Shikonin reduces oedema induced by phorbol ester by interfering with IκBα degradation thus inhibiting translocation of NF-κB to the nucleus

British Journal of Pharmacology

Volumn 160, Issue 2, 2010, Pages 376-388

  Andujar I ^a   Recio, M C ^a   Bacelli, T ^a   Giner, R M ^a   Rios J L ^a  

^a UNIVERSITY OF VALENCIA   (Spain)

Author keywords

Cyclooxygenase 2; Ear mouse; Inducible nitric oxide synthase; MAPK; NF B; P65; RAW 264.7 macrophages; Shikonin; TPA

Indexed keywords

CYCLOOXYGENASE 2; I KAPPA B ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDOMETACIN; INDUCIBLE NITRIC OXIDE SYNTHASE; LIPOPOLYSACCHARIDE; MITOGEN ACTIVATED PROTEIN KINASE P38; PHORBOL 13 ACETATE 12 MYRISTATE; PROTEIN KINASE C ALPHA; SHIKONIN; STRESS ACTIVATED PROTEIN KINASE; TRANSCRIPTION FACTOR RELA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CELL NUCLEUS; CELLULAR DISTRIBUTION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG DOSE COMPARISON; DRUG STRUCTURE; EDEMA; ENZYME ACTIVATION; FEMALE; IC 50; MACROPHAGE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DNA BINDING; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION;

ADMINISTRATION, TOPICAL; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CELL LINE; CELL NUCLEUS; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; EDEMA; FEMALE; I-KAPPA B PROTEINS; INFLAMMATION; INHIBITORY CONCENTRATION 50; MACROPHAGES; MICE; NAPHTHOQUINONES; NF-KAPPA B; PHOSPHORYLATION; PROTEIN TRANSPORT; TETRADECANOYLPHORBOL ACETATE;

EID: 77951683909     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/j.1476-5381.2010.00696.x     Document Type: Article

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