Reactive oxygen species-mediated induction of apoptosis by a plant alkaloid 6-methoxydihydrosanguinarine in HepG2 cells

Biochemical Pharmacology

Volumn 70, Issue 2, 2005, Pages 242-248

  Yin, Hu Quan ^a,b   Kim, Young Ho ^c   Moon, Chang Kiu ^a   Lee, Byung Hoon ^a,b  

^a Seoul National University   (South Korea)

^b Wonkwang University   (South Korea)

^c Chungnam National University   (South Korea)

Author keywords

6 Methoxydihydrosanguinarine (6ME); Antioxidant; Apoptosis; Cytochrome c; HepG2; p53 bax; Reactive oxygen species (ROS)

Indexed keywords

6 METHOXYDIHYDROSANGUINARINE; ALKALOID; ANTINEOPLASTIC AGENT; CYTOCHROME C; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROTEIN BAX; PROTEIN P53; PROTEINASE; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CELL GROWTH; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; ENZYME ACTIVATION; GROWTH INHIBITION; HEP 2 CELL; HUMAN; HUMAN CELL; INCUBATION TIME; LIVER CELL CARCINOMA; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION;

ALKALOIDS; APOPTOSIS; BENZOPHENANTHRIDINES; CELL LINE, TUMOR; HUMANS; ISOQUINOLINES; PHENANTHRIDINES; PLANT EXTRACTS; REACTIVE OXYGEN SPECIES;

EID: 20444502200     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcp.2005.04.020     Document Type: Article

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