia ^a   Maestroni, Silvia ^b   Belli, Riccardo ^a   Trinchero, Rita ^a   Spodick, David H ^f   Adler, Yehuda ^g  

^a MARIA VITTORIA HOSPITAL   (Italy)

^b PAPA GIOVANNI XXIII HOSPITAL   (Italy)

^c San Maurizio Regional Hospital   (Italy)

^d OSPEDALE DEGLI INFERMI   (Italy)

^e Department of Cardiology   (Italy)

^f SAINT VINCENT HOSPITAL   (United States)

^g SHEBA MEDICAL CENTER   (Israel)

^h NONE

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLSALICYLIC ACID; COLCHICINE; IBUPROFEN; PLACEBO;

ACUTE DISEASE; ADULT; ALOPECIA; ARTICLE; CONTROLLED STUDY; DISEASE SEVERITY; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; DRUG SAFETY; FEMALE; GASTROINTESTINAL SYMPTOM; HOSPITALIZATION; HUMAN; LIVER TOXICITY; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY; MUSCLE DISEASE; OUTCOME ASSESSMENT; PERICARDITIS; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RECURRENT DISEASE; RISK REDUCTION; SURVIVAL RATE; SYMPTOM; TREATMENT DURATION;

EID: 84885829032     PISSN: 00284793     EISSN: 15334406     Source Type: Journal    
DOI: 10.1056/NEJMoa1208536     Document Type: Article

References (22)

1. Cocco G, Chu DC, Pandolfi S. Colchicine in clinical medicine: a guide for internists. Eur J Intern Med 2010;21:503-8.
2. Imazio M, Brucato A, Trinchero R, Spodick D, Adler Y. Colchicine for pericarditis: hype or hope? Eur Heart J 2009;30:532-9.
3. Imazio M, Brucato A, Forno D, et al. Efficacy and safety of colchicine for pericarditis prevention: systematic review and meta-analysis. Heart 2012;98:1078-82.
4. Millaire A, Ducloux G. Treatment of acute or recurrent pericarditis with colchicine. Circulation 1991;83:1458-9.
5. Imazio M, Bobbio M, Cecchi E, et al. Colchicine in addition to conventional therapy for acute pericarditis: results of the COlchicine for acute PEricarditis (COPE) trial. Circulation 2005;112:2012-6.
6. Imazio M, Cecchi E, Ierna S, Trinchero R, ICAP Investigators. Investigation on Colchicine for Acute Pericarditis: a multicenter randomized placebo-controlled trial evaluating the clinical benefits of colchicine as adjunct to conventional therapy in the treatment and prevention of pericarditis: study design and rationale. J Cardiovasc Med (Hagerstown) 2007;8:613-7.
7. Permanyer-Miralda G, Sagristá-Sauleda J, Soler-Soler J. Primary acute pericardial disease: a prospective series of 231 consecutive patients. Am J Cardiol 1985;56:623-30.
8. Zayas R, Anguita M, Torres F, et al. Incidence of specific etiology and role of methods for specific etiologic diagnosis of primary acute pericarditis. Am J Cardiol 1995;75:378-82.
9. Imazio M, Demichelis B, Parrini I, et al. Day-hospital treatment of acute pericarditis: a management program for outpatient therapy. J Am Coll Cardiol 2004;43:1042-6.
10. Little WC, Freeman GL. Pericardial disease. Circulation 2006;113:1622-32. [Erratum, Circulation 2007;115(15):e406.]
11. Lange RA, Hillis LD. Acute pericarditis. N Engl J Med 2004;351:2195-202. [Erratum, N Engl J Med 2005;352:1163.]
12. Imazio M, Spodick DH, Brucato A, Trinchero R, Adler Y. Controversial issues in the management of pericardial diseases. Circulation 2010;121:916-28.
13. Imazio M. Contemporary management of pericardial diseases. Curr Opin Cardiol 2012;27:308-17.
14. Imazio M, Brucato A, Cumetti D, et al. Corticosteroids for recurrent pericarditis: high versus low doses: a nonrandomized observation. Circulation 2008;118:667-71.
15. Soler-Soler J, Sagristà-Sauleda J, Permanyer-Miralda G. Relapsing pericarditis. Heart 2004;90:1364-8.
16. Imazio M, Brucato A, Cemin R, et al. Colchicine for recurrent pericarditis (CORP): a randomized trial. Ann Intern Med 2011;155:409-14.
17. Adler Y, Finkelstein Y, Guindo J, et al. Colchicine treatment for recurrent pericarditis: a decade of experience. Circulation 1998;97:2183-5.
18. Maisch B, Seferović PM, Ristić AD, et al. Guidelines on the diagnosis and management of pericardial diseases executive summary: the Task Force on the Diagnosis and Management of Pericardial Diseases of the European Society of Cardiology. Eur Heart J 2004;25:587-610.
19. Imazio M, Bobbio M, Cecchi E, et al. Colchicine as first-choice therapy for recurrent pericarditis: results of the CORE (COlchicine for REcurrent pericarditis) trial. Arch Intern Med 2005;165:1987-91.
20. Brucato A, Maestroni S, Cumetti D, et al. Recurrent pericarditis: infectious or autoimmune? Autoimmun Rev 2008;8:44-7.
21. Caforio AL, Brucato A, Doria A, et al. Anti-heart and anti-intercalated disk autoantibodies: evidence for autoimmunity in idiopathic recurrent acute pericarditis. Heart 2010;96:779-84.
22. Imazio M, Brucato A, Derosa FG, et al. Aetiological diagnosis in acute and recurrent pericarditis: when and how. J Cardiovasc Med (Hagerstown) 2009;10:217-30.