Tyrosine kinase inhibitors prevent cytokine-induced expression of iNOS and COX-2 by human islets

American Journal of Physiology - Cell Physiology

Volumn 270, Issue 6 39-6, 1996, Pages

  Corbett, John A ^a   Kwon, Guim ^b   Marino, Margaret H ^b   Rodi, Charles P ^b   Sullivan, Patrick M ^b   Turk, John ^b   McDaniel, Michael L ^b  

^a SAINT LOUIS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b NONE

Author keywords

cyclooxygenase; diabetes; inducible cyclooxygenase; inducible nitric oxide synthase; islets of Langerhans; nitric oxide

Indexed keywords

GENISTEIN; HERBIMYCIN; N(G) METHYLARGININE; NITRIC OXIDE SYNTHASE; NITRITE; PROSTAGLANDIN E2; PROSTAGLANDIN SYNTHASE; PROTEIN TYROSINE KINASE; PROTEIN TYROSINE KINASE INHIBITOR; RECOMBINANT GAMMA INTERFERON; RECOMBINANT INTERLEUKIN 1BETA;

ANIMAL CELL; ARTICLE; AUTOIMMUNITY; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME INDUCTION; HUMAN; HUMAN CELL; INFLAMMATION; INSULIN DEPENDENT DIABETES MELLITUS; INSULITIS; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; RAT;

EID: 0029745336     PISSN: 03636143     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpcell.1996.270.6.c1581     Document Type: Article

References (40)

