메뉴 건너뛰기




Volumn 68, Issue 4, 2016, Pages 531-563

Phytoconstituents as apoptosis inducing agents: strategy to combat cancer

Author keywords

Apoptosis; Cancer chemoprevention; Caspases; NF B; Phytochemicals; ROS

Indexed keywords

ALKALOID; APOPTOSIS INDUCING FACTOR; CASPASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; NATURAL PRODUCT; PLANT MEDICINAL PRODUCT; REACTIVE OXYGEN METABOLITE; TRANSCRIPTION FACTOR AP 1;

EID: 84938635416     PISSN: 09209069     EISSN: 15730778     Source Type: Journal    
DOI: 10.1007/s10616-015-9897-2     Document Type: Review
Times cited : (45)

References (226)
  • 1
    • 4544342570 scopus 로고    scopus 로고
    • Nuclear factor-kappaB: the enemy within
    • COI: 1:CAS:528:DC%2BD2cXot1Kis78%3D
    • Aggarwal BB (2004) Nuclear factor-kappaB: the enemy within. Cancer Cell 6:203–208
    • (2004) Cancer Cell , vol.6 , pp. 203-208
    • Aggarwal, B.B.1
  • 4
    • 0027171266 scopus 로고
    • Oxidants, antioxidants and degenerative diseases of aging
    • COI: 1:CAS:528:DyaK3sXmtVSksL4%3D
    • Ames BN, Shigenaga MK, Hagen TM (1993) Oxidants, antioxidants and degenerative diseases of aging. Proc Natl Acad Sci USA 90:7915–7922
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 7915-7922
    • Ames, B.N.1    Shigenaga, M.K.2    Hagen, T.M.3
  • 5
    • 66849095259 scopus 로고    scopus 로고
    • Perspectives for cancer prevention with natural compounds
    • Amin AR, Kucuk O, Khuri FR, Shin DM (2009) Perspectives for cancer prevention with natural compounds. J Clin Oncol 27:2712–2725
    • (2009) J Clin Oncol , vol.27 , pp. 2712-2725
    • Amin, A.R.1    Kucuk, O.2    Khuri, F.R.3    Shin, D.M.4
  • 6
    • 0025720735 scopus 로고
    • The role of Jun, Fos and the AP-1 complex in cell-proliferation and transformation
    • COI: 1:CAS:528:DyaK38XjvVOlug%3D%3D
    • Angel P, Karin M (1991) The role of Jun, Fos and the AP-1 complex in cell-proliferation and transformation. Biochim Biophys Acta 1072:129–157
    • (1991) Biochim Biophys Acta , vol.1072 , pp. 129-157
    • Angel, P.1    Karin, M.2
  • 7
    • 0023625090 scopus 로고
    • Phorbol ester-inducible genes contain a common cis element recognized by a TPA-modulated trans-acting factor
    • COI: 1:CAS:528:DyaL1cXltVCntA%3D%3D
    • Angel P, Imagawa M, Chiu R, Stein B, Imbra RJ, Rahmsdorf HJ, Jonat C, Herrlich P, Karin M (1987) Phorbol ester-inducible genes contain a common cis element recognized by a TPA-modulated trans-acting factor. Cell 49:729–739
    • (1987) Cell , vol.49 , pp. 729-739
    • Angel, P.1    Imagawa, M.2    Chiu, R.3    Stein, B.4    Imbra, R.J.5    Rahmsdorf, H.J.6    Jonat, C.7    Herrlich, P.8    Karin, M.9
  • 8
    • 0025932984 scopus 로고
    • Apoptosis: mechanisms and roles in pathology
    • COI: 1:STN:280:DyaK3MzisVSqsQ%3D%3D
    • Arends MJ, Wyllie AH (1991) Apoptosis: mechanisms and roles in pathology. Int Rev Exp Pathol 32:223–254
    • (1991) Int Rev Exp Pathol , vol.32 , pp. 223-254
    • Arends, M.J.1    Wyllie, A.H.2
  • 9
    • 77956712197 scopus 로고    scopus 로고
    • Astragalus saponins modulate mTOR and ERK signaling to promote apoptosis through the extrinsic pathway in HT-29 colon cancer cells
    • COI: 1:CAS:528:DC%2BC3cXhtFSnu73N
    • Auyeung KK-W, Mok N-L, Wong C-M, Cho C-H, Ko JK-S (2010) Astragalus saponins modulate mTOR and ERK signaling to promote apoptosis through the extrinsic pathway in HT-29 colon cancer cells. Int J Mol Med 26:341–349
    • (2010) Int J Mol Med , vol.26 , pp. 341-349
    • Auyeung, K.K.-W.1    Mok, N.-L.2    Wong, C.-M.3    Cho, C.-H.4    Ko, J.K.-S.5
  • 10
  • 11
    • 0029874138 scopus 로고    scopus 로고
    • The NF-kB and IkB proteins: new discoveries and insights
    • COI: 1:CAS:528:DyaK28XitlCgtbc%3D
    • Baldwin AS (1996) The NF-kB and IkB proteins: new discoveries and insights. Annu Rev Immunol 14:649–681
    • (1996) Annu Rev Immunol , vol.14 , pp. 649-681
    • Baldwin, A.S.1
  • 12
    • 27844474247 scopus 로고    scopus 로고
    • Drug discovery from medicinal plants
    • COI: 1:CAS:528:DC%2BD2MXht1ejsrbP
    • Balunas MJ, Kinghorn AD (2005) Drug discovery from medicinal plants. Life Sci 78:431–441
    • (2005) Life Sci , vol.78 , pp. 431-441
    • Balunas, M.J.1    Kinghorn, A.D.2
  • 13
    • 0030567752 scopus 로고    scopus 로고
    • Apoptosis-the cell’s silent exit
    • COI: 1:CAS:528:DyaK28XksFWgtbY%3D
    • Bar PR (1996) Apoptosis-the cell’s silent exit. Life Sci 59:369–378
    • (1996) Life Sci , vol.59 , pp. 369-378
    • Bar, P.R.1
  • 14
    • 0348049803 scopus 로고    scopus 로고
    • Reactive oxygen species in oncogenic transformation
    • COI: 1:CAS:528:DC%2BD3sXps12jtLY%3D
    • Behrend L, Henderson G, Zwacka RM (2003) Reactive oxygen species in oncogenic transformation. Biochem Soc Trans 31:1441–1444
    • (2003) Biochem Soc Trans , vol.31 , pp. 1441-1444
    • Behrend, L.1    Henderson, G.2    Zwacka, R.M.3
  • 15
    • 84859770197 scopus 로고    scopus 로고
    • Bryonia dioica aqueous extract induces apoptosis through mitochondrial intrinsic pathway in BL41 Burkitt’s lymphoma cells
    • COI: 1:CAS:528:DC%2BC38XltVyjtbk%3D
    • Benarba B, Meddah B, Aoues A (2012) Bryonia dioica aqueous extract induces apoptosis through mitochondrial intrinsic pathway in BL41 Burkitt’s lymphoma cells. J Ethnopharmacol 141:510–516
    • (2012) J Ethnopharmacol , vol.141 , pp. 510-516
    • Benarba, B.1    Meddah, B.2    Aoues, A.3
  • 16
    • 54549093803 scopus 로고    scopus 로고
    • Ageing, oxidative stress and cancer: paradigms in parallax
    • COI: 1:CAS:528:DC%2BD1cXht1yjtbnJ
    • Benz CC, Yau C (2008) Ageing, oxidative stress and cancer: paradigms in parallax. Nat Rev Cancer 8:875–879
    • (2008) Nat Rev Cancer , vol.8 , pp. 875-879
    • Benz, C.C.1    Yau, C.2
  • 17
    • 0023572209 scopus 로고
    • Human proto-oncogene c-jun encodes a DNA binding protein with structural and functional properties of transcription factor AP-1
    • COI: 1:CAS:528:DyaL1cXjt12ksQ%3D%3D
    • Bohmann D, Bos TJ, Admon A, Nishimura T, Vogt PK, Tjian R (1987) Human proto-oncogene c-jun encodes a DNA binding protein with structural and functional properties of transcription factor AP-1. Science 238:1386–1392
    • (1987) Science , vol.238 , pp. 1386-1392
    • Bohmann, D.1    Bos, T.J.2    Admon, A.3    Nishimura, T.4    Vogt, P.K.5    Tjian, R.6
  • 18
    • 0032806596 scopus 로고    scopus 로고
    • Apoptosis: checkpoint at the mitochondrial frontier
    • COI: 1:CAS:528:DyaK1MXmtVKht7s%3D
    • Bossy-Wetzel E, Green DR (1999) Apoptosis: checkpoint at the mitochondrial frontier. Mutat Res 434:243–251
    • (1999) Mutat Res , vol.434 , pp. 243-251
    • Bossy-Wetzel, E.1    Green, D.R.2
  • 20
    • 0742269845 scopus 로고    scopus 로고
    • Fas (CD95/Apo-1) ligand regulation in T cell homeostasis, cell-mediated cytotoxicity and immune pathology
    • COI: 1:CAS:528:DC%2BD3sXmsl2rtLc%3D
    • Brunner T, Wasem C, Torgler R, Cima I, Jakob S, Corazza N (2003) Fas (CD95/Apo-1) ligand regulation in T cell homeostasis, cell-mediated cytotoxicity and immune pathology. Semin Immunol 15:167–176
    • (2003) Semin Immunol , vol.15 , pp. 167-176
    • Brunner, T.1    Wasem, C.2    Torgler, R.3    Cima, I.4    Jakob, S.5    Corazza, N.6
  • 21
    • 23044499010 scopus 로고    scopus 로고
    • Twenty-five years of research on medicinal plants in Latin America A personal view
    • Calixto JB (2005) Twenty-five years of research on medicinal plants in Latin America A personal view. J Ethnopharmacol 100:131–134
    • (2005) J Ethnopharmacol , vol.100 , pp. 131-134
    • Calixto, J.B.1
  • 22
    • 0028926263 scopus 로고
    • Parallel signal processing among mammalian MAPKs
    • COI: 1:CAS:528:DyaK2MXktlClsr0%3D
    • Cano E, Mahadevan LC (1995) Parallel signal processing among mammalian MAPKs. Trends Biochem Sci 20:117–122
    • (1995) Trends Biochem Sci , vol.20 , pp. 117-122
    • Cano, E.1    Mahadevan, L.C.2
  • 23
    • 0033596120 scopus 로고    scopus 로고
    • Regulation of DNA binding by Rel/NF-kappaB transcription factors: structural views
    • COI: 1:CAS:528:DyaK1MXotVyhtLw%3D
    • Chen FE, Ghosh G (1999) Regulation of DNA binding by Rel/NF-kappaB transcription factors: structural views. Oncogene 18:6845–6852
    • (1999) Oncogene , vol.18 , pp. 6845-6852
    • Chen, F.E.1    Ghosh, G.2
  • 24
    • 2342522110 scopus 로고    scopus 로고
    • Shaping the nuclear action of NF-kB
    • COI: 1:CAS:528:DC%2BD2cXjsFSltL0%3D
    • Chen LF, Greene WC (2004) Shaping the nuclear action of NF-kB. Nature Rev Mol Cell Biol 5:392–401
    • (2004) Nature Rev Mol Cell Biol , vol.5 , pp. 392-401
    • Chen, L.F.1    Greene, W.C.2
  • 25
    • 0029753773 scopus 로고    scopus 로고
    • The role of c-Jun N-terminal kinase (JNK) in apoptosis induced by ultraviolet C and gamma radiation. Duration of JNK activation may determine cell death and proliferation
    • COI: 1:CAS:528:DyaK2sXitFKitg%3D%3D
    • Chen YR, Wang X, Templeton D, Davis RJ, Tan TH (1996) The role of c-Jun N-terminal kinase (JNK) in apoptosis induced by ultraviolet C and gamma radiation. Duration of JNK activation may determine cell death and proliferation. J Biol Chem 271:31929–31936
    • (1996) J Biol Chem , vol.271 , pp. 31929-31936
    • Chen, Y.R.1    Wang, X.2    Templeton, D.3    Davis, R.J.4    Tan, T.H.5
  • 26
    • 47149092365 scopus 로고    scopus 로고
    • (−)-Anonaine induces apoptosis through Bax- and caspase-dependent pathways in human cervical cancer (HeLa) cells
    • COI: 1:CAS:528:DC%2BD1cXoslCnsLs%3D
    • Chen CY, Liu TZ, Tseng WC, Lu FJ, Hung RP, Chen CH, Chen CH (2008) (−)-Anonaine induces apoptosis through Bax- and caspase-dependent pathways in human cervical cancer (HeLa) cells. Food Chem Toxicol 46:2694–2702
    • (2008) Food Chem Toxicol , vol.46 , pp. 2694-2702
    • Chen, C.Y.1    Liu, T.Z.2    Tseng, W.C.3    Lu, F.J.4    Hung, R.P.5    Chen, C.H.6    Chen, C.H.7
  • 27
    • 71549150280 scopus 로고    scopus 로고
    • Gallic acid, a major component of Toona sinensis leaf extracts, contains a ROS-mediated anti-cancer activity in human prostate cancer cells
    • COI: 1:CAS:528:DC%2BD1MXhsVWmu7zF
    • Chen HM, Wu YC, Chia YC, Chang FR, Hsu HK, Hsieh YC, Chen CC, Yuan SS (2009) Gallic acid, a major component of Toona sinensis leaf extracts, contains a ROS-mediated anti-cancer activity in human prostate cancer cells. Cancer Lett 286:161–171
    • (2009) Cancer Lett , vol.286 , pp. 161-171
    • Chen, H.M.1    Wu, Y.C.2    Chia, Y.C.3    Chang, F.R.4    Hsu, H.K.5    Hsieh, Y.C.6    Chen, C.C.7    Yuan, S.S.8
  • 28
    • 79957642562 scopus 로고    scopus 로고
    • Obacunone and obacunone glucoside inhibit human colon cancer (SW480) cells by the induction of apoptosis
    • COI: 1:CAS:528:DC%2BC3MXmvFWit7k%3D
    • Chidambara Murthy KN, Jayaprakasha GK, Patil BS (2011) Obacunone and obacunone glucoside inhibit human colon cancer (SW480) cells by the induction of apoptosis. Food Chem Toxicol 49:1616–1625
    • (2011) Food Chem Toxicol , vol.49 , pp. 1616-1625
    • Chidambara Murthy, K.N.1    Jayaprakasha, G.K.2    Patil, B.S.3
  • 30
    • 76049083966 scopus 로고    scopus 로고
    • Reactive oxygen species, cellular redox systems, and apoptosis
    • COI: 1:CAS:528:DC%2BC3cXitVKms78%3D
    • Circu ML, Aw TY (2010) Reactive oxygen species, cellular redox systems, and apoptosis. Free Radic Biol Med 48:749–762
    • (2010) Free Radic Biol Med , vol.48 , pp. 749-762
    • Circu, M.L.1    Aw, T.Y.2
  • 31
    • 33845611585 scopus 로고    scopus 로고
    • Xanthohumol, a prenylflavonoid derived from hops induces apoptosis and inhibits NF-kappaB activation in prostate epithelial cells
    • Colgate EC, Miranda CL, Stevens JF, Bray TM, Ho E (2007) Xanthohumol, a prenylflavonoid derived from hops induces apoptosis and inhibits NF-kappaB activation in prostate epithelial cells. Cancer Lett 8:201–209
    • (2007) Cancer Lett , vol.8 , pp. 201-209
    • Colgate, E.C.1    Miranda, C.L.2    Stevens, J.F.3    Bray, T.M.4    Ho, E.5
  • 32
    • 7944220855 scopus 로고    scopus 로고
    • Cancer chemotherapy and antioxidants. J
    • Conklin KA (2004) Cancer chemotherapy and antioxidants. J. Nutrition 134:3201–3204
    • (2004) Nutrition , vol.134 , pp. 3201-3204
    • Conklin, K.A.1
  • 34
    • 0036716281 scopus 로고    scopus 로고
    • The Bcl2 family: regulators of the cellular life-or-death switch
    • COI: 1:CAS:528:DC%2BD38Xmslamsrw%3D
    • Cory S, Adams JM (2002) The Bcl2 family: regulators of the cellular life-or-death switch. Nat Rev Cancer 2:647–656
    • (2002) Nat Rev Cancer , vol.2 , pp. 647-656
    • Cory, S.1    Adams, J.M.2
  • 35
    • 34648813720 scopus 로고    scopus 로고
    • ROS as signaling molecules: mechanisms that generate specificity in ROS homeostasis
    • D’Autreaux B, Toledano MB (2007) ROS as signaling molecules: mechanisms that generate specificity in ROS homeostasis. Nature Rev Mol Cell Biol 8:813–824
    • (2007) Nature Rev Mol Cell Biol , vol.8 , pp. 813-824
    • D’Autreaux, B.1    Toledano, M.B.2
  • 36
    • 0033817663 scopus 로고    scopus 로고
    • Pharmacology of medicinal plants and natural products
    • COI: 1:CAS:528:DC%2BD3cXntVymtrc%3D
    • Dahanukar SA, Kulkarni RA, Rege NN (2000) Pharmacology of medicinal plants and natural products. Indian J Pharmacol 32:S81–S118
    • (2000) Indian J Pharmacol , vol.32 , pp. S81-S118
    • Dahanukar, S.A.1    Kulkarni, R.A.2    Rege, N.N.3
  • 37
    • 22344444616 scopus 로고    scopus 로고
    • Does autophagy contribute to cell death?
