-
1
-
-
0019829568
-
The causes of cancer: Quantitative estimates of avoidable risks of cancer in the United States today
-
Doll, R. & Peto, R. The causes of cancer: quantitative estimates of avoidable risks of cancer in the United States today. J. Natl Cancer Inst. 66, 1191-1308 (1981).
-
(1981)
J. Natl. Cancer Inst.
, vol.66
, pp. 1191-1308
-
-
Doll, R.1
Peto, R.2
-
2
-
-
0030242168
-
Chemoprevention of cancer
-
Greenwald, P. Chemoprevention of cancer. Sci. Am. 275, 96-99 (1996).
-
(1996)
Sci. Am.
, vol.275
, pp. 96-99
-
-
Greenwald, P.1
-
3
-
-
0021934758
-
Chemoprevention of cancer
-
Wattenberg, L. W. Chemoprevention of cancer. Cancer Res. 45, 1-8 (1985).
-
(1985)
Cancer Res.
, vol.45
, pp. 1-8
-
-
Wattenberg, L.W.1
-
4
-
-
0037248328
-
Cancer prevention: The potential for diet to modulate molecular signalling
-
Manson, M. M. Cancer prevention: the potential for diet to modulate molecular signalling. Trends Mol. Med. 9, 11-18 (2003). This seminal review (together with reference 11) discusses the dietary modulation of several key signalling cascades from mechanistic viewpoints.
-
(2003)
Trends Mol. Med.
, vol.9
, pp. 11-18
-
-
Manson, M.M.1
-
5
-
-
0035527471
-
Molecular targets for nutrients involved with cancer prevention
-
Milner, J. A., McDonald, S. S., Anderson, D. E. & Greenwald, P. Molecular targets for nutrients involved with cancer prevention. Nutr. Cancer 41, 1-16 (2001).
-
(2001)
Nutr. Cancer
, vol.41
, pp. 1-16
-
-
Milner, J.A.1
McDonald, S.S.2
Anderson, D.E.3
Greenwald, P.4
-
6
-
-
0031930629
-
Suppression of tumour development by substances derived from the diet: Mechanisms and clinical implications
-
Gescher, A., Pastorino, U., Plummer, S. M. & Manson, M. M. Suppression of tumour development by substances derived from the diet: mechanisms and clinical implications. Br. J. Clin. Pharmacol. 45, 1-12 (1998).
-
(1998)
Br. J. Clin. Pharmacol.
, vol.45
, pp. 1-12
-
-
Gescher, A.1
Pastorino, U.2
Plummer, S.M.3
Manson, M.M.4
-
7
-
-
0028839008
-
Diet, signal transduction and carcinogenesis
-
Ashendel, C. L. Diet, signal transduction and carcinogenesis. J. Nutr. 125, 686S-691S (1995).
-
(1995)
J. Nutr.
, vol.125
-
-
Ashendel, C.L.1
-
8
-
-
0001497590
-
Signal transduction events elicited by cancer prevention compounds
-
Kong, A. N. et al. Signal transduction events elicited by cancer prevention compounds. Mutat. Res. 480-481, 231-241 (2001).
-
(2001)
Mutat. Res.
, vol.480-481
, pp. 231-241
-
-
Kong, A.N.1
-
9
-
-
0034668148
-
Cell signaling and regulators of cell cycle as molecular targets for prostate cancer prevention by dietary agents
-
Agarwal, R. Cell signaling and regulators of cell cycle as molecular targets for prostate cancer prevention by dietary agents. Biochem. Pharmacol. 60, 1051-1059 (2000).
-
(2000)
Biochem. Pharmacol.
, vol.60
, pp. 1051-1059
-
-
Agarwal, R.1
-
10
-
-
0034334115
-
Signal transduction pathways: Targets for chemoprevention of skin cancer
-
Bode, A. M. & Dong, Z. Signal transduction pathways: targets for chemoprevention of skin cancer. Lancet Oncol. 1, 181-188 (2000).
-
(2000)
Lancet Oncol.
, vol.1
, pp. 181-188
-
-
Bode, A.M.1
Dong, Z.2
-
11
-
-
0034653353
-
Blocking and suppressing mechanisms of chemoprevention by dietary constituents
-
Manson, M. M. et al. Blocking and suppressing mechanisms of chemoprevention by dietary constituents. Toxicol. Lett. 112-113, 499-505 (2000).
-
(2000)
Toxicol. Lett.
, vol.112-113
, pp. 499-505
-
-
Manson, M.M.1
-
12
-
-
0036708902
-
Antioxidants and oxidants regulated signal transduction pathways
-
Owuor, E. D. & Kong, A. N. Antioxidants and oxidants regulated signal transduction pathways. Biochem. Pharmacol. 64, 765-770 (2002).
-
(2002)
Biochem. Pharmacol.
, vol.64
, pp. 765-770
-
-
Owuor, E.D.1
Kong, A.N.2
-
13
-
-
0029976817
-
An essential role for NF-κB in preventing TNF-α-induced cell death
-
Beg, A. A. & Baltimore, D. An essential role for NF-κB in preventing TNF-α-induced cell death. Science 274, 782-784 (1996).
-
(1996)
Science
, vol.274
, pp. 782-784
-
-
Beg, A.A.1
Baltimore, D.2
-
14
-
-
0032508414
-
NF-kB antiapoptosis: Induction of TRAF1 and TRAF2 and c-IAP1 and c-IAP2 to suppress caspase-8 activation
-
Wang, C. Y., Mayo, M. W., Korneluk, R. G., Goeddel, D. V. & Baldwin, A. S. Jr. NF-kB antiapoptosis: induction of TRAF1 and TRAF2 and c-IAP1 and c-IAP2 to suppress caspase-8 activation. Science 281, 1680-1683 (1998).
-
(1998)
Science
, vol.281
, pp. 1680-1683
-
-
Wang, C.Y.1
Mayo, M.W.2
Korneluk, R.G.3
Goeddel, D.V.4
Baldwin A.S., Jr.5
-
15
-
-
0030666532
-
Expression of the neoplastic phenotype by human thyroid carcinoma cell lines requires NFκB p65 protein expression
-
Visconti, R. et al. Expression of the neoplastic phenotype by human thyroid carcinoma cell lines requires NFκB p65 protein expression. Oncogene 15, 1987-1994 (1997).
-
(1997)
Oncogene
, vol.15
, pp. 1987-1994
-
-
Visconti, R.1
-
16
-
-
0036709174
-
Nuclear factor-κB and cancer: Its role in prevention and therapy
-
Bharti, A. C. & Aggarwal, B. B. Nuclear factor-κB and cancer: its role in prevention and therapy. Biochem. Pharmacol. 64, 883-888 (2002).
-
(2002)
Biochem. Pharmacol.
, vol.64
, pp. 883-888
-
-
Bharti, A.C.1
Aggarwal, B.B.2
-
17
-
-
0036217821
-
Natural products as targeted modulators of the nuclear factor-κB pathway
-
Bremner, P. & Heinrich, M. Natural products as targeted modulators of the nuclear factor-κB pathway. J. Pharm. Pharmacol. 54, 453-472 (2002).
-
(2002)
J. Pharm. Pharmacol.
, vol.54
, pp. 453-472
-
-
Bremner, P.1
Heinrich, M.2
-
18
-
-
0028079661
-
Blocking of tumor promoter-induced AP-1 activity inhibits induced transformation in JB6 mouse epidermal cells
-
Dong, Z., Birrer, M. J., Watts, R. G., Matrisian, L. M. & Colburn, N. H. Blocking of tumor promoter-induced AP-1 activity inhibits induced transformation in JB6 mouse epidermal cells. Proc. Natl Acad. Sci. USA 91, 609-613 (1994).
-
(1994)
Proc. Natl. Acad. Sci. USA
, vol.91
, pp. 609-613
-
-
Dong, Z.1
Birrer, M.J.2
Watts, R.G.3
Matrisian, L.M.4
Colburn, N.H.5
-
19
-
-
0028905444
-
Transformation reversion induced in JB6 RT101 cells by AP-1 inhibitors
-
Dong, Z., Lavrovsky, V. & Colburn, N. H. Transformation reversion induced in JB6 RT101 cells by AP-1 inhibitors. Carcinogenesis 16, 749-756 (1995).
-
(1995)
Carcinogenesis
, vol.16
, pp. 749-756
-
-
Dong, Z.1
Lavrovsky, V.2
Colburn, N.H.3
-
20
-
-
0030980026
-
Inhibition of activator protein 1 activity and neoplastic transformation by aspirin
-
Dong, Z., Huang, C., Brown, R. E. & Ma, W. Y. Inhibition of activator protein 1 activity and neoplastic transformation by aspirin. J. Biol. Chem. 272, 9962-9970 (1997).