1. Bendtzen, K., T. Mandrup-Poulsen, J. Nerup, J. H. Nielsen, C. A. Dinarello, and M. Svenson. Cytotoxicity of human pI 7 interleukin-1 for pancreatic islets of Langerhans. Science Wash. DC 232: 1545-1547, 1986.
2. Bottazzo, G. F., B. M. Dean, J. M. McNally, E. H. MacKay, P. G. F. Swift, and D. R. Gamble. In situ characterization of autoimmune phenomena and expression of HLA molecules in the pancreas in diabetic insulitis. N. Engl. J. Med. 313: 353-360, 1985.
3. Burd, P. R., H. W. Rogers, J. R. Gordon, C. A, Martin, S. Jayaraman, S. D. Wilson, A. M. Dvorak, S. J. Galli, and M. E. Dorf. Interleukin 3-dependent and -independent mast cells stimulated with IgE and antigen express multiple cytokines. J. Exp. Med. 170: 245-257, 1989.
4. Charles, I. G., R. M. J. Palmer, M. S. Hickery, M. T. Bayliss, A. P. Chubb, V. S. Hall, D. W. Moss, and S. Moncada. Cloning, characterization, and expression of a cDNA encoding an inducible nitric oxide synthase from the human chondrocyte. Proc. Natl. Acad. Sci. USA 90: 11419-11423, 1993.
5. Corbett, J. A., G. Kwon, J. R. Hill, and M. L. McDaniel. Role of nitric oxide in β-cell destruction associated with the development of autoimmune diabetes. In: Diabetes Annual, edited by S. M. Marshall. Amsterdam: Elsevier Science, 1995, p. 265-294.
6. Corbett, J. A., G. Kwon, T. P. Misko, C. P. Rodi, and M. L. McDaniel. Tyrosine kinase involvement in IL-1β-induced expression of iNOS by β-cells purified from islets of Langerhans. Am. J. Physiol. 267 (Cell Physiol. 36): C48-C54, 1994.
7. Corbett, J. A. G. Kwon, J. Turk, and M. L. McDaniel. IL-1β induces the coexpression of both nitric oxide synthase and cyclooxygenase by islets of Langerhans. Biochemistry 32: 13767-13770, 1993.
8. Corbett, J. A., J. R. Lancaster, Jr., M. A. Sweetland, and M. L. McDaniel. Interleukin-1β-induced formation of EPR-detectable iron-nitrosyl complexes in islets of Langerhans. J. Biol. Chem. 266: 21351-21354, 1991.
9. Corbett, J. A., and M. L. McDaniel. Does nitric oxide mediate autoimmune destruction of β-cells? Possible therapeutic interventions in IDDM. Diabetes 41: 897-903, 1992.
10. Corbett, J. A., and M. L. McDaniel. Intraislet release of interleukin 1 inhibits β-cell function by inducing β-cell expression of inducible nitric oxide synthase. J. Exp. Med. 181: 559-568, 1995.
11. Corbett, J. A., M. A. Sweetland, J. R. Lancaster, Jr., and M. L. McDaniel. A 1 hour pulse with IL-1β induces the formation of nitric oxide and inhibits insulin secretion by rat islets of Langerhans: evidence for a tyrosine kinase signaling mechanism. FASEB. J. 7: 369-374, 1993.
12. Corbett, J. A., M. A. Sweetland, J. L. Wang, J. R. Lancaster, Jr., and M. L. McDaniel. Nitric oxide mediates cytokine-induced inhibition of insulin secretion by human islets of Langerhans. Proc. Natl. Acad. Sci. USA 90: 1731-1735, 1993.
13. Corbett, J. A., J. L. Wang, J. H. Hughes, B. A. Wolf, M. A. Sweetland, J. R. Lancaster, Jr., and M. L. McDaniel. Nitric oxide and cyclic GMP formation induced by interleukin 1β in islets of Langerhans. Biochem. J. 287: 229-235, 1992.
14. Corbett, J. A., J. L. Wang, M. A. Sweetland, J. R. Lancaster, Jr., and M. L. McDaniel. IL-1β induces the formation of nitric oxide by β-cells purified from rodent islets of Langerhans. J. Clin. Invest. 90: 2384-2391, 1992.
15. Denis, M. Tumor necrosis factor and granulocyte macrophage-colony stimulating factor stimulate human macrophages to restrict growth of virulent Mycobacterium avaium and to kill avirulent M. avaium: killing effector mechanism depends on the generation of reactive nitrogen intermediates. J. Leukocyte Biol. 49: 380-387, 1991.
16. Eizirik, D. L., E. Cagliero, A. Bjorklund, and N. Welsh. Interleukin-1β induces the expression of an isoform of nitric oxide synthase in insulin-producing cells, which is similar to that observed in activated macrophages. FEBS Lett. 308: 249-252, 1992.
17. Eizirik, D. L., E. Cagliero, A. Bjorklund, and N. Welsh. Interleukin-1-induced expression of nitric oxide synthase in insulin-producing cells is preceded by c-fos induction and depends on gene transcription and protein synthesis. FEBS Lett. 317: 62-66, 1993.
18. Eizirik, D. L., D. G. Pipeleers, Z. Ling, N. Welsh, C. Hellerstrom, and A. Andersson. Major species differences between humans and rodents in the susceptibility to pancreatic β-cell injury. Proc. Natl. Acad. Sci. USA 91: 9253-9256, 1994.