    • COI: 1:CAS:528:DC%2BD2MXhtVyktL7M
    • Debnath J, Baehrecke EH, Kroemer G (2005) Does autophagy contribute to cell death? Autophagy 1:66–74
    • (2005) Autophagy , vol.1 , pp. 66-74
    • Debnath, J.1    Baehrecke, E.H.2    Kroemer, G.3
  • 39
    • 84919486388 scopus 로고    scopus 로고
    • Piperlongumine induces pancreatic cancer cell death by enhancing reactive oxygen species and DNA damage
    • COI: 1:CAS:528:DC%2BC2MXlvFWktr8%3D
    • Dhillon H, Chikara S, Reindl KM (2014) Piperlongumine induces pancreatic cancer cell death by enhancing reactive oxygen species and DNA damage. Toxicol Rep. 1:309–318
    • (2014) Toxicol Rep. , vol.1 , pp. 309-318
    • Dhillon, H.1    Chikara, S.2    Reindl, K.M.3
  • 40
    • 70149093188 scopus 로고    scopus 로고
    • Inhibition of activator protein-1 by sulforaphane involves interaction with cysteine in the cFos DNA-binding domain: implications for chemoprevention of UVB-induced skin cancer
    • COI: 1:CAS:528:DC%2BD1MXhtVOmtLnE
    • Dickinson SE, Melton TF, Olson ER, Zhang J, Saboda K, Bowden GT (2009) Inhibition of activator protein-1 by sulforaphane involves interaction with cysteine in the cFos DNA-binding domain: implications for chemoprevention of UVB-induced skin cancer. Cancer Res 69:7103–7110
    • (2009) Cancer Res , vol.69 , pp. 7103-7110
    • Dickinson, S.E.1    Melton, T.F.2    Olson, E.R.3    Zhang, J.4    Saboda, K.5    Bowden, G.T.6
  • 42
    • 74549159301 scopus 로고    scopus 로고
    • Inhibition of AP-1 and MAPK signaling and activation of Nrf2/ARE pathway by quercitrin
    • COI: 1:CAS:528:DC%2BC3cXmvVWqtQ%3D%3D
    • Ding M, Zhao J, Bowman L, Lu Y, Shi X (2010) Inhibition of AP-1 and MAPK signaling and activation of Nrf2/ARE pathway by quercitrin. Int J Oncol 36:59–67
    • (2010) Int J Oncol , vol.36 , pp. 59-67
    • Ding, M.1    Zhao, J.2    Bowman, L.3    Lu, Y.4    Shi, X.5
  • 43
    • 21244496344 scopus 로고    scopus 로고
    • NF-kB in development and progression of human cancer
    • COI: 1:CAS:528:DC%2BD2MXksl2gs74%3D
    • Dolcet X, Llobet D, Pallares J, Matias-Guiu X (2005) NF-kB in development and progression of human cancer. Virchows Arch 446:475–482
    • (2005) Virchows Arch , vol.446 , pp. 475-482
    • Dolcet, X.1    Llobet, D.2    Pallares, J.3    Matias-Guiu, X.4
  • 44
    • 0019829568 scopus 로고
    • The causes of cancer: quantitative estimates of avoidable risks of cancer in the United States today
    • COI: 1:STN:280:DyaL3M3hvFShsA%3D%3D
    • Doll R, Peto R (1981) The causes of cancer: quantitative estimates of avoidable risks of cancer in the United States today. J Natl Cancer Inst 66:1191–1308
    • (1981) J Natl Cancer Inst , vol.66 , pp. 1191-1308
    • Doll, R.1    Peto, R.2
  • 45
    • 0043066731 scopus 로고    scopus 로고
    • Regulating mammalian checkpoints through Cdc25 inactivation
    • COI: 1:CAS:528:DC%2BD3sXltVWhurk%3D
    • Donzelli M, Draetta GF (2003) Regulating mammalian checkpoints through Cdc25 inactivation. EMBO Rep 4:671–677
    • (2003) EMBO Rep , vol.4 , pp. 671-677
    • Donzelli, M.1    Draetta, G.F.2
  • 46
    • 5644283296 scopus 로고    scopus 로고
    • Role of chemopreventive agents in cancer therapy
    • COI: 1:CAS:528:DC%2BD2cXos1egt7o%3D
    • Dorai T, Aggarwal B (2004) Role of chemopreventive agents in cancer therapy. Cancer Lett 215:129–140
    • (2004) Cancer Lett , vol.215 , pp. 129-140
    • Dorai, T.1    Aggarwal, B.2
  • 47
    • 34250308322 scopus 로고    scopus 로고
    • Apoptosis: a review of programmed cell death
    • Elmore S (2007) Apoptosis: a review of programmed cell death. Toxicol Pathol 35:4495–4516
    • (2007) Toxicol Pathol , vol.35 , pp. 4495-4516
    • Elmore, S.1
  • 48
    • 0036199666 scopus 로고    scopus 로고
    • HMG2 interacts with the nucleosome assembly protein SET and is a target of the cytotoxic T-lymphocyte protease granzyme A
    • COI: 1:CAS:528:DC%2BD38XislWnt78%3D
    • Fan Z, Beresford PJ, Zhang D, Lieberman J (2002) HMG2 interacts with the nucleosome assembly protein SET and is a target of the cytotoxic T-lymphocyte protease granzyme A. Mol Cell Biol 22:2810–2820
    • (2002) Mol Cell Biol , vol.22 , pp. 2810-2820
    • Fan, Z.1    Beresford, P.J.2    Zhang, D.3    Lieberman, J.4
  • 49
    • 0037423932 scopus 로고    scopus 로고
    • Tumor Suppressor NM23-H1 is a granzyme A-activated DNase during CTL-mediated apoptosis, and the nucleosome assembly protein set is its inhibitor
    • COI: 1:CAS:528:DC%2BD3sXitFykurc%3D
    • Fan Z, Beresford PJ, Oh DY, Zhang D, Lieberman J (2003a) Tumor Suppressor NM23-H1 is a granzyme A-activated DNase during CTL-mediated apoptosis, and the nucleosome assembly protein set is its inhibitor. Cell 112:659–672
    • (2003) Cell , vol.112 , pp. 659-672
    • Fan, Z.1    Beresford, P.J.2    Oh, D.Y.3    Zhang, D.4    Lieberman, J.5
  • 51
    • 9744270759 scopus 로고    scopus 로고
    • Blackberry extracts inhibit activating protein 1 activation and cell transformation by perturbing the mitogenic signaling pathway
    • Feng R, Bowman LL, Lu Y, Leonard SS, Shi X, Jiang H-H, Castranova V, Vallyathan V, Ding M (2004) Blackberry extracts inhibit activating protein 1 activation and cell transformation by perturbing the mitogenic signaling pathway. Nutr Cancer 50:80–89
    • (2004) Nutr Cancer , vol.50 , pp. 80-89
    • Feng, R.1    Bowman, L.L.2    Lu, Y.3    Leonard, S.S.4    Shi, X.5    Jiang, H.-H.6    Castranova, V.7    Vallyathan, V.8    Ding, M.9
  • 54
    • 33847349283 scopus 로고    scopus 로고
    • Reactive oxygen species: a breath of life or death?
    • COI: 1:CAS:528:DC%2BD2sXhsVyrsrs%3D
    • Fruehauf JP, Meyskens FL Jr (2007) Reactive oxygen species: a breath of life or death? Clin Cancer Res 13:789–794
    • (2007) Clin Cancer Res , vol.13 , pp. 789-794
    • Fruehauf, J.P.1    Meyskens, F.L.2
  • 56
    • 85047699198 scopus 로고    scopus 로고
    • Nuclear transcription factor-kappaB as a target for cancer drug development
    • COI: 1:CAS:528:DC%2BD38XksFOnurs%3D
    • Garg A, Aggarwal BB (2002) Nuclear transcription factor-kappaB as a target for cancer drug development. Leukemia 16:1053–1068
    • (2002) Leukemia , vol.16 , pp. 1053-1068
    • Garg, A.1    Aggarwal, B.B.2
  • 57
    • 0036234459 scopus 로고    scopus 로고
    • Missing pieces in the NF-kB puzzle
    • COI: 1:CAS:528:DC%2BD38Xjt1equr4%3D
    • Ghosh S, Karin M (2002) Missing pieces in the NF-kB puzzle. Cell 109:S81–S96
    • (2002) Cell , vol.109 , pp. S81-S96
    • Ghosh, S.1    Karin, M.2
  • 58
    • 33750446341 scopus 로고    scopus 로고
    • Inhibitors of NF-kappaB signaling: 785 and counting
    • COI: 1:CAS:528:DC%2BD28XhtFektL%2FM
    • Gilmore TD, Herscovitch M (2006) Inhibitors of NF-kappaB signaling: 785 and counting. Oncogene 25:6887–6899
    • (2006) Oncogene , vol.25 , pp. 6887-6899
    • Gilmore, T.D.1    Herscovitch, M.2
  • 59
    • 81855218666 scopus 로고    scopus 로고
    • Shikonin, a Chinese plant-derived naphthoquinone, induces apoptosis in hepatocellular carcinoma cells through reactive oxygen species: a potential new treatment for hepatocellular carcinoma
    • COI: 1:CAS:528:DC%2BC3MXhsFegu73K
    • Gong K, Li W (2011) Shikonin, a Chinese plant-derived naphthoquinone, induces apoptosis in hepatocellular carcinoma cells through reactive oxygen species: a potential new treatment for hepatocellular carcinoma. Free Radic Biol Med 51:2259–2271
    • (2011) Free Radic Biol Med , vol.51 , pp. 2259-2271
    • Gong, K.1    Li, W.2
  • 60
    • 39149098194 scopus 로고    scopus 로고
    • Natural products as lead to anticancer drugs
    • COI: 1:CAS:528:DC%2BD1cXjsl2js7s%3D
    • Gordaliza M (2007) Natural products as lead to anticancer drugs. Clin Transl Oncol 9:767–776
    • (2007) Clin Transl Oncol , vol.9 , pp. 767-776
    • Gordaliza, M.1
  • 61
    • 0032575752 scopus 로고    scopus 로고
    • Mitochondria and apoptosis
    • COI: 1:CAS:528:DyaK1cXlvVegsLo%3D
    • Green DR, Reed JC (1998) Mitochondria and apoptosis. Science 281:1309–1312
    • (1998) Science , vol.281 , pp. 1309-1312
    • Green, D.R.1    Reed, J.C.2
  • 62
    • 0027536852 scopus 로고
    • The inducible transcription factor NF-kappaB: structure-function relationship of its protein subunits
    • COI: 1:CAS:528:DyaK3sXhvVCntL8%3D
    • Grimm S, Baeurle PA (1993) The inducible transcription factor NF-kappaB: structure-function relationship of its protein subunits. Biochem J 290:297–308
    • (1993) Biochem J , vol.290 , pp. 297-308
    • Grimm, S.1    Baeurle, P.A.2
  • 63
    • 0034522342 scopus 로고    scopus 로고
    • Caspases: key players in programmed cell death
    • Grütter MG (2000) Caspases: key players in programmed cell death. Curr Opin Struct Biol 10:649–655
    • (2000) Curr Opin Struct Biol , vol.10 , pp. 649-655
    • Grütter, M.G.1
  • 65
    • 84907202560 scopus 로고    scopus 로고
    • White tea (Camellia sinensis) inhibits proliferation of the colon cancer cell line, HT-29, activates caspases and protects DNA of normal cells against oxidative damage
    • COI: 1:CAS:528:DC%2BC2cXhsFOlu7zE
    • Hajiaghaalipour F, Kanthimathi MS, Sanusi J, Rajarajeswaran J (2015) White tea (Camellia sinensis) inhibits proliferation of the colon cancer cell line, HT-29, activates caspases and protects DNA of normal cells against oxidative damage. Food Chem 169:401–410
    • (2015) Food Chem , vol.169 , pp. 401-410
    • Hajiaghaalipour, F.1    Kanthimathi, M.S.2    Sanusi, J.3    Rajarajeswaran, J.4
  • 66
    • 0028587756 scopus 로고
    • Oxygen-derived species: their relation to human disease and environmental stress
    • COI: 1:CAS:528:DyaK2MXjsVaisLg%3D
    • Halliwell B, Cross CE (1994) Oxygen-derived species: their relation to human disease and environmental stress. Environ Health Perspect 102:5–12
    • (1994) Environ Health Perspect , vol.102 , pp. 5-12
    • Halliwell, B.1    Cross, C.E.2
  • 67
    • 79953115220 scopus 로고    scopus 로고
    • Harmine activates intrinsic and extrinsic pathways of apoptosis in B16F-10 melanoma
    • COI: 1:CAS:528:DC%2BC3MXksVOqtLw%3D
    • Hamsa TP, Kuttan G (2011) Harmine activates intrinsic and extrinsic pathways of apoptosis in B16F-10 melanoma. Chin Med 6:11. doi:10.1186/1749-8546-6-11
    • (2011) Chin Med , vol.6 , pp. 11
    • Hamsa, T.P.1    Kuttan, G.2
  • 68
    • 0035997978 scopus 로고    scopus 로고
    • Curcumin suppresses activation of NF-κB and AP-1 induced by phorbol ester in cultured human promyelocytic leukemia cells
    • COI: 1:CAS:528:DC%2BD38XksF2ktr8%3D
    • Han SS, Keum YS, Seo HJ, Surh YJ (2002) Curcumin suppresses activation of NF-κB and AP-1 induced by phorbol ester in cultured human promyelocytic leukemia cells. J Biochem Mol Biol 35:337–342
    • (2002) J Biochem Mol Biol , vol.35 , pp. 337-342
    • Han, S.S.1    Keum, Y.S.2    Seo, H.J.3    Surh, Y.J.4
  • 69
    • 84897398012 scopus 로고    scopus 로고
    • The effect of Amaryllidaceae alkaloids haemanthamine and haemanthidine on cell cycle progression and apoptosis in p53-negative human leukemic Jurkat cells
    • COI: 1:CAS:528:DC%2BC3sXhsleiu7nO
    • Havelek R, Seifrtova M, Kralovec K, Bruckova L, Cahlikova L, Dalecka M, Vavrova J, Rezacova M, Opletal L, Bilkova Z (2014) The effect of Amaryllidaceae alkaloids haemanthamine and haemanthidine on cell cycle progression and apoptosis in p53-negative human leukemic Jurkat cells. Phytomedicine 21:479–490
    • (2014) Phytomedicine , vol.21 , pp. 479-490
    • Havelek, R.1    Seifrtova, M.2    Kralovec, K.3    Bruckova, L.4    Cahlikova, L.5    Dalecka, M.6    Vavrova, J.7    Rezacova, M.8    Opletal, L.9    Bilkova, Z.10
  • 70
    • 4444376712 scopus 로고    scopus 로고