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 9962-9970
-
-
Dong, Z.1
Huang, C.2
Brown, R.E.3
Ma, W.Y.4
-
21
-
-
0031913814
-
Shortage of mitogen-activated protein kinase is responsible for resistance to AP-1 transactivation and transformation in mouse JB6 cells
-
Huang, C., Ma, W. Y., Young, M. R., Colburn, N. & Dong, Z. Shortage of mitogen-activated protein kinase is responsible for resistance to AP-1 transactivation and transformation in mouse JB6 cells. Proc. Natl Acad. Sci. USA 95, 156-161 (1998).
-
(1998)
Proc. Natl. Acad. Sci. USA
, vol.95
, pp. 156-161
-
-
Huang, C.1
Ma, W.Y.2
Young, M.R.3
Colburn, N.4
Dong, Z.5
-
22
-
-
0029843344
-
Requirement for phosphatidylinositol 3-kinase in epidermal growth factor-induced AP-1 transactivation and transformation in JB6 P+ cells
-
Huang, C., Ma, W. Y. & Dong, Z. Requirement for phosphatidylinositol 3-kinase in epidermal growth factor-induced AP-1 transactivation and transformation in JB6 P+ cells. Mol. Cell. Biol. 16, 6427-6435 (1996).
-
(1996)
Mol. Cell. Biol.
, vol.16
, pp. 6427-6435
-
-
Huang, C.1
Ma, W.Y.2
Dong, Z.3
-
23
-
-
0032585649
-
Expression of dominant negative Erk2 inhibits AP-1 transactivation and neoplastic transformation
-
Watts, R. G. et al. Expression of dominant negative Erk2 inhibits AP-1 transactivation and neoplastic transformation. Oncogene 17, 3493-3498 (1998). A crucial role of AP1 in malignant transformation, especially in the stage of tumour promotion, has been demonstrated in references 18-23. The signalling pathways that mediate AP1 activation have also been proposed in references 21-23.
-
(1998)
Oncogene
, vol.17
, pp. 3493-3498
-
-
Watts, R.G.1
-
24
-
-
0033613436
-
Inhibition of cyclo-oxygenase 2 expression in colon cells by the chemopreventive agent curcumin involves inhibition of NF-κB activation via the NIK/IKK signalling complex
-
Plummer, S. M. et al. Inhibition of cyclo-oxygenase 2 expression in colon cells by the chemopreventive agent curcumin involves inhibition of NF-κB activation via the NIK/IKK signalling complex. Oncogene 18, 6013-6020 (1999).
-
(1999)
Oncogene
, vol.18
, pp. 6013-6020
-
-
Plummer, S.M.1
-
25
-
-
0034490854
-
Inhibitory effects of curcumin and capsaicin on phorbol ester-induced activation of eukaryotic transcription factors, NF-κB and AP-1
-
Surh, Y. J., Han, S. S., Keum, Y. S., Seo, H. J. & Lee, S. S. Inhibitory effects of curcumin and capsaicin on phorbol ester-induced activation of eukaryotic transcription factors, NF-κB and AP-1. Biofactors 12, 107-112 (2000).
-
(2000)
Biofactors
, vol.12
, pp. 107-112
-
-
Surh, Y.J.1
Han, S.S.2
Keum, Y.S.3
Seo, H.J.4
Lee, S.S.5
-
26
-
-
0141814600
-
Curcumin inhibits phorbol ester-induced expression of cyclooxygenase-2 in mouse skin through suppression of extracellular signal-regulated kinase activity and NF-κB activation
-
Chun, K. S. et al. Curcumin inhibits phorbol ester-induced expression of cyclooxygenase-2 in mouse skin through suppression of extracellular signal-regulated kinase activity and NF-κB activation. Carcinogenesis 24, 1515-1524 (2003).
-
(2003)
Carcinogenesis
, vol.24
, pp. 1515-1524
-
-
Chun, K.S.1
-
27
-
-
0028867742
-
Activation of transcription factor NF-κB is suppressed by curcumin (diferuloylmethane)
-
Singh, S. & Aggarwal, B. B. Activation of transcription factor NF-κB is suppressed by curcumin (diferuloylmethane). J. Biol. Chem. 270, 24995-25000 (1995).
-
(1995)
J. Biol. Chem.
, vol.270
, pp. 24995-25000
-
-
Singh, S.1
Aggarwal, B.B.2
-
28
-
-
0037305821
-
Curcumin (diferuloylmethane) down-regulates the constitutive activation of nuclear factor-κB and IκBα kinase in human multiple myeloma cells, leading to suppression of proliferation and induction of apoptosis
-
Bharti, A. C., Donato, N., Singh, S. & Aggarwal, B. B. Curcumin (diferuloylmethane) down-regulates the constitutive activation of nuclear factor-κB and IκBα kinase in human multiple myeloma cells, leading to suppression of proliferation and induction of apoptosis. Blood 101, 1053-1062 (2003).
-
(2003)
Blood
, vol.101
, pp. 1053-1062
-
-
Bharti, A.C.1
Donato, N.2
Singh, S.3
Aggarwal, B.B.4
-
29
-
-
0038191064
-
Osteopontin induces nuclear factor κB-mediated promatrix metalloproteinase-2 activation through IλBα/IKK signaling pathways, and curcumin (diferulolylmethane) down-regulates these pathways
-
Philip, S. & Kundu, G. C. Osteopontin induces nuclear factor κB-mediated promatrix metalloproteinase-2 activation through IλBα/IKK signaling pathways, and curcumin (diferulolylmethane) down-regulates these pathways. J. Biol. Chem. 278, 14487-14497 (2003).
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 14487-14497
-
-
Philip, S.1
Kundu, G.C.2
-
30
-
-
0032547010
-
Inhibitory effects of [6]-gingerol, a major pungent principle of ginger, on phorbol ester-induced inflammation, epidermal ornithine decarboxylase activity and skin tumor promotion in ICR mice
-
Park, K. K., Chun, K. S., Lee, J. M., Lee, S. S. & Surh, Y. J. Inhibitory effects of [6]-gingerol, a major pungent principle of ginger, on phorbol ester-induced inflammation, epidermal ornithine decarboxylase activity and skin tumor promotion in ICR mice. Cancer Lett. 129, 139-144 (1998).
-
(1998)
Cancer Lett.
, vol.129
, pp. 139-144
-
-
Park, K.K.1
Chun, K.S.2
Lee, J.M.3
Lee, S.S.4
Surh, Y.J.5
-
31
-
-
0035110888
-
Inhibition of epidermal growth factor-induced cell transformation and activator protein 1 activation by [6]-gingerol
-
Bode, A. M., Ma, W. Y., Surh, Y. J. & Dong, Z. Inhibition of epidermal growth factor-induced cell transformation and activator protein 1 activation by [6]-gingerol. Cancer Res. 61, 850-853 (2001).
-
(2001)
Cancer Res.
, vol.61
, pp. 850-853
-
-
Bode, A.M.1
Ma, W.Y.2
Surh, Y.J.3
Dong, Z.4
-
32
-
-
0028913539
-
Capsaicin, a double-edged sword: Toxicity, metabolism, and chemopreventive potential
-
Surh, Y. J. & Lee, S. S. Capsaicin, a double-edged sword: toxicity, metabolism, and chemopreventive potential. Life Sci. 56, 1845-1855 (1995).
-
(1995)
Life Sci.
, vol.56
, pp. 1845-1855
-
-
Surh, Y.J.1
Lee, S.S.2
-
33
-
-
0029928940
-
Capsaicin in hot chili pepper: Carcinogen, co-carcinogen or anticarcinogen?
-
Surh, Y. J. & Lee, S. S. Capsaicin in hot chili pepper: carcinogen, co-carcinogen or anticarcinogen? Food Chem. Toxicol. 34, 313-316 (1996).
-
(1996)
Food Chem. Toxicol.
, vol.34
, pp. 313-316
-
-
Surh, Y.J.1
Lee, S.S.2
-
34
-
-
0028862921
-
Chemoprotective effects of capsaicin and diallyl sulfide against mutagenesis or tumorigenesis by vinyl carbamate and N-nitrosodimethylamine
-
Surh, Y. J. et al. Chemoprotective effects of capsaicin and diallyl sulfide against mutagenesis or tumorigenesis by vinyl carbamate and N-nitrosodimethylamine. Carcinogenesis 16, 2467-2471 (1995).
-
(1995)
Carcinogenesis
, vol.16
, pp. 2467-2471
-
-
Surh, Y.J.1
-
35
-
-
0037019748
-
More than spice: Capsaicin in hot chili peppers makes tumor cells commit suicide
-
Surh, Y. J. More than spice: capsaicin in hot chili peppers makes tumor cells commit suicide. J. Natl Cancer Instit. 94, 1263-1265 (2002).
