Butein induces G2/M phase arrest and apoptosis in human hepatoma cancer cells through ROS generation

Cancer Letters

Volumn 288, Issue 2, 2010, Pages 204-213

  Moon, Dong Oh ^a   Kim, Mun Ock ^a   Choi, Yung Hyun ^b   Hyun, Jin Won ^a,c   Chang, Weon Young ^a,c   Kim, Gi Young ^a  

^a Jeju National University   (South Korea)

^b Dong Eui University   (South Korea)

^c Jeju National University School of Medicine   (South Korea)

Author keywords

Apoptosis; Butein; G2 M phase arrest; JNK; ROS

Indexed keywords

ACETYLCYSTEINE; ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; ATM PROTEIN; BUTEIN; CDC25C PROTEIN; CELL CYCLE PROTEIN; CHECKPOINT KINASE 1; CHECKPOINT KINASE 2; CYCLIN DEPENDENT KINASE 1; GLUTATHIONE; REACTIVE OXYGEN METABOLITE; STRESS ACTIVATED PROTEIN KINASE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER INHIBITION; CELL CYCLE ARREST; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CELL STRAIN HEPG2; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG EFFECT; DRUG MECHANISM; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; HEPATOMA CELL; HUMAN; HUMAN CELL; LIVER CELL CARCINOMA; PRIORITY JOURNAL; PROTEIN FUNCTION;

ACETYLCYSTEINE; ANTHRACENES; ANTINEOPLASTIC AGENTS; ANTIOXIDANTS; APOPTOSIS; CARCINOMA, HEPATOCELLULAR; CELL CYCLE PROTEINS; CELL DIVISION; CELL PROLIFERATION; CELL SURVIVAL; CHALCONES; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME ACTIVATION; G2 PHASE; GLUTATHIONE; HEP G2 CELLS; HUMANS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; LIVER NEOPLASMS; PHOSPHORYLATION; PROTEIN KINASE INHIBITORS; REACTIVE OXYGEN SPECIES;

EID: 74849131331     PISSN: 03043835     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.canlet.2009.07.002     Document Type: Article

References (35)

