Involvement of NF-κB and c-myc signaling pathways in the apoptosis of HL-60 cells induced by alkaloids of Tripterygium hypoglaucum (levl.) Hutch

Phytomedicine

Volumn 11, Issue 4, 2004, Pages 295-302

  Zhuang, W J ^a   Fong, C C ^a   Cao, J ^b   Ao, L ^b   Leung, C H ^a   Cheung, H Y ^a   Xiao, P G ^c   Fong, W F ^a   Yang, M S ^a  

^a CITY UNIVERSITY OF HONG KONG   (Hong Kong)

^b THIRD MILITARY MEDICAL UNIVERSITY   (China)

^c PEKING UNION MEDICAL COLLEGE   (China)

Author keywords

Apoptosis; CDNA microarray; Cytotoxicity; Tripterygium hypoglaucum (levl.) Hutch extracts

Indexed keywords

ALKALOID; CASPASE 3; CASPASE 8; CELL PROTEIN; COMPLEMENTARY DNA; GENE PRODUCT; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MYC PROTEIN; PLANT EXTRACT; PROTEIN B2M; PROTEIN NFKBIB; PROTEIN PRG1; RNA; TRIPTERYGIUM HYPOGLAUCUM EXTRACT; UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT; DNA;

APOPTOSIS; ARTICLE; AUTOIMMUNE DISEASE; CELL STRAIN HL 60; CHINESE MEDICINE; CONFOCAL MICROSCOPY; DNA LIBRARY; DNA MICROARRAY; DNA STRUCTURE; DRUG CYTOTOXICITY; ENZYME ASSAY; ENZYME REGULATION; FLOW CYTOMETRY; FLUORESCENCE MICROSCOPY; GENE EXPRESSION REGULATION; GENE IDENTIFICATION; HUMAN; HUMAN CELL; IMMUNOMODULATION; MEDICINAL PLANT; MOLECULAR MECHANICS; NUCLEOTIDE SEQUENCE; PLANT ROOT; PRIORITY JOURNAL; PROTEIN BINDING; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA ANALYSIS; SIGNAL TRANSDUCTION; TRIPTERYGIUM HYPOGLAUCUM; WESTERN BLOTTING; DRUG EFFECT; METABOLISM; PHYTOTHERAPY; TRIPTERYGIUM;

CELASTRACEAE; TRIPTERYGIUM; TRIPTERYGIUM HYPOGLAUCUM;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; BLOTTING, WESTERN; DNA, NEOPLASM; FLOW CYTOMETRY; HL-60 CELLS; HUMANS; MICROSCOPY, CONFOCAL; NF-KAPPA B; PHYTOTHERAPY; PLANT EXTRACTS; PLANT ROOTS; PROTO-ONCOGENE PROTEINS C-MYC; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TRIPTERYGIUM;

EID: 2442637447     PISSN: 09447113     EISSN: None     Source Type: Journal    
DOI: 10.1078/0944711041495128     Document Type: Article

References (21)

1. Athanasios GP (1997) Transcription factors in Eukaryotes. Chapman and Hall, New York
2. Cameron RG and Feuer G, Eds. (2000) Apoptosis and its modulation by drug. Springer, New York
3. Cao J, Nusse M (1999) Tripterygium hypoglaucum induced apoptosis in Jurkat and two other cell lines. Ke Shui Ton Pao 44: 1169-1173
4. Chen M, Wang J (2002) Initiator caspases in apoptosis signaling pathway. Apoptosis 7: 313-319
5. Collins SJ, Gallo RC, Gallagher RE (1977) Continuous growth and differentiation of human myeloid leukemic cell in suspension culture. Nature 270: 347-349
6. Dang CV (1999) c-Myc target genes involved in cell growth, apoptosis, and metabolism. Mol Cell Biol 19: 1-11
7. Hegde P, Qi R, Abernathy K, Gay C, Dharap S, Gaspard R, Hughes JE, Snesrud E, Lee N, Quackenbush J (2000) A concise guide to cDNA microarray analysis. Biotechniques 29: 548-556
8. Hozumi M (1998) Differentiation therapy of leukemia: achievements, limitations and future prospects. Int J Hematol 68: 107-129
9. Jacobson MD, Weil M, Raff MC (1997) Programmed cell death in animal development. Cell 88: 347-354
10. Kerr JFR, Wyllie AH, Currie AR (1972) Apoptosis: a biological phenomenon with wide-ranging implications in tissue kinetics. Br J Cancer 26: 239-257
11. Mateyak MK, Obaya AJ, Adachi S, Sedivy JM (1997) Phenotypes of c-Myc-deficient rat fibroblasts isolated by targeted homologous recombination. Cell Growth Differ 8: 1039-1048
12. Nagane M, Huang H-JS, Cavenee WK (2001) The potential of TRAIL for cancer chemotherapy. Apoptosis 6: 191-197
13. Packham G, Cleveland JL (1995) c-Myc and apoptosis. Biochim Biophys Acta 1242: 11-28
14. Rendergast GC (1999) Mechanisms of apoptosis by c-Myc. Oncogene 18: 2967-2987
15. Ross GC, George F (1999) Apoptosis and its modulation by drug. Springer Press
16. Schafer H, Trauzold A, Siegel EG, Folsch UR, Schmidt WE (1996) PRG1: a novel early-response gene transcriptionally induced by pituitary adenylate cyclase activating polypeptide in a pancreatic carcinoma cell line. Cancer Res 56 (11): 2641-2648
17. Sonenshein GE (1997) Down-modulation of c-Myc expression induces apoptosis of B lymphocyte models of tolerance via clonal deletion. J Immunol 158: 1994-1997
18. Skew DS, Ashmun RA, Simmons BC, Cleveland JL (1991) Constitutive c-myc expression in an IL-3-dependent myeloid cell line suppresses cell cycle arrest and accelerates apoptosis. Oncogene 6: 1915-1922
19. Thornberry NA, Lazebnik Y (1998) Caspases: Enemies within. Science 281: 1312-1316
20. Wang X, Zhuo R, He Z (1993) Aneuploid induction by water extract from Tripterygium hypoglaucum (levl.) Hutch in mouse bone marrow cells. Mutagenesis 8: 395-398
21. Zhao XZ (1992) Effects of Astragalus membranaceus and Tripterygium hypoglancum on natural killer cell activity of peripheral blood mononuclear in systemic lupus erythematosus. Chung Kuo Chung Hsi I Chieh Ho Tsa Chih 12: 669-671