-
(2002)
J. Natl. Cancer Instit.
, vol.94
, pp. 1263-1265
-
-
Surh, Y.J.1
-
36
-
-
0032439878
-
Lack of tumor promoting activity of capsaicin, a principal pungent ingredient of red pepper, in mouse skin carcinogenesis
-
Park, K. K., Chun, K. S., Yook, J. I. & Surh, Y. J. Lack of tumor promoting activity of capsaicin, a principal pungent ingredient of red pepper, in mouse skin carcinogenesis. Anticancer Res. 18, 4201-4205 (1998).
-
(1998)
Anticancer Res.
, vol.18
, pp. 4201-4205
-
-
Park, K.K.1
Chun, K.S.2
Yook, J.I.3
Surh, Y.J.4
-
37
-
-
0035953182
-
Capsaicin suppresses phorbol ester-induced activation of NF-κB/Re1 and AP-1 transcription factors in mouse epidermis
-
Han, S. S. et al. Capsaicin suppresses phorbol ester-induced activation of NF-κB/Re1 and AP-1 transcription factors in mouse epidermis. Cancer Lett. 164, 119-126 (2001).
-
(2001)
Cancer Lett.
, vol.164
, pp. 119-126
-
-
Han, S.S.1
-
38
-
-
0036689903
-
Suppression of phorbol ester-induced NF-κB activation by capsaicin in cultured human promyelocytic leukemia cells
-
Han, S. S., Keum, Y. S., Chun, K. S. & Surh, Y. J. Suppression of phorbol ester-induced NF-κB activation by capsaicin in cultured human promyelocytic leukemia cells. Arch. Pharm. Res. 25, 475-479 (2002).
-
(2002)
Arch. Pharm. Res.
, vol.25
, pp. 475-479
-
-
Han, S.S.1
Keum, Y.S.2
Chun, K.S.3
Surh, Y.J.4
-
39
-
-
0036264366
-
Regulation of constitutive and induced NF-κB activation in malignant melanoma cells by capsaicin modulates interleukin-8 production and cell proliferation
-
Patel, P. S., Varney, M. L., Dave, B. J. & Singh, R. K. Regulation of constitutive and induced NF-κB activation in malignant melanoma cells by capsaicin modulates interleukin-8 production and cell proliferation. J. Interferon Cytokine Res. 22, 427-435 (2002).
-
(2002)
J. Interferon Cytokine Res.
, vol.22
, pp. 427-435
-
-
Patel, P.S.1
Varney, M.L.2
Dave, B.J.3
Singh, R.K.4
-
40
-
-
15144357925
-
Induction of apoptosis by vanilloid compounds does not require de novo gene transcription and activator protein 1 activity
-
Macho, A., Blazquez, M. V., Navas, P. & Munoz, E. Induction of apoptosis by vanilloid compounds does not require de novo gene transcription and activator protein 1 activity. Cell Growth Differ. 9, 277-286 (1998).
-
(1998)
Cell Growth Differ.
, vol.9
, pp. 277-286
-
-
Macho, A.1
Blazquez, M.V.2
Navas, P.3
Munoz, E.4
-
41
-
-
0037428673
-
Roles of JNK-1 and p38 in selective induction of apoptosis by capsaicin in ras-transfcrmed human breast epithelial cells
-
Kang, H. J. et al. Roles of JNK-1 and p38 in selective induction of apoptosis by capsaicin in ras-transfcrmed human breast epithelial cells. Int. J. Cancer 103, 475-482 (2003).
-
(2003)
Int. J. Cancer
, vol.103
, pp. 475-482
-
-
Kang, H.J.1
-
42
-
-
0030799429
-
Inhibition of tumor promoter-induced activator protein 1 activation and cell transformation by tea polyphenols, (-)-epigallocatechin gallate, and theaflavins
-
Dong, Z., Ma, W., Huang, C. & Fang, C. S. Inhibition of tumor promoter-induced activator protein 1 activation and cell transformation by tea polyphenols, (-)-epigallocatechin gallate, and theaflavins. Cancer Res. 57, 4414-4419 (1997).
-
(1997)
Cancer Res.
, vol.57
, pp. 4414-4419
-
-
Dong, Z.1
Ma, W.2
Huang, C.3
Fang, C.S.4
-
43
-
-
0033852003
-
Inhibition of ultraviolet B-induced AP-1 activation by theaflavins from black tea
-
Nomura, M. et al. Inhibition of ultraviolet B-induced AP-1 activation by theaflavins from black tea. Mol. Carcinog. 28, 148-155 (2000).
-
(2000)
Mol. Carcinog.
, vol.28
, pp. 148-155
-
-
Nomura, M.1
-
44
-
-
0033786929
-
Inhibition of 12-O-tetradecanoylphorbol-13-acetate-induced NF-κB activation by tea polyphenols, (-)-epigallocatechin gallate and theaflavins
-
Nomura, M., Ma, W., Chen, N., Bode, A. M. & Dong, Z. Inhibition of 12-O-tetradecanoylphorbol-13-acetate-induced NF-κB activation by tea polyphenols, (-)-epigallocatechin gallate and theaflavins. Carcinogenesis 21, 1885-1890 (2000).
-
(2000)
Carcinogenesis
, vol.21
, pp. 1885-1890
-
-
Nomura, M.1
Ma, W.2
Chen, N.3
Bode, A.M.4
Dong, Z.5
-
45
-
-
0037455718
-
Inhibition of ultraviolet B-mediated activation of nuclear factor κB in normal human epidermal keratinocytes by green tea Constituent (-)-epigallocatechin-3-gallate
-
Afaq, F., Adhami, V. M., Ahmad, N. & Mukhtar, H. Inhibition of ultraviolet B-mediated activation of nuclear factor κB in normal human epidermal keratinocytes by green tea Constituent (-)-epigallocatechin-3-gallate. Oncogene 22, 1035-1044 (2003).
-
(2003)
Oncogene
, vol.22
, pp. 1035-1044
-
-
Afaq, F.1
Adhami, V.M.2
Ahmad, N.3
Mukhtar, H.4
-
46
-
-
0033568515
-
Inhibition of activator protein 1 activity and cell growth by purified green tea and black tea polyphenols in H-ras-transformed cells: Structure-activity relationship and mechanisms involved
-
Chung, J. Y., Huang, C., Meng, X., Dong, Z. & Yang, C. S. Inhibition of activator protein 1 activity and cell growth by purified green tea and black tea polyphenols in H-ras-transformed cells: structure-activity relationship and mechanisms involved. Cancer Res. 59, 4610-4617 (1999). Provides the evidence for specific mechanisms of inhibition of the Mapk signalling pathway by tea polyphenols, including EGCG, as the molecular basis of their antineoplastic effects.
-
(1999)
Cancer Res.
, vol.59
, pp. 4610-4617
-
-
Chung, J.Y.1
Huang, C.2
Meng, X.3
Dong, Z.4
Yang, C.S.5
-
47
-
-
0033732496
-
2 production in transformed and non-transformed human bronchial cell lines: Possible mechanisms of cell growth inhibition and apoptosis induction
-
2 production in transformed and non-transformed human bronchial cell lines: possible mechanisms of cell growth inhibition and apoptosis induction. Carcinogenesis 21, 2035-2039 (2000).
-
(2000)
Carcinogenesis
, vol.21
, pp. 2035-2039
-
-
Yang, G.Y.1
-
48
-
-
0034959477
-
Suppression of cell transformation and induction of apoptosis by caffeic acid phenethyl ester
-
Nomura, M., Kaji, A., Ma, W., Miyamoto, K. & Dong, Z. Suppression of cell transformation and induction of apoptosis by caffeic acid phenethyl ester. Mol. Carcinog. 31, 83-89 (2001).
-
(2001)
Mol. Carcinog.
, vol.31
, pp. 83-89
-
-
Nomura, M.1
Kaji, A.2
Ma, W.3
Miyamoto, K.4
Dong, Z.5
-
49
-
-
0036468923
-
Green tea polyphenol epigallocatechin-3 gallate inhibits Her-2/neu signaling, proliferation, and transformed phenotype of breast cancer cells
-
Pianetti, S., Guo, S., Kavanagh, K. T. & Sonenshein, G. E. Green tea polyphenol epigallocatechin-3 gallate inhibits Her-2/neu signaling, proliferation, and transformed phenotype of breast cancer cells. Cancer Res. 62, 652-655 (2002).
-
(2002)
Cancer Res.
, vol.62
, pp. 652-655
-
-
Pianetti, S.1
Guo, S.2
Kavanagh, K.T.3
Sonenshein, G.E.4
-
50
-
-
0036842094
-
Epigallocatechin-3-gallate decreases VEGF production in head and neck and breast carcinoma cells by inhibiting EGFR-related pathways of signal transduction
-
Masuda, M. et al. Epigallocatechin-3-gallate decreases VEGF production in head and neck and breast carcinoma cells by inhibiting EGFR-related pathways of signal transduction. J. Exp. Ther. Oncol. 2, 350-359 (2002).
