Piperine Inhibits the Activities of Platelet Cytosolic Phospholipase A2 and Thromboxane A2 Synthase without Affecting Cyclooxygenase-1 Activity: Different Mechanisms of Action Are Involved in the Inhibition of Platelet Aggregation and Macrophage Inflammatory Response

Nutrients

Volumn 6, Issue 8, 2014, Pages 3336-3352

  Son, Dong Ju ^a   Akiba, Satoshi ^b   Hong, Jin Tae ^c   Yun, Yeo Pyo ^c   Hwang, Seock Yeon ^d   Park, Young Hyun ^e   Lee, Sung Eun ^a  

^a Kyungpook National University   (South Korea)

^b KYOTO PHARMACEUTICAL UNIVERSITY   (Japan)

^c Chungbuk National University   (South Korea)

^d Department of Nanobiomedical Science   (South Korea)

^e Department of Display Materials Engineering Soonchunhayng University   (South Korea)

Author keywords

Arachidonic acid; Cyclooxygenase; Pepper; Piperine; Platelet aggregation; Prostaglandins

Indexed keywords

AMINO ACID; COLLAGEN; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; LIPOPOLYSACCHARIDE; PHOSPHOLIPASE A2; PIPERINE; PROSTAGLANDIN D2; PROSTAGLANDIN E2; THROMBOXANE A2; THROMBOXANE SYNTHASE; 1,3 BENZODIOXOLE DERIVATIVE; ALKALOID; AMIDE; ANTITHROMBOCYTIC AGENT; ARACHIDONIC ACID; PHOSPHOLIPASE A2 INHIBITOR; PIPERIDINE DERIVATIVE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTIINFLAMMATORY ACTIVITY; ARACHIDONIC ACID METABOLISM; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME ASSAY; ENZYME IMMUNOASSAY; ENZYME REPRESSION; GENETIC TRANSCRIPTION; IC 50; INFLAMMATION; ISOTOPE LABELING; LIQUID SCINTILLATION COUNTING; MACROPHAGE; MALE; NONHUMAN; PROTEIN EXPRESSION; RABBIT; RADIOACTIVITY; THIN LAYER CHROMATOGRAPHY; THROMBOCYTE AGGREGATION INHIBITION; ANIMAL; ANTAGONISTS AND INHIBITORS; DRUG EFFECTS; METABOLISM; MOUSE; THROMBOCYTE; THROMBOCYTE AGGREGATION; TUMOR CELL LINE;

ALKALOIDS; ANIMALS; ARACHIDONIC ACID; BENZODIOXOLES; BLOOD PLATELETS; CELL LINE, TUMOR; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; MACROPHAGES; MALE; MICE; PHOSPHOLIPASE A2 INHIBITORS; PHOSPHOLIPASES A2; PIPERIDINES; PLATELET AGGREGATION; PLATELET AGGREGATION INHIBITORS; POLYUNSATURATED ALKAMIDES; RABBITS; THROMBOXANE-A SYNTHASE;

EID: 84927172907     PISSN: None     EISSN: 20726643     Source Type: Journal    
DOI: 10.3390/nu6083336     Document Type: Article

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