Arzanol, a prenylated heterodimeric phloroglucinyl pyrone, inhibits eicosanoid biosynthesis and exhibits anti-inflammatory efficacy in vivo

Biochemical Pharmacology

Volumn 81, Issue 2, 2011, Pages 259-268

  Bauer, Julia ^a   Koeberle, Andreas ^a   Dehm, Friederike ^a,b   Pollastro, Federica ^c   Appendino, Giovanni ^c   Northoff, Hinnak ^d   Rossi, Antonietta ^b   Sautebin, Lidia ^b   Werz, Oliver ^a,e  

^a UNIVERSITY OF TÜBINGEN   (Germany)

^b UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^c UNIVERSITY OF EASTERN PIEDMONT   (Italy)

^d UNIVERSITY HOSPITAL TÜBINGEN   (Germany)

^e FRIEDRICH SCHILLER UNIVERSITY JENA   (Germany)

Author keywords

5 Lipoxygenase; Inflammation; Leukotriene; Phloroglucinol; Prostaglandin

Indexed keywords

6 OXOPROSTAGLANDIN F1 ALPHA; ARACHIDONATE 5 LIPOXYGENASE; ARZANOL; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; ICOSANOID; LEUKOTRIENE; PROSTAGLANDIN E2; PROSTAGLANDIN SYNTHASE; PYRONE DERIVATIVE; THROMBOXANE B2; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; ENZYME INHIBITION; FATTY ACID SYNTHESIS; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MALE; MONOCYTE; NEUTROPHIL; NONHUMAN; PLEURISY; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ARACHIDONATE 5-LIPOXYGENASE; CARRAGEENAN; CELL LINE; DOSE-RESPONSE RELATIONSHIP, DRUG; EICOSANOIDS; HUMANS; MALE; MOLECULAR BIOLOGY; PHLOROGLUCINOL; PLEURISY; PYRONES; RATS; STEREOISOMERISM;

EID: 78650176358     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcp.2010.09.025     Document Type: Article

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