Herbacetin induces apoptosis in HepG2 cells: Involvements of ROS and PI3K/Akt pathway

Food and Chemical Toxicology

Volumn 51, Issue 1, 2013, Pages 426-433

  Qiao, Yan ^a   Xiang, Qisen ^a   Yuan, Li ^a   Xu, Li ^a   Liu, Zhigang ^a   Liu, Xuebo ^a  

^a NORTHWEST A F UNIVERSITY   (China)

Author keywords

Apoptosis; HepG2; Herbacetin; Mitochondria; PI3K Akt; ROS

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; ACETYLCYSTEINE; CASPASE 3; CYTOCHROME C; FLAVONOID; HERBACETIN; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN BAX; PROTEIN BCL 2; PROTEIN KINASE B; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CELL STRAIN HEPG2; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DNA FRAGMENTATION; DRUG EFFECT; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; INHIBITION KINETICS; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRION; OXIDATIVE STRESS; PHARMACOLOGICAL BLOCKING; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; PROTEIN SECRETION; WESTERN BLOTTING;

ACETYLCYSTEINE; ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; CASPASE 3; CYTOCHROMES C; DOSE-RESPONSE RELATIONSHIP, DRUG; FLAVONOIDS; HEAT-SHOCK PROTEINS; HEP G2 CELLS; HUMANS; MEMBRANE POTENTIAL, MITOCHONDRIAL; PHOSPHATIDYLINOSITOL 3-KINASES; PHOSPHORYLATION; POLY(ADP-RIBOSE) POLYMERASES; PROTO-ONCOGENE PROTEINS C-AKT; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTORS;

EQUISETUM;

EID: 84869114692     PISSN: 02786915     EISSN: 18736351     Source Type: Journal    
DOI: 10.1016/j.fct.2012.09.036     Document Type: Article

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