    • Signaling to NF-kappaB
    • COI: 1:CAS:528:DC%2BD2cXnslCntbY%3D
    • Hayden MS, Ghosh S (2004) Signaling to NF-kappaB. Genes Dev 18:2195–2224
    • (2004) Genes Dev , vol.18 , pp. 2195-2224
    • Hayden, M.S.1    Ghosh, S.2
  • 71
    • 0037482859 scopus 로고    scopus 로고
    • Hyperforin a constituent of St John’s wort (Hypericum perforatum L.) extract induces apoptosis by triggering activation of caspases and with hypericin synergistically exerts cytotoxicity towards human malignant cell lines
    • COI: 1:CAS:528:DC%2BD3sXltVSrt7Y%3D
    • Hostanska K, Reichling J, Bommer S, Weber M, Saller R (2003) Hyperforin a constituent of St John’s wort (Hypericum perforatum L.) extract induces apoptosis by triggering activation of caspases and with hypericin synergistically exerts cytotoxicity towards human malignant cell lines. Eur J Pharm Biopharm 56:121–132
    • (2003) Eur J Pharm Biopharm , vol.56 , pp. 121-132
    • Hostanska, K.1    Reichling, J.2    Bommer, S.3    Weber, M.4    Saller, R.5
  • 72
    • 28844466079 scopus 로고    scopus 로고
    • Actinodaphnine induces apoptosis through increased nitric oxide, reactive oxygen species and down regulation of NF-kappa B signaling in human hepatoma Mahlavu cells
    • COI: 1:CAS:528:DC%2BD2MXhtlaitb7M
    • Hsieh TJ, Liu TZ, Lu FJ, Hsieh PY, Chen CH (2006) Actinodaphnine induces apoptosis through increased nitric oxide, reactive oxygen species and down regulation of NF-kappa B signaling in human hepatoma Mahlavu cells. Food Chem Toxicol 44:344–354
    • (2006) Food Chem Toxicol , vol.44 , pp. 344-354
    • Hsieh, T.J.1    Liu, T.Z.2    Lu, F.J.3    Hsieh, P.Y.4    Chen, C.H.5
  • 73
    • 79955695767 scopus 로고    scopus 로고
    • Typhonium blumei extract inhibits proliferation of human lung adenocarcinoma A549 cells via induction of cell cycle arrest and apoptosis
    • Hsu H-F, Huang K-H, Lu K-J, Chiou S-J, Yen J-H, Chang C-C, Houng J-Y (2011) Typhonium blumei extract inhibits proliferation of human lung adenocarcinoma A549 cells via induction of cell cycle arrest and apoptosis. J Ethnopharmacol 135:492–500
    • (2011) J Ethnopharmacol , vol.135 , pp. 492-500
    • Hsu, H.-F.1    Huang, K.-H.2    Lu, K.-J.3    Chiou, S.-J.4    Yen, J.-H.5    Chang, C.-C.6    Houng, J.-Y.7
  • 74
    • 78651478136 scopus 로고    scopus 로고
    • Cancer chemopreventive activity of maslinic acid: suppression of COX-2 expression and inhibition of NF-κB and AP-1 activation in Raji cells
    • COI: 1:CAS:528:DC%2BC3MXjslKisL0%3D
    • Hsum YW, Yew WT, Hong PL, Soo KK, Hoon LS, Chieng YC, Mooi LY (2011) Cancer chemopreventive activity of maslinic acid: suppression of COX-2 expression and inhibition of NF-κB and AP-1 activation in Raji cells. Planta Med 77:152–157
    • (2011) Planta Med , vol.77 , pp. 152-157
    • Hsum, Y.W.1    Yew, W.T.2    Hong, P.L.3    Soo, K.K.4    Hoon, L.S.5    Chieng, Y.C.6    Mooi, L.Y.7
  • 75
    • 0346873049 scopus 로고    scopus 로고
    • Anticancer therapy targeting the apoptotic pathway
    • COI: 1:CAS:528:DC%2BD3sXps1OgsL0%3D
    • Hu W, Kavanagh JJ (2003) Anticancer therapy targeting the apoptotic pathway. Lancet Oncol 4:721–729
    • (2003) Lancet Oncol , vol.4 , pp. 721-729
    • Hu, W.1    Kavanagh, J.J.2
  • 76
    • 77954756984 scopus 로고    scopus 로고
    • Salidroside induces cell-cycle arrest and apoptosis in human breast cancer cells
    • COI: 1:CAS:528:DC%2BC3cXptVCltrw%3D
    • Hu X, Zhang X, Qiu S, Yu D, Lin S (2010) Salidroside induces cell-cycle arrest and apoptosis in human breast cancer cells. Biochem Biophys Res Commun 398:62–67
    • (2010) Biochem Biophys Res Commun , vol.398 , pp. 62-67
    • Hu, X.1    Zhang, X.2    Qiu, S.3    Yu, D.4    Lin, S.5
  • 77
    • 0031913814 scopus 로고    scopus 로고
    • Shortage of mitogen-activated protein kinase is responsible for resistance to AP-1 transactivation and transformation in mouse JB6 cells
    • COI: 1:CAS:528:DyaK1cXjtlyqsA%3D%3D
    • Huang C, Ma W-Y, Young MR, Colburn N, Dong Z (1998) Shortage of mitogen-activated protein kinase is responsible for resistance to AP-1 transactivation and transformation in mouse JB6 cells. Proc Natl Acad Sci USA 95:156–161
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 156-161
    • Huang, C.1    Ma, W.-Y.2    Young, M.R.3    Colburn, N.4    Dong, Z.5
  • 78
    • 0032865433 scopus 로고    scopus 로고
    • Caspases-3 and -7 are activated in goniothalamin-induced apoptosis in human Jurkat T-cells
    • COI: 1:CAS:528:DyaK1MXltVClsbo%3D
    • Inayat-Hussain SH, Osman AB, Din LB, Ali AM, Snowden RT, MacFarlane M, Cain K (1999) Caspases-3 and -7 are activated in goniothalamin-induced apoptosis in human Jurkat T-cells. FEBS Lett 456:379–383
    • (1999) FEBS Lett , vol.456 , pp. 379-383
    • Inayat-Hussain, S.H.1    Osman, A.B.2    Din, L.B.3    Ali, A.M.4    Snowden, R.T.5    MacFarlane, M.6    Cain, K.7
  • 80
    • 33646101483 scopus 로고    scopus 로고
    • Induction of apoptosis by carbazole alkaloids isolated from Murraya koenigii
    • COI: 1:CAS:528:DC%2BD28XmtFKks7o%3D
    • Ito C, Itoigawa M, Nakao K, Murata T, Tsuboi M, Kaneda N, Furukawa H (2006) Induction of apoptosis by carbazole alkaloids isolated from Murraya koenigii. Phytomedicine 13:359–365
    • (2006) Phytomedicine , vol.13 , pp. 359-365
    • Ito, C.1    Itoigawa, M.2    Nakao, K.3    Murata, T.4    Tsuboi, M.5    Kaneda, N.6    Furukawa, H.7
  • 81
    • 39049149816 scopus 로고    scopus 로고
    • The role of mitochondria in apoptosis
    • COI: 1:CAS:528:DC%2BD1cXisFyhu7c%3D
    • Jeong S-Y, Seol D-W (2008) The role of mitochondria in apoptosis. BMB reports 41:11–22
    • (2008) BMB reports , vol.41 , pp. 11-22
    • Jeong, S.-Y.1    Seol, D.-W.2
  • 82
    • 84934768010 scopus 로고    scopus 로고
    • Non-edible plants as an attractive source of compounds with chemopreventive potential
    • Ji S, Orlikova B, Diederich M (2014) Non-edible plants as an attractive source of compounds with chemopreventive potential. J Cancer Prev 19:1–6
    • (2014) J Cancer Prev , vol.19 , pp. 1-6
    • Ji, S.1    Orlikova, B.2    Diederich, M.3
  • 83
    • 0036274359 scopus 로고    scopus 로고
    • The fundamental role of epigenetic events in cancer
    • COI: 1:CAS:528:DC%2BD38XksFOmsrw%3D
    • Jones PA, Baylin SB (2002) The fundamental role of epigenetic events in cancer. Nature Rev Genet 3:415–428
    • (2002) Nature Rev Genet , vol.3 , pp. 415-428
    • Jones, P.A.1    Baylin, S.B.2
  • 84
    • 1442335327 scopus 로고    scopus 로고
    • Shooting at survivors: BCL-2 family members as drug targets for cancer
    • COI: 1:CAS:528:DC%2BD2cXhslWnsrY%3D
    • Juin P, Geneste O, Raimbaud E, Hickman JA (2004) Shooting at survivors: BCL-2 family members as drug targets for cancer. Biochim Biophys Acta 1644:251–260
    • (2004) Biochim Biophys Acta , vol.1644 , pp. 251-260
    • Juin, P.1    Geneste, O.2    Raimbaud, E.3    Hickman, J.A.4
  • 85
    • 0037969283 scopus 로고    scopus 로고
    • Cinnamaldehyde induces apoptosis by ROS-mediated mitochondrial permeability transition in human promyelocytic leukemia HL-60 cells
    • COI: 1:CAS:528:DC%2BD3sXlt1egs7s%3D
    • Ka H, Park HJ, Jung HJ, Choi JW, Cho KS, Ha J, Lee KT (2003) Cinnamaldehyde induces apoptosis by ROS-mediated mitochondrial permeability transition in human promyelocytic leukemia HL-60 cells. Cancer Lett 196:143–152
    • (2003) Cancer Lett , vol.196 , pp. 143-152
    • Ka, H.1    Park, H.J.2    Jung, H.J.3    Choi, J.W.4    Cho, K.S.5    Ha, J.6    Lee, K.T.7
  • 86
    • 0033692510 scopus 로고    scopus 로고
    • Apoptosis: mechanisms and clinical implications
    • COI: 1:STN:280:DC%2BD3M%2FkslGhtw%3D%3D
    • Kam PCA, Ferch NI (2000) Apoptosis: mechanisms and clinical implications. Anaesthesia 55:1081–1093
    • (2000) Anaesthesia , vol.55 , pp. 1081-1093
    • Kam, P.C.A.1    Ferch, N.I.2
  • 87
    • 0015383455 scopus 로고
    • Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics
    • COI: 1:STN:280:DyaE3s%2FgsFSksw%3D%3D
    • Kerr JF, Wyllie AH, Currie AR (1972) Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics. Br J Cancer 26:239–257
    • (1972) Br J Cancer , vol.26 , pp. 239-257
    • Kerr, J.F.1    Wyllie, A.H.2    Currie, A.R.3
  • 89
    • 0036889913 scopus 로고    scopus 로고
    • Apoptosis: biochemical aspects and clinical implications
    • COI: 1:CAS:528:DC%2BD38XosFertrw%3D
    • Kiechle FL, Zhang X (2002) Apoptosis: biochemical aspects and clinical implications. Clin Chim Acta 326:27–45
    • (2002) Clin Chim Acta , vol.326 , pp. 27-45
    • Kiechle, F.L.1    Zhang, X.2
  • 90
    • 27944482923 scopus 로고    scopus 로고
    • Induction of apoptosis by the aqueous extract of Rubus coreanum in HT-29 human colon cancer cells
    • Kim EJ, Lee YJ, Shin HK, Park JH (2005) Induction of apoptosis by the aqueous extract of Rubus coreanum in HT-29 human colon cancer cells. Nutrition 21:1141–1148
    • (2005) Nutrition , vol.21 , pp. 1141-1148
    • Kim, E.J.1    Lee, Y.J.2    Shin, H.K.3    Park, J.H.4
  • 91
    • 37549018171 scopus 로고    scopus 로고
    • Methanolic extracts of Plocamium telfairiae induce cytotoxicity and caspase-dependent apoptosis in HT-29 human colon carcinoma cells
    • COI: 1:CAS:528:DC%2BD1cXhtFSrtw%3D%3D
    • Kim JY, Yoon MY, Cha MR, Hwang JH, Park E, Choi SU, Park HR, Hwang YI (2007) Methanolic extracts of Plocamium telfairiae induce cytotoxicity and caspase-dependent apoptosis in HT-29 human colon carcinoma cells. J Med Food 10:587–593
    • (2007) J Med Food , vol.10 , pp. 587-593
    • Kim, J.Y.1    Yoon, M.Y.2    Cha, M.R.3    Hwang, J.H.4    Park, E.5    Choi, S.U.6    Park, H.R.7    Hwang, Y.I.8
  • 92
    • 33845808636 scopus 로고    scopus 로고
    • Enhanced induction of mitochondrial damage and apoptosis in human leukemia HL-60 cells by the Ganoderma lucidum and Duchesnea chrysantha extracts
    • COI: 1:CAS:528:DC%2BD2sXpvFWl
    • Kim KC, Kim JS, Son JK, Kim IG (2007) Enhanced induction of mitochondrial damage and apoptosis in human leukemia HL-60 cells by the Ganoderma lucidum and Duchesnea chrysantha extracts. Cancer Lett 246:210–217
    • (2007) Cancer Lett , vol.246 , pp. 210-217
    • Kim, K.C.1    Kim, J.S.2    Son, J.K.3    Kim, I.G.4
  • 93
    • 55949129696 scopus 로고    scopus 로고
    • Apoptosis of DU145 human prostate cancer cells induced by dehydrocostus lactone isolated from the root of Saussurea lappa
    • COI: 1:CAS:528:DC%2BD1cXhsVajtLrI
    • Kim EJ, Lim SS, Park SY, Shin HK, Kim JS, Park JHY (2008) Apoptosis of DU145 human prostate cancer cells induced by dehydrocostus lactone isolated from the root of Saussurea lappa. Food Chem Toxicol 46:3651–3658
    • (2008) Food Chem Toxicol , vol.46 , pp. 3651-3658
    • Kim, E.J.1    Lim, S.S.2    Park, S.Y.3    Shin, H.K.4    Kim, J.S.5    Park, J.H.Y.6
  • 94
    • 84862810518 scopus 로고    scopus 로고
    • Induction of apoptosis by ethanolic extract of mango peel and comparative analysis of the chemical constitutes of mango peel and flesh
    • COI: 1:CAS:528:DC%2BC38XitFals74%3D
    • Kim H, Kim H, Mosaddik A, Gyawali R, Ahn KS, Cho SK (2012) Induction of apoptosis by ethanolic extract of mango peel and comparative analysis of the chemical constitutes of mango peel and flesh. Food Chem 133:416–422
    • (2012) Food Chem , vol.133 , pp. 416-422
    • Kim, H.1    Kim, H.2    Mosaddik, A.3    Gyawali, R.4    Ahn, K.S.5    Cho, S.K.6
  • 96
    • 0028883850 scopus 로고
    • Cytotoxicity-dependent APO-1 (Fas/CD95)-associated proteins form a death-inducing signalling complex (DISC) with the receptor
    • COI: 1:CAS:528:DyaK2MXpslamtr4%3D