-
(2002)
J. Exp. Ther. Oncol.
, vol.2
, pp. 350-359
-
-
Masuda, M.1
-
51
-
-
0034655603
-
Green tea poyphenol epigallocatechin-3-gallate differentially modulates nuclear factor κB in cancer cells versus normal cells
-
Ahmad, N., Gupta, S. & Mukhtar, H. Green tea poyphenol epigallocatechin-3-gallate differentially modulates nuclear factor κB in cancer cells versus normal cells. Arch. Biochem. Biophys. 376, 338-346 (2000).
-
(2000)
Arch. Biochem. Biophys.
, vol.376
, pp. 338-346
-
-
Ahmad, N.1
Gupta, S.2
Mukhtar, H.3
-
52
-
-
0032807021
-
Cancer chemoprevention by tea polyphenols through mitotic signal transduction blockade
-
Lin, J. K., Uang, Y. C. & Lin-Shiau, S. Y. Cancer chemoprevention by tea polyphenols through mitotic signal transduction blockade. Biochem. Pharmacol. 58, 911-915 (1999).
-
(1999)
Biochem. Pharmacol.
, vol.58
, pp. 911-915
-
-
Lin, J.K.1
Uang, Y.C.2
Lin-Shiau, S.Y.3
-
53
-
-
0036780991
-
Cancer chemoprevention by tea polyphenols through modulating signal transduction pathways
-
Lin, J. K. Cancer chemoprevention by tea polyphenols through modulating signal transduction pathways. Arch. Pharm. Res. 25, 561-571 (2002).
-
(2002)
Arch. Pharm. Res.
, vol.25
, pp. 561-571
-
-
Lin, J.K.1
-
54
-
-
0035902801
-
Differences between human breast cell lines in susceptibility towards growth inhibition by genistein
-
Dampier, K. et al. Differences between human breast cell lines in susceptibility towards growth inhibition by genistein. Br. J. Cancer 85, 618-624 (2001).
-
(2001)
Br. J. Cancer
, vol.85
, pp. 618-624
-
-
Dampier, K.1
-
55
-
-
0034630462
-
Hepatocyte growth factor signal coupling to various transcription factors depends on triggering of Met receptor and protein kinase transducers in human hepatoma cells HepG2
-
Tacchini, L., Dansi, P., Matteucci, E. & Desiderio, M. A. Hepatocyte growth factor signal coupling to various transcription factors depends on triggering of Met receptor and protein kinase transducers in human hepatoma cells HepG2. Exp. Cell Res. 256, 272-281 (2000).
-
(2000)
Exp. Cell Res.
, vol.256
, pp. 272-281
-
-
Tacchini, L.1
Dansi, P.2
Matteucci, E.3
Desiderio, M.A.4
-
56
-
-
3542992037
-
Inhibition of ultraviolet B (UVB)-induced c-fos and c-jun expression in vivo by a tyrosine kinase inhibitor genistein
-
Wang, Y., Zhang, X., Lebwohl, M., DeLeo, V. & Wei, H. Inhibition of ultraviolet B (UVB)-induced c-fos and c-jun expression in vivo by a tyrosine kinase inhibitor genistein. Carcinogenesis 19, 649-654 (1998).
-
(1998)
Carcinogenesis
, vol.19
, pp. 649-654
-
-
Wang, Y.1
Zhang, X.2
Lebwohl, M.3
DeLeo, V.4
Wei, H.5
-
57
-
-
0033509354
-
Genistein inhibits NF-κB activation in prostate cancer cells
-
Davis, J. N., Kucuk, O. & Sarkar, F. H. Genistein inhibits NF-κB activation in prostate cancer cells. Nutr. Cancer 35, 167-174 (1999).
-
(1999)
Nutr. Cancer
, vol.35
, pp. 167-174
-
-
Davis, J.N.1
Kucuk, O.2
Sarkar, F.H.3
-
58
-
-
0035992417
-
Inhibition of nuclear factor κB activation in PC3 cells by genistein is mediated via Akt signaling pathway
-
Li, Y. & Sarkar, F. H. Inhibition of nuclear factor κB activation in PC3 cells by genistein is mediated via Akt signaling pathway. Clin. Cancer Res. 8, 2369-2377 (2002).
-
(2002)
Clin. Cancer Res.
, vol.8
, pp. 2369-2377
-
-
Li, Y.1
Sarkar, F.H.2
-
59
-
-
0041589149
-
Inactivation of NF-κB by genistein is mediated via Akt signaling pathway in breast cancer cells
-
Gong, L., Li, Y., Nedeljkovic-Kurepa, A. & Sarkar, F. H. Inactivation of NF-κB by genistein is mediated via Akt signaling pathway in breast cancer cells. Oncogene 22, 4702-4709 (2003). This study addresses a possible crosstalk between NF-κB and AKT signalling pathways, which are targets of antiproliferative activity exerted by genistein in human mammary carcinoma cells.
-
(2003)
Oncogene
, vol.22
, pp. 4702-4709
-
-
Gong, L.1
Li, Y.2
Nedeljkovic-Kurepa, A.3
Sarkar, F.H.4
-
60
-
-
0034283944
-
TNF-α-induced cyclooxygenase-2 expression in human lung epithelial cells: Involvement of the phospholipase C-γ2, protein kinase C-α, tyrosine kinase, NF-κB-inducing kinase, and I-κB kinase 1/2 pathway
-
Chen, C. C., Sun, Y. T., Chen, J. J. & Chiu, K. T. TNF-α-induced cyclooxygenase-2 expression in human lung epithelial cells: involvement of the phospholipase C-γ 2, protein kinase C-α, tyrosine kinase, NF-κB-inducing kinase, and I-κB kinase 1/2 pathway. J. Immunol. 165, 2719-2728 (2000).
-
(2000)
J. Immunol.
, vol.165
, pp. 2719-2728
-
-
Chen, C.C.1
Sun, Y.T.2
Chen, J.J.3
Chiu, K.T.4
-
61
-
-
0033538340
-
Differential IκB kinase activation and IκBα degradation by interleukin-1β and tumor necrosis factor-α in human U937 monocytic cells. Evidence for additional regulatory steps in κB-dependent transcription
-
Nasuhara, Y., Adcock, I. M., Catley, M., Barnes, P. J. & Newton, R. Differential IκB kinase activation and IκBα degradation by interleukin-1β and tumor necrosis factor-α in human U937 monocytic cells. Evidence for additional regulatory steps in κB-dependent transcription. J. Biol. Chem. 274, 19965-19972 (1999).
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 19965-19972
-
-
Nasuhara, Y.1
Adcock, I.M.2
Catley, M.3
Barnes, P.J.4
Newton, R.5
-
62
-
-
3542996841
-
Resveratrol inhibits cyclooxygenase-2 transcription and activity in phorbol ester-treated human mammary epithelial cells
-
Subbaramaiah, K. et al. Resveratrol inhibits cyclooxygenase-2 transcription and activity in phorbol ester-treated human mammary epithelial cells. J. Biol. Chem. 273, 21875-21882 (1998). This paper provides the first evidence for the inhibitory effects of resveratrol on the transcription and activity of COX2 by targeting CRE and PKC.
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 21875-21882
-
-
Subbaramaiah, K.1
-
63
-
-
0006365030
-
Resveratrol inhibits cyclooxygenase-2 transcription in human mammary epithelial cells
-
Subbaramaiah, K. et al. Resveratrol inhibits cyclooxygenase-2 transcription in human mammary epithelial cells. Ann. NY Acad. Sci. 889, 214-223 (1999).
-
(1999)
Ann. NY Acad. Sci.
, vol.889
, pp. 214-223
-
-
Subbaramaiah, K.1
-
64
-
-
0037051715
-
Food-derived poyphenols inhibit pancreatic cancer growth through mitochondrial cytochrome C release and apoptosis
-
Mouria, M. et al. Food-derived poyphenols inhibit pancreatic cancer growth through mitochondrial cytochrome C release and apoptosis. Int. J. Cancer 98, 761-769 (2002).
-
(2002)
Int. J. Cancer
, vol.98
, pp. 761-769
-
-
Mouria, M.1
-
65
-
-
0036733776
-
Suppression of 7,12-dimethylbenz(a)anthracene-induced mammary carcinogenesis in rats by resveratrol: Role of nuclear factor-κB, cyclooxygenase 2, and matrix metalloprotease 9
-
Banerjee, S., Bueso-Ramos, C. & Aggarwal, B. B. Suppression of 7,12-dimethylbenz(a)anthracene-induced mammary carcinogenesis in rats by resveratrol: role of nuclear factor-κB, cyclooxygenase 2, and matrix metalloprotease 9. Cancer Res. 62, 4945-4954 (2002).
