Flavokawain B, a novel chalcone from Alpinia pricei Hayata with potent apoptotic activity: Involvement of ROS and GADD153 upstream of mitochondria-dependent apoptosis in HCT116 cells

Free Radical Biology and Medicine

Volumn 49, Issue 2, 2010, Pages 214-226

  Kuo, Yu Feng ^a   Su, Ying Zhen ^a   Tseng, Yen Hsueh ^a   Wang, Sheng Yang ^a   Wang, Hsi Ming ^a   Chueh, Pin Ju ^a  

^a NATIONAL CHUNG HSING UNIVERSITY   (Taiwan)

Author keywords

Alpinia pricei Hayata; Anticancer; Apoptosis; Flavokawain B; Flavonoid; Free radicals; GADD153; ROS

Indexed keywords

ACETYLCYSTEINE; CHALCONE DERIVATIVE; CYTOCHROME C; FLAVOKAWAIN B; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; PROTEIN BAK; PROTEIN BCL 2; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG;

ALPINIA; ALPINIA PRICEI; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; AUTOPHAGY; CANCER CELL CULTURE; CANCER INHIBITION; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CELL PROLIFERATION; CELL STRAIN HCT116; CELL VIABILITY; COLON CANCER; COLONY FORMATION; CONFOCAL MICROSCOPY; CONTROLLED STUDY; CYTOFLUOROMETRY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; DRUG ACTIVITY; GENE SILENCING; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; MOLECULAR MECHANICS; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA INTERFERENCE; UPREGULATION; WESTERN BLOTTING;

ALPINIA; APOPTOSIS; CYTOCHROMES C; FLAVONOIDS; GENE EXPRESSION REGULATION; HCT116 CELLS; HUMANS; MEDICINE, CHINESE TRADITIONAL; MITOCHONDRIA; PROTO-ONCOGENE PROTEINS C-BCL-2; REACTIVE OXYGEN SPECIES; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTOR CHOP;

ALPINIA; ALPINIA PRICEI;

EID: 77953534370     PISSN: 08915849     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2010.04.005     Document Type: Article

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