    • Kischkel FC, Hellbartdt S, Behrmann I, Germer M, Pawlita M, Krammer PH, Peter ME (1995) Cytotoxicity-dependent APO-1 (Fas/CD95)-associated proteins form a death-inducing signalling complex (DISC) with the receptor. EMBO J 14:5579–5588
    • (1995) EMBO J , vol.14 , pp. 5579-5588
    • Kischkel, F.C.1    Hellbartdt, S.2    Behrmann, I.3    Germer, M.4    Pawlita, M.5    Krammer, P.H.6    Peter, M.E.7
  • 97
    • 1342344820 scopus 로고    scopus 로고
    • The role of oxidative stress in carcinogenesis
    • COI: 1:CAS:528:DC%2BD2cXhvVCktL8%3D
    • Klaunig JE, Kamendulis LM (2004) The role of oxidative stress in carcinogenesis. Annu Rev Pharmacol Toxicol 44:239–267
    • (2004) Annu Rev Pharmacol Toxicol , vol.44 , pp. 239-267
    • Klaunig, J.E.1    Kamendulis, L.M.2
  • 98
    • 0033862305 scopus 로고    scopus 로고
    • A threshold concept for cancer therapy
    • COI: 1:STN:280:DC%2BD3cvmsFeqtw%3D%3D
    • Kong Q, Beel JA, Lillehei KO (2000) A threshold concept for cancer therapy. Med Hypotheses 55:29–35
    • (2000) Med Hypotheses , vol.55 , pp. 29-35
    • Kong, Q.1    Beel, J.A.2    Lillehei, K.O.3
  • 99
    • 0037162768 scopus 로고    scopus 로고
    • Apoptosis. A cinderella caspase takes center stage
    • COI: 1:CAS:528:DC%2BD38Xms1Sksrk%3D
    • Kumar S, Vaux DL (2002) Apoptosis. A cinderella caspase takes center stage. Science 297:1290–1291
    • (2002) Science , vol.297 , pp. 1290-1291
    • Kumar, S.1    Vaux, D.L.2
  • 100
    • 79955570626 scopus 로고    scopus 로고
    • Apoptotic inducibility of Sapindus rarax water extract on A549 human lung cancer cell line
    • Kummalue T, Sujiwattanarat P, Jiratchariyakul W (2011) Apoptotic inducibility of Sapindus rarax water extract on A549 human lung cancer cell line. J Med Plants Res 5:1087–1094
    • (2011) J Med Plants Res , vol.5 , pp. 1087-1094
    • Kummalue, T.1    Sujiwattanarat, P.2    Jiratchariyakul, W.3
  • 101
    • 77953534370 scopus 로고    scopus 로고
    • Flavokawain B, a novel chalcone from Alpinia pricei Hayata with potent apoptotic activity: Involvement of ROS and GADD153 upstream of mitochondria-dependent apoptosis in HCT116 cells
    • COI: 1:CAS:528:DC%2BC3cXntVOnt7s%3D
    • Kuo YF, Su YZ, Tseng YH, Wang SY, Wang HM, Chueh PJ (2010) Flavokawain B, a novel chalcone from Alpinia pricei Hayata with potent apoptotic activity: Involvement of ROS and GADD153 upstream of mitochondria-dependent apoptosis in HCT116 cells. Free Radic Biol Med 49:214–226
    • (2010) Free Radic Biol Med , vol.49 , pp. 214-226
    • Kuo, Y.F.1    Su, Y.Z.2    Tseng, Y.H.3    Wang, S.Y.4    Wang, H.M.5    Chueh, P.J.6
  • 102
  • 103
    • 33645318137 scopus 로고    scopus 로고
    • Methanolic extract of Pterocarpus santalinus induces apoptosis in HeLa cells
    • COI: 1:STN:280:DC%2BD287ns1SktQ%3D%3D
    • Kwon HJ, Hong YK, Kim KH, Han CH, Cho SH, Choi JS, Kim B-W (2006) Methanolic extract of Pterocarpus santalinus induces apoptosis in HeLa cells. J Ethnopharmacol 105:229–234
    • (2006) J Ethnopharmacol , vol.105 , pp. 229-234
    • Kwon, H.J.1    Hong, Y.K.2    Kim, K.H.3    Han, C.H.4    Cho, S.H.5    Choi, J.S.6    Kim, B.-W.7
  • 105
    • 0030198344 scopus 로고    scopus 로고
    • Protein kinase cascades activated by stress and inflammatory cytokines
    • COI: 1:CAS:528:DyaK28XkvVWktb4%3D
    • Kyriakis JM, Avruch J (1996) Protein kinase cascades activated by stress and inflammatory cytokines. BioEssays 18:567–577
    • (1996) BioEssays , vol.18 , pp. 567-577
    • Kyriakis, J.M.1    Avruch, J.2
  • 106
    • 46549090195 scopus 로고    scopus 로고
    • Morusin induces apoptosis and suppresses NF-kB activity in human colorectal cancer HT-29 cells
    • COI: 1:CAS:528:DC%2BD1cXmvFekur8%3D
    • Lee JC, Won SJ, Chao CL, Wu FL, Liu HS, Ling P (2008) Morusin induces apoptosis and suppresses NF-kB activity in human colorectal cancer HT-29 cells. Biochem Biophys Res Commun 372:236–242
    • (2008) Biochem Biophys Res Commun , vol.372 , pp. 236-242
    • Lee, J.C.1    Won, S.J.2    Chao, C.L.3    Wu, F.L.4    Liu, H.S.5    Ling, P.6
  • 107
    • 84864144305 scopus 로고    scopus 로고
    • Zou GL (2012) Alantolactone induces activation of apoptosis in human hepatoma cells
    • COI: 1:CAS:528:DC%2BC38Xht1SkurrK
    • Lei JC, Yu JQ, Yin Y, Liu YW (2012) Zou GL (2012) Alantolactone induces activation of apoptosis in human hepatoma cells. Food Chem Toxicol 50:3313–3319
    • (2012) Food Chem Toxicol , vol.50 , pp. 3313-3319
    • Lei, J.C.1    Yu, J.Q.2    Yin, Y.3    Liu, Y.W.4
  • 108
    • 0242662773 scopus 로고    scopus 로고
    • Baicalein induced in vitro apoptosis undergo caspases activity in human promyelocytic leukemia HL-60 cells
    • Li YC, Tyan YS, Kuo HM, Chang WC, Hsia TC, Chung JG (2004) Baicalein induced in vitro apoptosis undergo caspases activity in human promyelocytic leukemia HL-60 cells. Food Chem Toxicol 42:37–43
    • (2004) Food Chem Toxicol , vol.42 , pp. 37-43
    • Li, Y.C.1    Tyan, Y.S.2    Kuo, H.M.3    Chang, W.C.4    Hsia, T.C.5    Chung, J.G.6
  • 109
    • 34547735967 scopus 로고    scopus 로고
    • Apoptosis of Hela cells induced by extract from Cremanthodium humile
    • COI: 1:CAS:528:DC%2BD2sXovFyht7c%3D
    • Li H, Wang LJ, Qiu GF, Yu JQ, Liang SC, Hu XM (2007) Apoptosis of Hela cells induced by extract from Cremanthodium humile. Food Chem Toxicol 45:2040–2046
    • (2007) Food Chem Toxicol , vol.45 , pp. 2040-2046
    • Li, H.1    Wang, L.J.2    Qiu, G.F.3    Yu, J.Q.4    Liang, S.C.5    Hu, X.M.6
  • 110
    • 77957932118 scopus 로고    scopus 로고
    • Icariin, a natural flavonol glycoside, induces apoptosis in human hepatoma SMMC-7721 cells via a ROS/JNK-dependent mitochondrial pathway
    • COI: 1:CAS:528:DC%2BC3cXhtlSgt7fJ
    • Li S, Dong P, Wang J, Zhang J, Gu J, Wu X, Wu W, Fei X, Zhang Z, Wang Y, Quan Z, Liu Y (2010) Icariin, a natural flavonol glycoside, induces apoptosis in human hepatoma SMMC-7721 cells via a ROS/JNK-dependent mitochondrial pathway. Cancer Lett 298:222–230
    • (2010) Cancer Lett , vol.298 , pp. 222-230
    • Li, S.1    Dong, P.2    Wang, J.3    Zhang, J.4    Gu, J.5    Wu, X.6    Wu, W.7    Fei, X.8    Zhang, Z.9    Wang, Y.10    Quan, Z.11    Liu, Y.12
  • 111
    • 77952428515 scopus 로고    scopus 로고
    • Chrysin sensitizes tumor necrosis factor-α-induced apoptosis in human tumor cells via suppression of nuclear factor-kappaB
    • COI: 1:CAS:528:DC%2BC3cXlsVyitr4%3D
    • Li X, Huang Q, Ong Choon-Nam, Yang Xing-Fen, Shen Han-Ming (2010) Chrysin sensitizes tumor necrosis factor-α-induced apoptosis in human tumor cells via suppression of nuclear factor-kappaB. Cancer Lett 293:109–116
    • (2010) Cancer Lett , vol.293 , pp. 109-116
    • Li, X.1    Huang, Q.2    Ong, C.-N.3    Yang, X.-F.4    Shen, H.-M.5
  • 112
    • 0141629512 scopus 로고    scopus 로고
    • Nuclear war: the granzyme A-bomb
    • COI: 1:CAS:528:DC%2BD3sXnt1GqtLY%3D
    • Lieberman J, Fan Z (2003) Nuclear war: the granzyme A-bomb. Curr Opin Immunol 15:553–559
    • (2003) Curr Opin Immunol , vol.15 , pp. 553-559
    • Lieberman, J.1    Fan, Z.2
  • 113
    • 60249097138 scopus 로고    scopus 로고
    • Induction of apoptosis in U937 human leukaemia cells by the hexane fraction of an extract of immature Citrus grandis Osbeck fruits
    • COI: 1:CAS:528:DC%2BD1MXitFCjsbs%3D
    • Lim HK, Moon JY, Kim H, Cho M, Cho SK (2009) Induction of apoptosis in U937 human leukaemia cells by the hexane fraction of an extract of immature Citrus grandis Osbeck fruits. Food Chem 114:1245–1250
    • (2009) Food Chem , vol.114 , pp. 1245-1250
    • Lim, H.K.1    Moon, J.Y.2    Kim, H.3    Cho, M.4    Cho, S.K.5
  • 114
    • 0037376895 scopus 로고    scopus 로고
    • NF-kB in cancer: a marked target
    • COI: 1:CAS:528:DC%2BD3sXitlWnsL8%3D
    • Lin A, Karin M (2003) NF-kB in cancer: a marked target. Semin Cancer Biol 13:107–114
    • (2003) Semin Cancer Biol , vol.13 , pp. 107-114
    • Lin, A.1    Karin, M.2
  • 115
    • 84874128795 scopus 로고    scopus 로고
    • Capsaicin induces cell cycle arrest and apoptosis in human KB cancer cells
    • COI: 1:CAS:528:DC%2BC3sXmt1Gks7k%3D
    • Lin C-H, Lu W-C, Wang C-W, Chan Y-C, Chen M-K (2013) Capsaicin induces cell cycle arrest and apoptosis in human KB cancer cells. BMC Complement Altern Med. 13:46. doi:10.1186/1472-6882-13-46
    • (2013) BMC Complement Altern Med. , vol.13 , pp. 46
    • Lin, C.-H.1    Lu, W.-C.2    Wang, C.-W.3    Chan, Y.-C.4    Chen, M.-K.5
  • 117
    • 33749257472 scopus 로고    scopus 로고
    • Apoptosis of HL-60 cells induced by extracts from Narcissus tazetta var. chinensis
    • COI: 1:CAS:528:DC%2BD28XhtVGit77E
    • Liu J, Li Y, Ren W, Hu W-X (2006) Apoptosis of HL-60 cells induced by extracts from Narcissus tazetta var. chinensis. Cancer Lett 242:133–140
    • (2006) Cancer Lett , vol.242 , pp. 133-140
    • Liu, J.1    Li, Y.2    Ren, W.3    Hu, W.-X.4
  • 118
    • 58749105634 scopus 로고    scopus 로고
    • Polygonatum cyrtonema lectin induces apoptosis and autophagy in human melanoma A375 cells through a mitochondria-mediated ROS-p38-p53 pathway
    • COI: 1:CAS:528:DC%2BD1MXhtVeiurY%3D
    • Liu B, Cheng Y, Zhang B, Bian HJ, Bao JK (2009) Polygonatum cyrtonema lectin induces apoptosis and autophagy in human melanoma A375 cells through a mitochondria-mediated ROS-p38-p53 pathway. Cancer Lett 275:54–60
    • (2009) Cancer Lett , vol.275 , pp. 54-60
    • Liu, B.1    Cheng, Y.2    Zhang, B.3    Bian, H.J.4    Bao, J.K.5
  • 120
    • 84899837018 scopus 로고    scopus 로고
    • 1α, 25-dihydroxyvitamin D3 inhibits cell growth and NFκB signaling in tamoxifen-resistant breast cancer cells
    • COI: 1:CAS:528:DC%2BC2cXotFylu7s%3D
    • Lundqvist J, Yde CW, Lykkesfeldt AE (2014) 1α, 25-dihydroxyvitamin D3 inhibits cell growth and NFκB signaling in tamoxifen-resistant breast cancer cells. Steroids 85:30–35
    • (2014) Steroids , vol.85 , pp. 30-35
    • Lundqvist, J.1    Yde, C.W.2    Lykkesfeldt, A.E.3
  • 121
    • 0028880855 scopus 로고
    • Cyclins, cyclin-dependent kinases and Cdk inhibitors: implications in cell cycle control and cancer
    • COI: 1:CAS:528:DyaK2MXpsVCjs7o%3D
    • MacLachlan TK, Sang N, Giordano A (1995) Cyclins, cyclin-dependent kinases and Cdk inhibitors: implications in cell cycle control and cancer. Crit Rev Eukaryot Gene Expr 5:127–156
    • (1995) Crit Rev Eukaryot Gene Expr , vol.5 , pp. 127-156
    • MacLachlan, T.K.1    Sang, N.2    Giordano, A.3
  • 122
    • 79955085632 scopus 로고    scopus 로고
    • Berberine modulates AP-1 activity to suppress HPV transcription and downstream signaling to induce growth arrest and apoptosis in cervical cancer cells
    • COI: 1:CAS:528:DC%2BC3MXltlKjsr0%3D
    • Mahata S, Bharti AC, Shukla S, Tyagi A, Husain SA, Das BC (2011) Berberine modulates AP-1 activity to suppress HPV transcription and downstream signaling to induce growth arrest and apoptosis in cervical cancer cells. Mol Cancer 10:39–53
    • (2011) Mol Cancer , vol.10 , pp. 39-53
    • Mahata, S.1    Bharti, A.C.2    Shukla, S.3    Tyagi, A.4    Husain, S.A.5    Das, B.C.6
  • 123
    • 0032557458 scopus 로고    scopus 로고
    • Overexpression of manganese superoxide dismutase suppresses tumor necrosis factor-induced apoptosis and activation of nuclear transcription fac-tor-b and activated protein-1
    • COI: 1:CAS:528:DyaK1cXjsVGhsL0%3D
    • Manna SK, Zhang HJ, Yan T, Oberley LW, Aggarwal BB (1998) Overexpression of manganese superoxide dismutase suppresses tumor necrosis factor-induced apoptosis and activation of nuclear transcription fac-tor-b and activated protein-1. J Biol Chem 273:13245–13254
    • (1998) J Biol Chem , vol.273 , pp. 13245-13254