-
(2002)
Cancer Res.
, vol.62
, pp. 4945-4954
-
-
Banerjee, S.1
Bueso-Ramos, C.2
Aggarwal, B.B.3
-
66
-
-
0037457308
-
Differential expression of genes induced by resveratrol in LNCaP cells: p53-mediated molecular targets
-
Narayanan, B. A., Narayanan, N. K., Re, G. G. & Nixon, D. W. Differential expression of genes induced by resveratrol in LNCaP cells: p53-mediated molecular targets. Int. J. Cancer 104, 204-212 (2003).
-
(2003)
Int. J. Cancer
, vol.104
, pp. 204-212
-
-
Narayanan, B.A.1
Narayanan, N.K.2
Re, G.G.3
Nixon, D.W.4
-
67
-
-
0035866404
-
Resveratrol-induced activation of p53 and apoptosis is mediated by extracellular-signal-regulated protein kinases and p38 kinase
-
She, Q. B., Bode, A. M., Ma, W. Y., Chen, N. Y. & Dong, Z. Resveratrol-induced activation of p53 and apoptosis is mediated by extracellular-signal-regulated protein kinases and p38 kinase. Cancer Res. 61, 1604-1610 (2001).
-
(2001)
Cancer Res.
, vol.61
, pp. 1604-1610
-
-
She, Q.B.1
Bode, A.M.2
Ma, W.Y.3
Chen, N.Y.4
Dong, Z.5
-
68
-
-
0034948728
-
Resveratrol inhibits phorbol ester and UV-induced activator protein 1 activation by interfering with mitogen-activated protein kinase pathways
-
Yu, R. et al. Resveratrol inhibits phorbol ester and UV-induced activator protein 1 activation by interfering with mitogen-activated protein kinase pathways. Mol. Pharmacol. 60, 217-224 (2001).
-
(2001)
Mol. Pharmacol.
, vol.60
, pp. 217-224
-
-
Yu, R.1
-
69
-
-
0037251437
-
Suppression of ultraviolet B exposure-mediated activation of NF-κB in normal human keratinocytes by resveratrol
-
Adhami, V. M., Afaq, F. & Ahmad, N. Suppression of ultraviolet B exposure-mediated activation of NF-κB in normal human keratinocytes by resveratrol. Neoplasia 5, 74-82 (2003).
-
(2003)
Neoplasia
, vol.5
, pp. 74-82
-
-
Adhami, V.M.1
Afaq, F.2
Ahmad, N.3
-
70
-
-
0034660659
-
Resveratrol suppresses TNF-induced activation of nuclear transcription factors NF-κB, activator protein-1, and apoptosis: Potential role of reactive oxygen intermediates and lipid peroxidation
-
Manna, S. K., Mukhopadhyay, A. & Aggarwal, B. B. Resveratrol suppresses TNF-induced activation of nuclear transcription factors NF-κB, activator protein-1, and apoptosis: potential role of reactive oxygen intermediates and lipid peroxidation. J. Immunol. 164, 6509-6519 (2000).
-
(2000)
J. Immunol.
, vol.164
, pp. 6509-6519
-
-
Manna, S.K.1
Mukhopadhyay, A.2
Aggarwal, B.B.3
-
71
-
-
0034234254
-
Chemopreventive properties of trans-resveratrol are associated with inhibition of activation of the IκB kinase
-
Holmes-McNary, M. & Baldwin, A. S. Jr. Chemopreventive properties of trans-resveratrol are associated with inhibition of activation of the IκB kinase. Cancer Res. 60, 3477-3483 (2000).
-
(2000)
Cancer Res.
, vol.60
, pp. 3477-3483
-
-
Holmes-McNary, M.1
Baldwin A.S., Jr.2
-
72
-
-
0035965945
-
Molecular basis for the contribution of the antioxidant responsive element to cancer chemoprevention
-
Hayes, J. D. & McMahon, M. Molecular basis for the contribution of the antioxidant responsive element to cancer chemoprevention. Cancer Lett. 174, 103-113 (2001).
-
(2001)
Cancer Lett.
, vol.174
, pp. 103-113
-
-
Hayes, J.D.1
McMahon, M.2
-
73
-
-
0031577292
-
An Nrf2/small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elements
-
Itoh, K. et al. An Nrf2/small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elements. Biochem. Biophys. Res. Commun. 236, 313-322 (1997). A pioneering study elucidating an essential role of NRF2 in the transcriptional induction of phase II enzymes. Targeted disruption of the Nrf2 gene abolished phase II enzyme induction (this paper) and Nrf2-deficient mice are prone to chemically-induced carcinogenesis (references 75 and 84).
-
(1997)
Biochem. Biophys. Res. Commun.
, vol.236
, pp. 313-322
-
-
Itoh, K.1
-
74
-
-
0037424262
-
Modulation of gene expression by cancer chemopreventive dithiolethiones through the Keap1-Nrf2 pathway. Identification of novel gene clusters for cell survival
-
Kwak, M. K. et al. Modulation of gene expression by cancer chemopreventive dithiolethiones through the Keap1-Nrf2 pathway. Identification of novel gene clusters for cell survival. J. Biol. Chem. 278, 8135-8145 (2003).
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 8135-8145
-
-
Kwak, M.K.1
-
75
-
-
0035853157
-
Sensitivity to carcinogenesis is increased and chemoprotective efficacy of enzyme inducers is lost in nrf2 transcription factor-deficient mice
-
Ramos-Gomez, M. et al. Sensitivity to carcinogenesis is increased and chemoprotective efficacy of enzyme inducers is lost in nrf2 transcription factor-deficient mice. Proc. Natl Acad. Sci. USA 98, 3410-3415 (2001).
-
(2001)
Proc. Natl. Acad. Sci. USA
, vol.98
, pp. 3410-3415
-
-
Ramos-Gomez, M.1
-
76
-
-
0035836698
-
An important function of Nrf2 in combating oxidative stress: Detoxification of acetaminophen
-
Chan, K., Han, X. D. & Kan, Y. W. An important function of Nrf2 in combating oxidative stress: detoxification of acetaminophen. Proc. Natl Acad Sci. USA 98, 4611-4616 (2001).
-
(2001)
Proc. Natl. Acad Sci. USA
, vol.98
, pp. 4611-4616
-
-
Chan, K.1
Han, X.D.2
Kan, Y.W.3
-
77
-
-
0035870298
-
The Cap'n'Collar basic leucine zipper transcription factor Nrf2 (NF-E2 p45-related factor 2) controls both constitutive and inducible expression of intestinal detoxification and glutathione biosynthetic enzymes
-
McMahon, M. et al. The Cap'n'Collar basic leucine zipper transcription factor Nrf2 (NF-E2 p45-related factor 2) controls both constitutive and inducible expression of intestinal detoxification and glutathione biosynthetic enzymes. Cancer Res. 61, 3299-3307 (2001).
-
(2001)
Cancer Res.
, vol.61
, pp. 3299-3307
-
-
McMahon, M.1
-
78
-
-
0036007313
-
Role of NRF2 in protection against hyperoxic lung injury in mice
-
Cho, H Y. et al. Role of NRF2 in protection against hyperoxic lung injury in mice. Am. J. Respir. Cell Mol. Biol. 26, 175-182 (2002).
-
(2002)
Am. J. Respir. Cell Mol. Biol.
, vol.26
, pp. 175-182
-
-
Cho, H.Y.1
-
79
-
-
0037101768
-
Loss of the Nrf2 transcription factor causes a marked reduction in constitutive and inducible expression of the glutathione S-transferase Gsta1, Gsta2, Gstm1, Gstm2, Gstm3 and Gstm4 genes in the livers of male and female mice
-
Chanas, S. A. et al. Loss of the Nrf2 transcription factor causes a marked reduction in constitutive and inducible expression of the glutathione S-transferase Gsta1, Gsta2, Gstm1, Gstm2, Gstm3 and Gstm4 genes in the livers of male and female mice. Biochem J. 365, 405-416 (2002).
-
(2002)
Biochem J.
, vol.365
, pp. 405-416
-
-
Chanas, S.A.1
-
80
-
-
0037106099
-
Identification of Nrf2-regulated genes induced by the chemopreventive agent sulforaphane by oligonucleotide microarray
-
Thimmulappa, R. K. et al. Identification of Nrf2-regulated genes induced by the chemopreventive agent sulforaphane by oligonucleotide microarray. Cancer Res. 62, 5196-5203 (2002).
-
(2002)
Cancer Res.