1. Nowak A.K., Chow P.K.H., and Findlay M. Systemic therapy for advanced hepatocellular carcinoma: a review. Eur. J. Cancer 40 (2004) 1474-1484
2. Wang X.W., Hussain S.P., Huo T.I., Wu C.G., Forgues M., Hofseth L.J., Brechot C., and Harris C.C. Molecular pathogenesis of human hepatocellular carcinoma. Toxicology 181-182 (2002) 43-47
3. Feig D.I., Reid T.M., and Loeb L.A. Reactive oxygen species in tumorigenesis. Cancer Res. 54 (1994) 1890-1894
4. Schumacker P.T. Reactive oxygen species in cancer cells: live by the sword, die by the sword. Cancer Cell 10 (2006) 175-176
5. Le B.M., Clement M.V., Pervaiz S., and Brenner C. Reactive oxygen species and the mitochondrial signaling pathway of cell death. Histol. Histopathol. 20 (2005) 205-219
6. Sauer H., Wartenberg M., and Hescheler J. Reactive oxygen species as intracellular messengers during cell growth and differentiation. Cell. Physiol. Biochem. 11 (2001) 173-186
7. Piret B., Schoonbroodt S., and Piette J. The ATM protein is required for sustained activation of NF-κB following DNA damage. Oncogene 18 (1999) 2261-2271
8. Moungjaroen J., Nimmannit U., Callery P.S., Wang L., Azad N., Lipipun V., Chanvorachote P., and Rojanasakul Y. Reactive oxygen species mediate caspase activation and apoptosis induced by lipoic acid in human lung epithelial cancer cells through Bcl-2 down-regulation. J. Pharmacol. Exp. Ther. 319 (2006) 1062-1069
9. 2-terminal kinase-dependent activation of mitochondrial pathway. Biochem. Pharmacol. 70 (2005) 1398-1407
10. 2-terminal kinase (JNK). Cancer Res. 64 (2004) 1902-1905
11. Ling Y.H., Liebes L., Zou Y., and Perez-Soler R. Reactive oxygen species generation and mitochondrial dysfunction in the apoptotic response to Bortezomib, a novel proteasome inhibitor, in human H460 non-small cell lung cancer cells. J. Biol. Chem. 278 (2003) 33714-33723
12. Kuo P.L., Chen C.Y., and Hsu Y.L. Isoobtusilactone A induces cell cycle arrest and apoptosis through reactive oxygen species/apoptosis signal-regulating kinase 1 signaling pathway in human breast cancer cells. Cancer Res. 67 (2007) 7406-7420
13. Kim N.Y., Pae H.O., Oh G.S., Kang T.H., Kim Y.C., Rhew H.Y., and Chung H.T. Butein, a plant polyphenol, induces apoptosis concomitant with increased caspase-3 activity, decreased Bcl-2 expression and increased Bax expression in HL-60 cells. Pharmacol. Toxicol. 88 (2001) 261-266
14. Iwashita K., Kobori M., Yamaki K., and Tsushida T. Flavonoids inhibit cell growth and induce apoptosis in B16 melanoma 4A5 cells. Biosci. Biotechnol. Biochem. 64 (2000) 1813-1820
15. Wang Y., Chan F.L., Chen S., and Leung L.K. The plant polyphenol butein inhibits testosterone-induced proliferation in breast cancer cells expressing aromatase. Life Sci. 77 (2005) 39-51
16. Samoszuk M., Tan J., and Chorn G. The chalcone butein from Rhus verniciflua stokes inhibits clonogenic growth of human breast cancer cells co-cultured with fibroblasts, BMC complement. Altern. Med. 5 (2005) 1-5
17. Yit C.C., and Das N.P. Cytotoxic effect of butein on human colon adenocarcinoma cell proliferation. Cancer Lett. 82 (1994) 65-72
18. Jang H.S., Kook S.H., Son Y.O., Kim J.G., Jeon Y.M., Jang Y.S., Choi K.C., Kim J., Han S.K., Lee K.Y., Park B.K., Cho N.P., and Lee J.C. Flavonoids purified from Rhus verniciflua stokes actively inhibit cell growth and induce apoptosis in human osteosarcoma cells. Biochim. Biophys. Acta 1726 (2005) 309-316
19. Lee S.H., Seo G.S., Kim H.S., Woo S.W., Ko G., and Sohn D.H. 2′, 4′, 6′-Tris(methoxymethoxy) chalcone attenuates hepatic stellate cell proliferation by a heme oxygenase-dependent pathway. Biochem. Pharmacol. 72 (2006) 1322-1333
20. Krejsa C.M., and Schieven G.L. Detection of oxidative stress in lymphocytes using dichlorodihydrofluorescein diacetate. Methods Mol. Biol. 99 (2000) 35-47
21. Gautier J., Solomon M.J., Booher R.N., Bazan J.F., and Kirschner M.W. Cdc25 is a specific tyrosine phosphatase that directly activates p34cdc2. Cell 67 (1991) 197-211
22. Sanchez Y., Wong C., Thoma R.S., Richman R., Wu Z., Piwnica-Worms H., and Elledge S.J. Conservation of the Chk1 checkpoint pathway in mammals: linkage of DNA damage to Cdk regulation through Cdc25. Science 277 (1997) 1497-1501
23. 2-terminal kinase 1 activation in HeLa cells. J. Pharmacol. Exp. Ther. 319 (2006) 1276-1285
24. Cory S., and Adams J.M. The Bcl2 family: regulators of the cellular life-or-death switch. Nat. Rev. Cancer 2 (2002) 647-656
25. Stennicke H.R., and Salvesen G.S. Properties of the caspases. Biochim. Biophys. Acta 1387 (1998) 17-31
26. Ka H., Park H.J., Jung H.J., Choi J.W., Cho K.S., Ha J., and Lee K.T. Cinnamaldehyde induces apoptosis by ROS-mediated mitochondrial permeability transition in human promyelocytic leukemia HL-60 cells. Cancer Lett. 196 (2003) 143-152
27. Ueda S., Nakamura H., Masutani H., Sasada T., Takabayashi A., Yamaoka Y., and Yodoi J. Baicalin induces apoptosis via mitochondrial pathway as prooxidant. Mol. Immunol. 38 (2002) 781-791
28. Davies K.J., and Hochstein P. Ubisemiquinone radicals in liver: implications for a mitochondrial Q cycle in vivo. Biochem. Biophys. Res. Commun. 107 (1982) 1292-1299
29. Oh S.H., and Lim S.C. A rapid and transient ROS generation by cadmium triggers apoptosis via caspase-dependent pathway in HepG2 cells and this is inhibited through N-acetylcysteine-mediated catalase upregulation. Toxicol. Appl. Pharmacol. 212 (2006) 212-223
30. Haddad J.J. Redox and oxidant-mediated regulation of apoptosis signaling pathways: immuno-pharmaco-redox conception of oxidative siege versus cell death commitment. Int. Immunopharmacol. 4 (2004) 475-493
31. Melchionna R., Chen X.B., Blasina A., and McGowan C.H. Threonine 68 is required for radiation-induced phosphorylation and activation of Cds1. Nat. Cell Biol. 2 (2000) 762-765
32. Matsuoka S., Rotman G., Ogawa A., Shiloh Y., Tamai K., and Elledge S.J. Ataxia telangiectasia-mutated phosphorylates Chk2 in vivo and in vitro. Proc. Natl. Acad. Sci. USA 97 (2000) 10389-10394
33. Bartek J., and Lukas J. Chk1 and Chk2 kinases in checkpoint control and cancer. Cancer Cell 3 (2003) 421-429
34. Ikegami T., Matsuzaki Y., Al Rashid M., Ceryak S., Zhang Y., and Bouscarel B. Enhancement of DNA topoisomerase I inhibitor-induced apoptosis by ursodeoxycholic acid. Mol. Cancer Ther. 5 (2006) 68-79
35. 2-terminal kinase pathway. Mol. Cancer Ther. 6 (2007) 184-192