    • Manna, S.K.1    Zhang, H.J.2    Yan, T.3    Oberley, L.W.4    Aggarwal, B.B.5
  • 124
    • 84878012866 scopus 로고    scopus 로고
    • (−)-Epigallocatechin-3-gallate induces apoptosis in human endometrial adenocarcinoma cells via ROS generation and p38 MAP kinase activation
    • COI: 1:CAS:528:DC%2BC38XhtlSktb%2FM
    • Manohar M, Fatima I, Saxena R, Chandra V, Sankhwar PL, Dwived A (2013) (−)-Epigallocatechin-3-gallate induces apoptosis in human endometrial adenocarcinoma cells via ROS generation and p38 MAP kinase activation. J Nutr Biochem 24:940–947
    • (2013) J Nutr Biochem , vol.24 , pp. 940-947
    • Manohar, M.1    Fatima, I.2    Saxena, R.3    Chandra, V.4    Sankhwar, P.L.5    Dwived, A.6
  • 125
    • 0037248328 scopus 로고    scopus 로고
    • Cancer prevention: the potential for diet to modulate molecular signalling
    • COI: 1:CAS:528:DC%2BD3sXmsF2n
    • Manson MM (2003) Cancer prevention: the potential for diet to modulate molecular signalling. Trends Mol Med 9:11–18
    • (2003) Trends Mol Med , vol.9 , pp. 11-18
    • Manson, M.M.1
  • 126
    • 43449137552 scopus 로고    scopus 로고
    • Ursolic acid induces apoptosis by activating p53 and caspase-3 gene expressions and suppressing NF-κB mediated activation of bcl-2 in B16F-10 melanoma cells
    • COI: 1:CAS:528:DC%2BD1cXmtVWltr8%3D
    • Manu K, Kuttan G (2008) Ursolic acid induces apoptosis by activating p53 and caspase-3 gene expressions and suppressing NF-κB mediated activation of bcl-2 in B16F-10 melanoma cells. Int Immunopharmacol 8:974–981
    • (2008) Int Immunopharmacol , vol.8 , pp. 974-981
    • Manu, K.1    Kuttan, G.2
  • 127
    • 0033782031 scopus 로고    scopus 로고
    • Cytochrome c release from mitochondria: all or nothing
    • COI: 1:CAS:528:DC%2BD3cXhvVGntr8%3D
    • Martinou JC, Desagher S, Antonsson B (2000) Cytochrome c release from mitochondria: all or nothing. Nature Cell Biol 2:E41–E43
    • (2000) Nature Cell Biol , vol.2 , pp. E41-E43
    • Martinou, J.C.1    Desagher, S.2    Antonsson, B.3
  • 128
    • 0031962986 scopus 로고    scopus 로고
    • Methods for detecting and quantifying apoptosis
    • COI: 1:CAS:528:DyaK1cXktFKl
    • McCarthy NJ, Evan GI (1998) Methods for detecting and quantifying apoptosis. Curr Top Dev Biol 36:259–278
    • (1998) Curr Top Dev Biol , vol.36 , pp. 259-278
    • McCarthy, N.J.1    Evan, G.I.2
  • 129
    • 0029891162 scopus 로고    scopus 로고
    • Apoptosis molecular mechanisms and biomedical implications
    • COI: 1:CAS:528:DyaK28Xktlens74%3D
    • McConkey DJ, Zhivotovsky B, Orrenius S (1996) Apoptosis molecular mechanisms and biomedical implications. Mol Aspects Med 17:1–10
    • (1996) Mol Aspects Med , vol.17 , pp. 1-10
    • McConkey, D.J.1    Zhivotovsky, B.2    Orrenius, S.3
  • 130
    • 0034183775 scopus 로고    scopus 로고
    • Cell cycle control as a basis for cancer drug development (Review)
    • COI: 1:CAS:528:DC%2BD3cXjtVGlur0%3D
    • McDonald ER, El-Deiry WS (2000) Cell cycle control as a basis for cancer drug development (Review). Int J Oncol 16:871–886
    • (2000) Int J Oncol , vol.16 , pp. 871-886
    • McDonald, E.R.1    El-Deiry, W.S.2
  • 131
    • 21244484687 scopus 로고    scopus 로고
    • Pancratistatin: a natural anti-cancer compound that targets mitochondria specifically in cancer cells to induce apoptosis
    • COI: 1:CAS:528:DC%2BD2MXktl2rsLo%3D
    • McLachlan A, Kekre N, McNulty J, Pandey S (2005) Pancratistatin: a natural anti-cancer compound that targets mitochondria specifically in cancer cells to induce apoptosis. Apoptosis 10:619–630
    • (2005) Apoptosis , vol.10 , pp. 619-630
    • McLachlan, A.1    Kekre, N.2    McNulty, J.3    Pandey, S.4
  • 132
    • 38549150854 scopus 로고    scopus 로고
    • Aqueous extract of Rhodiola imbricata rhizome inhibits proliferation of an erythroleukemic cell line K-562 by inducing apoptosis and cell cycle arrest at G2/M phase
    • COI: 1:CAS:528:DC%2BD1cXjtlKmsbg%3D
    • Mishra KP, Padwad YS, Dutta A, Ganju L, Sairam M, Banerjee PK, Sawhney RC (2008) Aqueous extract of Rhodiola imbricata rhizome inhibits proliferation of an erythroleukemic cell line K-562 by inducing apoptosis and cell cycle arrest at G2/M phase. Immunobiology 213:125–131
    • (2008) Immunobiology , vol.213 , pp. 125-131
    • Mishra, K.P.1    Padwad, Y.S.2    Dutta, A.3    Ganju, L.4    Sairam, M.5    Banerjee, P.K.6    Sawhney, R.C.7
  • 134
    • 74849131331 scopus 로고    scopus 로고
    • Butein induces G(2)/M phase arrest and apoptosis in human hepatoma cancer cells through ROS generation
    • COI: 1:CAS:528:DC%2BC3cXhtlSjurc%3D
    • Moon DO, Kim MO, Choi YH, Hyun JW, Chang WY, Kim GY (2010) Butein induces G(2)/M phase arrest and apoptosis in human hepatoma cancer cells through ROS generation. Cancer Lett 288:204–213
    • (2010) Cancer Lett , vol.288 , pp. 204-213
    • Moon, D.O.1    Kim, M.O.2    Choi, Y.H.3    Hyun, J.W.4    Chang, W.Y.5    Kim, G.Y.6
  • 135
    • 78049423971 scopus 로고    scopus 로고
    • The chloroform fraction of guava (Psidium cattleianum sabine) leaf extract inhibits human gastric cancer cell proliferation via induction of apoptosis
    • COI: 1:CAS:528:DC%2BC3cXhtlGmt7%2FN
    • Moon JY, Mosaddik A, Kim H, Cho M, Choi HK, Kim YS, Cho SK (2011) The chloroform fraction of guava (Psidium cattleianum sabine) leaf extract inhibits human gastric cancer cell proliferation via induction of apoptosis. Food Chem 125:369–375
    • (2011) Food Chem , vol.125 , pp. 369-375
    • Moon, J.Y.1    Mosaddik, A.2    Kim, H.3    Cho, M.4    Choi, H.K.5    Kim, Y.S.6    Cho, S.K.7
  • 136
    • 68649089717 scopus 로고    scopus 로고
    • Role of caspases and Bax protein in saffron-induced apoptosis in MCF-7 cells
    • COI: 1:CAS:528:DC%2BD1MXosV2gsbk%3D
    • Mousavi SH, Tavakkol-Afshari J, Brook A, Jafari-Anarkooli I (2009) Role of caspases and Bax protein in saffron-induced apoptosis in MCF-7 cells. Food Chem Toxicol 47:1909–1913
    • (2009) Food Chem Toxicol , vol.47 , pp. 1909-1913
    • Mousavi, S.H.1    Tavakkol-Afshari, J.2    Brook, A.3    Jafari-Anarkooli, I.4
  • 137
    • 84876730141 scopus 로고    scopus 로고
    • Apoptogenic activity of ethyl acetate extract of leaves of Memecylon edule on human gastric carcinoma cells via mitochondrial dependent pathway
    • COI: 1:STN:280:DC%2BC3srnsFKisw%3D%3D
    • Naidu VG, Mahesh BU, Giddam AK, Babu KR, Ding J, Ramesh B, Ramesh B, Gopalakrishnakone P (2013) Apoptogenic activity of ethyl acetate extract of leaves of Memecylon edule on human gastric carcinoma cells via mitochondrial dependent pathway. Asian Pac J Trop Med 6:337–345
    • (2013) Asian Pac J Trop Med , vol.6 , pp. 337-345
    • Naidu, V.G.1    Mahesh, B.U.2    Giddam, A.K.3    Babu, K.R.4    Ding, J.5    Ramesh, B.6    Ramesh, B.7    Gopalakrishnakone, P.8
  • 138
    • 0042844744 scopus 로고    scopus 로고
    • Natural products as sources of new drugs over the period 1981–2002
    • COI: 1:CAS:528:DC%2BD3sXksVylu7g%3D
    • Newman DJ, Cragg GM, Snader KM (2003) Natural products as sources of new drugs over the period 1981–2002. J Nat Prod 66:1022–1037
    • (2003) J Nat Prod , vol.66 , pp. 1022-1037
    • Newman, D.J.1    Cragg, G.M.2    Snader, K.M.3
  • 139
    • 0032785021 scopus 로고    scopus 로고
    • Caspase structure, proteolytic substrates, and function during apoptotic cell death
    • COI: 1:CAS:528:DC%2BD3cXivVeqsQ%3D%3D
    • Nicholson DW (1999) Caspase structure, proteolytic substrates, and function during apoptotic cell death. Cell Death Differ 6:1028–1042
    • (1999) Cell Death Differ , vol.6 , pp. 1028-1042
    • Nicholson, D.W.1
  • 140
    • 0034641932 scopus 로고    scopus 로고
    • From bench to clinic with apoptosis-based therapeutic agents
    • COI: 1:CAS:528:DC%2BD3cXnsFWrtr8%3D
    • Nicholson DW (2000) From bench to clinic with apoptosis-based therapeutic agents. Nature 407:810–816
    • (2000) Nature , vol.407 , pp. 810-816
    • Nicholson, D.W.1
  • 142
    • 0027166048 scopus 로고
    • Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death
    • COI: 1:CAS:528:DyaK3sXms1eqtbs%3D
    • Oltvai Z, Milliman C, Korsmeyer S (1993) Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death. Cell 74:609–619
    • (1993) Cell , vol.74 , pp. 609-619
    • Oltvai, Z.1    Milliman, C.2    Korsmeyer, S.3
  • 143
    • 78650679196 scopus 로고    scopus 로고
    • Selective induction of apoptosis through activation of caspase-8 in human leukemia cells (Jurkat) by dandelion root extract
    • COI: 1:CAS:528:DC%2BC3cXhs1WntLzP
    • Ovadje P, Chatterjee S, Griffin C, Tran C, Hamm C, Pandey S (2011) Selective induction of apoptosis through activation of caspase-8 in human leukemia cells (Jurkat) by dandelion root extract. J Ethnopharmacol 133:86–91
    • (2011) J Ethnopharmacol , vol.133 , pp. 86-91
    • Ovadje, P.1    Chatterjee, S.2    Griffin, C.3    Tran, C.4    Hamm, C.5    Pandey, S.6
  • 144
    • 77956172542 scopus 로고    scopus 로고
    • Activation of caspases and poly (ADP-ribose) polymerase cleavage to induce apoptosis in leukemia HL-60 cells by Inula racemosa
    • COI: 1:CAS:528:DC%2BC3cXhtV2htbbP
    • Pal HC, Sehar I, Bhushan S, Gupta BD, Saxena AK (2010) Activation of caspases and poly (ADP-ribose) polymerase cleavage to induce apoptosis in leukemia HL-60 cells by Inula racemosa. Toxicol In Vitro 24:1599–1609
    • (2010) Toxicol In Vitro , vol.24 , pp. 1599-1609
    • Pal, H.C.1    Sehar, I.2    Bhushan, S.3    Gupta, B.D.4    Saxena, A.K.5
  • 145
    • 38949162199 scopus 로고    scopus 로고
    • Food bioactives, apoptosis, and cancer
    • COI: 1:CAS:528:DC%2BD1cXhsFSjtb8%3D
    • Pan MH, Ghai G, Ho CT (2008) Food bioactives, apoptosis, and cancer. Mol Nutr Food Res 52:43–52
    • (2008) Mol Nutr Food Res , vol.52 , pp. 43-52
    • Pan, M.H.1    Ghai, G.2    Ho, C.T.3
  • 146
    • 0032008099 scopus 로고    scopus 로고
    • Novel therapeutic strategies to selectively kill cancer cells
    • COI: 1:CAS:528:DyaK1cXhtFWhsg%3D%3D
    • Panchal RG (1998) Novel therapeutic strategies to selectively kill cancer cells. Biochem Pharmacol 55:247–252
    • (1998) Biochem Pharmacol , vol.55 , pp. 247-252
    • Panchal, R.G.1
  • 147
    • 10344245518 scopus 로고    scopus 로고
    • Antitumour activity of Annona squamosa seed extracts is through the generation of free radicals and induction of apoptosis
    • COI: 1:CAS:528:DC%2BD2cXhtVWisb7K
    • Pardhasaradhi BV, Reddy M, Ali AM, Kumari AL, Khar A (2004) Antitumour activity of Annona squamosa seed extracts is through the generation of free radicals and induction of apoptosis. Indian J Biochem Biophys 41:167–172
    • (2004) Indian J Biochem Biophys , vol.41 , pp. 167-172
    • Pardhasaradhi, B.V.1    Reddy, M.2    Ali, A.M.3    Kumari, A.L.4    Khar, A.5
  • 148
    • 20444476123 scopus 로고    scopus 로고
    • Coptis japonica root extract induces apoptosis through caspase3 activation in SNU-668 human gastric cancer cells
    • COI: 1:STN:280:DC%2BD2M3ps1GjtA%3D%3D
    • Park HJ, Kim YJ, Leem K, Park SJ, Seo JC, Kim HK, Chung JH (2005) Coptis japonica root extract induces apoptosis through caspase 3 activation in SNU-668 human gastric cancer cells. Phytother Res 19:189–192
    • (2005) Phytother Res , vol.19 , pp. 189-192
    • Park, H.J.1    Kim, Y.J.2    Leem, K.3    Park, S.J.4    Seo, J.C.5    Kim, H.K.6    Chung, J.H.7
  • 149
    • 80053950522 scopus 로고    scopus 로고
    • β-Caryophyllene oxide inhibits growth and induces apoptosis through the suppression of PI3K/AKT/mTOR/S6K1 pathways and ROS-mediated MAPKs activation
    • COI: 1:CAS:528:DC%2BC3MXhtlars7nK