19. Eizirik, D. L., S. Sandler, N. Welsh, M. Cetkovic-Cvrlje, A. Nieman, D. A. Geller, D. G. Pipeleers, K. Bendtzen, and C. Hellerstrom. Cytokines suppress human islet function irrespective of their effects on nitric oxide generation. J. Clin. Invest. 93: 1968-1974, 1994.
20. Geller, D. A., C. J. Lowenstein, R. A. Shapiro, A. K. Nussler, M. D. Silvio, S. C. Wang, D. K. Nakayama, R. L. Simmons, S. H. Snyder, and T. R, Billiar. Molecular cloning and expression of inducible nitric oxide synthase from human hepatocytes. Proc. Natl. Acad. Sci. USA 90: 3491-3495, 1993.
21. Gepts, W. Pathologic anatomy of the pancreas in juvenile diabetes mellitus. Diabetes 14: 619-633, 1965.
22. 15N] nitrate in biological fluids. Anal. Biochem. 126: 131-138, 1982.
23. Kolb, J. P., N. Paul-Eugene, C. Damais, K. Yamaoka, J. C. Drapier, and B. Dugas. Interleukin-4 stimulates cGMP production by IFN-γ-activated human monocytes. J. Biol. Chem. 269: 9811-9816, 1994.
24. Laemmli, U. K. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature Lond, 227: 680-685, 1970.
25. Lyons, C. R., G. J. Orloff, and J. M. Cunningham. Molecular cloning and functional expression of an inducible nitric oxide synthase from a murine macrophage cell line. J. Biol. Chem. 267: 6370-6374, 1992.
26. Mandrup-Poulsen, T., K. Bendtzen, H. Nielsen, G. Bendixen, and J. Nerup. Cytokines cause functional and structural damage to isolated islets of Langerhans. Allergy 40: 424-429, 1985.
27. Mandrup-Poulsen, T., J. I. Reimers, H. U. Andersen, F. Pociot, A. E. Karlsen, J. Bjerre, and J. Nerup. Nicotinamide treatment in the prevention of insulin-dependent diabetes mellitus. Diabetes Metab. Rev. 9: 295-309, 1993.
28. Marietta, M. A., P. S. Yoon, R. Iyengar, C. D. Leaf, and J. S. Wishnok. Macrophage oxidation of L-arginine to nitrite and nitrate: nitric oxide is an intermediate. Biochemistry 27: 8706-8711, 1988.
29. Needleman, P., J. Turk, B. A. Jakschik, A. R. Morrison, and A. R. Lefkowith. Arachidonic acid metabolism. Annu. Rev. Biochem. 55: 69-102, 1986.
30. Padget, E. L., and S. B. Pruett. Evaluation of nitrite production by human monocyte-derived macrophages. Biochem. Biophys. Res. Commun. 186: 775-781, 1992.
31. Rabinovitch, A. Roles of cytokines in IDDM pathogenesis and islet β-cell destruction. Diabetes Rev. 1: 215-240, 1993.
32. Salvemini, D., T. P. Misko, J. L. Masterrer, K. Seibert, M. G. Currie, and P. Needleman. Nitric oxide activates cyclooxygenase enzymes. Proc. Natl. Acad. Sci. USA 90: 7240-7244, 1993.
33. Salvemini, D., K. Seibert, J. L. Masterrer, T. P. Misko, M. G. Currie, and P. Needleman. Endogenous nitric oxide enhances prostaglandin production in a model of renal inflammation. J. Clin. Invest. 93: 1940-1947, 1994.
34. Scharp, D. W., P. E. Lacy, E. Finke, and B. Olack. Low-temperature culture of human islets isolated by the distention method and purified with Ficoll or Percoll gradients. Surgery 102: 869-879, 1987.
35. Seiden, R. F. Preparation and analysis of RNA In: Current Protocols in Molecular Biology, edited by F. M. Ausubel, R. Brent, R. E. Kingston, D. D. Moore, J. G. Seidman, J. A. Smith, and K. Struhl. New York: Green Publishing and Wiley-Interscience, 1991, vol. 1, p. 4.2.1-4.2.6.
36. Sibley, R. K., D. E. Sutherland, F. Goetz, and A. F. Michael. Recurrent diabetes mellitus in the pancreas iso- and allograft. A light and electron microscopic and immunohistochemical analysis of four cases. Lab. Invest. 53: 132-144, 1985.
37. Southern, C., D. Schulster, and I. C. Green. Inhibition of insulin secretion by interleukin-1β and tumor necrosis factor-α via an L-arginine-dependent nitric oxide generation mechanism. FEBS. Lett. 276: 42-44, 1990.
38. Tracy, R. W., C. Xue, V. Klinghofer, J. Barlow, J. S. Pollock, U. Forstermann, and R. A. Johns. Immunochemical detection of inducible NO synthase in human lung. Am. J. Physiol. 266 (Lung Cell. Mol. Physiol. 10): L722-L727, 1994.
39. Welsh, N., D. L. Eizirik, K. Bendtzen, and S. Sandier. Interleukin-1β-induced nitric oxide production in isolated rat pancreatic islets requires gene transcription and may lead to inhibition of Krebs cycle enzyme aconitase. Endocrinology 129: 3167-3173, 1991.
40. Wie, Q.-W., H. J. Cho, J. Calaycay, R. A. Mumford, K. M. Swiderek, T. D. Lee, A. Ding, T. Troso, and C. Nathan. Cloning and characterization of inducible nitric oxide synthase from mouse macrophages. Science Wash. DC 256: 225-228, 1992.