, vol.62
, pp. 5196-5203
-
-
Thimmulappa, R.K.1
-
81
-
-
0035153227
-
High sensitivity of Nrf2 knockout mice to acetaminophen hepatotoxicity associated with decreased expression of ARE-regulated drug metabolizing enzymes and antioxidant genes
-
Enomoto, A. et al. High sensitivity of Nrf2 knockout mice to acetaminophen hepatotoxicity associated with decreased expression of ARE-regulated drug metabolizing enzymes and antioxidant genes. Toxicol. Sci. 59, 169-177 (2001).
-
(2001)
Toxicol. Sci.
, vol.59
, pp. 169-177
-
-
Enomoto, A.1
-
82
-
-
0034717329
-
Transcription factor Nrf2 coordinately regulates a group of oxidative stress-inducible genes in macrophages
-
Ishii, T. et al. Transcription factor Nrf2 coordinately regulates a group of oxidative stress-inducible genes in macrophages. J. Biol. Chem. 275, 16023-16029 (2000).
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 16023-16029
-
-
Ishii, T.1
-
83
-
-
13044304201
-
Nrf2 is essential for protection against acute pulmonary injury in mice
-
Chan, K. & Kan, Y. W. Nrf2 is essential for protection against acute pulmonary injury in mice. Proc. Natl Acad. Sci. USA 96, 12731-12736 (1999).
-
(1999)
Proc. Natl. Acad. Sci. USA
, vol.96
, pp. 12731-12736
-
-
Chan, K.1
Kan, Y.W.2
-
84
-
-
0037356451
-
Interactive effects of nrf2 genotype and oltipraz on benzo[alpyrene-DNA adducts and tumor yield in mice
-
Ramos-Gomez, M., Dolan, P. M., Itoh, K., Yamamoto, M. & Kensler, T. W. Interactive effects of nrf2 genotype and oltipraz on benzo[alpyrene-DNA adducts and tumor yield in mice. Carcinogenesis 24, 461-467 (2003).
-
(2003)
Carcinogenesis
, vol.24
, pp. 461-467
-
-
Ramos-Gomez, M.1
Dolan, P.M.2
Itoh, K.3
Yamamoto, M.4
Kensler, T.W.5
-
85
-
-
0035451390
-
Role of phase 2 enzyme induction in chemoprotection by dithiolethiones
-
Kwak, M. K. et al. Role of phase 2 enzyme induction in chemoprotection by dithiolethiones. Mutat. Res. 480-481, 305-315 (2001).
-
(2001)
Mutat. Res.
, vol.480-481
, pp. 305-315
-
-
Kwak, M.K.1
-
86
-
-
0033543566
-
Nrf2, a Cap'n'Collar transcription factor, regulates induction of the heme oxygenase-1 gene
-
Alam, J. et al. Nrf2, a Cap'n'Collar transcription factor, regulates induction of the heme oxygenase-1 gene. J. Biol. Chem. 274, 26071-26078 (1999).
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 26071-26078
-
-
Alam, J.1
-
87
-
-
0034672595
-
Impared expression of glutathione synthetic enzyme genes in mice with targeted deletion of the Nrf2 basic-leucine zipper protein
-
Chan, J. Y. & Kwong, M. Impared expression of glutathione synthetic enzyme genes in mice with targeted deletion of the Nrf2 basic-leucine zipper protein. Biochim. Biophys. Acta 1517, 19-26 (2000).
-
(2000)
Biochim. Biophys. Acta
, vol.1517
, pp. 19-26
-
-
Chan, J.Y.1
Kwong, M.2
-
88
-
-
0034685897
-
Transcriptional regulation of the antioxidant response element. Activation by Nrf2 and repression by MafK
-
Nguyen, T., Huang, H. C. & Pickett, C. B. Transcriptional regulation of the antioxidant response element. Activation by Nrf2 and repression by MafK. J. Biol. Chem. 275, 15456-15473 (2000).
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 15456-15473
-
-
Nguyen, T.1
Huang, H.C.2
Pickett, C.B.3
-
89
-
-
0032953192
-
Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain
-
Itoh, K. et al. Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain. Genes Dev. 13, 76-86 (1999).
-
(1999)
Genes Dev.
, vol.13
, pp. 76-86
-
-
Itoh, K.1
-
90
-
-
0035853101
-
Potency of Michael reaction acceptors as inducers of enzymes that protect against carcinogenesis depends on their reactivity with sulfhydryl groups
-
Dinkova-Kostova, A. T., Massiah, M. A., Bozak, R. E., Hicks, R. J. & Talalay, P. Potency of Michael reaction acceptors as inducers of enzymes that protect against carcinogenesis depends on their reactivity with sulfhydryl groups. Proc. Natl Acad. Sci. USA 98, 3404-3409 (2001).
-
(2001)
Proc. Natl. Acad. Sci. USA
, vol.98
, pp. 3404-3409
-
-
Dinkova-Kostova, A.T.1
Massiah, M.A.2
Bozak, R.E.3
Hicks, R.J.4
Talalay, P.5
-
91
-
-
0037015035
-
Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants
-
Dinkova-Kostova, A. T. et al. Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants. Proc. Nat. Acad. Sci. USA 99, 11908-11913 (2002). This work provides the first direct evidence for the formation of complexes of KEAP1 with the NEH2 domain of NRF2, which is disrupted by phase II enzyme inducers, such as sulphoraphane. Sulphoraphane directly reacts with critical cysteine residues of KEAP1 stoichiometrically.
-
(2002)
Proc. Nat. Acad. Sci. USA
, vol.99
, pp. 11908-11913
-
-
Dinkova-Kostova, A.T.1
-
92
-
-
0035853138
-
Chemoprevention: Increased potential to bear fruit
-
Wolf, C. R. Chemoprevention: increased potential to bear fruit. Proc. Natl Acad. Sci. USA 98, 2941-2943 (2001).
-
(2001)
Proc. Natl. Acad. Sci. USA
, vol.98
, pp. 2941-2943
-
-
Wolf, C.R.1
-
93
-
-
0142144332
-
Peroxisome proliferator-activated receptor γ (PPARγ) ligands as bifunctional regulators of cell proliferation
-
Na, H.-K. & Surh, Y.-J. Peroxisome proliferator-activated receptor γ (PPARγ) ligands as bifunctional regulators of cell proliferation. Biochem. Pharmacol. 66, 1381-1391 (2003).
-
(2003)
Biochem. Pharmacol.
, vol.66
, pp. 1381-1391
-
-
Na, H.-K.1
Surh, Y.-J.2
-
94
-
-
0031408813
-
Activation of mitogen-activated protein kinases by green tea polyphenols: Potential signaling pathways in the regulation of antioxidant-responsive element-mediated phase II enzyme gene expression
-
Yu, R. et al. Activation of mitogen-activated protein kinases by green tea polyphenols: potential signaling pathways in the regulation of antioxidant-responsive element-mediated phase II enzyme gene expression. Carcinogenesis 18, 451-456 (1997). Here, the molecular basis for induction of phase II enzymes by green-tea polyphenol was demonstrated. Green-tea polyphenol stimulates transcription of phase II enzymes through ARE, which seems to be regulated by MAPK.
-
(1997)
Carcinogenesis
, vol.18
, pp. 451-456
-
-
Yu, R.1
-
95
-
-
0034573074
-
Activation of antioxidant-response element (ARE), mitogen-activated protein kinases (MAPKs) and caspases by major green tea polyphenol components during cell survival and death
-
Chen, C., Yu, R., Owuor, E. D. & Kong, A. N. Activation of antioxidant-response element (ARE), mitogen-activated protein kinases (MAPKs) and caspases by major green tea polyphenol components during cell survival and death. Arch. Pharm. Res. 23, 605-612 (2000).
-
(2000)
Arch. Pharm. Res.
, vol.23
, pp. 605-612
-
-
Chen, C.1
Yu, R.2
Owuor, E.D.3
Kong, A.N.4
-
96
-
-
0035212419
-
Induction of xenobiotic enzymes by the MAP kinase pathway and the antioxidant or electrophile response element (ARE/EpRE)
-
Kong, A. N. et al. Induction of xenobiotic enzymes by the MAP kinase pathway and the antioxidant or electrophile response element (ARE/EpRE). Drug Metab. Rev. 33, 255-271 (2001).
-
(2001)
Drug Metab. Rev.
, vol.33
, pp. 255-271
-
-
Kong, A.N.1
-
97
-
-
0033600914
-
Role of a mitogen-activated protein kinase pathway in the induction of phase II detoxifying enzymes by chemicals
-
Yu, R. et al. Role of a mitogen-activated protein kinase pathway in the induction of phase II detoxifying enzymes by chemicals. J. Biol. Chem. 274, 27545-27552 (1999).
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 27545-27552
-
-
Yu, R.1
-
98
-
-
0036479330
-
A sulforaphane analogue that potently activates the Nrf2-dependent detoxification pathway
-
Morimitsu, Y. et al. A sulforaphane analogue that potently activates the Nrf2-dependent detoxification pathway. J. Biol. Chem. 277, 3456-3463 (2002).