    • Park KR, Nam D, Yun HM, Lee SG, Jang HJ, Sethi G, Cho SK, Ahn KS (2011) β-Caryophyllene oxide inhibits growth and induces apoptosis through the suppression of PI3K/AKT/mTOR/S6K1 pathways and ROS-mediated MAPKs activation. Cancer Lett 312:178–188
    • (2011) Cancer Lett , vol.312 , pp. 178-188
    • Park, K.R.1    Nam, D.2    Yun, H.M.3    Lee, S.G.4    Jang, H.J.5    Sethi, G.6    Cho, S.K.7    Ahn, K.S.8
  • 150
    • 2942593991 scopus 로고    scopus 로고
    • ROS stress in cancer cells and therapeutic implications
    • COI: 1:CAS:528:DC%2BD2cXkt1Wquro%3D
    • Pelicano H, Carney D, Huang P (2004) ROS stress in cancer cells and therapeutic implications. Drug Resist Update 7:97–110
    • (2004) Drug Resist Update , vol.7 , pp. 97-110
    • Pelicano, H.1    Carney, D.2    Huang, P.3
  • 151
    • 0036284778 scopus 로고    scopus 로고
    • The Anaphase-promoting complex: proteolysis in mitosis and beyond
    • COI: 1:CAS:528:DC%2BD38XksFKjtL8%3D
    • Peters JM (2002) The Anaphase-promoting complex: proteolysis in mitosis and beyond. Mol Cell 9:931–943
    • (2002) Mol Cell , vol.9 , pp. 931-943
    • Peters, J.M.1
  • 154
    • 4644324186 scopus 로고    scopus 로고
    • NF-kappaB functions as a tumour promoter in inflammation-associated cancer
    • COI: 1:CAS:528:DC%2BD2cXnslelsrc%3D
    • Pikarsky E, Porat RM, Stein I, Abramovitch R, Amit S, Kasem S (2004) NF-kappaB functions as a tumour promoter in inflammation-associated cancer. Nature 431:461–466
    • (2004) Nature , vol.431 , pp. 461-466
    • Pikarsky, E.1    Porat, R.M.2    Stein, I.3    Abramovitch, R.4    Amit, S.5    Kasem, S.6
  • 157
    • 58149497648 scopus 로고    scopus 로고
    • Medicinal plants from deccan ecoregion, India—traditional knowledge, ethnophamacology, cultivation, utilization, biotechnology and conservation
    • Prasad MNV, Padmalatha K, Jayaram K., Raju NL, Teixeira da Silva J (2007) Medicinal plants from deccan ecoregion, India—traditional knowledge, ethnophamacology, cultivation, utilization, biotechnology and conservation. Med Aromat Plant Sci Biotechnol 1:155–208
    • (2007) Med Aromat Plant Sci Biotechnol , vol.1 , pp. 155-208
    • Prasad, M.N.V.1    Padmalatha, K.2    Jayaram, K.3    Raju, N.L.4    Teixeira da Silva, J.5
  • 158
    • 12644291915 scopus 로고    scopus 로고
    • Inhibition by uridine but not thymidine of p53-dependent intestinal apoptosis initiated by 5-fluorouracil: evidence for the involvement of RNA perturbation
    • COI: 1:CAS:528:DyaK2sXhslars7g%3D
    • Pritchard DM, Watson AJ, Potten CS, Jackman AL, Hickman JA (1997) Inhibition by uridine but not thymidine of p53-dependent intestinal apoptosis initiated by 5-fluorouracil: evidence for the involvement of RNA perturbation. Proc Natl Acad Sci USA 94:1795–1799
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 1795-1799
    • Pritchard, D.M.1    Watson, A.J.2    Potten, C.S.3    Jackman, A.L.4    Hickman, J.A.5
  • 159
    • 84869114692 scopus 로고    scopus 로고
    • Herbacetin induces apoptosis in HepG2 cells: involvements of ROS and PI3K/Akt pathway
    • COI: 1:CAS:528:DC%2BC38XhvV2ktL3E
    • Qiao Y, Xiang Q, Yuan L, Xu L, Liu Z, Liu X (2013) Herbacetin induces apoptosis in HepG2 cells: involvements of ROS and PI3K/Akt pathway. Food Chem Toxicol 51:426–433
    • (2013) Food Chem Toxicol , vol.51 , pp. 426-433
    • Qiao, Y.1    Xiang, Q.2    Yuan, L.3    Xu, L.4    Liu, Z.5    Liu, X.6
  • 160
    • 84872768208 scopus 로고    scopus 로고
    • Effect of extracts from Phyllanthus watsonii Airy Shaw on cell apoptosis in cultured human breast cancer MCF-7 cells
    • COI: 1:CAS:528:DC%2BC3sXhs1Chtrs%3D
    • Ramasamy S, Abdul WN, Zainal AN, Manickam S (2013) Effect of extracts from Phyllanthus watsonii Airy Shaw on cell apoptosis in cultured human breast cancer MCF-7 cells. Exp Toxicol Pathol 65:341–349
    • (2013) Exp Toxicol Pathol , vol.65 , pp. 341-349
    • Ramasamy, S.1    Abdul, W.N.2    Zainal, A.N.3    Manickam, S.4
  • 161
    • 0038221064 scopus 로고    scopus 로고
    • Bioactive phytochemicals in Indian foods and their potential in health promotion and disease prevention
    • COI: 1:CAS:528:DC%2BD3sXktVantLc%3D
    • Rao N (2003) Bioactive phytochemicals in Indian foods and their potential in health promotion and disease prevention. Asia Pac J Clin Nutr 12:9–22
    • (2003) Asia Pac J Clin Nutr , vol.12 , pp. 9-22
    • Rao, N.1
  • 162
    • 58149483490 scopus 로고    scopus 로고
    • Anti-proliferative and cytotoxic effects of Strychnos nux-vomicaroot extract on human multiple myeloma cell line—RPMI 8226
    • COI: 1:CAS:528:DC%2BD1MXotl2ksA%3D%3D
    • Rao PS, Ramanadham M, Prasad MNV (2009) Anti-proliferative and cytotoxic effects of Strychnos nux-vomicaroot extract on human multiple myeloma cell line—RPMI 8226. Food Chem Toxicol 47:283–288
    • (2009) Food Chem Toxicol , vol.47 , pp. 283-288
    • Rao, P.S.1    Ramanadham, M.2    Prasad, M.N.V.3
  • 163
    • 0028095981 scopus 로고
    • Rapid Communication: oxidative stress induces apoptosis in embryonic cortical neurons
    • COI: 1:CAS:528:DyaK2cXhtVeqs7g%3D
    • Ratan RR, Murphy TH, Baraban JM (1994) Rapid Communication: oxidative stress induces apoptosis in embryonic cortical neurons. J Neurochem 62:376–379
    • (1994) J Neurochem , vol.62 , pp. 376-379
    • Ratan, R.R.1    Murphy, T.H.2    Baraban, J.M.3
  • 164
    • 0030782177 scopus 로고    scopus 로고
    • Cytochrome C: can’t live with it; can’t live without it
    • COI: 1:CAS:528:DyaK2sXnvFWrsLg%3D
    • Reed JC (1997) Cytochrome C: can’t live with it; can’t live without it. Cell 91:559–562
    • (1997) Cell , vol.91 , pp. 559-562
    • Reed, J.C.1
  • 165
    • 33749556242 scopus 로고    scopus 로고
    • Effect of rhodoxanthin from Potamogeton crispus L. on cell apoptosis in Hela cells
    • COI: 1:CAS:528:DC%2BD28XhtVyit7zK
    • Ren D, Peng G, Huang H, Wang H, Zhang S (2006) Effect of rhodoxanthin from Potamogeton crispus L. on cell apoptosis in Hela cells. Toxicol In Vitro 20:1411–1418
    • (2006) Toxicol In Vitro , vol.20 , pp. 1411-1418
    • Ren, D.1    Peng, G.2    Huang, H.3    Wang, H.4    Zhang, S.5
  • 166
    • 84856466035 scopus 로고    scopus 로고
    • Induction of apoptosis and cell cycle arrest by pericarp polyphenol-rich extract of Baneh in human colon carcinoma HT29 cells
    • COI: 1:CAS:528:DC%2BC38Xjs1Whurg%3D
    • Rezaei PF, Fouladdel S, Hassani S, Yousefbeyk F, Ghaffari SM, Amin G, Azizi E (2012) Induction of apoptosis and cell cycle arrest by pericarp polyphenol-rich extract of Baneh in human colon carcinoma HT29 cells. Food Chem Toxicol 50:1054–1059
    • (2012) Food Chem Toxicol , vol.50 , pp. 1054-1059
    • Rezaei, P.F.1    Fouladdel, S.2    Hassani, S.3    Yousefbeyk, F.4    Ghaffari, S.M.5    Amin, G.6    Azizi, E.7
  • 167
    • 84877592269 scopus 로고    scopus 로고
    • Induction of apoptosis in human leukemic Cell Lines U937, K562 and HL-60 by Litchi chinensis leaf extract via activation of mitochondria mediated caspase cascades
    • Roya S, Besra SE, De T, Banerjee B, Mukherjee J, Vedasiromoni JR (2008) Induction of apoptosis in human leukemic Cell Lines U937, K562 and HL-60 by Litchi chinensis leaf extract via activation of mitochondria mediated caspase cascades. Open Leukemia J 1:1–14
    • (2008) Open Leukemia J , vol.1 , pp. 1-14
    • Roya, S.1    Besra, S.E.2    De, T.3    Banerjee, B.4    Mukherjee, J.5    Vedasiromoni, J.R.6
  • 169
    • 0038394624 scopus 로고    scopus 로고
    • Caspases and apoptosis
    • COI: 1:CAS:528:DC%2BD3sXhtVShsbc%3D
    • Salvesen GS (2002) Caspases and apoptosis. Essays Biochem 38:9–19
    • (2002) Essays Biochem , vol.38 , pp. 9-19
    • Salvesen, G.S.1
  • 170
    • 84884912614 scopus 로고    scopus 로고
    • Cyathula prostrata ethanol extract activates the extrinsic pathway of apoptosis in HeLa and U937 cell lines
    • Schnablegger GE, Venables L, Koekemoer TC, Sowemimo AA, Van de Venter M (2013) Cyathula prostrata ethanol extract activates the extrinsic pathway of apoptosis in HeLa and U937 cell lines. South Afr J Bot 88:380–387
    • (2013) South Afr J Bot , vol.88 , pp. 380-387
    • Schnablegger, G.E.1    Venables, L.2    Koekemoer, T.C.3    Sowemimo, A.A.4    Van de Venter, M.5
  • 171
    • 0035206383 scopus 로고    scopus 로고
    • Mechanisms of p53-dependent apoptosis
    • COI: 1:CAS:528:DC%2BD3MXpt1Crs7w%3D
    • Schuler M, Green DR (2001) Mechanisms of p53-dependent apoptosis. Biochem Soc Trans 29:684–688
    • (2001) Biochem Soc Trans , vol.29 , pp. 684-688
    • Schuler, M.1    Green, D.R.2
  • 172
    • 33748165596 scopus 로고    scopus 로고
    • Reactive oxygen species in cancer cells: live by the sword, die by the sword
    • COI: 1:CAS:528:DC%2BD28XhtVSlu73M
    • Schumacker PT (2006) Reactive oxygen species in cancer cells: live by the sword, die by the sword. Cancer Cell 10:175–176
    • (2006) Cancer Cell , vol.10 , pp. 175-176
    • Schumacker, P.T.1
  • 174
    • 0022481133 scopus 로고
    • Multiple nuclear factors interact with the immunoglobulin enhancer sequences
    • COI: 1:CAS:528:DyaL28XmtVCjs74%3D
    • Sen R, Baltimore D (1986) Multiple nuclear factors interact with the immunoglobulin enhancer sequences. Cell 46:705–716
    • (1986) Cell , vol.46 , pp. 705-716
    • Sen, R.1    Baltimore, D.2
  • 176
    • 0035922193 scopus 로고    scopus 로고
    • Eupatilin, a pharmacologically active flavone derived from Artemisia plants, induces apoptosis in human promyelocytic leukemia cells
    • COI: 1:CAS:528:DC%2BD3MXls1ehtLc%3D
    • Seo HJ, Surh YJ (2001) Eupatilin, a pharmacologically active flavone derived from Artemisia plants, induces apoptosis in human promyelocytic leukemia cells. Mutat Res 496:191–198
    • (2001) Mutat Res , vol.496 , pp. 191-198
    • Seo, H.J.1    Surh, Y.J.2
  • 177
    • 84862016307 scopus 로고    scopus 로고
    • Apigenin induces apoptosis via extrinsic pathway, inducing p53 and inhibiting STAT3 and NFκB signaling in HER2-overexpressing breast cancer cells
    • COI: 1:CAS:528:DC%2BC38XotFWqtro%3D
    • Seo HS, Choi HS, Kim SR, Choi YK, Woo SM, Shin I, Woo JK, Park SY, Shin YC, Ko SG (2012) Apigenin induces apoptosis via extrinsic pathway, inducing p53 and inhibiting STAT3 and NFκB signaling in HER2-overexpressing breast cancer cells. Mol Cell Biochem 366:319–334
    • (2012) Mol Cell Biochem , vol.366 , pp. 319-334
    • Seo, H.S.1    Choi, H.S.2    Kim, S.R.3    Choi, Y.K.4    Woo, S.M.5    Shin, I.6    Woo, J.K.7    Park, S.Y.8    Shin, Y.C.9    Ko, S.G.10
  • 178
    • 84861488719 scopus 로고    scopus 로고
    • Luffa echinata Roxb. induces human colon cancer cell (HT-29) death by triggering the mitochondrial apoptosis pathway
    • COI: 1:CAS:528:DC%2BC38XnvFGlur4%3D
    • Shang LH, Li CM, Yang ZY, Che DH, Cao JY, Yu Y (2012) Luffa echinata Roxb. induces human colon cancer cell (HT-29) death by triggering the mitochondrial apoptosis pathway. Molecules 17:5780–5794
    • (2012) Molecules , vol.17 , pp. 5780-5794
    • Shang, L.H.1    Li, C.M.2    Yang, Z.Y.3    Che, D.H.4    Cao, J.Y.5    Yu, Y.6
  • 179
    • 0035971493 scopus 로고    scopus 로고
    • AP-1 in cell proliferation and survival
    • COI: 1:CAS:528:DC%2BD3MXjslyrsro%3D
    • Shaulian E, Karin M (2001) AP-1 in cell proliferation and survival. Oncogene 20:2390–2400
    • (2001) Oncogene , vol.20 , pp. 2390-2400
    • Shaulian, E.1    Karin, M.2
  • 180
    • 0029849620 scopus 로고    scopus 로고
    • Cancer cell cycles
    • COI: 1:CAS:528:DyaK28XntlyktLs%3D
    • Sherr CJ (1996) Cancer cell cycles. Science 274:1672–1677
    • (1996) Science , vol.274 , pp. 1672-1677
    • Sherr, C.J.1
  • 181
    • 4143134494 scopus 로고    scopus 로고
    • Nuclear factor-kB: a friend or a foe in cancer?
