Casearin X exhibits cytotoxic effects in leukemia cells triggered by apoptosis

Chemico-Biological Interactions

Volumn 188, Issue 3, 2010, Pages 497-504

  Ferreira, Paulo M Pinheiro ^a   Santos, André G ^b   Tininis, Aristeu G ^c   Costa, Patricia M ^d   Cavalheiro, Alberto J ^b   Bolzani, Vanderlan S ^b   Moraes, Manoel O ^b   Costa Lotufo, Letícia V ^d   Montenegro, Raquel C ^d   Pessoa, Cláudia ^d  

^a FEDERAL UNIVERSITY OF PIAUÍ   (Brazil)

^b SÃO PAULO STATE UNIVERSITY UNESP   (Brazil)

^c INSTITUTO FEDERAL DE EDUCAÇÃO   (Brazil)

^d FEDERAL UNIVERSITY OF CEARÁ   (Brazil)

Author keywords

Apoptosis activation; Casearia sylvestris; Casearin X; Clerodane Diterpenes; Cytotoxicity

Indexed keywords

ANTINEOPLASTIC AGENT; BROXURIDINE; CASEARIN L; CASEARIN O; CASEARIN X; CASPASE 3; CASPASE 7; CLERODANE DERIVATIVE; HARDWICKIIC ACID; PHOSPHATIDYLSERINE; UNCLASSIFIED DRUG;

ADULT; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CASEARIN SYLVESTRIS; CELL MEMBRANE DEPOLARIZATION; CELL STRUCTURE; CELL VACUOLE; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; DNA FRAGMENTATION; DNA SYNTHESIS; DRUG MECHANISM; DRUG SCREENING; DRUG STRUCTURE; ENZYME ACTIVATION; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IN VITRO STUDY; LEUKEMIA CELL; MEDICINAL PLANT; NORMAL HUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL;

APOPTOSIS; CASPASE 3; CASPASE 7; CELL MEMBRANE; CELL SURVIVAL; DITERPENES; DITERPENES, CLERODANE; DNA; DNA FRAGMENTATION; ENZYME ACTIVATION; FLOW CYTOMETRY; HL-60 CELLS; HUMANS; LEUKEMIA; MITOCHONDRIA; PHOSPHATIDYLSERINES;

CASEARIA SYLVESTRIS;

EID: 78149465403     PISSN: 00092797     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cbi.2010.08.008     Document Type: Article

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