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 3456-3463
-
-
Morimitsu, Y.1
-
99
-
-
0037569694
-
Curcumin activates the haem oxygenase-1 gene via regulation of Nrf2 and the antioxidant-responsive element
-
Balogun, E. et al. Curcumin activates the haem oxygenase-1 gene via regulation of Nrf2 and the antioxidant-responsive element. Biochem. J. 371, 887-895 (2003).
-
(2003)
Biochem. J.
, vol.371
, pp. 887-895
-
-
Balogun, E.1
-
100
-
-
0037366092
-
Curcumin alters EpRE and AP-1 binding complexes and elevates glutamate-cysteine ligase gene expression
-
Dickinson, D. A., Iles, K. E., Zhang, H., Blank, V. & Forman, H. J. Curcumin alters EpRE and AP-1 binding complexes and elevates glutamate-cysteine ligase gene expression. FASEB J. 17, 473-475 (2003).
-
(2003)
FASEB J.
, vol.17
, pp. 473-475
-
-
Dickinson, D.A.1
Iles, K.E.2
Zhang, H.3
Blank, V.4
Forman, H.J.5
-
101
-
-
0027185632
-
From cadherins to catenins: Cytoplasmic protein interactions and regulation of cell adhesion
-
Kemler, R. From cadherins to catenins: cytoplasmic protein interactions and regulation of cell adhesion. Trends Genet. 9, 317-321 (1993).
-
(1993)
Trends Genet.
, vol.9
, pp. 317-321
-
-
Kemler, R.1
-
102
-
-
0030000980
-
Cadherin-catenin complex: Protein interactions and their implications for cadherin function
-
Aberle, H., Schwartz, H. & Kemler, R. Cadherin-catenin complex: protein interactions and their implications for cadherin function. J. Cell Biochem. 61, 514-523 (1996).
-
(1996)
J. Cell Biochem.
, vol.61
, pp. 514-523
-
-
Aberle, H.1
Schwartz, H.2
Kemler, R.3
-
103
-
-
0033486152
-
β-catenin signaling and cancer
-
Morin, P. J. β-catenin signaling and cancer. Bioessays 21, 1021-1030 (1999).
-
(1999)
Bioessays
, vol.21
, pp. 1021-1030
-
-
Morin, P.J.1
-
104
-
-
0028987249
-
Regulation of intracellular β-catenin levels by the adenomatous polyposis coli (APC) tumor-suppressor protein
-
Munemitsu, S., Albert, I., Souza, B., Rubinfeld, B. & Polakis, P. Regulation of intracellular β-catenin levels by the adenomatous polyposis coli (APC) tumor-suppressor protein. Proc. Natl Acad. Sci. USA 92, 3046-3050 (1995).
-
(1995)
Proc. Natl. Acad. Sci. USA
, vol.92
, pp. 3046-3050
-
-
Munemitsu, S.1
Albert, I.2
Souza, B.3
Rubinfeld, B.4
Polakis, P.5
-
105
-
-
0029664368
-
Binding of GSK3β to the APC-β-catenin complex and regulation of complex assembly
-
Rubinfeld, B. et al. Binding of GSK3β to the APC-β-catenin complex and regulation of complex assembly. Science 272, 1023-1026 (1996). This important paper provides evidence for the role of GSK-3β as a regulator of APC β-catenin binding. APC is a good substrate for GSK.
-
(1996)
Science
, vol.272
, pp. 1023-1026
-
-
Rubinfeld, B.1
-
106
-
-
0030779038
-
Serine phospharylation-regulated ubiquitination and degradation of β-catenin
-
Orford, K., Crockett, C., Jensen, J. P., Weissman, A. M. & Byers, S. W. Serine phospharylation-regulated ubiquitination and degradation of β-catenin. J. Biol. Chem. 272, 24735-24738 (1997).
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 24735-24738
-
-
Orford, K.1
Crockett, C.2
Jensen, J.P.3
Weissman, A.M.4
Byers, S.W.5
-
107
-
-
0036855439
-
Phosphorylation and regulation of β-catenin by casein kinase I epsilon
-
Sakanaka, C. Phosphorylation and regulation of β-catenin by casein kinase I epsilon. J. Biochem. 132, 697-703 (2002).
-
(2002)
J. Biochem.
, vol.132
, pp. 697-703
-
-
Sakanaka, C.1
-
108
-
-
0036571011
-
Axin-mediated CKI phosphorylation of β-catenin at Ser 45: A molecular switch for the Wnt pathway
-
Amit, S. et al. Axin-mediated CKI phosphorylation of β-catenin at Ser 45: a molecular switch for the Wnt pathway. Genes Dev. 16, 1066-1076 (2002).
-
(2002)
Genes Dev.
, vol.16
, pp. 1066-1076
-
-
Amit, S.1
-
109
-
-
0037155691
-
Control of β-catenin phosphorylation/degradation by a dual-kinase mechanism
-
Liu, C. et al. Control of β-catenin phosphorylation/degradation by a dual-kinase mechanism. Cell 108, 837-847 (2002).
-
(2002)
Cell
, vol.108
, pp. 837-847
-
-
Liu, C.1
-
110
-
-
0034859101
-
The multifaceted roles of glycogen synthase kinase 3β in cellular signaling
-
Grimes, C. A. & Jope, R. S. The multifaceted roles of glycogen synthase kinase 3β in cellular signaling. Prog. Neurobiol. 85, 391-426 (2001).
-
(2001)
Prog. Neurobiol.
, vol.85
, pp. 391-426
-
-
Grimes, C.A.1
Jope, R.S.2
-
111
-
-
0033895709
-
Wnt signaling and cancer
-
Polakis, P. Wnt signaling and cancer. Genes Dev. 14, 1837-1851 (2000).
-
(2000)
Genes Dev.
, vol.14
, pp. 1837-1851
-
-
Polakis, P.1
-
112
-
-
0034088858
-
AXIN1 mutations in hepatocellular carcinomas, and growth suppression in cancer cells by virus-mediated transfer of AXIN1
-
Satoh, S. et al. AXIN1 mutations in hepatocellular carcinomas, and growth suppression in cancer cells by virus-mediated transfer of AXIN1. Nature Genet. 24, 245-250 (2000).
-
(2000)
Nature Genet.
, vol.24
, pp. 245-250
-
-
Satoh, S.1
-
113
-
-
0032729458
-
Signaling through β-catenin and Lef/Tcf
-
Novak, A. & Dedhar, S. Signaling through β-catenin and Lef/Tcf. Cell Mol. Life Sci. 56, 523-537 (1999).
-
(1999)
Cell Mol. Life Sci.
, vol.56
, pp. 523-537
-
-
Novak, A.1
Dedhar, S.2
-
114
-
-
0036174452
-
β-catenin: A linchpin in colorectal carcinogenesis?
-
Wong, N. A. & Pignatelli, M. β-catenin: a linchpin in colorectal carcinogenesis? Am. J. Pathol. 160, 389-401 (2002).
-
(2002)
Am. J. Pathol.
, vol.160
, pp. 389-401
-
-
Wong, N.A.1
Pignatelli, M.2
-
115
-
-
1642562179
-
ITF-2, a downstream target of the Wnt/TCF pathway, is activated in human cancers with β-catenin defects and promotes neoplastic transformation
-
Kolligs, F. T. et al. ITF-2, a downstream target of the Wnt/TCF pathway, is activated in human cancers with β-catenin defects and promotes neoplastic transformation. Cancer Cell 1, 145-155 (2002).
-
(2002)
Cancer Cell
, vol.1
, pp. 145-155
-
-
Kolligs, F.T.1
-
116
-
-
0037310126
-
Regulation of cyclooxygenase-2 expresson by the Wnt and ras pathways
-
Araki, Y. et al. Regulation of cyclooxygenase-2 expresson by the Wnt and ras pathways. Cancer Res. 63, 728-734 (2003).
-
(2003)
Cancer Res.
, vol.63
, pp. 728-734
-
-
Araki, Y.1
-
117
-
-
0034019660
-
Plant phenolics decrease intestinal tumors in an animal model of familial adenomatous polyposis
-
Mahmoud, N. N. et al. Plant phenolics decrease intestinal tumors in an animal model of familial adenomatous polyposis. Carcinogenesis 21, 921-927 (2000).
-
(2000)
Carcinogenesis
, vol.21
, pp. 921-927
-
-
Mahmoud, N.N.1
-
118
-
-
0037028207
-
β-catenin-mediated transactivation and cell-cell adhesion pathways are important in curcumin (diferaylmethane)-induced growth arrest and apoptosis in colon cancer cells
-
Jaiswal, A. S., Marlow, B. P., Gupta, N. & Narayan, S. β-catenin-mediated transactivation and cell-cell adhesion pathways are important in curcumin (diferaylmethane)-induced growth arrest and apoptosis in colon cancer cells. Oncogene 21, 8414-8427 (2002).