    • COI: 1:CAS:528:DC%2BD2cXmslOnsr0%3D
    • Shishodia S, Aggarwal BB (2004) Nuclear factor-kB: a friend or a foe in cancer? Biochem Pharmacol 68:1071–1080
    • (2004) Biochem Pharmacol , vol.68 , pp. 1071-1080
    • Shishodia, S.1    Aggarwal, B.B.2
  • 182
    • 77957587417 scopus 로고    scopus 로고
    • Phytochemicals: cancer chemoprevention and suppression of tumor onset and metastasis
    • COI: 1:CAS:528:DC%2BC3cXhtFWqt7rI
    • Shu L, Cheung KL, Khor TO, Chen C, Kong AN (2010) Phytochemicals: cancer chemoprevention and suppression of tumor onset and metastasis. Cancer Metastasis Rev 29:483–502
    • (2010) Cancer Metastasis Rev , vol.29 , pp. 483-502
    • Shu, L.1    Cheung, K.L.2    Khor, T.O.3    Chen, C.4    Kong, A.N.5
  • 183
    • 84907984814 scopus 로고    scopus 로고
    • Epigenetic regulation by selected dietary phytochemicals in cancer chemoprevention
    • COI: 1:CAS:528:DC%2BC2cXhsFynsb3E
    • Shukla S, Meeran SM, Katiyar SK (2014) Epigenetic regulation by selected dietary phytochemicals in cancer chemoprevention. Cancer Lett 355:9–17
    • (2014) Cancer Lett , vol.355 , pp. 9-17
    • Shukla, S.1    Meeran, S.M.2    Katiyar, S.K.3
  • 184
    • 0034468736 scopus 로고    scopus 로고
    • Role of reactive oxygen species (ROS) in apoptosis induction
    • COI: 1:CAS:528:DC%2BD3MXitV2ru7k%3D
    • Simon HU, Haj-Yehia A, Levi-Schaffer F (2000) Role of reactive oxygen species (ROS) in apoptosis induction. Apoptosis 5:415–418
    • (2000) Apoptosis , vol.5 , pp. 415-418
    • Simon, H.U.1    Haj-Yehia, A.2    Levi-Schaffer, F.3
  • 185
    • 0142121431 scopus 로고    scopus 로고
    • Myriadenolide, a labdane diterpene isolated from Alomia myriadenia (asteraceae) induces depolarization of mitochondrial membranes and apoptosis associated with activation of caspases-8, -9, and -3 in Jurkat and THP-1 cells
    • COI: 1:CAS:528:DC%2BD3sXotVCitbk%3D
    • Souza-Fagundes SM, Brumatti G, Martins-Filho OA, Corrêa-Oliveira R, Zani CL, Amarante-Mendes GP (2003) Myriadenolide, a labdane diterpene isolated from Alomia myriadenia (asteraceae) induces depolarization of mitochondrial membranes and apoptosis associated with activation of caspases-8, -9, and -3 in Jurkat and THP-1 cells. Exp Cell Res 290:420–426
    • (2003) Exp Cell Res , vol.290 , pp. 420-426
    • Souza-Fagundes, S.M.1    Brumatti, G.2    Martins-Filho, O.A.3    Corrêa-Oliveira, R.4    Zani, C.L.5    Amarante-Mendes, G.P.6
  • 186
    • 30844435905 scopus 로고    scopus 로고
    • Crude extract of garlic induced caspase-3 gene expression leading to apoptosis in human colon cancer cells
    • Su CC, Chen GW, Tan TW, Lin JG, Chung JG (2006) Crude extract of garlic induced caspase-3 gene expression leading to apoptosis in human colon cancer cells. Vivo 20:85–90
    • (2006) Vivo , vol.20 , pp. 85-90
    • Su, C.C.1    Chen, G.W.2    Tan, T.W.3    Lin, J.G.4    Chung, J.G.5
  • 187
    • 33646708527 scopus 로고    scopus 로고
    • Ethanolic neem (Azadirachta indica) leaf extract induces apoptosis in the hamster buccal pouch carcinogenesis model by modulation of Bcl-2, Bim, caspase 8 and caspase 3
    • COI: 1:STN:280:DC%2BD28%2FltVWqtg%3D%3D
    • Subapriya R, Bhuvaneswari V, Nagini S (2005) Ethanolic neem (Azadirachta indica) leaf extract induces apoptosis in the hamster buccal pouch carcinogenesis model by modulation of Bcl-2, Bim, caspase 8 and caspase 3. Asian Pac J Cancer Prev 6:515–520
    • (2005) Asian Pac J Cancer Prev , vol.6 , pp. 515-520
    • Subapriya, R.1    Bhuvaneswari, V.2    Nagini, S.3
  • 188
    • 3242798367 scopus 로고    scopus 로고
    • NF-kappaB activation in human prostate cancer: important mediator or epiphenomenon?
    • COI: 1:CAS:528:DC%2BD2cXlvV2gtA%3D%3D
    • Suh J, Rabson AB (2004) NF-kappaB activation in human prostate cancer: important mediator or epiphenomenon? J Cell Biochem 91:100–117
    • (2004) J Cell Biochem , vol.91 , pp. 100-117
    • Suh, J.1    Rabson, A.B.2
  • 189
    • 80052082287 scopus 로고    scopus 로고
    • Plumbagin treatment leads to apoptosis in human K562 leukemia cells through increased ROS and elevated TRAIL receptor expression
    • COI: 1:CAS:528:DC%2BC3MXhtFShu7zI
    • Sun J, McKallip RJ (2011) Plumbagin treatment leads to apoptosis in human K562 leukemia cells through increased ROS and elevated TRAIL receptor expression. Leuk Res 35:1402–1408
    • (2011) Leuk Res , vol.35 , pp. 1402-1408
    • Sun, J.1    McKallip, R.J.2
  • 190
    • 0142166328 scopus 로고    scopus 로고
    • Cancer chemoprevention with dieatary phytochemicals
    • COI: 1:CAS:528:DC%2BD3sXotFChsLw%3D
    • Surh YJ (2003) Cancer chemoprevention with dieatary phytochemicals. Nat Rev Cancer 3:768–780
    • (2003) Nat Rev Cancer , vol.3 , pp. 768-780
    • Surh, Y.J.1
  • 191
    • 0026021362 scopus 로고
    • Production of large amounts of hydrogen peroxide by human tumor cells
    • COI: 1:CAS:528:DyaK3MXpvFagsw%3D%3D
    • Szatrowski TP, Nathan CF (1991) Production of large amounts of hydrogen peroxide by human tumor cells. Cancer Res 51:794–798
    • (1991) Cancer Res , vol.51 , pp. 794-798
    • Szatrowski, T.P.1    Nathan, C.F.2
  • 192
    • 33645834096 scopus 로고    scopus 로고
    • Biodiversity as a source of anticancer drugs
    • COI: 1:CAS:528:DC%2BD28Xis1Cms7o%3D
    • Tan G, Gyllenhaal C, Soejarto DD (2006) Biodiversity as a source of anticancer drugs. Curr Drug Targets 7:265–277
    • (2006) Curr Drug Targets , vol.7 , pp. 265-277
    • Tan, G.1    Gyllenhaal, C.2    Soejarto, D.D.3
  • 193
    • 0012285509 scopus 로고    scopus 로고
    • Natural products as inducers of apoptosis: implication for cancer therapy and prevention
    • COI: 1:CAS:528:DC%2BD3MXkvF2ltLY%3D
    • Taraphdar AK, Roy M, Bhattacharya RK (2001) Natural products as inducers of apoptosis: implication for cancer therapy and prevention. Curr Sci 80:1387–1396
    • (2001) Curr Sci , vol.80 , pp. 1387-1396
    • Taraphdar, A.K.1    Roy, M.2    Bhattacharya, R.K.3
  • 194
    • 0030665927 scopus 로고    scopus 로고
    • Apoptosis: clinical relevance and pharmacological manipulation
    • COI: 1:CAS:528:DyaK2sXmvFyqs78%3D
    • Thatte U, Dahanukar S (1997) Apoptosis: clinical relevance and pharmacological manipulation. Drugs 54:511–532
    • (1997) Drugs , vol.54 , pp. 511-532
    • Thatte, U.1    Dahanukar, S.2
  • 195
    • 54349099181 scopus 로고    scopus 로고
    • Rapid reactive oxygen species (ROS) generation induced by curcumin leads to caspase-dependent and -independent apoptosis in L929 cells
    • COI: 1:CAS:528:DC%2BD1cXhtlaqtLbF
    • Thayyullathil F, Chathoth S, Hago A, Patel M, Galadari S (2008) Rapid reactive oxygen species (ROS) generation induced by curcumin leads to caspase-dependent and -independent apoptosis in L929 cells. Free Radic Biol Med 45:1403–1412
    • (2008) Free Radic Biol Med , vol.45 , pp. 1403-1412
    • Thayyullathil, F.1    Chathoth, S.2    Hago, A.3    Patel, M.4    Galadari, S.5
  • 196
    • 33845987035 scopus 로고    scopus 로고
    • Induction of caspase-3 activated DNase mediated apoptosis by hexane fraction of Tinospora cordifolia in EAT cells
    • COI: 1:CAS:528:DC%2BD2sXltFSisw%3D%3D
    • Thippeswamy G, Salimath BP (2007) Induction of caspase-3 activated DNase mediated apoptosis by hexane fraction of Tinospora cordifolia in EAT cells. Environ Toxicol Pharmacol 23:212–220
    • (2007) Environ Toxicol Pharmacol , vol.23 , pp. 212-220
    • Thippeswamy, G.1    Salimath, B.P.2
  • 197
    • 0036779576 scopus 로고    scopus 로고
    • Functional significance of the perforin/granzyme cell death pathway
    • COI: 1:CAS:528:DC%2BD38XnsVGqsbk%3D
    • Trapani JA, Smyth MJ (2002) Functional significance of the perforin/granzyme cell death pathway. Nat Rev Immunol 2:735–747
    • (2002) Nat Rev Immunol , vol.2 , pp. 735-747
    • Trapani, J.A.1    Smyth, M.J.2
  • 198
    • 33846935734 scopus 로고    scopus 로고
    • Magnolol suppresses NF-kB activation and NF-kB regulated gene expression through inhibition of IkappaB kinase activation
    • COI: 1:CAS:528:DC%2BD2sXhvVSls7s%3D
    • Tse AKW, Wan CK, Zhua GY, Shen XL, Cheunga HY, Yang M, Fong WF (2007) Magnolol suppresses NF-kB activation and NF-kB regulated gene expression through inhibition of IkappaB kinase activation. Mol Immunol 44:2647–2658
    • (2007) Mol Immunol , vol.44 , pp. 2647-2658
    • Tse, A.K.W.1    Wan, C.K.2    Zhua, G.Y.3    Shen, X.L.4    Cheunga, H.Y.5    Yang, M.6    Fong, W.F.7
  • 199
    • 0142150051 scopus 로고    scopus 로고
    • Mitochondrial formation of reactive oxygen species
    • COI: 1:CAS:528:DC%2BD3sXps1ehtLc%3D
    • Turrens JF (2003) Mitochondrial formation of reactive oxygen species. J Physiol 552:335–344
    • (2003) J Physiol , vol.552 , pp. 335-344
    • Turrens, J.F.1
  • 202
    • 0038052805 scopus 로고    scopus 로고
    • The cell cycle: a review of regulation, deregulation and therapeutic targets in cancer
    • COI: 1:CAS:528:DC%2BD3sXmtVOitr4%3D
    • Vermeulen K, Bockstaele DRV, Berneman ZN (2003) The cell cycle: a review of regulation, deregulation and therapeutic targets in cancer. Cell Prolif 36:131–149
    • (2003) Cell Prolif , vol.36 , pp. 131-149
    • Vermeulen, K.1    Bockstaele, D.R.V.2    Berneman, Z.N.3
  • 203
    • 0025126386 scopus 로고
    • JUN: oncogene and transcription factor
    • COI: 1:CAS:528:DyaK3cXmtVGmtLc%3D
    • Vogt PK, Bos TJ (1990) JUN: oncogene and transcription factor. Adv Cancer Res 55:1–35
    • (1990) Adv Cancer Res , vol.55 , pp. 1-35
    • Vogt, P.K.1    Bos, T.J.2
  • 204
    • 0037204952 scopus 로고    scopus 로고
    • The FAS signaling pathway: more than a paradigm
    • COI: 1:CAS:528:DC%2BD38XktlChtrk%3D
    • Wajant H (2002) The FAS signaling pathway: more than a paradigm. Science 296:1635–1636
    • (2002) Science , vol.296 , pp. 1635-1636
    • Wajant, H.1
  • 205
    • 0032508414 scopus 로고    scopus 로고
    • NF-kappaB antiapoptosis: induction of TRAF1 and TRAF2 and c-IAP1 and c-IAP2 to suppress caspase-8 activation
    • COI: 1:CAS:528:DyaK1cXmtVWhurk%3D
    • Wang CY, Mayo MW, Korneluk RG, Goeddel DV, Baldwin AS Jr (1998) NF-kappaB antiapoptosis: induction of TRAF1 and TRAF2 and c-IAP1 and c-IAP2 to suppress caspase-8 activation. Science 281:1680–1683
    • (1998) Science , vol.281 , pp. 1680-1683
    • Wang, C.Y.1    Mayo, M.W.2    Korneluk, R.G.3    Goeddel, D.V.4    Baldwin, A.S.5
  • 206
    • 78649784579 scopus 로고    scopus 로고
    • Reactive oxygen species-mediated apoptosis contributes to chemosensitization effect of saikosaponins on cisplatin-induced cytotoxicity in cancer cells
    • COI: 1:CAS:528:DC%2BC3cXhs1amsb7E