-
(2002)
Oncogene
, vol.21
, pp. 8414-8427
-
-
Jaiswal, A.S.1
Marlow, B.P.2
Gupta, N.3
Narayan, S.4
-
119
-
-
0036301453
-
Resveratrol induces growth inhibition, S-phase arrest, apoptosis, and changes in biomarker expression in several human cancer cell lines
-
Joe, A. K. et al. Resveratrol induces growth inhibition, S-phase arrest, apoptosis, and changes in biomarker expression in several human cancer cell lines. Clin. Cancer Res. 8, 893-903 (2002).
-
(2002)
Clin. Cancer Res.
, vol.8
, pp. 893-903
-
-
Joe, A.K.1
-
120
-
-
0036384133
-
Inhibition of β-catenin/Tcf activity by white tea, green tea, and epigallocatechin-3-gallate (EGCG): Minor contribution of H(2)O(2) at physiologically relevant EGCG concentrations
-
Dashwood, W. M., Orner, G. A. & Dashwood, R. H. Inhibition of β-catenin/Tcf activity by white tea, green tea, and epigallocatechin-3-gallate (EGCG): minor contribution of H(2)O(2) at physiologically relevant EGCG concentrations. Biochem. Biophys. Res. Commun. 296, 584-588 (2002).
-
(2002)
Biochem. Biophys. Res. Commun.
, vol.296
, pp. 584-588
-
-
Dashwood, W.M.1
Orner, G.A.2
Dashwood, R.H.3
-
121
-
-
0037201536
-
ΔNβ-cat mutant mice to treatment with tea, sulindac, and 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)
-
ΔNβ-cat mutant mice to treatment with tea, sulindac, and 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP). Mutat. Res. 506-507, 121-127 (2002).
-
(2002)
Mutat. Res.
, vol.506-507
, pp. 121-127
-
-
Orner, G.A.1
-
122
-
-
0035112690
-
β-Catenin mutation in rat colon tumors initiated by 1,2-dimethylhydrazine and 2-amino-3-methylimidazo[4,5-f]quinoline, and the effect of post-initiation treatment with chlorophyllin and indole-3-carbinol
-
Blum, C. A. et al. β-Catenin mutation in rat colon tumors initiated by 1,2-dimethylhydrazine and 2-amino-3-methylimidazo[4,5-f]quinoline, and the effect of post-initiation treatment with chlorophyllin and indole-3-carbinol. Carcinogenesis 22, 315-320 (2001).
-
(2001)
Carcinogenesis
, vol.22
, pp. 315-320
-
-
Blum, C.A.1
-
123
-
-
0034042381
-
Suppression of breast cancer invasion and migration by indole-3-carbinol: Associated with upregulation of BRCA1 and E-cadherin/catenin complexes
-
Meng, Q. et al. Suppression of breast cancer invasion and migration by indole-3-carbinol: associated with upregulation of BRCA1 and E-cadherin/catenin complexes. J. Mol. Med. 78, 155-165 (2000).
-
(2000)
J. Mol. Med.
, vol.78
, pp. 155-165
-
-
Meng, Q.1
-
124
-
-
0035989520
-
The citrus methoxyflavone tangeretin affects human cell-cell interactions
-
Brack, M. E. et al. The citrus methoxyflavone tangeretin affects human cell-cell interactions. Adv. Exp. Med. Biol. 505, 135-139 (2002).
-
(2002)
Adv. Exp. Med. Biol.
, vol.505
, pp. 135-139
-
-
Brack, M.E.1
-
125
-
-
0033028647
-
Relationship of β-catenin and Bcl-2 expression to sulindac-induced regression of intestinal tumors in Min mice
-
McEntee, M. F., Chiu, C. H. & Whelan, J. Relationship of β-catenin and Bcl-2 expression to sulindac-induced regression of intestinal tumors in Min mice. Carcinogenesis 20, 635-640 (1999).
-
(1999)
Carcinogenesis
, vol.20
, pp. 635-640
-
-
McEntee, M.F.1
Chiu, C.H.2
Whelan, J.3
-
126
-
-
0035252741
-
The nonsteroidal anti-inflammatory drugs aspirin and indomethacin attenuate β-catenin/TCF-4 signaling
-
Dihlmann, S., Siermann, A. & von Knebel Doeberitz, M. The nonsteroidal anti-inflammatory drugs aspirin and indomethacin attenuate β-catenin/TCF-4 signaling. Oncogene 20, 645-653 (2001).
-
(2001)
Oncogene
, vol.20
, pp. 645-653
-
-
Dihlmann, S.1
Siermann, A.2
Von Knebel Doeberitz, M.3
-
127
-
-
17144451419
-
Chemoprevention of large bowel carcinogenesis; the role of control of cell proliferation and significance of β-catenin-accumulated crypts as a new biomarker
-
Mori, H. et al. Chemoprevention of large bowel carcinogenesis; the role of control of cell proliferation and significance of β-catenin-accumulated crypts as a new biomarker. Eur. J. Cancer Prev. 11 (Suppl. 2), S71-S75 (2002).
-
(2002)
Eur. J. Cancer Prev.
, vol.11
, Issue.SUPPL. 2
-
-
Mori, H.1
-
128
-
-
0032813348
-
Molecular mechanisms of chemopreventive effects of selected dietary and medicinal phenolic substances
-
Surh, Y. Molecular mechanisms of chemopreventive effects of selected dietary and medicinal phenolic substances. Mut. Res. 428, 305-327 (1999).
-
(1999)
Mut. Res.
, vol.428
, pp. 305-327
-
-
Surh, Y.1
-
129
-
-
0042709227
-
Osteopontin stimulates cell motility and nuclear factor κB-mediated secretion of urokinase type plasminogen activator through phosphatidylinositol 3-kinase/Akt signaling pathways in breast cancer cells
-
in the press
-
Das, R., Mahabeleshwar, G. H. & Kundu, G. C. Osteopontin stimulates cell motility and nuclear factor κB-mediated secretion of urokinase type plasminogen activator through phosphatidylinositol 3-kinase/Akt signaling pathways in breast cancer cells. J. Biol. Chem. (in the press).
-
J. Biol. Chem.
-
-
Das, R.1
Mahabeleshwar, G.H.2
Kundu, G.C.3
-
130
-
-
0034859081
-
The green tea polyphenol (-)-epigallocatechin-3-gallate blocks nuclear factor-κB activation by inhibiting Iκ B kinase activity in the intestinal epithelial cell line IEC-6
-
Yang, F. et al. The green tea polyphenol (-)-epigallocatechin-3-gallate blocks nuclear factor-κB activation by inhibiting Iκ B kinase activity in the intestinal epithelial cell line IEC-6. Mol. Pharm. 60, 528-533 (2001).
-
(2001)
Mol. Pharm.
, vol.60
, pp. 528-533
-
-
Yang, F.1
-
131
-
-
0037044791
-
Phosphorylation of Nrf2 at Ser-40 by protein kinase C regulates antioxidant response element-mediated transcription
-
Huang, H. C., Nguyen, T. & Pickett, C. B. Phosphorylation of Nrf2 at Ser-40 by protein kinase C regulates antioxidant response element-mediated transcription. J. Biol. Chem. 277, 42769-42774 (2002).
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 42769-42774
-
-
Huang, H.C.1
Nguyen, T.2
Pickett, C.B.3
-
132
-
-
0037357385
-
Activation of CCAAT/enhancer-binding protein β by 2′-amino-3′-methoxyflavone (PD98059) leads to the induction of glutathione S-transferase A2
-
Kang, K. W., Park, E. Y. & Kim, S. G. Activation of CCAAT/enhancer-binding protein β by 2′-amino-3′-methoxyflavone (PD98059) leads to the induction of glutathione S-transferase A2. Carcinogenesis 24, 475-482 (2003).
-
(2003)
Carcinogenesis
, vol.24
, pp. 475-482
-
-
Kang, K.W.1
Park, E.Y.2
Kim, S.G.3
-
133
-
-
0035827505
-
Phosphatidylinositol 3-kinase, not extracellular signal-regulated kinase, regulates activation of the antioxidant-responsive element in IMR-32 human neuroblastoma cells
-
Lee, J. M., Hanson, J. M., Chu, W. A. & Johnson, J. A. Phosphatidylinositol 3-kinase, not extracellular signal-regulated kinase, regulates activation of the antioxidant-responsive element in IMR-32 human neuroblastoma cells. J. Biol. Chem. 276, 20011-20016 (2001).
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 20011-20016
-
-
Lee, J.M.1
Hanson, J.M.2
Chu, W.A.3
Johnson, J.A.4
|