    • Wang Q, Zheng X-L, Yang L, Shi F, Gao Lin-bo, Zhong Ying-jia, Sun H, He F, Lin Y, Wang X (2010) Reactive oxygen species-mediated apoptosis contributes to chemosensitization effect of saikosaponins on cisplatin-induced cytotoxicity in cancer cells. J Exp Clin Cancer Res 29:159
    • (2010) J Exp Clin Cancer Res , vol.29 , pp. 159
    • Wang, Q.1    Zheng, X.-L.2    Yang, L.3    Shi, F.4    Gao, L.-B.5    Zhong, Y.-J.6    Sun, H.7    He, F.8    Lin, Y.9    Wang, X.10
  • 207
    • 78650302190 scopus 로고    scopus 로고
    • Codonopsis lanceolata extract induces G0/G1 arrest and apoptosis in human colon tumor HT-29 cells-involvement of ROS generation and polyamine depletion
    • COI: 1:CAS:528:DC%2BC3cXhs1agsbnJ
    • Wang L, Xu ML, Hu JH, Rasmussen SK, Wang MH (2011) Codonopsis lanceolata extract induces G0/G1 arrest and apoptosis in human colon tumor HT-29 cells-involvement of ROS generation and polyamine depletion. Food Chem Toxicol 49:149–154
    • (2011) Food Chem Toxicol , vol.49 , pp. 149-154
    • Wang, L.1    Xu, M.L.2    Hu, J.H.3    Rasmussen, S.K.4    Wang, M.H.5
  • 208
    • 0029808748 scopus 로고    scopus 로고
    • Transcription factor AP-1 regulation by mitogen-activated protein kinase signal transduction pathways
    • COI: 1:CAS:528:DyaK28XmsFaksrg%3D
    • Whitmarsh AJ, Davis RJ (1996) Transcription factor AP-1 regulation by mitogen-activated protein kinase signal transduction pathways. J Mol Med 74:589–607
    • (1996) J Mol Med , vol.74 , pp. 589-607
    • Whitmarsh, A.J.1    Davis, R.J.2
  • 209
    • 4344588130 scopus 로고    scopus 로고
    • Chemopreventive activity of parthenolide against UVB-induced skin cancer and its mechanisms
    • COI: 1:CAS:528:DC%2BD2cXmtF2nt78%3D
    • Won YK, Ong CN, Shi X, Shen HM (2004) Chemopreventive activity of parthenolide against UVB-induced skin cancer and its mechanisms. Carcinogenesis 25:1449–1458
    • (2004) Carcinogenesis , vol.25 , pp. 1449-1458
    • Won, Y.K.1    Ong, C.N.2    Shi, X.3    Shen, H.M.4
  • 210
    • 67349115692 scopus 로고    scopus 로고
    • Supercritical carbon dioxide extract of Physalis peruviana induced cell cycle arrest and apoptosis in human lung cancer H661 cells
    • COI: 1:CAS:528:DC%2BD1MXlsVartLg%3D
    • Wu SJ, Chang SP, Lin DL, Wang SS, Hou FF, Ng LT (2009) Supercritical carbon dioxide extract of Physalis peruviana induced cell cycle arrest and apoptosis in human lung cancer H661 cells. Food Chem Toxicol 47:1132–1138
    • (2009) Food Chem Toxicol , vol.47 , pp. 1132-1138
    • Wu, S.J.1    Chang, S.P.2    Lin, D.L.3    Wang, S.S.4    Hou, F.F.5    Ng, L.T.6
  • 211
    • 0030829777 scopus 로고    scopus 로고
    • Apoptosis: an overview
    • COI: 1:STN:280:DyaK1c%2FktFCjug%3D%3D
    • Wyllie AH (1997) Apoptosis: an overview. Br Med Bull 53:451–465
    • (1997) Br Med Bull , vol.53 , pp. 451-465
    • Wyllie, A.H.1
  • 212
    • 79951983968 scopus 로고    scopus 로고
    • Reactive oxygen species-dependent apoptosis by gugulipid extract of ayurvedic medicine plant Commiphora mukul in human prostate cancer cells is regulated by c-Jun N-terminal kinase
    • COI: 1:CAS:528:DC%2BC3MXivVWisro%3D
    • Xiao D, Zeng Y, Prakash L, Badmaev V, Majeed M, Singh SV (2011) Reactive oxygen species-dependent apoptosis by gugulipid extract of ayurvedic medicine plant Commiphora mukul in human prostate cancer cells is regulated by c-Jun N-terminal kinase. Mol Pharmacol 79:499–507
    • (2011) Mol Pharmacol , vol.79 , pp. 499-507
    • Xiao, D.1    Zeng, Y.2    Prakash, L.3    Badmaev, V.4    Majeed, M.5    Singh, S.V.6
  • 213
    • 77950085770 scopus 로고    scopus 로고
    • Plumbagin induces ROS-mediated apoptosis in human promyelocytic leukemia cells in vivo
    • COI: 1:CAS:528:DC%2BC3cXjvFylur4%3D
    • Xu KH, Lu DP (2010) Plumbagin induces ROS-mediated apoptosis in human promyelocytic leukemia cells in vivo. Leuk Res 34:658–665
    • (2010) Leuk Res , vol.34 , pp. 658-665
    • Xu, K.H.1    Lu, D.P.2
  • 214
    • 69549114443 scopus 로고    scopus 로고
    • Corosolic acid induces apoptosis through mitochondrial pathway and caspases activation in human cervix adenocarcinoma HeLa cells
    • COI: 1:CAS:528:DC%2BD1MXhtV2lt7rE
    • Xu Y, Ge R, Du J, Xin H, Yi T, Sheng J, Wang Y, Ling C (2009) Corosolic acid induces apoptosis through mitochondrial pathway and caspases activation in human cervix adenocarcinoma HeLa cells. Cancer Lett 284:229–237
    • (2009) Cancer Lett , vol.284 , pp. 229-237
    • Xu, Y.1    Ge, R.2    Du, J.3    Xin, H.4    Yi, T.5    Sheng, J.6    Wang, Y.7    Ling, C.8
  • 215
    • 67349227379 scopus 로고    scopus 로고
    • Antiproliferation and apoptosis of human tumor cell lines by a lectin (AMML) of Astragalus mongholicus
    • COI: 1:CAS:528:DC%2BD1MXotVCgt70%3D
    • Yan Q, Li Y, Jiang Z, Sun Y, Zhu L, Ding Z (2009) Antiproliferation and apoptosis of human tumor cell lines by a lectin (AMML) of Astragalus mongholicus. Phytomedicine 16:586–593
    • (2009) Phytomedicine , vol.16 , pp. 586-593
    • Yan, Q.1    Li, Y.2    Jiang, Z.3    Sun, Y.4    Zhu, L.5    Ding, Z.6
  • 216
    • 84863784690 scopus 로고    scopus 로고
    • Antiproliferative effects of goniothalamin on Ca9-22 oral cancer cells through apoptosis, DNA damage and ROS induction
    • COI: 1:CAS:528:DC%2BC38XpsVOmu7o%3D
    • Yen CY, Chiu CC, Haung RW, Yeh CC, Huang KJ, Chang KF, Hseu YC, Chang FR, Chang HW, Wu YC (2012) Antiproliferative effects of goniothalamin on Ca9-22 oral cancer cells through apoptosis, DNA damage and ROS induction. Mutat Res 747:253–258
    • (2012) Mutat Res , vol.747 , pp. 253-258
    • Yen, C.Y.1    Chiu, C.C.2    Haung, R.W.3    Yeh, C.C.4    Huang, K.J.5    Chang, K.F.6    Hseu, Y.C.7    Chang, F.R.8    Chang, H.W.9    Wu, Y.C.10
  • 217
    • 20444502200 scopus 로고    scopus 로고
    • Reactive oxygen species-mediated induction of apoptosis by a plant alkaloid 6-methoxydihydrosanguinarine in HepG2 cells
    • COI: 1:CAS:528:DC%2BD2MXlt1Skt7g%3D
    • Yin HQ, Kim YH, Moon CK, Lee BH (2005) Reactive oxygen species-mediated induction of apoptosis by a plant alkaloid 6-methoxydihydrosanguinarine in HepG2 cells. Biochem Pharmacol 70:242–248
    • (2005) Biochem Pharmacol , vol.70 , pp. 242-248
    • Yin, H.Q.1    Kim, Y.H.2    Moon, C.K.3    Lee, B.H.4
  • 218
    • 19544362882 scopus 로고    scopus 로고
    • Eugenol isolated from the essential oil of Eugenia caryophyllata induces a reactive oxygen species-mediated apoptosis in HL-60 human promyelocytic leukemia cells
    • COI: 1:CAS:528:DC%2BD2MXks1Ggsb8%3D
    • Yoo CB, Han KT, Cho KS, Ha J, Park HJ, Nam JH, Kil UH, Lee KT (2005) Eugenol isolated from the essential oil of Eugenia caryophyllata induces a reactive oxygen species-mediated apoptosis in HL-60 human promyelocytic leukemia cells. Cancer Lett 225:41–52
    • (2005) Cancer Lett , vol.225 , pp. 41-52
    • Yoo, C.B.1    Han, K.T.2    Cho, K.S.3    Ha, J.4    Park, H.J.5    Nam, J.H.6    Kil, U.H.7    Lee, K.T.8
  • 220
    • 0027525104 scopus 로고
    • The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-b-converting enzyme
    • COI: 1:CAS:528:DyaK2cXhsFGhsL0%3D
    • Yuan J, Shaham S, Ledoux HM, Horvitz HR (1993) The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-b-converting enzyme. Cell 75:641–652
    • (1993) Cell , vol.75 , pp. 641-652
    • Yuan, J.1    Shaham, S.2    Ledoux, H.M.3    Horvitz, H.R.4
  • 221
    • 4444268690 scopus 로고    scopus 로고
    • Mechanisms that regulate production of reactive oxygen species by cytochrome P450
    • COI: 1:CAS:528:DC%2BD2cXnsFGgurY%3D
    • Zangar RC, Davydov DR, Verma S (2004) Mechanisms that regulate production of reactive oxygen species by cytochrome P450. Toxicol Appl Pharmacol 199:316–331
    • (2004) Toxicol Appl Pharmacol , vol.199 , pp. 316-331
    • Zangar, R.C.1    Davydov, D.R.2    Verma, S.3
  • 222
    • 2542527768 scopus 로고    scopus 로고
    • Unique CD40-mediated biological program in B cell activation requires both type 1 and type 2 NF-kappaB activation pathways
    • COI: 1:CAS:528:DC%2BD2cXkslCitrY%3D
    • Zarnegar B, He JQ, Oganesyan G, Hoffmann A, Baltimore D, Cheng G (2004) Unique CD40-mediated biological program in B cell activation requires both type 1 and type 2 NF-kappaB activation pathways. Proceedings of the National Academy of Sciences USA 101:8108–8113
    • (2004) Proceedings of the National Academy of Sciences USA , vol.101 , pp. 8108-8113
    • Zarnegar, B.1    He, J.Q.2    Oganesyan, G.3    Hoffmann, A.4    Baltimore, D.5    Cheng, G.6
  • 223
    • 56349164239 scopus 로고    scopus 로고
    • Noncanonical NF-kappaB activation requires coordinated assembly of a regulatory complex of the adaptors cIAP1, cIAP2, TRAF2 and TRAF3 and the kinase NIK
    • COI: 1:CAS:528:DC%2BD1cXhtlOjsbrM
    • Zarnegar BJ, Wang Y, Mahoney DJ, Dempsey PW, Cheung HH, He J, Shiba T, Yang X, Yeh WC, Mak TW (2008) Noncanonical NF-kappaB activation requires coordinated assembly of a regulatory complex of the adaptors cIAP1, cIAP2, TRAF2 and TRAF3 and the kinase NIK. Nat Immunol 9:1371–1378
    • (2008) Nat Immunol , vol.9 , pp. 1371-1378
    • Zarnegar, B.J.1    Wang, Y.2    Mahoney, D.J.3    Dempsey, P.W.4    Cheung, H.H.5    He, J.6    Shiba, T.7    Yang, X.8    Yeh, W.C.9    Mak, T.W.10
  • 224
    • 84867735817 scopus 로고    scopus 로고
    • Effects of Ficus hirta Vahl. (Wuzhimaotao) extracts on growth inhibition of HeLa cells
    • Zeng YW, Liu XZ, Lv ZC, Peng YH (2012) Effects of Ficus hirta Vahl. (Wuzhimaotao) extracts on growth inhibition of HeLa cells. Exp Toxicol Pathol 64:743–749
    • (2012) Exp Toxicol Pathol , vol.64 , pp. 743-749
    • Zeng, Y.W.1    Liu, X.Z.2    Lv, Z.C.3    Peng, Y.H.4
  • 225
    • 34548445866 scopus 로고    scopus 로고
    • Discovery and development of sulforaphane as a cancer chemopreventive phytochemical
    • COI: 1:CAS:528:DC%2BD2sXhtVKmtL7K
    • Zhang Y, Tang LI (2007) Discovery and development of sulforaphane as a cancer chemopreventive phytochemical. Acta Pharmacol Sin 28:1343–1354
    • (2007) Acta Pharmacol Sin , vol.28 , pp. 1343-1354
    • Zhang, Y.1    Tang, L.I.2
  • 226
    • 2442637447 scopus 로고    scopus 로고
    • Involvement of NF-[kappa]B and c-myc signaling pathways in the apoptosis of HL-60 cells induced by alkaloids of Tripterygium hypoglaucum (levl.) Hutch
    • COI: 1:CAS:528:DC%2BD2cXls1Smsr0%3D
    • Zhuang WJ, Fong CC, Cao J, Ao L, Leung CH, Cheung HY, Xiao PG, Fong WF, Yang MS (2004) Involvement of NF-[kappa]B and c-myc signaling pathways in the apoptosis of HL-60 cells induced by alkaloids of Tripterygium hypoglaucum (levl.) Hutch. Phytomedicine 11:295–302
    • (2004) Phytomedicine , vol.11 , pp. 295-302
    • Zhuang, W.J.1    Fong, C.C.2    Cao, J.3    Ao, L.4    Leung, C.H.5    Cheung, H.Y.6    Xiao, P.G.7    Fong, W.F.8    Yang, M.S.9


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.